BRPI0516384A - dispositivo e uso do mesmo - Google Patents

dispositivo e uso do mesmo

Info

Publication number
BRPI0516384A
BRPI0516384A BRPI0516384-6A BRPI0516384A BRPI0516384A BR PI0516384 A BRPI0516384 A BR PI0516384A BR PI0516384 A BRPI0516384 A BR PI0516384A BR PI0516384 A BRPI0516384 A BR PI0516384A
Authority
BR
Brazil
Prior art keywords
cover layer
membranophilic
region
surfactant
iii
Prior art date
Application number
BRPI0516384-6A
Other languages
English (en)
Inventor
Anders Karlsson
Roger Karlsson
Johan Pihl
Mattias Karlsson
Owe Orwar
Tatiana Lobovkina
Aldo Jesorka
Max Davidson
Original Assignee
Nanoxis Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanoxis Ab filed Critical Nanoxis Ab
Publication of BRPI0516384A publication Critical patent/BRPI0516384A/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/005—Dielectrophoresis, i.e. dielectric particles migrating towards the region of highest field strength
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B7/00—Microstructural systems ; Auxiliary parts of microstructural devices or systems
    • B81B7/04—Networks or arrays of similar microstructural devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44747—Composition of gel or of carrier mixture
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
    • G01N30/92—Construction of the plate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N37/00—Details not covered by any other group of this subclass
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/976—Trypsin; Chymotrypsin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Nanotechnology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Dispersion Chemistry (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Manufacturing & Machinery (AREA)
  • Computer Hardware Design (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

DISPOSITIVO E USO DO MESMO. A presente invenção refere-se a um dispositivo compreendendo pelo menos uma superfície sólida suporte compreendendo pelo menos uma região de membranofílica; uma camada de cobertura que é pelo menos parcialmente imobilizada para a região de membranofílica, a dita camada de cobertura consistindo em (i) uma membrana tensoativa, (ii) um polímero imitando lipídeo, (iii) um tensoativo ou sistema de emulsão ou (iv) um cristal líquido; e uma substância incluída em ou ligada a, conectada a ou associada com a camada de cobertura. São também mostrados processos em que o dispositivo é usado e uso do dispositivo.
BRPI0516384-6A 2004-12-23 2005-12-23 dispositivo e uso do mesmo BRPI0516384A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0403139A SE0403139D0 (sv) 2004-12-23 2004-12-23 Device and use thereof
PCT/SE2005/002022 WO2006068619A1 (en) 2004-12-23 2005-12-23 Device and use thereof

Publications (1)

Publication Number Publication Date
BRPI0516384A true BRPI0516384A (pt) 2008-09-02

Family

ID=34075266

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0516384-6A BRPI0516384A (pt) 2004-12-23 2005-12-23 dispositivo e uso do mesmo

Country Status (10)

Country Link
US (1) US20110091864A1 (pt)
EP (3) EP2174908B1 (pt)
JP (1) JP5001171B2 (pt)
KR (1) KR101287406B1 (pt)
CN (1) CN101163638B (pt)
AU (1) AU2005319755B2 (pt)
BR (1) BRPI0516384A (pt)
CA (1) CA2592097A1 (pt)
SE (1) SE0403139D0 (pt)
WO (1) WO2006068619A1 (pt)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008538280A (ja) * 2005-03-29 2008-10-23 ザ・ボード・オブ・トラスティーズ・オブ・ザ・レランド・スタンフォード・ジュニア・ユニバーシティ 脂質二分子膜の製造方法
JP4519794B2 (ja) * 2006-03-16 2010-08-04 日本電信電話株式会社 マイクロ流路素子
KR20080012605A (ko) 2006-08-04 2008-02-12 삼성에스디아이 주식회사 탄성 에너지 장벽을 이용한 생체막 소자
JP2010510247A (ja) 2006-11-21 2010-04-02 アプライド バイオシステムズ インコーポレイテッド 酸化物層上に不動態化表面を形成するための中間体および方法およびこれにより製造される製品
WO2009024869A2 (en) * 2007-03-26 2009-02-26 Owe Orwar Methods and devices for controlled monolayer formation
GB0718073D0 (en) * 2007-09-17 2007-10-24 Foundation For Res And Technol Analysing the binding of cell membrane bound molecules
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
US8173198B2 (en) 2008-07-23 2012-05-08 Life Technologies Corporation Deposition of metal oxides onto surfaces as an immobilization vehicle for carboxylated or phophated particles or polymers
EP2168646A1 (en) 2008-09-30 2010-03-31 Qiagen GmbH Method of loading a crystallization device
JP5585204B2 (ja) * 2010-05-18 2014-09-10 大日本印刷株式会社 マイクロチップ及びその製造方法
US8821702B2 (en) 2010-08-27 2014-09-02 Empire Technology Development Llc Devices and methods for electroosmotic transport of non-polar solvents
DE102011008205A1 (de) 2011-01-10 2012-07-12 Albert-Ludwigs-Universität Freiburg Verfahren zur automaisierten Herstellung einer Molekülschicht aus amphiphilen Molekülen und Vorrichtung zum Herstellen dieser Molekülschicht
JP2014101273A (ja) * 2011-02-28 2014-06-05 Tokyo Medical And Dental Univ 脂質構造体の製造方法
US12397363B2 (en) 2011-03-31 2025-08-26 Norsk Titanium As Method and arrangement for building metallic objects by solid freeform fabrication
GB2489493B (en) * 2011-03-31 2013-03-13 Norsk Titanium Components As Method and arrangement for building metallic objects by solid freeform fabrication
CN107315086B (zh) 2011-06-29 2019-09-10 中央研究院 使用表面涂层对生物物质的捕获、纯化和释放
WO2013049636A1 (en) 2011-09-30 2013-04-04 The Regents Of The University Of Michigan System for detecting rare cells
US10130946B2 (en) 2011-09-30 2018-11-20 The Regents Of The University Of Michigan System for detecting rare cells
FR2982778A1 (fr) * 2011-11-21 2013-05-24 Centre Nat Rech Scient Procede de separation membranaire en regime discontinu.
JP5839706B2 (ja) * 2012-08-10 2016-01-06 日本電信電話株式会社 マイクロホール基板の製造方法
US9494500B2 (en) * 2012-10-29 2016-11-15 Academia Sinica Collection and concentration system for biologic substance of interest and use thereof
US10073024B2 (en) * 2012-10-29 2018-09-11 The Regents Of The University Of Michigan Microfluidic device and method for detecting rare cells
DE102012110664A1 (de) * 2012-11-07 2014-05-08 Henkel Ag & Co. Kgaa In Beschichtungsmitteln, Haftvermittlern oder Klebstoffen für oxidische Oberflächen einsetzbare Peptide
US8809769B2 (en) 2012-11-29 2014-08-19 Bruker Daltonics, Inc. Apparatus and method for cross-flow ion mobility spectrometry
US9352315B2 (en) 2013-09-27 2016-05-31 Taiwan Semiconductor Manufacturing Company, Ltd. Method to produce chemical pattern in micro-fluidic structure
TW201623605A (zh) 2014-04-01 2016-07-01 中央研究院 用於癌症診斷及預後之方法及系統
JP6465374B2 (ja) * 2014-04-25 2019-02-06 コニカミノルタ株式会社 膜タンパク質評価法
US10112198B2 (en) 2014-08-26 2018-10-30 Academia Sinica Collector architecture layout design
MA41842A (fr) 2015-03-31 2018-02-06 Oblique Therapeutics Ab Nouveaux procédés de sélection d'épitope
US10317406B2 (en) 2015-04-06 2019-06-11 The Regents Of The University Of Michigan System for detecting rare cells
US10145906B2 (en) 2015-12-17 2018-12-04 Analog Devices Global Devices, systems and methods including magnetic structures
US10107726B2 (en) 2016-03-16 2018-10-23 Cellmax, Ltd. Collection of suspended cells using a transferable membrane
GB201617002D0 (en) 2016-10-06 2016-11-23 Oblique Therapeutics Ab Multi-protease method
JP6784843B2 (ja) * 2017-07-19 2020-11-11 シャープ株式会社 センサおよびセンサアレイ
US12138606B2 (en) * 2017-11-21 2024-11-12 Dh Technologies Development Pte. Ltd. 3-d mixing and particle delivery via movable electromagnets assemblies
CN108144745B (zh) * 2017-12-20 2020-06-16 天康生物股份有限公司 一种分离装置以及减少布氏菌病活疫苗的内毒素含量的方法
US11577248B2 (en) * 2017-12-21 2023-02-14 Mcmaster University Biological membrane-based sensor
NL2021377B1 (en) 2018-07-03 2020-01-08 Illumina Inc Interposer with first and second adhesive layers
US11145772B2 (en) 2019-03-11 2021-10-12 At&T Intellectual Property I, L.P. Device for photo spectroscopy having an atomic-scale bilayer
CN110931344B (zh) * 2019-12-09 2022-06-03 广东省半导体产业技术研究院 一种用于质谱检测的介电型样品靶片及其制作方法
US12411064B2 (en) 2020-05-08 2025-09-09 Waters Technologies Corporation Methods for heat-assisted enzyme digestion
EP4147026A1 (en) 2020-05-08 2023-03-15 Waters Technologies Corporation Methods for heat-assisted enzyme digestion
CN120189828B (zh) * 2025-05-26 2025-09-09 杭州水处理技术研究开发中心有限公司 反渗透复合膜及其制备方法和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL93020A (en) * 1990-01-09 1995-06-29 Yeda Res & Dev Biosensors comprising a lipid bilayer doped with ion channels anchored to a recording electrode by bridging molecules
EP0842418A4 (en) * 1995-08-01 2004-08-18 Ambri Ltd Composite membrane sensor
DE69735601T2 (de) * 1996-11-29 2007-10-18 The Board Of Trustees Of The Leland Stanford Junior University, Stanford Anordnungen von unabhängig voneinander ansteuerbaren, gestützten flüssigbilayer-membranen und ihre anwendungsverfahren
US6066446A (en) * 1997-12-19 2000-05-23 Nen Life Science Products, Inc. Assay member and method for its manufacture
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
EP1218097A1 (en) * 1999-10-08 2002-07-03 The Board Of Trustees Of The Leland Stanford Junior University Lipid-bilayer arrays and methods of making and using same
SE9904802D0 (sv) * 1999-12-23 1999-12-23 Amersham Pharm Biotech Ab Microfluidic surfaces
US20050053642A1 (en) * 2000-08-23 2005-03-10 Mathias Ulbricht Biocompatible materials
US7998746B2 (en) * 2000-08-24 2011-08-16 Robert Otillar Systems and methods for localizing and analyzing samples on a bio-sensor chip
WO2002026626A1 (en) * 2000-09-27 2002-04-04 Mitsubishi Rayon Co., Ltd. Non-porous spherical silica and method for production thereof
SE0003506D0 (sv) 2000-09-28 2000-09-28 Daniel Chiu Microscopic networks of containers and nanotubes
US20030044843A1 (en) * 2001-01-09 2003-03-06 Mitsubishi Pharma Corporation Novel proteome analysis method and devices therefor
AU2002243129B2 (en) * 2001-03-14 2007-07-19 Ge Healthcare Bio-Sciences Ab Method of preparing supported lipid film membranes and use thereof
CA2441206A1 (en) * 2001-03-19 2002-09-26 Gyros Ab Characterization of reaction variables
EP1404707A4 (en) * 2001-05-29 2005-02-02 Univ Michigan SYSTEMS AND METHOD FOR THE ANALYSIS OF PROTEINS
US8815577B2 (en) * 2001-07-30 2014-08-26 Meso Scale Technologies, Llc Assay electrode having immobilized lipid/protein layers, methods of making the same and methods of using the same for luminescence test measurements
CN1630707A (zh) * 2002-02-12 2005-06-22 色雷特康公司 用于快速改变传感器周围溶液环境的系统与方法
WO2003086960A1 (en) * 2002-04-09 2003-10-23 Gyros Ab Microfluidic devices with new inner surfaces
KR100455293B1 (ko) * 2002-05-15 2004-11-06 삼성전자주식회사 친수성 영역과 소수성 영역으로 구성되는 생물분자용어레이 판의 제조방법
WO2004025262A2 (en) * 2002-09-11 2004-03-25 Synamem Corporation Membrane-based assays
US20040185445A1 (en) * 2003-03-19 2004-09-23 Ye Fang Universal readout for target identification using biological microarrays
JP4150793B2 (ja) * 2003-03-27 2008-09-17 独立行政法人産業技術総合研究所 光重合性脂質膜による膜内分子の水平拡散制御
WO2004108762A1 (en) * 2003-06-04 2004-12-16 Universite De Liege Immobilized membrane proteins and methods of use therefor
JP2005283567A (ja) * 2005-02-15 2005-10-13 Kenji Sato プロテインチップ

Also Published As

Publication number Publication date
CN101163638A (zh) 2008-04-16
CN101163638B (zh) 2012-07-04
WO2006068619A1 (en) 2006-06-29
AU2005319755A1 (en) 2006-06-29
EP2174908A3 (en) 2010-05-05
EP2174908A2 (en) 2010-04-14
EP2366659A3 (en) 2014-11-05
EP1828049A1 (en) 2007-09-05
KR101287406B1 (ko) 2013-07-23
JP5001171B2 (ja) 2012-08-15
AU2005319755B2 (en) 2012-05-17
SE0403139D0 (sv) 2004-12-23
KR20070119611A (ko) 2007-12-20
JP2008525797A (ja) 2008-07-17
EP2174908B1 (en) 2015-09-30
EP2366659A2 (en) 2011-09-21
CA2592097A1 (en) 2006-06-29
US20110091864A1 (en) 2011-04-21

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