NO20072933L - Potente LNA Oligonukleotider for hemming av HIF-1A ekspresjon - Google Patents

Potente LNA Oligonukleotider for hemming av HIF-1A ekspresjon

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Publication number
NO20072933L
NO20072933L NO20072933A NO20072933A NO20072933L NO 20072933 L NO20072933 L NO 20072933L NO 20072933 A NO20072933 A NO 20072933A NO 20072933 A NO20072933 A NO 20072933A NO 20072933 L NO20072933 L NO 20072933L
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Norway
Prior art keywords
lna
deoxynucleotide
designates
lna nucleotide
hif
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NO20072933A
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English (en)
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NO341878B1 (no
Inventor
Henrik Frydenlund Hansen
Frank Winther Rasmussen
Majken Westergaard
Charlotte Albaek Thrue
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Santaris Pharma As
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Application filed by Santaris Pharma As filed Critical Santaris Pharma As
Publication of NO20072933L publication Critical patent/NO20072933L/no
Publication of NO341878B1 publication Critical patent/NO341878B1/no

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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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Abstract

Foreliggende beskrivelse angår et LNA oligonukleotid som består av en sekvens valgt fra gruppen bestående av 5'-(Tx)GxGxcsasasgscsastscscsTxGxT-3 og 5-GxTxTxascstsgscscststscsTxTxA-3 der store bokstaver betegner en beta-D-oksy-LNA nukleotid analog, små bokstaver betegner en 2-deoksynukleotid, understreket betegner enten en beta-D-oksy-LNA nukleotid analog eller en 2-deoksynukleotid, nedsenket skrift "s" betegner en fosfortioat binding mellom nabostilte nukleotider/LNA nukleotid analoger, og nedsenket skrift "x" betegner enten en fosfortioat binding eller en fosfordiester binding mellom nabostilte nukleotider/LNA nukleotid analoger, og der sekvensen eventuelt er utvidet med opp til fem 2-deoksynukleotid enheter. LNA oligonukleotider er nyttige for modulering av ekspresjon av hypoksi-induserbar faktorla (HIF- la), for eksempel i behandling av cancer sykdommer, hemming av angiogenese, indusering av apoptose, forhindring av cellular proliferasjon, eller behandling av en angiogen sykdom, for eksempel diabetisk retinopati, makulær degenerasjon (ARMD), psoriasis, reumatoid artritt og andre inflammatoriske sykdommer.
NO20072933A 2004-11-09 2007-06-08 LNA oligonukleotid eller konjugat derav for hemming av HIF-1A ekspresjon, en farmasøytisk sammensetning inneholdende dette, samt anvendelse derav som et medikament NO341878B1 (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US62656304P 2004-11-09 2004-11-09
US64718605P 2005-01-25 2005-01-25
US69972105P 2005-07-15 2005-07-15
US72462105P 2005-10-07 2005-10-07
PCT/DK2005/000721 WO2006050734A2 (en) 2004-11-09 2005-11-09 Potent lna oligonucleotides for the inhibition of hif-1a expression

Publications (2)

Publication Number Publication Date
NO20072933L true NO20072933L (no) 2007-06-08
NO341878B1 NO341878B1 (no) 2018-02-12

Family

ID=36177326

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20072933A NO341878B1 (no) 2004-11-09 2007-06-08 LNA oligonukleotid eller konjugat derav for hemming av HIF-1A ekspresjon, en farmasøytisk sammensetning inneholdende dette, samt anvendelse derav som et medikament

Country Status (16)

Country Link
US (3) US7589190B2 (no)
EP (1) EP1833840B9 (no)
JP (3) JP4825807B2 (no)
KR (1) KR101176245B1 (no)
AT (1) ATE476441T1 (no)
AU (1) AU2005304112B2 (no)
BR (1) BRPI0515726A8 (no)
CA (1) CA2587173C (no)
DE (1) DE602005022768D1 (no)
DK (1) DK1833840T3 (no)
EA (1) EA014097B1 (no)
IL (1) IL183054A0 (no)
MX (1) MX2007005558A (no)
NO (1) NO341878B1 (no)
NZ (1) NZ555644A (no)
WO (1) WO2006050734A2 (no)

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