NO20072547L - 4-metoksymetyl-pyrrolidin-2-karboksylsyreforbindelser og derivater derav som hepatitt C virusinhibitorer - Google Patents

4-metoksymetyl-pyrrolidin-2-karboksylsyreforbindelser og derivater derav som hepatitt C virusinhibitorer

Info

Publication number
NO20072547L
NO20072547L NO20072547A NO20072547A NO20072547L NO 20072547 L NO20072547 L NO 20072547L NO 20072547 A NO20072547 A NO 20072547A NO 20072547 A NO20072547 A NO 20072547A NO 20072547 L NO20072547 L NO 20072547L
Authority
NO
Norway
Prior art keywords
methoxymethyl
thiazol
pyrrolidine
hepatitis
derivatives
Prior art date
Application number
NO20072547A
Other languages
English (en)
Inventor
Charles David Hartley
Stephen Allan Smith
Fabrizio Nerozzi
Rossella Guidetti
David Haigh
Peter David Howes
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33485164&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20072547(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO20072547L publication Critical patent/NO20072547L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Anti-virale midler med formel (la) hvori: A representerer hydroksy; D representerer 4-tert-butyl-3-metoksyfenyl; E representerer l,3-tiazol-2-yl eller 5-metyl-l,3-tiazol-2-yl; G representerer metoksymetyl; J representerer l,3-tiazol-2-ylmetyl, l,3-tiazol-4-ylmetyl, l,2-tiazol-3-ylmetyl, eller lH-pyrazol-1-ylmetyl; og salter, solvater og estere derav; forutsatt at når A er forestret for å danne -OR, hvor R er valgt fra rett eller forgrenet alkyl, aralkyl, aryloksyalkyl eller aryl er R forskjellig fra tert-butyl; fremgangsmåter for deres fremstilling og deres anvendelse i HCV behandling er tilveiebrakt.
NO20072547A 2004-10-25 2007-05-18 4-metoksymetyl-pyrrolidin-2-karboksylsyreforbindelser og derivater derav som hepatitt C virusinhibitorer NO20072547L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0423673.3A GB0423673D0 (en) 2004-10-25 2004-10-25 Compounds
PCT/EP2005/011532 WO2006045613A1 (en) 2004-10-25 2005-10-24 4-methoxymethyl-pyrrolidine-2-carboxylic acid compounds and derivatives thereof as hepatitis c virus inhibitors

Publications (1)

Publication Number Publication Date
NO20072547L true NO20072547L (no) 2007-07-23

Family

ID=33485164

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20072547A NO20072547L (no) 2004-10-25 2007-05-18 4-metoksymetyl-pyrrolidin-2-karboksylsyreforbindelser og derivater derav som hepatitt C virusinhibitorer

Country Status (18)

Country Link
US (1) US20070270475A1 (no)
EP (1) EP1805172A1 (no)
JP (1) JP2008517968A (no)
KR (1) KR20070072614A (no)
CN (1) CN101087785A (no)
AR (1) AR051340A1 (no)
AU (1) AU2005298849A1 (no)
BR (1) BRPI0517023A (no)
CA (1) CA2585170A1 (no)
GB (1) GB0423673D0 (no)
IL (1) IL182583A0 (no)
MA (1) MA29000B1 (no)
MX (1) MX2007004914A (no)
NO (1) NO20072547L (no)
PE (1) PE20060602A1 (no)
RU (1) RU2007119390A (no)
TW (1) TW200630365A (no)
WO (1) WO2006045613A1 (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE554085T1 (de) 2006-11-30 2012-05-15 Probiodrug Ag Neue inhibitoren von glutaminylcyclase
MX2009011930A (es) 2007-05-04 2009-11-18 Vertex Pharma Terapia de combinacion para el tratamiento de infeccion de virus de hepatitis c.
UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
BRPI0917458A2 (pt) 2008-08-11 2015-12-01 Glaxosmithkline Llc composto, método de tratamento de doenças e condições, composição farmacêutica, método para tratar ou prevenir doença, e, uso de um composto
CN102176911B (zh) 2008-08-11 2014-12-10 葛兰素史密丝克莱恩有限责任公司 新的腺嘌呤衍生物
US8575340B2 (en) 2010-02-10 2013-11-05 Glaxosmithkline Llc Purine derivatives and their pharmaceutical uses
RS53745B1 (sr) 2010-02-10 2015-06-30 Glaxosmithkline Llc 6-amino-2-{[(1s)-1-metilbutil]oksi}-9-[5-(1-piperidinil)pentil]-7,9-dihidro-8h-purin-8-on-maleat
KR20160124157A (ko) 2014-02-20 2016-10-26 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 인간 인터페론의 유도인자로서의 피롤로[3,2]피리미딘 유도체
CA2948071C (en) 2014-05-07 2022-08-30 Boehringer Ingelheim International Gmbh Container, nebulizer and use
ES2917887T3 (es) 2014-11-13 2022-07-12 Glaxosmithkline Biologicals Sa Derivados de adenina que son útiles en el tratamiento de enfermedades alérgicas u otras afecciones inflamatorias
JP6411676B2 (ja) 2015-12-03 2018-10-24 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｓｔｉｎｇの調節因子としての環状プリンジヌクレオチド
WO2017175156A1 (en) 2016-04-07 2017-10-12 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides useful as protein modulators
SG10201900628RA (en) 2016-04-07 2019-02-27 Glaxosmithkline Ip Dev Ltd Heterocyclic amides useful as protein modulators
AU2018344902B2 (en) 2017-10-05 2021-06-03 Glaxosmithkline Intellectual Property Development Limited Modulators of stimulator of interferon genes (STING) useful in treating HIV
US11377440B2 (en) 2017-10-05 2022-07-05 Glaxosmithkline Intellectual Property Development Limited Modulators of stimulator of interferon genes (STING)
GB201807924D0 (en) 2018-05-16 2018-06-27 Ctxt Pty Ltd Compounds
JP2022533390A (ja) 2019-05-16 2022-07-22 スティングセラ インコーポレイテッド オキソアクリジニル酢酸誘導体および使用方法
US20220251079A1 (en) 2019-05-16 2022-08-11 Stingthera, Inc. Benzo[b][1,8]naphthyridine acetic acid derivatives and methods of use
GB201910305D0 (en) 2019-07-18 2019-09-04 Ctxt Pty Ltd Compounds
GB201910304D0 (en) 2019-07-18 2019-09-04 Ctxt Pty Ltd Compounds
WO2021119753A1 (en) 2019-12-18 2021-06-24 Ctxt Pty Limited Compounds
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200418848A (en) * 2002-10-24 2004-10-01 Glaxo Group Ltd Compounds

Also Published As

Publication number Publication date
MA29000B1 (fr) 2007-11-01
CN101087785A (zh) 2007-12-12
AU2005298849A1 (en) 2006-05-04
JP2008517968A (ja) 2008-05-29
US20070270475A1 (en) 2007-11-22
GB0423673D0 (en) 2004-11-24
WO2006045613A1 (en) 2006-05-04
AR051340A1 (es) 2007-01-03
CA2585170A1 (en) 2006-05-04
BRPI0517023A (pt) 2008-09-30
KR20070072614A (ko) 2007-07-04
MX2007004914A (es) 2007-06-12
TW200630365A (en) 2006-09-01
IL182583A0 (en) 2007-07-24
PE20060602A1 (es) 2006-07-15
EP1805172A1 (en) 2007-07-11
RU2007119390A (ru) 2008-12-10

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