BRPI0514741A - derivados de hexahidro-pirazino[1, 2-a]pirimidina-4, 7-diona substituìdos por aminoácidos - Google Patents

derivados de hexahidro-pirazino[1, 2-a]pirimidina-4, 7-diona substituìdos por aminoácidos

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Publication number
BRPI0514741A
BRPI0514741A BRPI0514741-7A BRPI0514741A BRPI0514741A BR PI0514741 A BRPI0514741 A BR PI0514741A BR PI0514741 A BRPI0514741 A BR PI0514741A BR PI0514741 A BRPI0514741 A BR PI0514741A
Authority
BR
Brazil
Prior art keywords
pyrimidine
pyrazino
amino acid
acid substituted
dione derivatives
Prior art date
Application number
BRPI0514741-7A
Other languages
English (en)
Inventor
Peter Lennig
Siegfried Stengelin
Thomas Klabunde
Matthias Gossel
Pavel Safar
Martin Smrcina
James Spoonamore
Gregory Merriman
Joseph T Klein
Brian Whiteley
Carolina Lanter
Kenneth Bordeau
Zhaoxia Yang
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of BRPI0514741A publication Critical patent/BRPI0514741A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
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  • Cardiology (AREA)
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  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
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Abstract

DERIVADOS DE HEXAHIDRO-PIRAZINO¢1,2-A!PIRIMIDINA-4,7-DIONA SUBSTITUìDOS POR AMINOáCIDOS A invenção refere-se a derivados de hexahidropirazino¢1 ,2-a!pirimidina-4,7-diona assim como a seus sais fisiologicamente compatíveis e derivados fisiologicamente funcionais. São descritos compostos de fórmula (I) nos quais os radicais têm os significados indicados, assim como seus sais fisiologicamente compatíveis, e processos para sua preparação. Os compostos são apropriados por exemplo como anoréticos.
BRPI0514741-7A 2004-08-31 2005-08-16 derivados de hexahidro-pirazino[1, 2-a]pirimidina-4, 7-diona substituìdos por aminoácidos BRPI0514741A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004042441A DE102004042441A1 (de) 2004-08-31 2004-08-31 Mit Aminosäuren substituierte Hexahydro-pyrazino(1,2-a)pyrimidin-4,7-dionderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PCT/EP2005/008873 WO2006024390A1 (de) 2004-08-31 2005-08-16 Mit aminosäuren substituierte hexahydro-pyrazino[1,2-a]pyrimidin-4, 7-dionderivate

Publications (1)

Publication Number Publication Date
BRPI0514741A true BRPI0514741A (pt) 2008-06-24

Family

ID=35624108

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514741-7A BRPI0514741A (pt) 2004-08-31 2005-08-16 derivados de hexahidro-pirazino[1, 2-a]pirimidina-4, 7-diona substituìdos por aminoácidos

Country Status (12)

Country Link
US (1) US7994168B2 (pt)
EP (1) EP1799683A1 (pt)
JP (1) JP2008511562A (pt)
KR (1) KR20070047818A (pt)
CN (1) CN1993364A (pt)
AU (1) AU2005279407A1 (pt)
BR (1) BRPI0514741A (pt)
CA (1) CA2578780A1 (pt)
DE (1) DE102004042441A1 (pt)
IL (1) IL181520A0 (pt)
MX (1) MX2007002361A (pt)
WO (1) WO2006024390A1 (pt)

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EP2794565B1 (en) 2011-12-21 2017-07-26 Novira Therapeutics Inc. Hepatitis b antiviral agents
CA2881057C (en) 2012-08-28 2020-10-27 Janssen Sciences Ireland Uc Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b
JP6466348B2 (ja) 2013-02-28 2019-02-06 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー スルファモイル−アリールアミドおよびｂ型肝炎を処置するための医薬品としてのその使用
HUE033542T2 (en) 2013-04-03 2017-12-28 Janssen Sciences Ireland Uc Their use as medicaments for the treatment of N-phenylcarboxamide derivatives and hepatitis B
HUE040446T2 (hu) 2013-05-17 2019-03-28 Janssen Sciences Ireland Uc Szulfamoiltiofenamid-származékok és gyógyszerként történõ alkalmazásuk hepatitis B kezelésére
TW202126620A (zh) 2013-05-17 2021-07-16 愛爾蘭商健生科學愛爾蘭無限公司 胺磺醯基吡咯醯胺衍生物及其作為用於治療ｂ型肝炎藥物的用途
WO2015011281A1 (en) 2013-07-25 2015-01-29 Janssen R&D Ireland Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
MX368158B (es) 2013-10-23 2019-09-20 Janssen Sciences Ireland Uc Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b.
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US10392349B2 (en) 2014-01-16 2019-08-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
JP6553059B2 (ja) 2014-02-05 2019-07-31 ノヴィラ・セラピューティクス・インコーポレイテッド Ｈｂｖ感染の治療のための併用療法
PL3102572T3 (pl) 2014-02-06 2019-04-30 Janssen Sciences Ireland Uc Pochodne sulfamoilopirolamidu i ich zastosowanie jako leki do leczenia wirusowego zapalenia wątroby typu B
EP3271019A1 (en) 2015-03-19 2018-01-24 Novira Therapeutics Inc. Azocane and azonane derivatives and methods of treating hepatitis b infections
US10875876B2 (en) 2015-07-02 2020-12-29 Janssen Sciences Ireland Uc Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
AR106192A1 (es) 2015-09-29 2017-12-20 Novira Therapeutics Inc Formas cristalinas de un agente antiviral contra la hepatitis b
WO2017181141A2 (en) 2016-04-15 2017-10-19 Novira Therapeutics, Inc. Combinations and methods comprising a capsid assembly inhibitor
SG11202007097QA (en) 2018-03-14 2020-08-28 Janssen Sciences Ireland Unlimited Co Capsid assembly modulator dosing regimen
AU2020223865A1 (en) 2019-02-22 2021-07-15 Janssen Sciences Ireland Unlimited Company Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases
BR112021021454A2 (pt) 2019-05-06 2021-12-21 Janssen Sciences Ireland Unlimited Co Derivados de amida úteis no tratamento da infecção por hbv ou doenças induzidas por hbv

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184223B1 (en) * 1995-10-27 2001-02-06 Molecumetics Ltd. Reverse-turn mimetics and methods relating thereto
US6294525B1 (en) * 1999-09-01 2001-09-25 Molecumetics Ltd. Reverse-turn mimetics and methods relating thereto
AU2004212043A1 (en) * 2003-02-13 2004-08-26 Sanofi-Aventis Deutschland Gmbh Nitrogen-substituted hexahydropyrazino(1,2-a)pyrimidine-4,7-dione derivatives, method for the production and use thereof as medicaments
US7652007B2 (en) * 2003-02-13 2010-01-26 Sanofi-Aventis Deutschland Gmbh Nitrogen-substituted hexahydropyrazino[1,2-A]pyrimidine-4,7-dione derivatives, processes for their preparation and their use as medicaments
US7390814B2 (en) * 2003-02-13 2008-06-24 Sanofi-Aventis Deutschland Gmbh Substituted hexahydropyrazino [1,2-a] pyrimidine-4,7-dione derivatives, process for their preparation and their use as medicaments
ATE472548T1 (de) * 2003-02-13 2010-07-15 Sanofi Aventis Deutschland Substituierte hexahydro-pyrazino(1,2-a)pyrimidin- 4,7-dionderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
KR20070047818A (ko) 2007-05-07
AU2005279407A1 (en) 2006-03-09
IL181520A0 (en) 2007-07-04
DE102004042441A1 (de) 2006-04-06
WO2006024390A1 (de) 2006-03-09
CN1993364A (zh) 2007-07-04
EP1799683A1 (de) 2007-06-27
CA2578780A1 (en) 2006-03-09
US20070197539A1 (en) 2007-08-23
JP2008511562A (ja) 2008-04-17
MX2007002361A (es) 2007-05-07
US7994168B2 (en) 2011-08-09

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