BR0207172A - Pirido-pirimidinas 6-substituìdas - Google Patents

Pirido-pirimidinas 6-substituìdas

Info

Publication number
BR0207172A
BR0207172A BR0207172-0A BRPI0207172A BR0207172A BR 0207172 A BR0207172 A BR 0207172A BR PI0207172 A BRPI0207172 A BR PI0207172A BR 0207172 A BR0207172 A BR 0207172A
Authority
BR
Brazil
Prior art keywords
substituted pyrido
pyrimidines
pyrido pyrimidines
formula
substituted
Prior art date
Application number
BR0207172-0A
Other languages
English (en)
Inventor
Jian Jeffrey Chen
James Patrick Dunn
David Michael Goldstein
Christoph Martin Stahl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0207172A publication Critical patent/BR0207172A/pt
Publication of BRPI0207172B1 publication Critical patent/BRPI0207172B1/pt
Publication of BRPI0207172B8 publication Critical patent/BRPI0207172B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"PIRIDO-PIRIMIDINAS 6-SUBSTITUìDAS". A presente invenção refere-se a compostos da Fórmula I e II: Fórmula II em que R^ 1^, R^ 3^, W, Z, X^ 1^, ?, ~ x~2, ~ Ar~1<sym>, R^ 8^ e R^ 9^ são como definidos aqui, processos e intermediários para sua preparação e seu uso para o tratamento de distúrbios mediados por p38.
BR0207172-0 2001-02-12 2002-02-04 pirido-pirimidinas 6-substituída, sua composição e seu uso, bem como seu intermediário BRPI0207172B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26837501P 2001-02-12 2001-02-12
US60/268,375 2001-02-12
US33465401P 2001-11-30 2001-11-30
US60/334,654 2001-11-30
PCT/EP2002/001106 WO2002064594A2 (en) 2001-02-12 2002-02-04 6-substituted pyrido-pyrimidines

Publications (3)

Publication Number Publication Date
BR0207172A true BR0207172A (pt) 2004-03-30
BRPI0207172B1 BRPI0207172B1 (pt) 2019-04-09
BRPI0207172B8 BRPI0207172B8 (pt) 2021-05-25

Family

ID=26953040

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0207172-0 BRPI0207172B8 (pt) 2001-02-12 2002-02-04 pirido-pirimidinas 6-substituída, sua composição e seu uso, bem como seu intermediário

Country Status (31)

Country Link
US (3) US6696566B2 (pt)
EP (1) EP1361880B1 (pt)
JP (1) JP4064818B2 (pt)
KR (1) KR100639772B1 (pt)
CN (1) CN100376571C (pt)
AR (1) AR035854A1 (pt)
AT (1) ATE305303T1 (pt)
AU (1) AU2002256615B2 (pt)
BR (1) BRPI0207172B8 (pt)
CA (1) CA2434834C (pt)
CZ (1) CZ20032416A3 (pt)
DE (1) DE60206363T2 (pt)
DK (1) DK1361880T3 (pt)
ES (1) ES2249574T3 (pt)
HR (1) HRP20030624B1 (pt)
HU (1) HU229604B1 (pt)
IL (2) IL156872A0 (pt)
JO (1) JO2410B1 (pt)
MA (1) MA26993A1 (pt)
MX (1) MXPA03007166A (pt)
MY (1) MY131518A (pt)
NO (1) NO326133B1 (pt)
NZ (1) NZ526961A (pt)
PA (1) PA8539201A1 (pt)
PE (1) PE20020976A1 (pt)
PL (1) PL366918A1 (pt)
RU (1) RU2269527C2 (pt)
SK (1) SK11322003A3 (pt)
WO (1) WO2002064594A2 (pt)
YU (1) YU63703A (pt)
ZA (1) ZA200305938B (pt)

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ATE314370T1 (de) * 2002-01-22 2006-01-15 Warner Lambert Co 2-(pyridin-2-ylamino)-pyrido(2,3-d)pyrimidin-7- one
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CA2492112A1 (en) * 2002-08-06 2004-02-19 F. Hoffmann-La Roche Ag 6-alkoxy-pyrido-pyrimidines as p-38 map kinase inhibitors
US20040225077A1 (en) 2002-12-30 2004-11-11 Angiotech International Ag Drug delivery from rapid gelling polymer composition
RS53118B (sr) * 2003-02-26 2014-06-30 Sugen Inc. Aminoheteroaril jedinjenja kao inhibitori protein kinaze
EP1620105B1 (en) * 2003-04-16 2007-01-10 F. Hoffmann-La Roche Ag (6-(phenoxy)-pyrido¬3,4-d|pyrimidin-2-yl)-amine derivatives as p38 kinase inhibitors for the treatment of inflammatory conditions such as rheumatoid arthritis
BRPI0416030A (pt) * 2003-11-13 2007-01-02 Hoffmann La Roche pirido-7-pirimidin-7-onas substituìdas com hidroxialquila
US20090131430A1 (en) * 2004-11-23 2009-05-21 Palle Venkata P Pyrido'2,3-dipyrimidines as anti-inflammatory agents
US20060142312A1 (en) * 2004-12-23 2006-06-29 Pfizer Inc C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones
EP1846403A1 (en) * 2005-02-02 2007-10-24 Ranbaxy Laboratories Limited Azabicyclo derivatives as anti-inflammatory agents
WO2006119504A2 (en) * 2005-05-04 2006-11-09 Renovis, Inc. Fused heterocyclic compounds, and compositions and uses thereof
WO2007009911A1 (en) * 2005-07-21 2007-01-25 F. Hoffmann-La Roche Ag PYRIDO [2 , 3-D] PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS
AU2006279992A1 (en) * 2005-08-09 2007-02-22 Irm Llc Compounds and compositions as protein kinase inhibitors
EP1917245A1 (de) 2005-08-21 2008-05-07 Abbott GmbH & Co. KG Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
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MX2008014908A (es) * 2006-05-26 2009-05-13 Toyama Chemical Co Ltd Compuesto heterociclico nuevo o sal del mismo e intermedio del mismo.
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US8022085B2 (en) 2007-05-07 2011-09-20 Amgen Inc. Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof
WO2008151992A2 (en) 2007-06-15 2008-12-18 F. Hoffmann-La Roche Ag A novel process for the preparation of 3-amino-pentan-1,5-diol
US8367671B2 (en) 2008-03-21 2013-02-05 Amgen Inc. Pyrazolo[3.4-B]pyrazine compounds as p38 modulators and methods of use as anti-inflamatory agents
EP2112150B1 (en) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Improved raf inhibitors
JP2012505927A (ja) * 2008-10-22 2012-03-08 エフ．ホフマン−ラ ロシュ アーゲー Ｊｎｋのピリミジニルピリドン阻害剤
WO2010071846A2 (en) 2008-12-19 2010-06-24 Afraxis, Inc. Compounds for treating neuropsychiatric conditions
EP2486037A4 (en) 2009-10-09 2013-01-16 Afraxis Inc 8-ETHYL-6- (ARYL) PYRIDO [2,3-D] PYRIMIDIN-7 (8H) -ONES FOR THE TREATMENT OF CNS DISORDERS
JP5797664B2 (ja) * 2009-12-18 2015-10-21 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイションＴｅｍｐｌｅ Ｕｎｉｖｅｒｓｉｔｙ−Ｏｆ Ｔｈｅ Ｃｏｍｍｏｎｗｅａｌｔｈ Ｓｙｓｔｅｍ Ｏｆ Ｈｉｇｈｅｒ Ｅｄｕｃａｔｉｏｎ 置換ピリド［２，３−ｄ］ピリミジン−７（８Ｈ）−オン及びそれらの治療用の使用
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PL3468604T3 (pl) * 2016-06-08 2021-07-12 Support-Venture Gmbh Kombinacje farmaceutyczne do leczenia nowotworu złośliwego
BR112019002610A2 (pt) 2016-08-15 2019-07-02 Pfizer piridopirimidinonas inibidoras de cdk2/4/6
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US11117858B2 (en) 2017-01-11 2021-09-14 The General Hospital Corporation Voltage gated sodium channel imaging agents
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Also Published As

Publication number Publication date
NO326133B1 (no) 2008-10-06
CA2434834A1 (en) 2002-08-22
HK1066170A1 (en) 2005-03-18
YU63703A (sh) 2006-05-25
MXPA03007166A (es) 2003-11-18
AU2002256615B2 (en) 2007-09-13
ZA200305938B (en) 2005-01-26
ATE305303T1 (de) 2005-10-15
CZ20032416A3 (cs) 2004-07-14
BRPI0207172B1 (pt) 2019-04-09
RU2269527C2 (ru) 2006-02-10
NO20033540L (no) 2003-08-11
DE60206363T2 (de) 2006-07-06
WO2002064594A2 (en) 2002-08-22
NO20033540D0 (no) 2003-08-11
EP1361880A2 (en) 2003-11-19
JP2004525896A (ja) 2004-08-26
JO2410B1 (en) 2007-06-17
JP4064818B2 (ja) 2008-03-19
IL156872A0 (en) 2004-02-08
US20070135458A1 (en) 2007-06-14
WO2002064594A3 (en) 2003-01-09
SK11322003A3 (en) 2004-10-05
RU2003125887A (ru) 2005-03-20
US20040116698A1 (en) 2004-06-17
ES2249574T3 (es) 2006-04-01
KR20040018254A (ko) 2004-03-02
PL366918A1 (en) 2005-02-07
CN1503672A (zh) 2004-06-09
US6696566B2 (en) 2004-02-24
BRPI0207172B8 (pt) 2021-05-25
NZ526961A (en) 2005-03-24
MA26993A1 (fr) 2004-12-20
PE20020976A1 (es) 2002-10-29
DK1361880T3 (da) 2006-01-23
HU229604B1 (en) 2014-02-28
EP1361880B1 (en) 2005-09-28
PA8539201A1 (es) 2004-08-31
HRP20030624A2 (en) 2005-06-30
MY131518A (en) 2007-08-30
US7169794B2 (en) 2007-01-30
HUP0303458A3 (en) 2012-12-28
US20030171584A1 (en) 2003-09-11
AR035854A1 (es) 2004-07-21
US7449581B2 (en) 2008-11-11
CN100376571C (zh) 2008-03-26
DE60206363D1 (de) 2006-02-09
HUP0303458A2 (hu) 2004-01-28
HRP20030624B1 (en) 2007-03-31
CA2434834C (en) 2010-09-14
IL156872A (en) 2009-07-20
KR100639772B1 (ko) 2006-10-30

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