BRPI0516083A - 4-(fenilmetil e 4-fenilmetil substituìdo)-imidazol-2-tionas que atuam como agonistas alfa2 adrenérgicos - Google Patents

4-(fenilmetil e 4-fenilmetil substituìdo)-imidazol-2-tionas que atuam como agonistas alfa2 adrenérgicos

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Publication number
BRPI0516083A
BRPI0516083A BRPI0516083-9A BRPI0516083A BRPI0516083A BR PI0516083 A BRPI0516083 A BR PI0516083A BR PI0516083 A BRPI0516083 A BR PI0516083A BR PI0516083 A BRPI0516083 A BR PI0516083A
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BR
Brazil
Prior art keywords
phenylmethyl
alpha
compounds
imidazol
adrenergic
Prior art date
Application number
BRPI0516083-9A
Other languages
English (en)
Inventor
Todd M Heidelbaugh
Ken Chow
Phong X Nguyen
John E Donello
Michael E Garst
Larry A Wheeler
Original Assignee
Allergan Sales Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Sales Inc filed Critical Allergan Sales Inc
Publication of BRPI0516083A publication Critical patent/BRPI0516083A/pt

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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Cardiology (AREA)
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  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"4-(FENILMETIL E 4-FENILMETIL SUBSTITUìDO)-IMIDAZOL-2-TIONAS QUE ATUAM COMO AGONISTAS ALFA2 ADRENéRGICOS". A presente invenção refere-se a compostos de fórmula (1)em que as variáveis possuem o significado definido no relatório descritivo são agonistas de receptores alfa~ 2~ adrenérgicos. Diversos compostos da descrição são específicas ou seletivos a receptores alfa~ 2B~ e/ou alfa~ 2c~ adrenérgicos de preferência a receptores alfa~ 2A~ adrenérgicos. Adicionalmente, alguns dos compostos reivindicados não possuem ou possuem atividade cardiovascular e/ou sedativa mínima. Os compostos da Fórmula (1) são úteis como medicamentos em mamíferos, incluindo seres humanos, para o tratamento de doenças e ou alívios de condições que são responsivas ao tratamento por agonistas de receptores alfa~ 2~ adrenérgicos. Os compostos da Fórmula (1) que não possuem ou possuem atividade cardiovascular e/ou sedativa significativa são úteis para o tratamento de dor e outras condições com efeitos colaterais mínimos.
BRPI0516083-9A 2004-09-24 2005-09-07 4-(fenilmetil e 4-fenilmetil substituìdo)-imidazol-2-tionas que atuam como agonistas alfa2 adrenérgicos BRPI0516083A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61292304P 2004-09-24 2004-09-24
PCT/US2005/031790 WO2006036480A1 (en) 2004-09-24 2005-09-07 4-(phenylmethyl and substituted phenylmethyl)-imidazole-2-thiones acting as specific alpha2 adrenergic agonists

Publications (1)

Publication Number Publication Date
BRPI0516083A true BRPI0516083A (pt) 2008-08-19

Family

ID=35559467

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0516083-9A BRPI0516083A (pt) 2004-09-24 2005-09-07 4-(fenilmetil e 4-fenilmetil substituìdo)-imidazol-2-tionas que atuam como agonistas alfa2 adrenérgicos

Country Status (17)

Country Link
US (1) US7683089B1 (pt)
EP (1) EP1797043A1 (pt)
JP (1) JP2008514601A (pt)
KR (1) KR20070054213A (pt)
CN (1) CN101031549A (pt)
AR (1) AR051107A1 (pt)
AU (1) AU2005290075A1 (pt)
BR (1) BRPI0516083A (pt)
CA (1) CA2581579A1 (pt)
IL (1) IL181749A0 (pt)
MX (1) MX2007003068A (pt)
NO (1) NO20071403L (pt)
NZ (1) NZ553341A (pt)
RU (2) RU2383535C2 (pt)
TW (1) TW200626147A (pt)
WO (1) WO2006036480A1 (pt)
ZA (1) ZA200701427B (pt)

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
RU2008130448A (ru) * 2006-01-27 2010-03-10 Ф. Хоффманн-Ля Рош Аг (Ch) Применение производных 4-имидазола для расстройств цнс
EP1918282A1 (en) * 2006-11-06 2008-05-07 "Joint Stock Company Grindeks" Method for preparing medetomidine and its salts
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US8455548B2 (en) * 2007-10-18 2013-06-04 Allergan, Inc. Method of treating sensorimotor disorders with alpha-2 adrenergic receptor agonists
AU2010213649A1 (en) * 2009-02-13 2011-09-08 Allergan, Inc. 4-(1-(3-(hydroxymethyl)-2-methylphenyl)ethyl)-1H-imidazole-2(3H)-thione
EP2605771B1 (en) * 2010-08-16 2018-04-04 Allergan, Inc. Method of activating regulatory t cells with alpha-2b adrenergic receptor agonists
US8653123B2 (en) * 2010-09-16 2014-02-18 Allergan, Inc. Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating retinal diseases
EP2782569A1 (en) 2011-11-21 2014-10-01 Allergan, Inc. Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases
CN105884691B (zh) * 2016-06-02 2017-08-25 江苏恒瑞医药股份有限公司 一种制备右美托咪定及其中间体的方法

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Also Published As

Publication number Publication date
CA2581579A1 (en) 2006-04-06
MX2007003068A (es) 2007-05-21
AU2005290075A1 (en) 2006-04-06
AR051107A1 (es) 2006-12-20
KR20070054213A (ko) 2007-05-28
US7683089B1 (en) 2010-03-23
CN101031549A (zh) 2007-09-05
NZ553341A (en) 2010-11-26
JP2008514601A (ja) 2008-05-08
TW200626147A (en) 2006-08-01
EP1797043A1 (en) 2007-06-20
RU2009141800A (ru) 2011-05-20
IL181749A0 (en) 2007-07-04
ZA200701427B (en) 2008-08-27
RU2383535C2 (ru) 2010-03-10
NO20071403L (no) 2007-05-22
RU2007110711A (ru) 2008-10-27
WO2006036480A1 (en) 2006-04-06

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