BRPI0515726A - oligonucleotìdeos de lna potentes para a inibição de expressão de hif-1a - Google Patents

oligonucleotìdeos de lna potentes para a inibição de expressão de hif-1a

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Publication number
BRPI0515726A
BRPI0515726A BRPI0515726-9A BRPI0515726A BRPI0515726A BR PI0515726 A BRPI0515726 A BR PI0515726A BR PI0515726 A BRPI0515726 A BR PI0515726A BR PI0515726 A BRPI0515726 A BR PI0515726A
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BR
Brazil
Prior art keywords
lna
deoxynucleotide
designates
lna nucleotide
hif
Prior art date
Application number
BRPI0515726-9A
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English (en)
Inventor
Frank Winther Rasmussen
Majken Westergaard
Henrik Frydenlund Hansen
Charlotte Albaek Thrue
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Santaris Pharma As
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Application filed by Santaris Pharma As filed Critical Santaris Pharma As
Publication of BRPI0515726A publication Critical patent/BRPI0515726A/pt
Publication of BRPI0515726A8 publication Critical patent/BRPI0515726A8/pt

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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Abstract

"OLIGONUCLEOTPIDEOS DE LNA POTENTES PARA A INIBIçãO DE EXPRESSãO DE HIF-1A". A presente descrição refere-se a um oligonucleotídeo de LNA que consiste em uma seqüência selecionada deo grupo de que consiste em 5'-5'(T<sym>)-3 e5-(<sym>)<sym>(A) -3', em que as letras maiúsculas designam um análago de nucleotídeo de beta-D-óxi-LNA, as letras minúsculas designa um 2-desoxinucleotídeo, sublinhado designa ou um análogo de nucleotídeo de beta-D-óxi-LNA ou um 2-desoxinucleotídeo, subscrito "s" designa uma ligação de fosforotioato entre análogos de nucleotídeo de LNA/nucleotídeos próximos, e subscrito "x" designa ou uma ligação de fosforotioato ou uma ligação de fosforodiéster entre análogos de nucleotídeo de LNA/nucleotídeos próximos, e em que a seqüência é opcionalmente estendida por até cinco unidades de 2-desoxinucleotídeo. Os oligonucleotídeos de LNA são úteis para a modulação da expressão de fator induzível por hipoxia 1a (HIF-1a), por exemplo, no tratamento de doenças de câncer, inibição de angiogênese, induzindo apopto-se, prevenção de proliferação celular, ou tratamento de uma doença angiogênica, por exemplo, retinopatia diabética, degeneração macular (ARMD), psoríase, artrite reumatóide e outras doenças inflamatórias.
BRPI0515726A 2004-11-09 2005-11-09 Oligonucleotídeos de lna potentes para a inibição de expressão de hif-1a BRPI0515726A8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US62656304P 2004-11-09 2004-11-09
US64718605P 2005-01-25 2005-01-25
US69972105P 2005-07-15 2005-07-15
US72462105P 2005-10-07 2005-10-07
PCT/DK2005/000721 WO2006050734A2 (en) 2004-11-09 2005-11-09 Potent lna oligonucleotides for the inhibition of hif-1a expression

Publications (2)

Publication Number Publication Date
BRPI0515726A true BRPI0515726A (pt) 2008-08-05
BRPI0515726A8 BRPI0515726A8 (pt) 2017-09-12

Family

ID=36177326

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515726A BRPI0515726A8 (pt) 2004-11-09 2005-11-09 Oligonucleotídeos de lna potentes para a inibição de expressão de hif-1a

Country Status (16)

Country Link
US (3) US7589190B2 (pt)
EP (1) EP1833840B9 (pt)
JP (3) JP4825807B2 (pt)
KR (1) KR101176245B1 (pt)
AT (1) ATE476441T1 (pt)
AU (1) AU2005304112B2 (pt)
BR (1) BRPI0515726A8 (pt)
CA (1) CA2587173C (pt)
DE (1) DE602005022768D1 (pt)
DK (1) DK1833840T3 (pt)
EA (1) EA014097B1 (pt)
IL (1) IL183054A0 (pt)
MX (1) MX2007005558A (pt)
NO (1) NO341878B1 (pt)
NZ (1) NZ555644A (pt)
WO (1) WO2006050734A2 (pt)

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