BRPI0516221A - método de produção de vìrus de uma cultura de células, composição, e, método de produção de reovìrus infeccioso - Google Patents
método de produção de vìrus de uma cultura de células, composição, e, método de produção de reovìrus infecciosoInfo
- Publication number
- BRPI0516221A BRPI0516221A BRPI0516221-1A BRPI0516221A BRPI0516221A BR PI0516221 A BRPI0516221 A BR PI0516221A BR PI0516221 A BRPI0516221 A BR PI0516221A BR PI0516221 A BRPI0516221 A BR PI0516221A
- Authority
- BR
- Brazil
- Prior art keywords
- virus
- production
- cell culture
- composition
- infectious
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 9
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 238000004113 cell culture Methods 0.000 title abstract 3
- 208000015181 infectious disease Diseases 0.000 title abstract 3
- 230000002458 infectious effect Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 241000702263 Reovirus sp. Species 0.000 title abstract 2
- 238000004440 column chromatography Methods 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/13—Tumour cells, irrespective of tissue of origin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12051—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
MéTODO DE PRODUçãO DE VìRUS DE UMA CULTURA DE CéLULAS, COMPOSIçãO, E, MéTODO DE PRODUçãO DE REOVìRUS INFECCIOSO. A invenção refere-se a um método melhorado de purificação de vírus, particularmente reovírus. O vírus infeccioso pode ser extraído de uma cultura celular com um detergente para produzir altos títulos de vírus, e o vírus pode então ser purificado por etapas simples, tais como filtração e cromatografia em coluna. Os vírus e as composições que compreendem os vírus preparados de acordo com a presente invenção são também providos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62125704P | 2004-10-22 | 2004-10-22 | |
| PCT/CA2005/001617 WO2006042414A1 (en) | 2004-10-22 | 2005-10-21 | Improved viral purification methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0516221A true BRPI0516221A (pt) | 2008-08-26 |
Family
ID=36202651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0516221-1A BRPI0516221A (pt) | 2004-10-22 | 2005-10-21 | método de produção de vìrus de uma cultura de células, composição, e, método de produção de reovìrus infeccioso |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7901921B2 (pt) |
| EP (1) | EP1814982B1 (pt) |
| JP (2) | JP4898690B2 (pt) |
| CN (2) | CN101098959A (pt) |
| AU (1) | AU2005297372B2 (pt) |
| BR (1) | BRPI0516221A (pt) |
| CA (1) | CA2584142C (pt) |
| DK (1) | DK1814982T3 (pt) |
| ES (1) | ES2562237T3 (pt) |
| IL (1) | IL182562A0 (pt) |
| MX (1) | MX2007004696A (pt) |
| SG (1) | SG156673A1 (pt) |
| WO (1) | WO2006042414A1 (pt) |
| ZA (1) | ZA200704034B (pt) |
Families Citing this family (68)
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| DE60327069D1 (de) * | 2002-04-30 | 2009-05-20 | Oncolytics Biotech Inc | Verbesserte reinigungsmethode für viren |
| US10668119B2 (en) | 2005-08-01 | 2020-06-02 | Virocure, Inc. | Attenuated reovirus |
| WO2007099401A2 (en) * | 2005-08-01 | 2007-09-07 | University Technologies International, Inc. | Oncolytic attenuated reoviruses for treatment of proliferative disorders |
| US20080131955A1 (en) * | 2006-11-30 | 2008-06-05 | Canon U.S. Life Sciences, Inc. | Method of Separating Target DNA from Mixed DNA |
| US10369171B2 (en) | 2007-03-13 | 2019-08-06 | Virocure, Inc. | Attenuated reoviruses for selection of cell populations |
| AU2009214768B2 (en) * | 2008-02-12 | 2015-01-22 | Sanofi Pasteur Limited | Methods using ion exchange and gel filtration chromatography for poxvirus purification |
| CN101270350A (zh) * | 2008-03-05 | 2008-09-24 | 辽宁依生生物制药有限公司 | 一种提取狂犬病病毒的方法 |
| SG176554A1 (en) | 2009-05-12 | 2012-01-30 | Transgene Sa | Method for orthopoxvirus production and purification |
| CN102191226A (zh) * | 2010-03-08 | 2011-09-21 | 北京清大天一科技有限公司 | 细胞培养混合物的分离纯化方法 |
| SG184833A1 (en) | 2010-04-14 | 2012-11-29 | Emd Millipore Corp | Methods of producing high titer, high purity virus stocks and methods of use thereof |
| CA2819236A1 (en) | 2010-12-02 | 2012-06-07 | Oncolytics Biotech Inc. | Lyophilized viral formulations |
| MX373096B (es) | 2010-12-02 | 2020-04-27 | Oncolytics Biotech Inc | Formulaciones virales líquidas. |
| EA201391605A1 (ru) | 2011-04-29 | 2014-02-28 | Онколитикс Байотек Инк. | Способы очистки вирусов с использованием гельпроникающей хроматографии |
| CN102628030B (zh) * | 2012-01-20 | 2013-12-04 | 宁波大学 | 三疣梭子蟹呼肠孤病毒的鸡胚培养方法 |
| CN103571800B (zh) * | 2012-07-27 | 2018-04-24 | 江苏康润生物科技有限公司 | 一种去除疫苗中宿主dna的方法 |
| US10577627B2 (en) | 2014-06-09 | 2020-03-03 | Voyager Therapeutics, Inc. | Chimeric capsids |
| DK3172317T3 (da) * | 2014-07-24 | 2019-07-22 | Janssen Vaccines & Prevention Bv | Fremgangsmåde til oprensning af poliovirus fra cellekulturer |
| EP3215191B1 (en) | 2014-11-05 | 2024-08-14 | Voyager Therapeutics, Inc. | Aadc polynucleotides for the treatment of parkinson's disease |
| CN114717264A (zh) | 2014-11-14 | 2022-07-08 | 沃雅戈治疗公司 | 治疗肌萎缩性侧索硬化(als)的组合物和方法 |
| KR20230145206A (ko) | 2014-11-14 | 2023-10-17 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
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| DK3307878T3 (da) * | 2015-06-10 | 2021-10-11 | Us Health | Fremgangsmåder til fremstilling og oprensning af nukleinsyreholdige sammensætninger |
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| MX2019013172A (es) | 2017-05-05 | 2020-09-07 | Voyager Therapeutics Inc | Composiciones y metodos para tratar la enfermedad de huntington. |
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| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
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| TW202413649A (zh) | 2017-10-16 | 2024-04-01 | 美商航海家醫療公司 | 肌萎縮性脊髓側索硬化症(als)之治療 |
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| US11603527B2 (en) * | 2017-12-27 | 2023-03-14 | Global Life Sciences Solutions Usa Llc | Method and kit for viral vector isolation |
| EP3762500A1 (en) | 2018-03-06 | 2021-01-13 | Voyager Therapeutics, Inc. | Insect cell manufactured partial self-complementary aav genomes |
| CN112424359A (zh) | 2018-05-15 | 2021-02-26 | 沃雅戈治疗公司 | 用于治疗帕金森氏病的组合物和方法 |
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| US11696948B2 (en) | 2018-06-12 | 2023-07-11 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
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| US11690907B2 (en) | 2018-06-12 | 2023-07-04 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
| US20210254103A1 (en) | 2018-07-02 | 2021-08-19 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis and disorders associated with the spinal cord |
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| WO2020023612A1 (en) | 2018-07-24 | 2020-01-30 | Voyager Therapeutics, Inc. | Systems and methods for producing gene therapy formulations |
| US12281321B2 (en) | 2018-09-28 | 2025-04-22 | Voyager Therapeutics, Inc. | Frataxin expression constructs having engineered promoters and methods of use thereof |
| WO2020072849A1 (en) | 2018-10-04 | 2020-04-09 | Voyager Therapeutics, Inc. | Methods for measuring the titer and potency of viral vector particles |
| CA3125770A1 (en) | 2019-01-18 | 2020-07-23 | Voyager Therapeutics, Inc. | Methods and systems for producing aav particles |
| KR102228267B1 (ko) * | 2019-01-25 | 2021-03-17 | 바이로큐어 주식회사 | Bhk-21 세포를 이용한 바이러스 생산방법 |
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| CN116463300A (zh) * | 2023-03-07 | 2023-07-21 | 武汉科前生物股份有限公司 | 一种犬细小病毒生产纯化工艺及应用 |
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| CN116855461A (zh) * | 2023-04-25 | 2023-10-10 | 浙江恒驭生物科技有限公司 | 一种呼肠孤病毒3型的纯化方法及应用 |
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-
2005
- 2005-10-20 US US11/255,800 patent/US7901921B2/en active Active
- 2005-10-21 AU AU2005297372A patent/AU2005297372B2/en not_active Expired
- 2005-10-21 SG SG200907055-8A patent/SG156673A1/en unknown
- 2005-10-21 CN CNA2005800444124A patent/CN101098959A/zh active Pending
- 2005-10-21 JP JP2007537090A patent/JP4898690B2/ja not_active Expired - Lifetime
- 2005-10-21 BR BRPI0516221-1A patent/BRPI0516221A/pt not_active IP Right Cessation
- 2005-10-21 ZA ZA200704034A patent/ZA200704034B/xx unknown
- 2005-10-21 DK DK05799134.1T patent/DK1814982T3/en active
- 2005-10-21 ES ES05799134.1T patent/ES2562237T3/es not_active Expired - Lifetime
- 2005-10-21 WO PCT/CA2005/001617 patent/WO2006042414A1/en not_active Ceased
- 2005-10-21 EP EP05799134.1A patent/EP1814982B1/en not_active Expired - Lifetime
- 2005-10-21 CN CN201510475203.0A patent/CN105062980A/zh active Pending
- 2005-10-21 CA CA2584142A patent/CA2584142C/en not_active Expired - Lifetime
- 2005-10-21 MX MX2007004696A patent/MX2007004696A/es active IP Right Grant
-
2007
- 2007-04-16 IL IL182562A patent/IL182562A0/en unknown
-
2011
- 2011-11-28 JP JP2011258983A patent/JP2012040026A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1814982B1 (en) | 2015-12-23 |
| CN101098959A (zh) | 2008-01-02 |
| AU2005297372B2 (en) | 2010-08-26 |
| IL182562A0 (en) | 2007-07-24 |
| CA2584142C (en) | 2011-11-29 |
| ZA200704034B (en) | 2008-08-27 |
| EP1814982A1 (en) | 2007-08-08 |
| JP2012040026A (ja) | 2012-03-01 |
| JP2008516616A (ja) | 2008-05-22 |
| US7901921B2 (en) | 2011-03-08 |
| HK1100959A1 (en) | 2007-10-05 |
| ES2562237T3 (es) | 2016-03-03 |
| DK1814982T3 (en) | 2016-03-21 |
| SG156673A1 (en) | 2009-11-26 |
| EP1814982A4 (en) | 2009-03-04 |
| US20060088869A1 (en) | 2006-04-27 |
| AU2005297372A1 (en) | 2006-04-27 |
| JP4898690B2 (ja) | 2012-03-21 |
| CA2584142A1 (en) | 2006-04-27 |
| MX2007004696A (es) | 2007-06-14 |
| WO2006042414A1 (en) | 2006-04-27 |
| CN105062980A (zh) | 2015-11-18 |
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