BRPI0514741A - derivados de hexahidro-pirazino[1, 2-a]pirimidina-4, 7-diona substituìdos por aminoácidos - Google Patents

derivados de hexahidro-pirazino[1, 2-a]pirimidina-4, 7-diona substituìdos por aminoácidos

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Publication number
BRPI0514741A
BRPI0514741A BRPI0514741-7A BRPI0514741A BRPI0514741A BR PI0514741 A BRPI0514741 A BR PI0514741A BR PI0514741 A BRPI0514741 A BR PI0514741A BR PI0514741 A BRPI0514741 A BR PI0514741A
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BR
Brazil
Prior art keywords
pyrimidine
pyrazino
amino acid
acid substituted
dione derivatives
Prior art date
Application number
BRPI0514741-7A
Other languages
English (en)
Inventor
Peter Lennig
Siegfried Stengelin
Thomas Klabunde
Matthias Gossel
Pavel Safar
Martin Smrcina
James Spoonamore
Gregory Merriman
Joseph T Klein
Brian Whiteley
Carolina Lanter
Kenneth Bordeau
Zhaoxia Yang
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of BRPI0514741A publication Critical patent/BRPI0514741A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Dermatology (AREA)
  • Endocrinology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Communicable Diseases (AREA)
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  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
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Abstract

DERIVADOS DE HEXAHIDRO-PIRAZINO¢1,2-A!PIRIMIDINA-4,7-DIONA SUBSTITUìDOS POR AMINOáCIDOS A invenção refere-se a derivados de hexahidropirazino¢1 ,2-a!pirimidina-4,7-diona assim como a seus sais fisiologicamente compatíveis e derivados fisiologicamente funcionais. São descritos compostos de fórmula (I) nos quais os radicais têm os significados indicados, assim como seus sais fisiologicamente compatíveis, e processos para sua preparação. Os compostos são apropriados por exemplo como anoréticos.
BRPI0514741-7A 2004-08-31 2005-08-16 derivados de hexahidro-pirazino[1, 2-a]pirimidina-4, 7-diona substituìdos por aminoácidos BRPI0514741A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004042441A DE102004042441A1 (de) 2004-08-31 2004-08-31 Mit Aminosäuren substituierte Hexahydro-pyrazino(1,2-a)pyrimidin-4,7-dionderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PCT/EP2005/008873 WO2006024390A1 (de) 2004-08-31 2005-08-16 Mit aminosäuren substituierte hexahydro-pyrazino[1,2-a]pyrimidin-4, 7-dionderivate

Publications (1)

Publication Number Publication Date
BRPI0514741A true BRPI0514741A (pt) 2008-06-24

Family

ID=35624108

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514741-7A BRPI0514741A (pt) 2004-08-31 2005-08-16 derivados de hexahidro-pirazino[1, 2-a]pirimidina-4, 7-diona substituìdos por aminoácidos

Country Status (12)

Country Link
US (1) US7994168B2 (pt)
EP (1) EP1799683A1 (pt)
JP (1) JP2008511562A (pt)
KR (1) KR20070047818A (pt)
CN (1) CN1993364A (pt)
AU (1) AU2005279407A1 (pt)
BR (1) BRPI0514741A (pt)
CA (1) CA2578780A1 (pt)
DE (1) DE102004042441A1 (pt)
IL (1) IL181520A0 (pt)
MX (1) MX2007002361A (pt)
WO (1) WO2006024390A1 (pt)

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BR112014015197A8 (pt) 2011-12-21 2017-06-13 Novira Therapeutics Inc agentes antivirais de hepatite b
KR102271574B1 (ko) 2012-08-28 2021-07-01 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 설파모일-아릴아미드 및 b형 간염 치료제로서의 그 용도
WO2014131847A1 (en) 2013-02-28 2014-09-04 Janssen R&D Ireland Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b
MX353412B (es) 2013-04-03 2018-01-10 Janssen Sciences Ireland Uc Derivados de n-fenil-carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b.
DK2997019T3 (en) 2013-05-17 2018-12-03 Janssen Sciences Ireland Uc SULFAMOYLTHIOPHENAMIDE DERIVATIVES AND USE THEREOF AS MEDICINES FOR TREATING HEPATITIS B
TWI733288B (zh) 2013-05-17 2021-07-11 愛爾蘭商健生科學愛爾蘭無限公司 胺磺醯基吡咯醯胺衍生物及其作為用於治療ｂ型肝炎藥物的用途
HRP20180791T1 (hr) 2013-07-25 2018-09-07 Janssen Sciences Ireland Uc Glioksamid supstituirani derivati pirolamida i njihova uporaba kao lijekova za liječenje hepatitisa b
CA2923712C (en) 2013-10-23 2021-11-02 Janssen Sciences Ireland Uc Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US10392349B2 (en) 2014-01-16 2019-08-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
CA2936947A1 (en) 2014-02-05 2015-08-13 Novira Therapeutics, Inc. Combination therapy for treatment of hbv infections
TW201620893A (zh) 2014-02-06 2016-06-16 健生科學愛爾蘭無限公司 磺醯胺基吡咯醯胺衍生物及其用作治療ｂ型肝炎之醫藥品的用途
JP2018510159A (ja) 2015-03-19 2018-04-12 ノヴィラ・セラピューティクス・インコーポレイテッド アゾカン及びアゾナン誘導体及びｂ型肝炎感染症の治療法
US10875876B2 (en) 2015-07-02 2020-12-29 Janssen Sciences Ireland Uc Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
TW201718496A (zh) 2015-09-29 2017-06-01 諾維拉治療公司 B型肝炎抗病毒劑之晶型
AU2017248828A1 (en) 2016-04-15 2018-11-01 Janssen Sciences Ireland Uc Combinations and methods comprising a capsid assembly inhibitor
MX2020009531A (es) 2018-03-14 2020-10-05 Janssen Sciences Ireland Unlimited Co Regimen posologico del modulador del ensamblaje de la capside.
WO2020169784A1 (en) 2019-02-22 2020-08-27 Janssen Sciences Ireland Unlimited Company Amide derivatives useful in the treatment of hbv infection or hbv-induced diseases
AR119732A1 (es) 2019-05-06 2022-01-05 Janssen Sciences Ireland Unlimited Co Derivados de amida útiles en el tratamiento de la infección por vhb o de enfermedades inducidas por vhb

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
US6184223B1 (en) * 1995-10-27 2001-02-06 Molecumetics Ltd. Reverse-turn mimetics and methods relating thereto
US6294525B1 (en) * 1999-09-01 2001-09-25 Molecumetics Ltd. Reverse-turn mimetics and methods relating thereto
WO2004072077A1 (de) * 2003-02-13 2004-08-26 Aventis Pharma Deutshland Gmbh STICKSTOFF SUBSTITUIERTE HEXAHYDRO-PYRAZINO[1,2-a]PYRIMIDIN-4,7-DIONDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL
US7652007B2 (en) * 2003-02-13 2010-01-26 Sanofi-Aventis Deutschland Gmbh Nitrogen-substituted hexahydropyrazino[1,2-A]pyrimidine-4,7-dione derivatives, processes for their preparation and their use as medicaments
US7390814B2 (en) * 2003-02-13 2008-06-24 Sanofi-Aventis Deutschland Gmbh Substituted hexahydropyrazino [1,2-a] pyrimidine-4,7-dione derivatives, process for their preparation and their use as medicaments
RU2005128497A (ru) * 2003-02-13 2006-01-27 Санофи-Авентис Дойчленд Гмбх (De) Замещенные производные гексагидропиразино (1,2-а) пиримидин-4,7-диона, способы их получения и их применение в качестве лекарственных средств

Also Published As

Publication number Publication date
US7994168B2 (en) 2011-08-09
MX2007002361A (es) 2007-05-07
CN1993364A (zh) 2007-07-04
US20070197539A1 (en) 2007-08-23
AU2005279407A1 (en) 2006-03-09
JP2008511562A (ja) 2008-04-17
WO2006024390A1 (de) 2006-03-09
CA2578780A1 (en) 2006-03-09
DE102004042441A1 (de) 2006-04-06
EP1799683A1 (de) 2007-06-27
IL181520A0 (en) 2007-07-04
KR20070047818A (ko) 2007-05-07

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