BRPI0515027A - processo de revestimento de substáncias ativas sólidas pulverulentas, partìculas de substáncia ativa revestidas e sua utilização - Google Patents

processo de revestimento de substáncias ativas sólidas pulverulentas, partìculas de substáncia ativa revestidas e sua utilização

Info

Publication number
BRPI0515027A
BRPI0515027A BRPI0515027-2A BRPI0515027A BRPI0515027A BR PI0515027 A BRPI0515027 A BR PI0515027A BR PI0515027 A BRPI0515027 A BR PI0515027A BR PI0515027 A BRPI0515027 A BR PI0515027A
Authority
BR
Brazil
Prior art keywords
active substance
supercritical
solid
coated
present
Prior art date
Application number
BRPI0515027-2A
Other languages
English (en)
Inventor
Marilyn Calderone
Elisabeth Rodier
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of BRPI0515027A publication Critical patent/BRPI0515027A/pt

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/003—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic followed by coating of the granules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/006—Coating of the granules without description of the process or the device by which the granules are obtained
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A23P10/35—Encapsulation of particles, e.g. foodstuff additives with oils, lipids, monoglycerides or diglycerides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J3/00—Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Birds (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Glanulating (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

PROCESSO DE REVESTIMENTO DE SUBSTáNCIAS ATIVAS SóLIDAS PULVERULENTAS, PARTìCULAS DE SUBSTáNCIA ATIVA REVESTIDAS E SUA UTILIZAçãO A presente invenção se refere a um processo de revestimento de substâncias ativas sólidas pulverulentas caracterizado pelo fato de que compreende as seguintes etapas: a) fornecer (2; 3; 4) uma mistura que compreende pelo menos um revestidor no qual é dissolvido até a saturação um fluido supercrítico ou subcrítico em condições de temperatura e de pressão que permitem a manutenção do fluido em condições supercríticas ou subcríticas; b) fornecer (7) partículas individualizadas em movimento pelo menos de uma substância ativa sólida pulverulenta; e) colocar em contato (8) a mistura e as partículas individualizadas em movimento de substância ativa em condições de temperatura e de pressão que asseguram simultaneamente: a expansão do fluido supercrítico ou subcrítico e o seu retomo ao estado gasoso, a pulverização do revestidor e a sua solidificação em torno das partículas individualizadas em movimento (9). A presente invenção se refere além disso a micropartículas de substância ativa revestidas, cada micropartícula compreendendo sucessivamente um núcleo compreendendo a substância ativa e uma casca compreendendo o revestidor, caracterizadas pelo fato de que elas são suscetíveis de serem obtidas pelo processo de acordo com a presente invenção, em que a substância ativa é sólida à temperatura ambiente e termossensível e em que o tamanho médio do núcleo de substância ativa é inferior a 50 <109>m.
BRPI0515027-2A 2004-09-09 2005-09-08 processo de revestimento de substáncias ativas sólidas pulverulentas, partìculas de substáncia ativa revestidas e sua utilização BRPI0515027A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0409563A FR2874836B1 (fr) 2004-09-09 2004-09-09 Procede d'enrobage de poudres
PCT/FR2005/002236 WO2006030112A1 (fr) 2004-09-09 2005-09-08 Procede d'enrobage de poudres

Publications (1)

Publication Number Publication Date
BRPI0515027A true BRPI0515027A (pt) 2008-07-01

Family

ID=34949152

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515027-2A BRPI0515027A (pt) 2004-09-09 2005-09-08 processo de revestimento de substáncias ativas sólidas pulverulentas, partìculas de substáncia ativa revestidas e sua utilização

Country Status (19)

Country Link
US (2) US20080102275A1 (pt)
EP (1) EP1807187B1 (pt)
JP (1) JP5358948B2 (pt)
KR (1) KR101248347B1 (pt)
CN (1) CN100571856C (pt)
AR (1) AR054311A1 (pt)
AU (1) AU2005284088B2 (pt)
BR (1) BRPI0515027A (pt)
CA (1) CA2579581C (pt)
ES (1) ES2737839T3 (pt)
FR (1) FR2874836B1 (pt)
IL (1) IL181623A (pt)
MX (1) MX2007002835A (pt)
NO (1) NO341130B1 (pt)
NZ (1) NZ553531A (pt)
RU (1) RU2395331C2 (pt)
TW (1) TWI376263B (pt)
WO (1) WO2006030112A1 (pt)
ZA (1) ZA200702883B (pt)

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KR101027071B1 (ko) * 2008-08-28 2011-04-11 한국과학기술원 에멀젼 화염 분무 열분해법을 이용한 세라믹 입자의 코팅 방법
FR2941225B1 (fr) * 2009-01-19 2012-08-31 Otv Sa Dispositif d'enrobage avec un materiau polymere floculant a l'etat liquide de grains de ballast utilises pour le traitement de l'eau par floculation lestee, et installation correspondante.
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IT1398648B1 (it) * 2010-03-09 2013-03-08 Probiotical Spa Prodotto alimentare comprendente batteri probiotici rivestiti con un rivestimento di origine vegetale.
DE102011085685A1 (de) * 2011-11-03 2013-05-08 Beiersdorf Ag Kosmetische Zubereitung mit pulverisierten Stoffen zur Verbesserung der Parfümhaftung
DE102011085688A1 (de) * 2011-11-03 2013-05-08 Beiersdorf Ag Kosmetische Zubereitungen mit pulverisierten hydrophoben Stoffen
DE102011085694A1 (de) * 2011-11-03 2013-05-08 Beiersdorf Ag Kosmetische Zubereitung mit pulverisierten hydrophilen Stoffen
WO2014052973A1 (en) * 2012-09-28 2014-04-03 Stelo Technologies Methods of making silver nanoparticles and their applications
CN108559236B (zh) * 2018-03-21 2020-11-17 奚桢浩 一种具有微纳结构的组织工程支架材料及其制备方法

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Also Published As

Publication number Publication date
FR2874836A1 (fr) 2006-03-10
RU2007112919A (ru) 2008-10-27
NZ553531A (en) 2011-01-28
CN101035610A (zh) 2007-09-12
AR054311A1 (es) 2007-06-20
AU2005284088A1 (en) 2006-03-23
TWI376263B (en) 2012-11-11
JP5358948B2 (ja) 2013-12-04
WO2006030112A1 (fr) 2006-03-23
FR2874836B1 (fr) 2007-04-27
US20120189679A1 (en) 2012-07-26
AU2005284088B2 (en) 2010-06-03
NO341130B1 (no) 2017-08-28
US20080102275A1 (en) 2008-05-01
KR20070097019A (ko) 2007-10-02
EP1807187B1 (fr) 2019-05-08
IL181623A0 (en) 2007-07-04
IL181623A (en) 2014-05-28
CN100571856C (zh) 2009-12-23
CA2579581A1 (fr) 2006-03-23
TW200609036A (en) 2006-03-16
CA2579581C (fr) 2012-12-04
ES2737839T3 (es) 2020-01-16
NO20071821L (no) 2007-06-08
EP1807187A1 (fr) 2007-07-18
ZA200702883B (en) 2008-08-27
JP2008512233A (ja) 2008-04-24
RU2395331C2 (ru) 2010-07-27
KR101248347B1 (ko) 2013-04-02
MX2007002835A (es) 2007-04-30

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Legal Events

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07C Technical examination (opinion): republication [chapter 7.3 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements