BRPI0515770A - piperidinassulfoniluréias e tiouréias, preparação das mesmas, uso das mesma e composições farmacêuticas compreendendo-as - Google Patents

piperidinassulfoniluréias e tiouréias, preparação das mesmas, uso das mesma e composições farmacêuticas compreendendo-as

Info

Publication number
BRPI0515770A
BRPI0515770A BRPI0515770-6A BRPI0515770A BRPI0515770A BR PI0515770 A BRPI0515770 A BR PI0515770A BR PI0515770 A BRPI0515770 A BR PI0515770A BR PI0515770 A BRPI0515770 A BR PI0515770A
Authority
BR
Brazil
Prior art keywords
formula
piperidinesulfonylureas
pharmaceutical compositions
thioureas
compounds
Prior art date
Application number
BRPI0515770-6A
Other languages
English (en)
Inventor
Stephanie Knieps
Heinrich Christian Dr Englert
Uwe Gerlach
Heinz Goegelein
Holger Heitsch
Karl-Heinz Lehr
Stefania Pfeiffer-Marek
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of BRPI0515770A publication Critical patent/BRPI0515770A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

"PIPERIDINASSULFONILURéIAS E TIOURéIAS, PREPARAçãO DAS MESMAS, USO DAS MESMAS E COMPOSIçõES FARMACêUTICAS COMPREENDENDO-AS". A pesente invenção refere-se a piperidinassulfoniluréias e piperidinassulfoniltiouréias da fórmual I, e, que A, X, R(1), R(2) e R(3) têm os significados indicados nas reivindicações. Os compostos da fórmula I são valiosos ingredientes farmacêuticos ativos que mostram em particular um efeito inibidor sobre canais de potássio sensíveis a ATP do músculo cardíaco e são adequados, por exemplo, para o tratamento de distúrbios do sistema cardiovascular tal como cardiopatia coronariana, arritmias, insuficiência cardíaca, cardiomiopatias ou contratibilidade reduzida do coração ou para a prevenção de morte cardíaca súbita. A invenção também refere-se a processos para preparar os compostos da fórmula (I), seu uso e composições farmacêuticas compreendendo-os.
BRPI0515770-6A 2004-12-18 2005-12-07 piperidinassulfoniluréias e tiouréias, preparação das mesmas, uso das mesma e composições farmacêuticas compreendendo-as BRPI0515770A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004061017A DE102004061017A1 (de) 2004-12-18 2004-12-18 Piperidinsulfonylharnstoffe und -thioharnstoffe, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
PCT/EP2005/013087 WO2006063722A1 (en) 2004-12-18 2005-12-07 Piperidinesulfonylureas and -thioureas, their preparation, their use and pharmaceutical compositions comprising them

Publications (1)

Publication Number Publication Date
BRPI0515770A true BRPI0515770A (pt) 2008-07-29

Family

ID=35811666

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515770-6A BRPI0515770A (pt) 2004-12-18 2005-12-07 piperidinassulfoniluréias e tiouréias, preparação das mesmas, uso das mesma e composições farmacêuticas compreendendo-as

Country Status (16)

Country Link
US (1) US8586612B2 (pt)
EP (1) EP1828131B1 (pt)
JP (1) JP5231807B2 (pt)
KR (1) KR101261251B1 (pt)
CN (1) CN101080388B (pt)
AT (1) ATE397588T1 (pt)
AU (1) AU2005315927B2 (pt)
BR (1) BRPI0515770A (pt)
CA (1) CA2590405C (pt)
DE (2) DE102004061017A1 (pt)
DK (1) DK1828131T3 (pt)
ES (1) ES2306252T3 (pt)
IL (1) IL183807A (pt)
MX (1) MX2007006679A (pt)
PT (1) PT1828131E (pt)
WO (1) WO2006063722A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201249795A (en) 2010-11-30 2012-12-16 Astrazeneca Ab New IKACh blockers
CN104788425A (zh) * 2015-03-12 2015-07-22 佛山市赛维斯医药科技有限公司 一类含烟酸酰胺和哌啶结构ptp1b抑制剂、制备方法及其用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3914416A (en) * 1966-12-23 1975-10-21 Exsymol Sa Certain monomethyl trisilanol mannuronate complexes for treating cellulitis
US3829434A (en) * 1972-11-10 1974-08-13 Pfizer Piperidinesulfonylurea derivatives
US3914426A (en) * 1972-11-10 1975-10-21 Pfizer Piperidinesulfonylurea derivatives for lowering blood sugar levels
US3887561A (en) * 1972-11-10 1975-06-03 Pfizer Piperidinesulfonylurea derivatives
US3944524A (en) * 1974-04-26 1976-03-16 Pfizer Inc. 4-Substituted-1-piperidinesulfonamides
US3987172A (en) * 1974-04-26 1976-10-19 Pfizer Inc. Piperidinesulfonylurea derivatives
US3936455A (en) * 1975-01-31 1976-02-03 Pfizer Inc. Piperidinesulfonylurea derivatives
DE2948434A1 (de) * 1979-12-01 1981-06-11 Hoechst Ag, 6000 Frankfurt 1-piperidinsulfonylharnstoffe und verfahren zu ihrer herstellung
DE4032766A1 (de) * 1990-10-16 1992-04-30 Basf Ag Phenylpiperidinoylamine und diese enthaltende arzneimittel
US5574843A (en) 1991-04-26 1996-11-12 Escom Ag Methods and apparatus providing for a presentation system for multimedia applications
DE59401361D1 (de) * 1993-02-23 1997-02-06 Hoechst Ag Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe- Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika
DE4341655A1 (de) * 1993-12-07 1995-06-08 Hoechst Ag Aminosubstituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika
DE19503136A1 (de) * 1995-02-01 1996-08-08 Hoechst Ag Substituierte Thiophenylsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19505397A1 (de) * 1995-02-17 1996-08-22 Hoechst Ag Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19647000A1 (de) * 1996-11-14 1998-05-20 Hoechst Ag 3-Amido-chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19832009A1 (de) * 1998-07-16 2000-01-20 Hoechst Marion Roussel De Gmbh 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate
HK1040187B (zh) * 1998-09-10 2005-09-02 萨诺费－阿文蒂斯德国有限公司 苯磺酰(硫)脲與β-受體阻滯劑聯合在製備用於心臟迷走神經機能障礙治療和預防的藥物中的用途
US6414036B1 (en) * 1999-09-01 2002-07-02 Van Beek Global/Ninkov Llc Composition for treatment of infections of humans and animals

Also Published As

Publication number Publication date
HK1113353A1 (en) 2008-10-03
IL183807A0 (en) 2007-09-20
PT1828131E (pt) 2008-07-24
IL183807A (en) 2011-10-31
JP5231807B2 (ja) 2013-07-10
ES2306252T3 (es) 2008-11-01
ATE397588T1 (de) 2008-06-15
US20080033016A1 (en) 2008-02-07
JP2008524132A (ja) 2008-07-10
US8586612B2 (en) 2013-11-19
DE102004061017A1 (de) 2006-06-22
AU2005315927B2 (en) 2012-02-09
CN101080388B (zh) 2010-12-22
EP1828131B1 (en) 2008-06-04
WO2006063722A1 (en) 2006-06-22
AU2005315927A1 (en) 2006-06-22
CA2590405C (en) 2013-03-12
KR101261251B1 (ko) 2013-05-07
MX2007006679A (es) 2007-08-14
DK1828131T3 (da) 2008-09-29
CN101080388A (zh) 2007-11-28
CA2590405A1 (en) 2006-06-22
DE602005007381D1 (de) 2008-07-17
EP1828131A1 (en) 2007-09-05
KR20070086366A (ko) 2007-08-27

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 11A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]