BRPI0517023A - compostos de ácidos 4-metóxi-metil-pirrolidino-2-carboxìlicos e seus derivados como inibidores de vìrus de hepatite c - Google Patents
compostos de ácidos 4-metóxi-metil-pirrolidino-2-carboxìlicos e seus derivados como inibidores de vìrus de hepatite cInfo
- Publication number
- BRPI0517023A BRPI0517023A BRPI0517023-0A BRPI0517023A BRPI0517023A BR PI0517023 A BRPI0517023 A BR PI0517023A BR PI0517023 A BRPI0517023 A BR PI0517023A BR PI0517023 A BRPI0517023 A BR PI0517023A
- Authority
- BR
- Brazil
- Prior art keywords
- methyl
- thiazol
- hepatitis
- derivatives
- carboxylic acid
- Prior art date
Links
- 241000711549 Hepacivirus C Species 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- LCRFCICIBIZKQT-UHFFFAOYSA-N 4-methoxy-1-methylpyrrolidine-2-carboxylic acid Chemical class COC1CC(C(O)=O)N(C)C1 LCRFCICIBIZKQT-UHFFFAOYSA-N 0.000 title 1
- -1 4-tert-butyl-3-methoxyphenyl Chemical group 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005160 aryl oxy alkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
COMPOSTOS DE ACIDOS 4-METOXI-METIL-PIRROLIDINO-2- CARBOXILICOS E SEUS DERIVADOS COMO INIBIDORES DE VìRUS DE HEPATITE C. São propostos agentes antivirais da Fórmula (Ia), em que: A representa hidróxi; D representa 4-terc-butil-3-metóxi-fenila; E representa 1,3-tiazol-2-ila ou 5-metil-l,3-tiazol-2-ila; G representa metóxi-metila; J representa 1,3-tiazol-2-ilmetila, 1,3-tiazol-4-ilmetila, 1,2-tiazol-3-ilmetila, ou 1H-pirazol-1-ilmetila; e seus sais, solvatos e esteres; desde que, quando A for esterificado para formar - OR, em que R é selecionado de alquila de cadeia reta ou ramificada, aralquila, arilóxi-alquila ou arila, então R será diferente de terc-butila; processos para a sua preparação e o seu uso no tratamento de HCV.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0423673.3A GB0423673D0 (en) | 2004-10-25 | 2004-10-25 | Compounds |
| PCT/EP2005/011532 WO2006045613A1 (en) | 2004-10-25 | 2005-10-24 | 4-methoxymethyl-pyrrolidine-2-carboxylic acid compounds and derivatives thereof as hepatitis c virus inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0517023A true BRPI0517023A (pt) | 2008-09-30 |
Family
ID=33485164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0517023-0A BRPI0517023A (pt) | 2004-10-25 | 2005-10-24 | compostos de ácidos 4-metóxi-metil-pirrolidino-2-carboxìlicos e seus derivados como inibidores de vìrus de hepatite c |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20070270475A1 (pt) |
| EP (1) | EP1805172A1 (pt) |
| JP (1) | JP2008517968A (pt) |
| KR (1) | KR20070072614A (pt) |
| CN (1) | CN101087785A (pt) |
| AR (1) | AR051340A1 (pt) |
| AU (1) | AU2005298849A1 (pt) |
| BR (1) | BRPI0517023A (pt) |
| CA (1) | CA2585170A1 (pt) |
| GB (1) | GB0423673D0 (pt) |
| IL (1) | IL182583A0 (pt) |
| MA (1) | MA29000B1 (pt) |
| MX (1) | MX2007004914A (pt) |
| NO (1) | NO20072547L (pt) |
| PE (1) | PE20060602A1 (pt) |
| RU (1) | RU2007119390A (pt) |
| TW (1) | TW200630365A (pt) |
| WO (1) | WO2006045613A1 (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| EP2142215B1 (en) | 2007-05-04 | 2012-03-07 | Vertex Pharmceuticals Incorporated | Combination therapy for the treatment of hcv infection |
| UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
| BRPI0917458A2 (pt) | 2008-08-11 | 2015-12-01 | Glaxosmithkline Llc | composto, método de tratamento de doenças e condições, composição farmacêutica, método para tratar ou prevenir doença, e, uso de um composto |
| BRPI0917013A2 (pt) | 2008-08-11 | 2016-02-16 | Glaxosmithkline Llc | métodos para tratar doenças alérgicas e outras condições inflamatórias, e para tratar ou prevenir doença, composto, composição farmacêutica, e, uso de um composto |
| WO2011098451A1 (en) | 2010-02-10 | 2011-08-18 | Glaxosmithkline Llc | Purine derivatives and their pharmaceutical uses |
| DK2534149T3 (da) | 2010-02-10 | 2015-01-05 | Glaxosmithkline Llc | 6-amino-2-{ [ (1s)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8h-purin-8-on-maleat |
| KR20160124157A (ko) | 2014-02-20 | 2016-10-26 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | 인간 인터페론의 유도인자로서의 피롤로[3,2]피리미딘 유도체 |
| IL247927B (en) | 2014-05-07 | 2022-09-01 | Boehringer Ingelheim Int | Container, a device that turns a liquid into a fine spray and use |
| MX2017006302A (es) | 2014-11-13 | 2018-02-16 | Glaxosmithkline Biologicals Sa | Derivados de adenina que son utiles en el tratamiento de enfermedades alergicas u otras afecciones inflamatorias. |
| CN107849084B (zh) | 2015-12-03 | 2021-09-14 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为sting调节剂的环状嘌呤二核苷酸 |
| JP2019510802A (ja) | 2016-04-07 | 2019-04-18 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | タンパク質調節物質として有用な複素環アミド |
| PT3440076T (pt) | 2016-04-07 | 2022-07-29 | Glaxosmithkline Ip Dev Ltd | Amidas heterocíclicas úteis como modeladores de proteína |
| CA3077337A1 (en) | 2017-10-05 | 2019-04-11 | Glaxosmithkline Intellectual Property Development Limited | Modulators of stimulator of interferon genes (sting) |
| AU2018344902B2 (en) | 2017-10-05 | 2021-06-03 | Glaxosmithkline Intellectual Property Development Limited | Modulators of stimulator of interferon genes (STING) useful in treating HIV |
| GB201807924D0 (en) | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
| US20220227761A1 (en) | 2019-05-16 | 2022-07-21 | Stingthera, Inc. | Oxoacridinyl acetic acid derivatives and methods of use |
| WO2020232378A1 (en) | 2019-05-16 | 2020-11-19 | Silicon Swat, Inc. | Benzo[b][1,8]naphthyridine acetic acid derivatives and methods of use |
| GB201910304D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| GB201910305D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| EP4077318B1 (en) | 2019-12-18 | 2025-10-15 | Ctxt Pty Ltd | Benzimidazole dimers as modulators of sting |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60325498D1 (de) * | 2002-10-24 | 2009-02-05 | Glaxo Group Ltd | 1-acyl-pyrrolidin-derivate für die behandlung von viralen infektionen |
-
2004
- 2004-10-25 GB GBGB0423673.3A patent/GB0423673D0/en not_active Ceased
-
2005
- 2005-10-21 PE PE2005001239A patent/PE20060602A1/es not_active Application Discontinuation
- 2005-10-24 RU RU2007119390/04A patent/RU2007119390A/ru unknown
- 2005-10-24 WO PCT/EP2005/011532 patent/WO2006045613A1/en not_active Ceased
- 2005-10-24 KR KR1020077011741A patent/KR20070072614A/ko not_active Withdrawn
- 2005-10-24 US US11/568,127 patent/US20070270475A1/en not_active Abandoned
- 2005-10-24 JP JP2007538336A patent/JP2008517968A/ja active Pending
- 2005-10-24 AU AU2005298849A patent/AU2005298849A1/en not_active Abandoned
- 2005-10-24 CN CNA2005800447014A patent/CN101087785A/zh active Pending
- 2005-10-24 AR ARP050104434A patent/AR051340A1/es not_active Application Discontinuation
- 2005-10-24 BR BRPI0517023-0A patent/BRPI0517023A/pt not_active Application Discontinuation
- 2005-10-24 EP EP05799541A patent/EP1805172A1/en not_active Withdrawn
- 2005-10-24 MX MX2007004914A patent/MX2007004914A/es unknown
- 2005-10-24 TW TW094137066A patent/TW200630365A/zh unknown
- 2005-10-24 CA CA002585170A patent/CA2585170A1/en not_active Abandoned
-
2007
- 2007-04-16 IL IL182583A patent/IL182583A0/en unknown
- 2007-04-25 MA MA29846A patent/MA29000B1/fr unknown
- 2007-05-18 NO NO20072547A patent/NO20072547L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2007119390A (ru) | 2008-12-10 |
| AR051340A1 (es) | 2007-01-03 |
| CA2585170A1 (en) | 2006-05-04 |
| JP2008517968A (ja) | 2008-05-29 |
| GB0423673D0 (en) | 2004-11-24 |
| WO2006045613A1 (en) | 2006-05-04 |
| EP1805172A1 (en) | 2007-07-11 |
| US20070270475A1 (en) | 2007-11-22 |
| IL182583A0 (en) | 2007-07-24 |
| PE20060602A1 (es) | 2006-07-15 |
| AU2005298849A1 (en) | 2006-05-04 |
| NO20072547L (no) | 2007-07-23 |
| TW200630365A (en) | 2006-09-01 |
| CN101087785A (zh) | 2007-12-12 |
| MX2007004914A (es) | 2007-06-12 |
| MA29000B1 (fr) | 2007-11-01 |
| KR20070072614A (ko) | 2007-07-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |