BRPI0516110A - compostos para supressão sem sentido e métodos para seu uso - Google Patents

compostos para supressão sem sentido e métodos para seu uso

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Publication number
BRPI0516110A
BRPI0516110A BRPI0516110-0A BRPI0516110A BRPI0516110A BR PI0516110 A BRPI0516110 A BR PI0516110A BR PI0516110 A BRPI0516110 A BR PI0516110A BR PI0516110 A BRPI0516110 A BR PI0516110A
Authority
BR
Brazil
Prior art keywords
methods
compounds
senseless
compositions
present
Prior art date
Application number
BRPI0516110-0A
Other languages
English (en)
Inventor
Neil Almstead
Gary M Karp
Ellen Welch
Richard Wilde
Jeffrey A Campbell
Guangming Chen
Original Assignee
Ptc Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ptc Therapeutics Inc filed Critical Ptc Therapeutics Inc
Publication of BRPI0516110A publication Critical patent/BRPI0516110A/pt

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    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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Abstract

COMPOSTOS PARA SUPRESSãO SEM SENTIDO E MéTODOS PARA SEU USO. A presente invenção se refere a métodos, compostos, e composições para tratar ou prevenir doenças associadas com mutações sem sentido em um mRNA administrando-se os compostos ou composições da presente invenção. Mais particularmente, a presente invenção se refere a métodos, compostos, e composições para suprimir a terminação de translação prematura associada com uma mutação sem sentido em um mRNA.
BRPI0516110-0A 2004-10-13 2005-10-13 compostos para supressão sem sentido e métodos para seu uso BRPI0516110A (pt)

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US61765504P 2004-10-13 2004-10-13
US62417004P 2004-11-03 2004-11-03
PCT/US2005/036673 WO2006044456A1 (en) 2004-10-13 2005-10-13 Compounds for nonsense suppression, and methods for their use

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