BRPI0516025A - 4-(heteroaril-metil e heteroaril-metil substituìda)-imidazol-2-tionas que atuam como agonistas alfa2 adrenérgicos - Google Patents

4-(heteroaril-metil e heteroaril-metil substituìda)-imidazol-2-tionas que atuam como agonistas alfa2 adrenérgicos

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Publication number
BRPI0516025A
BRPI0516025A BRPI0516025-1A BRPI0516025A BRPI0516025A BR PI0516025 A BRPI0516025 A BR PI0516025A BR PI0516025 A BRPI0516025 A BR PI0516025A BR PI0516025 A BRPI0516025 A BR PI0516025A
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Prior art keywords
methyl
alpha
compounds
heteroaryl
adrenergic
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Application number
BRPI0516025-1A
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English (en)
Inventor
Todd M Heidelbaugh
Ken Chow
Phong X Nguyen
Daniel W Gil
John E Donello
Michael E Garst
Larry A Wheeler
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Allergan Sales Inc
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Publication date
Application filed by Allergan Sales Inc filed Critical Allergan Sales Inc
Publication of BRPI0516025A publication Critical patent/BRPI0516025A/pt

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Abstract

"4(HETEROARIL-METIL E HETEROARIL-METIL SUBSTITUìDA)-IMIDAZOL-2-TIONAS QUE ATUAM COMO AGONISTAS ALFA2 ADRENéRGICOS". Os compostos de fórmula (I), onde as variáveis têm o significado definido no relatório descritivo, são agonistas de receptores alfa~2~ adrenérgicos. Diversos compostos da divulgação são específicos ou seletivos para os receptores alfa~ 2B e/ou alfa~ 2c~ adrenérgicos na preferência, sobre os receptores alfa~ 2A~ drenérgicos. Adicionalmente, alguns dos compostos reivindicados não têm nenhuma, ou têm somente mínima, atividade cardiovascular e/ou sedativa. Os compostos de fórmula (I) são úteis como medicamentos em mamíferos, incluindo os seres humanos, para o tratamento de doenças e ou alívios de condições que sejam responsivas ao tratamento por agonistas de receptores alfa~ 2~ adrenérgicos. Os compostos de fórmula (I), os quais não têm nenhuma atividade cardiovascular e/ou sedativa significativa, são úteis para o tratamento de dor e outras condições, com efeitos colaterais mínimos.
BRPI0516025-1A 2004-09-24 2005-09-07 4-(heteroaril-metil e heteroaril-metil substituìda)-imidazol-2-tionas que atuam como agonistas alfa2 adrenérgicos BRPI0516025A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61294504P 2004-09-24 2004-09-24
PCT/US2005/032128 WO2006036507A1 (en) 2004-09-24 2005-09-07 4-(heteroaryl-methyl and substituted heteroaryl-methyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists

Publications (1)

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BRPI0516025A true BRPI0516025A (pt) 2008-08-19

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ID=35636634

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BRPI0516025-1A BRPI0516025A (pt) 2004-09-24 2005-09-07 4-(heteroaril-metil e heteroaril-metil substituìda)-imidazol-2-tionas que atuam como agonistas alfa2 adrenérgicos

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US (2) US7399868B2 (pt)
EP (1) EP1791832A1 (pt)
JP (1) JP2008514603A (pt)
AR (1) AR051108A1 (pt)
AU (1) AU2005290008A1 (pt)
BR (1) BRPI0516025A (pt)
CA (1) CA2581828A1 (pt)
TW (1) TW200624430A (pt)
WO (1) WO2006036507A1 (pt)

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US7399868B2 (en) 2008-07-15
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