CR20230164A - Compuestos fosfolípidos y usos de estos - Google Patents

Compuestos fosfolípidos y usos de estos

Info

Publication number
CR20230164A
CR20230164A CR20230164A CR20230164A CR20230164A CR 20230164 A CR20230164 A CR 20230164A CR 20230164 A CR20230164 A CR 20230164A CR 20230164 A CR20230164 A CR 20230164A CR 20230164 A CR20230164 A CR 20230164A
Authority
CR
Costa Rica
Prior art keywords
compounds
phospholipid compounds
phospholipid
alone
treatment
Prior art date
Application number
CR20230164A
Other languages
English (en)
Inventor
Philip A Morganelli
Peiyuan Wang
Thomas P Stratton
Jonathan William Medley
Scott E Lazerwith
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of CR20230164A publication Critical patent/CR20230164A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen compuestos y métodos para usar dichos compuestos, solos o en combinación con agentes adicionales, y composiciones farmacéuticas de dichos compuestos para el tratamiento de infecciones virales.
CR20230164A 2020-10-16 2021-10-15 Compuestos fosfolípidos y usos de estos CR20230164A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063093037P 2020-10-16 2020-10-16
US202163151456P 2021-02-19 2021-02-19
PCT/US2021/055183 WO2022081973A1 (en) 2020-10-16 2021-10-15 Phospholipid compounds and uses thereof

Publications (1)

Publication Number Publication Date
CR20230164A true CR20230164A (es) 2023-06-23

Family

ID=78536645

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20230164A CR20230164A (es) 2020-10-16 2021-10-15 Compuestos fosfolípidos y usos de estos

Country Status (17)

Country Link
US (2) US12208110B2 (es)
EP (1) EP4228685A1 (es)
JP (2) JP7633394B2 (es)
KR (1) KR20230088432A (es)
CN (1) CN116322759A (es)
AU (1) AU2021361059B2 (es)
CA (1) CA3193879A1 (es)
CL (2) CL2023001062A1 (es)
CO (1) CO2023004594A2 (es)
CR (1) CR20230164A (es)
DO (2) DOP2023000074A (es)
IL (1) IL301809A (es)
MX (1) MX2023004188A (es)
PE (1) PE20230858A1 (es)
SA (1) SA523440384B1 (es)
TW (1) TWI811812B (es)
WO (1) WO2022081973A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021312946A1 (en) * 2020-07-24 2023-03-09 The Regents Of The University Of California Antiviral prodrugs, pharmaceutical formulations, and methods
MX2023002233A (es) 2020-08-24 2023-03-15 Gilead Sciences Inc Compuestos fosfolipidos y usos de estos.
TWI811812B (zh) 2020-10-16 2023-08-11 美商基利科學股份有限公司 磷脂化合物及其用途
JP7719954B2 (ja) 2021-08-18 2025-08-06 ギリアード サイエンシーズ， インコーポレイテッド リン脂質化合物並びにその製造方法及び使用方法
CA3247143A1 (en) * 2022-01-26 2023-08-03 The Regents Of The University Of California Antiviral prodrugs, intermediate and long-acting formulations, and methods
CN114903897B (zh) * 2022-04-27 2024-02-13 中国人民解放军海军军医大学 千金藤素在制备抗蜱传脑炎病毒药物中的应用
CN117281807A (zh) * 2022-06-17 2023-12-26 北京化工大学 千金藤素在治疗和预防ev71感染中的应用
CN117024479A (zh) * 2023-08-04 2023-11-10 杭州居维叶生物医药有限公司 一种聚乙二醇化磷酸前药及其制备与应用
AU2024352221A1 (en) * 2023-09-26 2026-04-09 Board Of Regents Of The University Of Nebraska Phosphonate prodrugs and use thereof
WO2025128913A1 (en) * 2023-12-12 2025-06-19 The Trustees Of The University Of Pennsylvania Inhibition of endosomal escape detection to ameliorate the inflammatory side-effects of lipid nanoparticles
CN119302919A (zh) * 2024-12-16 2025-01-14 江苏长泰药业股份有限公司 一种丙酮酸钠雾化吸入制剂及其制备方法

Family Cites Families (163)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223263A (en) 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
EP0262876B1 (en) 1986-09-27 1992-04-29 Toyo Jozo Kabushiki Kaisha Nucleoside-phospholipid conjugate
US7517858B1 (en) 1995-06-07 2009-04-14 The Regents Of The University Of California Prodrugs of pharmaceuticals with improved bioavailability
AUPQ105499A0 (en) 1999-06-18 1999-07-08 Biota Scientific Management Pty Ltd Antiviral agents
AU785355B2 (en) 1999-12-03 2007-02-01 Regents Of The University Of California At San Diego, The Phosphonate compounds
PY0111577A (es) 2000-05-23 2017-01-02 Idenix Cayman Ltd Métodos y composiciones para el tratamiento del virus de la hepatitis c
US6596700B2 (en) 2000-05-26 2003-07-22 Idenix Pharmaceuticals Inc. Methods of treating hepatitis delta virus infection with β-L-2'-deoxy-nucleosides
AUPR213700A0 (en) 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
BRPI0411900B8 (pt) 2003-06-26 2021-05-25 Biotron Ltd compostos e composições farmacêuticas compreendendo os mesmos
ES2401285T3 (es) 2004-12-16 2013-04-18 The Regents Of The University Of California Fármacos con el pulmón como diana
US20090156545A1 (en) 2005-04-01 2009-06-18 Hostetler Karl Y Substituted Phosphate Esters of Nucleoside Phosphonates
PT2826770T (pt) 2005-06-24 2018-12-18 Biotron Ltd Compostos acilguanidinas com atividade antiviral
WO2009018609A1 (en) 2007-08-03 2009-02-12 Biotrom Limited Hepatitis c antiviral compositions and methods
HRP20130048T1 (hr) * 2008-04-23 2013-02-28 Gilead Sciences, Inc. Karba-nukleozidni analozi za antivirusnu terapiju
EP2313102A2 (en) 2008-07-03 2011-04-27 Biota Scientific Management Bycyclic nucleosides and nucleotides as therapeutic agents
EP2342616A2 (en) 2008-09-23 2011-07-13 Alnylam Pharmaceuticals Inc. Chemical modifications of monomers and oligonucleotides with cycloaddition
JP5752599B2 (ja) 2008-11-06 2015-07-22 ヴァスキュラー バイオジェニックス リミテッド 酸化脂質化合物およびその使用
WO2011100131A2 (en) 2010-01-28 2011-08-18 Alnylam Pharmacuticals, Inc. Monomers and oligonucleotides comprising cycloaddition adduct(s)
TW201201815A (en) * 2010-05-28 2012-01-16 Gilead Sciences Inc 1'-substituted-carba-nucleoside prodrugs for antiviral treatment
EA025311B1 (ru) * 2010-07-19 2016-12-30 Гайлид Сайэнсиз, Инк. Способы получения диастереомерно чистых фосфорамидатных пролекарств
SG10201610936RA (en) 2011-12-22 2017-02-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
MX2015002954A (es) 2012-09-10 2015-06-05 Hoffmann La Roche Nuevas 6-aminoacido-heteroarilhidropirimidinas para el tratamiento y profilaxis de la infeccion del virus de la hepatitis b.
GEP201706757B (en) 2012-12-21 2017-10-25 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
SMT201800538T1 (it) 2013-03-15 2019-01-11 Univ California Diesteri di fosfonato nucleosidico aciclico
HK1224229A1 (zh) 2013-06-26 2017-08-18 Alios Biopharma, Inc. 取代的核苷，核苷酸及其类似物
PL3043865T3 (pl) 2013-09-11 2021-07-05 Institut National De La Santé Et De La Recherche Médicale (Inserm) SPOSOBY I KOMPOZYCjE FARMACEUTYCZNE W LECZENIU ZAKAŻENIA WIRUSEM ZAPALENIA WĄTROBY TYPU B
JP6562908B2 (ja) 2013-10-11 2019-08-21 ヤンセン バイオファーマ インク． 置換ヌクレオシド、置換ヌクレオチドおよびその類似体
UA119050C2 (uk) * 2013-11-11 2019-04-25 Ґілеад Саєнсиз, Інк. ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ
JP2017504633A (ja) 2014-01-30 2017-02-09 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂ型肝炎ウイルス感染の治療及び予防のための新規なジヒドロキノリジノン
ES2714110T3 (es) 2014-03-07 2019-05-27 Hoffmann La Roche Heteroarildihidropirimidinas 6-fusionadas novedosas para el tratamiento y profilaxis de la infección por el virus de la hepatitis B
CA2948080A1 (en) 2014-05-13 2015-11-19 F. Hoffmann-La Roche Ag Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection
HUE051986T2 (hu) 2014-06-24 2021-04-28 Janssen Biopharma Inc Helyettesített nukleozidok, nukleotidek és analógjaik virális fertõzés kezelésére való alkalmazásra
TN2016000566A1 (en) 2014-06-24 2018-04-04 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
WO2016012470A1 (en) 2014-07-25 2016-01-28 F. Hoffmann-La Roche Ag New amorphous and crystalline forms of (3s)-4-[[(4r)-4-(2-chloro-4-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1, 4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
CN106573898B (zh) 2014-08-14 2018-11-09 豪夫迈·罗氏有限公司 治疗和预防乙型肝炎病毒感染的新的哒嗪酮和三嗪酮
US9637485B2 (en) 2014-11-03 2017-05-02 Hoffmann-La Roche Inc. 6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection
US9676793B2 (en) 2014-12-23 2017-06-13 Hoffmann-Laroche Inc. Co-crystals of 5-amino-2-oxothiazolo[4,5-d]pyrimidin-3(2H)-yl-5-hydroxymethyl tetrahydrofuran-3-yl acetate and methods for preparing and using the same
AR103222A1 (es) 2014-12-23 2017-04-26 Hoffmann La Roche Procedimiento para la preparación de análogos de 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-dihidropirimidina
CN107108610B (zh) 2014-12-30 2019-06-04 豪夫迈·罗氏有限公司 用于治疗和预防肝炎b病毒感染的新的四氢吡啶并嘧啶和四氢吡啶并吡啶化合物
CN107109497A (zh) 2014-12-31 2017-08-29 豪夫迈·罗氏有限公司 通过实时PCR从细胞裂解物定量HBV cccDNA的高通量新方法
MA41338B1 (fr) 2015-01-16 2019-07-31 Hoffmann La Roche Composés de pyrazine pour le traitement de maladies infectieuses
WO2016120186A1 (en) 2015-01-27 2016-08-04 F. Hoffmann-La Roche Ag Recombinant hbv cccdna, the method to generate thereof and the use thereof
EP3256471B1 (en) 2015-02-11 2018-12-12 F. Hoffmann-La Roche AG Novel 2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection
US11963972B2 (en) 2016-03-23 2024-04-23 Emory University Antiviral agents and nucleoside analogs for treatment of Zika virus
AU2018218179B2 (en) 2017-02-08 2023-05-04 Biotron Limited Methods of treating influenza
CN116036112A (zh) 2017-03-14 2023-05-02 吉利德科学公司 治疗猫冠状病毒感染的方法
US11306111B2 (en) 2017-07-31 2022-04-19 January Therapeutics, Inc. Organophosphate derivatives
CA3075950A1 (en) 2017-09-18 2019-03-21 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
CA3087192A1 (en) 2017-12-27 2019-07-04 Raymond F. Schinazi Combined modalities for nucleosides and/or nadph oxidase (nox) inhibitors as myeloid-specific antiviral agents
WO2019169323A1 (en) 2018-03-02 2019-09-06 January Therapeutics, Inc. Nanoparticle compositions
JP7678802B2 (ja) 2019-11-04 2025-05-16 アレクトル エルエルシー Ｓｉｇｌｅｃ－９ＥＣＤ融合分子及びその使用方法
TWI791193B (zh) 2020-02-18 2023-02-01 美商基利科學股份有限公司 抗病毒化合物
CN113292565B (zh) 2020-02-24 2023-01-31 浙江森科建设有限公司 核苷类化合物及其制备方法和应用
CN111233929B (zh) 2020-02-28 2023-02-28 成都阿奇生物医药科技有限公司 一种核苷类似物的氘代物及其制备方法和用途
CN111393243B (zh) 2020-04-22 2022-12-13 深圳市宝安区新材料研究院 一种磷手性核苷类药物的合成方法及该方法得到的药物
AU2021312946A1 (en) 2020-07-24 2023-03-09 The Regents Of The University Of California Antiviral prodrugs, pharmaceutical formulations, and methods
MX2023002233A (es) 2020-08-24 2023-03-15 Gilead Sciences Inc Compuestos fosfolipidos y usos de estos.
CN112010916B (zh) 2020-09-09 2022-12-27 广东东阳光药业有限公司 核苷化合物的氨基磷酸酯衍生物及其用途
CA3196712A1 (en) 2020-09-23 2022-03-31 Scorpion Therapeutics, Inc. Pyrrolo[3,2-c]pyridin-4-one derivatives useful in the treatment of cancer
TWI811812B (zh) 2020-10-16 2023-08-11 美商基利科學股份有限公司 磷脂化合物及其用途
WO2022081976A1 (en) 2020-10-16 2022-04-21 Dana-Farber Cancer Institute, Inc. Piperidinyl small molecule degraders of helios and methods of use
US12083099B2 (en) 2020-10-28 2024-09-10 Accencio LLC Methods of treating symptoms of coronavirus infection with viral protease inhibitors
CN112645982B (zh) 2020-12-22 2023-04-07 苏州正济药业有限公司 一种瑞德西韦关键中间体的制备和纯化方法
EP4294798A1 (en) 2021-02-19 2023-12-27 Kalvista Pharmaceuticals Limited Factor xiia inhibitors
US11795159B2 (en) 2021-05-26 2023-10-24 Purdue Research Foundation Compounds for the treatment of SARS
US11834408B2 (en) 2021-05-28 2023-12-05 Purdue Research Foundation Compounds for the treatment of SARS
TW202317144A (zh) 2021-06-14 2023-05-01 美商維納拓爾斯製藥公司 口服生物可利用的核苷類似物
CN115475171B (zh) 2021-06-16 2025-03-07 中国医学科学院医药生物技术研究所 一种具有抗冠状病毒活性的化合物及其应用
WO2022270478A1 (ja) 2021-06-21 2022-12-29 国立大学法人北海道大学 抗ウイルス剤
CN115504940A (zh) 2021-06-23 2022-12-23 中国科学院上海药物研究所 一种酰胺类化合物、其制备方法和制药用途
WO2022268111A1 (zh) 2021-06-25 2022-12-29 前沿生物药业(南京)股份有限公司 抗病毒药物组合物及其制备方法和应用
KR102766444B1 (ko) 2021-06-28 2025-02-11 재단법인 대구경북첨단의료산업진흥재단 트리아지노인돌 유도체를 유효성분으로 하는 항바이러스제
WO2023279031A1 (en) 2021-06-29 2023-01-05 The Regents Of The University Of California Methods and compositions for treatment of covid-19
WO2023272571A1 (zh) 2021-06-30 2023-01-05 中国人民解放军军事科学院军事医学研究院 2,3-环氧丁二酰衍生物的医药用途
US20250057802A1 (en) 2021-07-08 2025-02-20 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Broad-spectrum antiviral drugs
CA3224494A1 (en) 2021-07-09 2023-01-12 Koen Vandyck Anti-viral compounds
WO2023283831A1 (zh) 2021-07-14 2023-01-19 上海药明康德新药开发有限公司 病毒主蛋白酶抑制剂及其制备方法和用途
EP4159211A4 (en) 2021-07-15 2024-10-30 National Center for Global Health and Medicine ASSOCIATED WITH PHYSIOLOGICAL ACTIVITY SUCH AS ANTIVIRAL ACTIVITY
EP4119145A1 (en) 2021-07-15 2023-01-18 Dompe' Farmaceutici S.P.A. Compounds for the treatment of covid-19
WO2023004291A1 (en) 2021-07-19 2023-01-26 Baylor College Of Medicine Coronavirus main protease inhibitors and methods using same
TW202321210A (zh) 2021-07-22 2023-06-01 瑞士商諾華公司 用於治療冠狀病毒相關疾病之化合物及組成物
WO2023003610A1 (en) 2021-07-23 2023-01-26 Enanta Pharmaceuticals, Inc. Novel spiropyrrolidine derived antiviral agents
WO2023009187A1 (en) 2021-07-29 2023-02-02 Enanta Pharmaceuticals, Inc. Novel spiropyrrolidine derived antiviral agents
KR102806503B1 (ko) 2021-07-29 2025-05-16 가톨릭대학교 산학협력단 렘데시비르와 면역조절제 병용투여법을 통한 자가면역류마티스 질환 치료용 조성물
JPWO2023008530A1 (es) 2021-07-30 2023-02-02
JP7810788B2 (ja) 2021-08-02 2026-02-03 北京華益健康薬物研究中心 コロナウイルス感染症の治療又は予防のための３ｃｌプロテア－ゼ小分子阻害剤及びその用途
EP4130001A1 (en) 2021-08-03 2023-02-08 Studiengesellschaft Kohle mbH Process for the direct catalytic glycosylation of arenes
JP2024530920A (ja) 2021-08-03 2024-08-27 コクリスタル ファーマ，インコーポレイテッド コロナウイルスに対する阻害剤
WO2023012329A1 (en) 2021-08-06 2023-02-09 Intervet International B.V. Method of treating veterinary viral diseases
CN115703796A (zh) 2021-08-09 2023-02-17 苏州恩泰新材料科技有限公司 一种瑞德西韦重要中间体制备方法
JP2023026155A (ja) 2021-08-13 2023-02-24 国立研究開発法人理化学研究所 感染症治療薬
WO2023039330A2 (en) 2021-08-17 2023-03-16 Southwest Research Institute Antiviral drugs targeting the n-terminal domain (ntd) of the coronavirus spike receptor binding domain (rbd)
EP4387625A1 (en) 2021-08-17 2024-06-26 Farahani, Ensieh Compounds for treatment of viral infections by neurotropic virus
JP2024531898A (ja) 2021-08-17 2024-09-03 サウスウエスト リサーチ インスティテュート コロナウイルスに対する阻害剤
WO2023023631A1 (en) 2021-08-18 2023-02-23 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
EP4387629A1 (en) 2021-08-18 2024-06-26 Katholieke Universiteit Leuven KU Leuven Research & Development 6-substituted- and 6,7-disubstituted-7-deazapurine ribonucleoside analogues
CN113648293B (zh) 2021-08-19 2022-07-05 山东达因海洋生物制药股份有限公司 对苯醌和/或对苯醌衍生物在制备抗新型冠状病毒药物中的应用
US20240391876A1 (en) 2021-08-19 2024-11-28 Arizona Board Of Regents On Behalf Of The University Of Arizona Quinacrine and derivatives thereof for treatment of viral infections
WO2023022216A1 (ja) 2021-08-20 2023-02-23 塩野義製薬株式会社 ウイルス増殖抑制作用を有するヌクレオシド誘導体及びそれらのプロドラッグ
JPWO2023022231A1 (es) 2021-08-20 2023-02-23
CN115716833A (zh) 2021-08-26 2023-02-28 苏州旺山旺水生物医药有限公司 一种抗病毒核苷类似物的制备方法
CN117886870A (zh) 2021-08-27 2024-04-16 南京知和医药科技有限公司 一种新型的胞苷衍生物及其药物组合物和用途
US12234202B2 (en) 2021-08-27 2025-02-25 Ut-Battelle, Llc Covalent inhibitors of coronavirus papain-like protease
WO2023034854A1 (en) 2021-08-31 2023-03-09 Pardes Biosciences, Inc. Crystalline inhibitors of cysteine proteases and methods of use thereof
CN115721661A (zh) 2021-09-01 2023-03-03 常晓宇 嘌呤核苷类药物预防或治疗冠状病毒感染性疾病的用途
CN115745960B (zh) 2021-09-02 2024-08-30 中国科学院上海药物研究所 一类含喹啉酮酰胺的化合物及其制备方法、药物组合物和用途
CN115737665A (zh) 2021-09-02 2023-03-07 广州谷森制药有限公司 胞苷衍生物和与其相关的抗病毒用途
JP2024178473A (ja) 2021-09-03 2024-12-25 塩野義製薬株式会社 ウイルス増殖阻害活性を有する二環性含窒素複素環誘導体およびそれらを含有する医薬組成物
JP2024534270A (ja) 2021-09-07 2024-09-18 上海齊魯制藥研究中心有限公司 ３ＣＬｐｒｏプロテアーゼ阻害剤
JP7735531B2 (ja) 2021-09-09 2025-09-08 広東衆生睿創生物科技有限公司 ケトアミド誘導体およびその用途
EP4148042A1 (en) 2021-09-10 2023-03-15 Centre National de la Recherche Scientifique Phenoxy-acetyl-thioureido-benzenesulfonamide derivatives, and their uses
WO2023043830A1 (en) 2021-09-15 2023-03-23 Clear Creek Bio, Inc. Combination therapies to treat viral infections
US20240400560A1 (en) 2021-09-17 2024-12-05 Shionogi & Co., Ltd. Bicyclic heterocyclic derivative having viral growth inhibitory activity and pharmaceutical composition containing same
WO2023044462A1 (en) 2021-09-17 2023-03-23 Pardes Biosciences, Inc. Cysteine protease inhibitor formulations and method of use thereof
WO2023043816A1 (en) 2021-09-17 2023-03-23 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
CN115819391A (zh) 2021-09-17 2023-03-21 中国科学院上海药物研究所 一类黄芩素衍生物、其制备方法和用途
CN115554303B (zh) 2021-09-18 2024-07-09 上海科技大学 一种三环类化合物、其制备方法及其应用
WO2023044171A1 (en) 2021-09-20 2023-03-23 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
WO2023048151A1 (ja) 2021-09-22 2023-03-30 塩野義製薬株式会社 ウイルス増殖阻害活性を有する環状ペプチド
EP4405357A1 (en) 2021-09-23 2024-07-31 Katholieke Universiteit Leuven KU Leuven Research & Development Ribonucleoside analogues against -sars-cov-2
WO2023049643A1 (en) 2021-09-23 2023-03-30 City Of Hope Inhibitors of sars-cov-2
US12186309B2 (en) 2021-09-27 2025-01-07 The Governors Of The University Of Alberta RNA virus inhibitor compounds and uses thereof
TW202320793A (zh) 2021-09-28 2023-06-01 日商塩野義製藥股份有限公司 含有三嗪衍生物之醫藥組合物
TW202330513A (zh) 2021-09-28 2023-08-01 加拿大商愛彼特生物製藥公司 )抑制劑及其使用方法
GB202114032D0 (en) 2021-09-30 2021-11-17 Univ Strathclyde Antivirals
EP4159721A1 (en) 2021-09-30 2023-04-05 Qubit Pharmaceuticals Condensed 3,3-difluoro-piperidine derivatives as inhibitors of coronaviruses 3-chymotrypsin-like protease
CN116113631B (zh) 2021-09-30 2023-09-26 中国科学院上海药物研究所 一类氰基化合物、其制备方法及用途
CN115894587B (zh) 2021-09-30 2026-05-05 南京赛弗斯医药科技有限公司 一种核苷衍生物的制备及其在抗病毒药物领域中的用途
WO2023054759A1 (ko) 2021-09-30 2023-04-06 한국화학연구원 2-아미노퀴나졸린 유도체 및 이를 포함하는 항바이러스용 조성물
KR20230049329A (ko) 2021-10-06 2023-04-13 (주)스파크바이오파마 피리미도디아제핀계 화합물 및 코로나바이러스 감염의 치료 또는 예방을 위한 이의 용도
WO2023059792A1 (en) 2021-10-06 2023-04-13 C4 Thrapeutics, Inc. Coronavirus non-structural protein 3 degrading compounds
CN115947758A (zh) 2021-10-07 2023-04-11 南京知和医药科技有限公司 一种核苷酸衍生物及其药物组合物和用途
WO2023063884A2 (en) 2021-10-12 2023-04-20 Nanyang Technological University Generation of chiral sulfinate esters
JP2024540877A (ja) 2021-10-13 2024-11-06 クリア クリーク バイオ， インコーポレイテッド コロナウイルスを処置するための化合物および方法
CN115710297A (zh) 2021-10-20 2023-02-24 知和(山东)大药厂有限公司 一种新型核苷酸衍生物类及其药物组合物和用途
EP4417608A1 (en) 2021-11-04 2024-08-21 Shenzhen Antiv Pharma Co., Ltd. Crystal form of isobutyrate nucleoside compound, and preparation method
CN115806570B (zh) 2021-11-15 2023-09-12 南京知和医药科技有限公司 一种拟肽衍生物及其药物组合物和用途
EP4289432A4 (en) 2021-11-24 2025-01-15 Shionogi & Co., Ltd PREPARATION FOR ORAL ADMINISTRATION CONTAINING TRIAZINE DERIVATIVES
US11541071B1 (en) 2021-12-16 2023-01-03 Ascletis BioScience Co., Ltd Nucleoside derivatives and methods of use thereof
CN115518058A (zh) 2021-12-29 2022-12-27 河北医科大学 N-环烷基取代的芳甲胺类化合物在制备抗病毒药物中的用途及结构和制备方法
US11760722B2 (en) 2022-01-18 2023-09-19 Ascletis Bioscience Co., Ltd. Inhibitors of cysteine proteases and methods of use thereof
WO2023054732A2 (ja) 2022-01-19 2023-04-06 塩野義製薬株式会社 新型コロナウイルス感染症治療用医薬
CN116925040B (zh) 2022-03-31 2025-07-29 陕西盘龙药业集团股份有限公司 一种靶向冠状病毒3CL蛋白酶的PROTACs及其制备方法与应用
CN115504964A (zh) 2022-04-12 2022-12-23 海创药业股份有限公司 氘代杂环酮类化合物及其用途
CN115650959B (zh) 2022-05-20 2023-10-20 南京济群医药科技股份有限公司 化合物的制备方法或纯化方法
CN115636817B (zh) 2022-06-20 2023-11-24 山东大学 含三唑环的靛红类衍生物及其制备方法与应用
CN116496266A (zh) 2022-07-08 2023-07-28 歌礼生物科技（杭州）有限公司 三嗪衍生物
CN115572298B (zh) 2022-07-22 2024-11-08 苏州旺山旺水生物医药股份有限公司 一种核苷类似物及其盐的晶型、制备方法和应用
CN115466225B (zh) 2022-08-16 2025-03-07 中国科学院上海药物研究所 一种酰胺类化合物及其制备方法、药物组合物和用途
CN115521208B (zh) 2022-09-21 2023-09-01 天津科技大学 新型冠状病毒3cl蛋白酶抑制剂和应用
CN115521316B (zh) 2022-09-23 2024-07-26 深圳安泰维生物医药有限公司 一种核苷类化合物或其中间体的制备方法和核苷类化合物的中间体
CN115521337A (zh) 2022-09-26 2022-12-27 南京康立瑞生物科技有限公司 一种瑞德西韦中间体的合成方法
CN115894498A (zh) 2022-10-01 2023-04-04 海化生命(厦门)科技有限公司 一种潜在抗病毒药物中间体bl及其合成方法
US11655255B2 (en) 2022-10-17 2023-05-23 Sph No.1 Biochemical & Pharmaceutical Co., Ltd. Method for catalytic asymmetric synthesis of phosphorus-stereogenic (P-stereogenic) nucleoside derivative and catalyst used therein
CN115894504A (zh) 2022-10-21 2023-04-04 深圳信立泰药业股份有限公司 一种冠状病毒3cl蛋白酶抑制剂及其用途
CN115651022A (zh) 2022-10-27 2023-01-31 南京康立瑞生物科技有限公司 一种高纯度瑞德西韦中间体的合成方法
CN115887471B (zh) 2022-11-01 2024-02-13 南开大学 瑞德西韦在制备治疗皮肤纤维化疾病药物中的应用
CN115894443B (zh) 2022-11-17 2024-03-29 上海市重大传染病和生物安全研究院 一种化合物艾奎斯韦及其应用
CN116514783A (zh) 2022-11-21 2023-08-01 歌礼生物科技（杭州）有限公司 三嗪衍生物
CN115819423B (zh) 2022-11-29 2024-11-22 武汉大学 一种瑞德西韦或其中间体的protac化合物及其制备方法与抗ev71的应用
CN115850338A (zh) 2022-12-12 2023-03-28 西安交通大学 一种含有双吖丙啶核苷类化合物及制备方法和应用
CN115947759A (zh) 2022-12-13 2023-04-11 安徽大学 一种治疗新冠药物瑞德西韦的制备方法
CN115785080B (zh) 2022-12-16 2024-10-11 陕西盘龙药业集团股份有限公司 一种尿嘧啶母核类化合物及其制备方法和应用

Also Published As

Publication number Publication date
CA3193879A1 (en) 2022-04-21
JP2023547599A (ja) 2023-11-13
JP7633394B2 (ja) 2025-02-19
KR20230088432A (ko) 2023-06-19
AU2021361059B2 (en) 2026-03-19
PE20230858A1 (es) 2023-05-29
US11963967B2 (en) 2024-04-23
CO2023004594A2 (es) 2023-04-17
JP2024111292A (ja) 2024-08-16
CN116322759A (zh) 2023-06-23
TW202344257A (zh) 2023-11-16
AU2021361059A1 (en) 2023-06-08
CL2023001062A1 (es) 2023-11-10
US12208110B2 (en) 2025-01-28
AU2021361059A9 (en) 2024-08-01
IL301809A (en) 2023-05-01
TWI811812B (zh) 2023-08-11
SA523440384B1 (ar) 2025-06-17
TW202233203A (zh) 2022-09-01
US20220143052A1 (en) 2022-05-12
WO2022081973A1 (en) 2022-04-21
CL2024001186A1 (es) 2024-10-11
US20230248753A1 (en) 2023-08-10
EP4228685A1 (en) 2023-08-23
DOP2023000074A (es) 2023-05-31
MX2023004188A (es) 2023-05-03
DOP2025000232A (es) 2025-10-31

Similar Documents

Publication Publication Date Title
SA523440384B1 (ar) مركبات الفوسفوليبيدات واستخداماتها
ZA202301437B (en) Compounds and methods for treatment of viral infections
MX2024010591A (es) Compuestos y metodos para el tratamiento de infecciones virales.
PH12022551441A1 (en) Diacylglycerol kinase modulating compounds
WO2021262826A3 (en) 1'-cyano nucleoside analogs and uses thereof
EP4537828A3 (en) Phospholipid compounds and uses thereof
SG10201902429PA (en) Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers
NO20064547L (no) Fremgangsmater for behandling av HIV infeksjon
MX2021001612A (es) Compuestos utiles en terapia del vih.
MX2022001261A (es) Derivados de dihidropirimidina y usos de los mismos en el tratamiento de infeccion por vhb o de enfermedades inducidas por vhb.
MX2023005913A (es) Derivados de bencenosulfonamida y usos de los mismos.
MX2026002369A (es) Compuestos antivirales y metodos de elaboracion y uso de los mismos
CR20240365A (es) Compuestos antivirales y métodos de elaboración y uso de los mismos
MX2017014080A (es) Compuestos heterociclicos y su uso en la prevencion o tratamiento de las infecciones bacterianas.
BR112018014723A2 (pt) fantasmas bacterianos para o tratamento de câncer
MX2017013795A (es) Combinaciones terapeuticas de tratamientos antivirales y antiinflamatorios.
WO2021004958A3 (en) Compositions comprising bacterial strains
MX382439B (es) Compuestos de carbapenem
CR20210029A (es) MÉTODOS DE TRATAMIENTO DE HFpEF EMPLEANDO DAPAGLIFLOZINA Y COMPOSICIONES QUE COMPRENDEN LA MISMA
WO2022063869A3 (en) Compounds for the treatment of viral infections
MX2022001271A (es) Derivados de dihidropirimidina y usos de estos en el tratamiento de la infeccion por vhb o de enfermedades inducidas por vhb.
MX2022001266A (es) Derivados de dihidropirimidina y usos de estos en el tratamiento de la infeccion por vhb o de enfermedades inducidas por vhb.
PH12020550059A1 (en) Novel ophthalmic composition and methods of use