DK1828131T3 - Piperidinsulfonylurinstoffer og -thiourinstoffer, deres fremstilling, deres anvendelse og farmaceutiske sammensætninger indeholdende samme - Google Patents

Piperidinsulfonylurinstoffer og -thiourinstoffer, deres fremstilling, deres anvendelse og farmaceutiske sammensætninger indeholdende samme

Info

Publication number: DK1828131T3
Authority: DK; Denmark
Prior art keywords: pharmaceutical compositions; formula; thioureas; sulfonylureas; piperidine
Prior art date: 2004-12-18

Application number

DK05811326T

Other languages

Danish (da)

English (en)

Inventor

Stephanie Hachtel

Karl-Heinz Lehr

Heinrich Christian Englert

Uwe Gerlach

Heinz Goegelein

Holger Heitsch

Stefania Pfeiffer-Marek

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-18

Filing date

2005-12-07

Publication date

2008-09-29

2005-12-07 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2008-09-29 Application granted granted Critical

2008-09-29 Publication of DK1828131T3 publication Critical patent/DK1828131T3/da

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 2
229940100389 Sulfonylurea Drugs 0.000 title 1
150000003585 thioureas Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
208000031229 Cardiomyopathies Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
102000016924 KATP Channels Human genes 0.000 abstract 1
108010053914 KATP Channels Proteins 0.000 abstract 1
206010049418 Sudden Cardiac Death Diseases 0.000 abstract 1
239000008186 active pharmaceutical agent Substances 0.000 abstract 1
206010003119 arrhythmia Diseases 0.000 abstract 1
230000006793 arrhythmia Effects 0.000 abstract 1
210000000748 cardiovascular system Anatomy 0.000 abstract 1
208000029078 coronary artery disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
210000004165 myocardium Anatomy 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)

DK05811326T 2004-12-18 2005-12-07 Piperidinsulfonylurinstoffer og -thiourinstoffer, deres fremstilling, deres anvendelse og farmaceutiske sammensætninger indeholdende samme DK1828131T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE102004061017A DE102004061017A1 (de)	2004-12-18	2004-12-18	Piperidinsulfonylharnstoffe und -thioharnstoffe, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
PCT/EP2005/013087 WO2006063722A1 (en)	2004-12-18	2005-12-07	Piperidinesulfonylureas and -thioureas, their preparation, their use and pharmaceutical compositions comprising them

Publications (1)

Publication Number	Publication Date
DK1828131T3 true DK1828131T3 (da)	2008-09-29

Family

ID=35811666

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK05811326T DK1828131T3 (da)	2004-12-18	2005-12-07	Piperidinsulfonylurinstoffer og -thiourinstoffer, deres fremstilling, deres anvendelse og farmaceutiske sammensætninger indeholdende samme

Country Status (16)

Country	Link
US (1)	US8586612B2 (pt)
EP (1)	EP1828131B1 (pt)
JP (1)	JP5231807B2 (pt)
KR (1)	KR101261251B1 (pt)
CN (1)	CN101080388B (pt)
AT (1)	ATE397588T1 (pt)
AU (1)	AU2005315927B2 (pt)
BR (1)	BRPI0515770A (pt)
CA (1)	CA2590405C (pt)
DE (2)	DE102004061017A1 (pt)
DK (1)	DK1828131T3 (pt)
ES (1)	ES2306252T3 (pt)
IL (1)	IL183807A (pt)
MX (1)	MX2007006679A (pt)
PT (1)	PT1828131E (pt)
WO (1)	WO2006063722A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UY33755A (es)	2010-11-30	2012-06-29	Astrazeneca Ab	Nuevos bloqueadores de ikach
CN104788425A (zh) *	2015-03-12	2015-07-22	佛山市赛维斯医药科技有限公司	一类含烟酸酰胺和哌啶结构ptp1b抑制剂、制备方法及其用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3914416A (en) *	1966-12-23	1975-10-21	Exsymol Sa	Certain monomethyl trisilanol mannuronate complexes for treating cellulitis
US3914426A (en) *	1972-11-10	1975-10-21	Pfizer	Piperidinesulfonylurea derivatives for lowering blood sugar levels
US3887561A (en) *	1972-11-10	1975-06-03	Pfizer	Piperidinesulfonylurea derivatives
US3829434A (en) *	1972-11-10	1974-08-13	Pfizer	Piperidinesulfonylurea derivatives
US3987172A (en) *	1974-04-26	1976-10-19	Pfizer Inc.	Piperidinesulfonylurea derivatives
US3944524A (en) *	1974-04-26	1976-03-16	Pfizer Inc.	4-Substituted-1-piperidinesulfonamides
US3936455A (en) *	1975-01-31	1976-02-03	Pfizer Inc.	Piperidinesulfonylurea derivatives
DE2948434A1 (de) *	1979-12-01	1981-06-11	Hoechst Ag, 6000 Frankfurt	1-piperidinsulfonylharnstoffe und verfahren zu ihrer herstellung
DE4032766A1 (de) *	1990-10-16	1992-04-30	Basf Ag	Phenylpiperidinoylamine und diese enthaltende arzneimittel
US5574843A (en)	1991-04-26	1996-11-12	Escom Ag	Methods and apparatus providing for a presentation system for multimedia applications
DE59401361D1 (de) *	1993-02-23	1997-02-06	Hoechst Ag	Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe- Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika
DE4341655A1 (de) *	1993-12-07	1995-06-08	Hoechst Ag	Aminosubstituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika
DE19503136A1 (de) *	1995-02-01	1996-08-08	Hoechst Ag	Substituierte Thiophenylsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19505397A1 (de) *	1995-02-17	1996-08-22	Hoechst Ag	Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19647000A1 (de) *	1996-11-14	1998-05-20	Hoechst Ag	3-Amido-chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19832009A1 (de) *	1998-07-16	2000-01-20	Hoechst Marion Roussel De Gmbh	2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate
TR200100692T2 (tr) *	1998-09-10	2001-07-23	Aventis Pharma Deutschland Gmbh	Otonom sinir sisteminin disfonksiyonlarının önlenmesinde Benzensulfonil (Tiyo) ürelerin kullanımı
US6414036B1 (en) *	1999-09-01	2002-07-02	Van Beek Global/Ninkov Llc	Composition for treatment of infections of humans and animals

2004
- 2004-12-18 DE DE102004061017A patent/DE102004061017A1/de not_active Withdrawn
2005
- 2005-12-07 DK DK05811326T patent/DK1828131T3/da active
- 2005-12-07 AU AU2005315927A patent/AU2005315927B2/en not_active Ceased
- 2005-12-07 JP JP2007545899A patent/JP5231807B2/ja not_active Expired - Fee Related
- 2005-12-07 MX MX2007006679A patent/MX2007006679A/es active IP Right Grant
- 2005-12-07 BR BRPI0515770-6A patent/BRPI0515770A/pt not_active IP Right Cessation
- 2005-12-07 CN CN2005800431711A patent/CN101080388B/zh not_active Expired - Fee Related
- 2005-12-07 EP EP05811326A patent/EP1828131B1/en not_active Expired - Lifetime
- 2005-12-07 ES ES05811326T patent/ES2306252T3/es not_active Expired - Lifetime
- 2005-12-07 KR KR1020077013758A patent/KR101261251B1/ko not_active Expired - Fee Related
- 2005-12-07 PT PT05811326T patent/PT1828131E/pt unknown
- 2005-12-07 AT AT05811326T patent/ATE397588T1/de active
- 2005-12-07 DE DE602005007381T patent/DE602005007381D1/de not_active Expired - Lifetime
- 2005-12-07 WO PCT/EP2005/013087 patent/WO2006063722A1/en not_active Ceased
- 2005-12-07 CA CA2590405A patent/CA2590405C/en not_active Expired - Fee Related
2007
- 2007-06-10 IL IL183807A patent/IL183807A/en not_active IP Right Cessation
- 2007-06-12 US US11/761,565 patent/US8586612B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATE397588T1 (de)	2008-06-15
BRPI0515770A (pt)	2008-07-29
CA2590405A1 (en)	2006-06-22
KR20070086366A (ko)	2007-08-27
JP5231807B2 (ja)	2013-07-10
EP1828131B1 (en)	2008-06-04
AU2005315927B2 (en)	2012-02-09
DE102004061017A1 (de)	2006-06-22
CN101080388B (zh)	2010-12-22
EP1828131A1 (en)	2007-09-05
HK1113353A1 (en)	2008-10-03
JP2008524132A (ja)	2008-07-10
US8586612B2 (en)	2013-11-19
IL183807A (en)	2011-10-31
ES2306252T3 (es)	2008-11-01
KR101261251B1 (ko)	2013-05-07
AU2005315927A1 (en)	2006-06-22
IL183807A0 (en)	2007-09-20
PT1828131E (pt)	2008-07-24
US20080033016A1 (en)	2008-02-07
CN101080388A (zh)	2007-11-28
WO2006063722A1 (en)	2006-06-22
MX2007006679A (es)	2007-08-14
CA2590405C (en)	2013-03-12
DE602005007381D1 (de)	2008-07-17

Publication	Publication Date	Title
NO20072784L (no)	2007-07-17	Pyridenkarboksamidderivater for anvendelse som anticancer midler
MXPA06011194A (es)	2007-03-21	Tiadiazolidinonas como inhibidores de gsk-3.
NO20071776L (no)	2007-04-25	Kinoksaliner som B RAF inhibitorer.
NO20073719L (no)	2007-08-22	Kjemiske forbindelser
NO20082709L (no)	2008-08-13	Kjemiske forbindelser
NO20051165L (no)	2005-03-04	Benzotiazolderivater som har -adrenoerseptorantagonist aktivitet
ATE290525T1 (de)	2005-03-15	Acylaminoalkyl-substituierte benzolsulfonamidderivate
TNSN04237A1 (en)	2007-03-12	N- ((3-oxo2, 3-dihydro-1h-isoindol-1-yl) acetyl) guanidine derivatives as nhe-1 inhibitors for the treatment of infarction and angina pectoris
WO2005080345A3 (en)	2006-12-21	Imidazoline derivatives having cb1-antagonistic activity
NO20082690L (no)	2008-08-12	Kjemiske forbindelser
DE60006936D1 (de)	2004-01-15	Substituierte 4-amino-2-aryltetrahydrochinazoline, deren herstellung, deren verwendung und diese enthaltende pharmazeutische zusammenstellungen
MY139310A (en)	2009-09-30	Pentafluorosulfanylbenzoylguanidines, process for their preparation, their use as. medicament or diagnostic aid, and medicament comprising them
MX2009012644A (es)	2009-12-10	Derivados de di(hetero)arilciclohexano, su preparacion, su uso y composiciones farmaceuticas que los comprenden.
MXPA05011267A (es)	2006-05-25	Derivados de la triaza-y tetraaza-antracenodiona, su preparacion y su uso como productos farmaceuticos.
DK1828131T3 (da)	2008-09-29	Piperidinsulfonylurinstoffer og -thiourinstoffer, deres fremstilling, deres anvendelse og farmaceutiske sammensætninger indeholdende samme
CA2337397A1 (en)	2000-01-27	2,5-substituted benzolsulfonylureas and thioureas, methods for the production thereof, use thereof and pharmaceutical preparations containing the same
NO330964B1 (no)	2011-08-29	Kolkisosidanaloger
YU81701A (sh)	2004-07-15	Cinamoilaminoalkil-supstituisani derivati benzensulfonamida
NO20073710L (no)	2007-08-31	Kjemiske forbindelser
NO20053825L (no)	2005-10-17	Thienopyridazinoner og deres anvendelse ved modulering av autoimmune sykdommer.
NO20062635L (no)	2006-08-11	Pentafluorsulfanyl-benzoylguanidiner, produksjonsmetode, deres anvendelse som medikamenter eller diagnostiserende midler og medikamenter inneholdende disse
ATE410414T1 (de)	2008-10-15	Heteroarylacryloylaminoalkyl-substituierte benzolsulfonamidderivate, deren herstellung, deren verwendung und pharmazeutische zusammensetzungen, die diese verbindungen enthalten
WO2002083641A3 (en)	2003-02-27	Amino-aza-cyclohexanes for the treatment of malaria
CA2310055A1 (en)	1999-06-17	New urethanes, the thio and dithio analogues thereof,the salts thereof, pharmaceutical compositions containing these compounds and their use as well as process for preparing them
WO2005007104A3 (en)	2005-06-23	Novel compositions, pharmaceutical compositions, and methods for the treatment and prevention of heart disease