BRPI0517065A - derivado de ácido carboxìlico que contém anel de tiazol e uso farmacêutico deste - Google Patents

derivado de ácido carboxìlico que contém anel de tiazol e uso farmacêutico deste

Info

Publication number
BRPI0517065A
BRPI0517065A BRPI0517065-6A BRPI0517065A BRPI0517065A BR PI0517065 A BRPI0517065 A BR PI0517065A BR PI0517065 A BRPI0517065 A BR PI0517065A BR PI0517065 A BRPI0517065 A BR PI0517065A
Authority
BR
Brazil
Prior art keywords
carboxylic acid
acid derivative
pharmaceutical use
containing carboxylic
thiazole ring
Prior art date
Application number
BRPI0517065-6A
Other languages
English (en)
Inventor
Takashi Tozawa
Osamu Tsuruta
Hiroshi Katajima
Yoshiyuki Aoki
Naoko Ando
Hiroki Tamakawa
Original Assignee
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp
Publication of BRPI0517065A publication Critical patent/BRPI0517065A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

DERIVADO DE áCIDO CARBOXìLICO QUE CONTéM ANEL DE TIAZOL E USO FARMACêUTICO DESTE. De acordo com a presente invenção, um composto representado pela seguinte fórmula (1) tendo um ação agonista de PPAR<244> superior e concomitantemente mostrando uma ação hipolipidêmica pode ser fornecida, e além disso, um composto útil como um intermediário sintéticos para o composto pode ser fornecido.
BRPI0517065-6A 2004-11-04 2005-11-04 derivado de ácido carboxìlico que contém anel de tiazol e uso farmacêutico deste BRPI0517065A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004321347 2004-11-04
PCT/JP2005/020262 WO2006049232A1 (ja) 2004-11-04 2005-11-04 チアゾール環を含むカルボン酸誘導体およびその医薬用途

Publications (1)

Publication Number Publication Date
BRPI0517065A true BRPI0517065A (pt) 2008-09-30

Family

ID=36319233

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517065-6A BRPI0517065A (pt) 2004-11-04 2005-11-04 derivado de ácido carboxìlico que contém anel de tiazol e uso farmacêutico deste

Country Status (10)

Country Link
US (1) US8026370B2 (pt)
EP (1) EP1816128A4 (pt)
JP (1) JP4939226B2 (pt)
KR (1) KR100918523B1 (pt)
CN (1) CN101068797A (pt)
AU (1) AU2005301626B2 (pt)
BR (1) BRPI0517065A (pt)
CA (1) CA2587023C (pt)
TW (1) TWI359810B (pt)
WO (1) WO2006049232A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200533357A (en) 2004-01-08 2005-10-16 Millennium Pharm Inc 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases
WO2007126043A1 (ja) * 2006-04-27 2007-11-08 Mitsubishi Tanabe Pharma Corporation チアゾール環を含むカルボン酸誘導体の医薬用途
US20090270398A1 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Pyridazine Derivatives
US8207205B2 (en) 2008-04-21 2012-06-26 Institute For Oneworld Health Compounds, compositions and methods comprising oxadiazole derivatives
US8236838B2 (en) * 2008-04-21 2012-08-07 Institute For Oneworld Health Compounds, compositions and methods comprising isoxazole derivatives
WO2009131958A2 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising triazine derivatives
WO2010033626A1 (en) * 2008-09-19 2010-03-25 Institute For Oneworld Health Compounds, compositions and methods comprising imidazole and triazole derivatives
TW201022221A (en) * 2008-12-01 2010-06-16 Mitsubishi Tanabe Pharma Corp Carboxylic acid derivatives containing thiazole ring and pharmaceutical use thereof
US8511216B2 (en) * 2009-03-30 2013-08-20 Kanzaki Kokyukoki Mfg. Co., Ltd. Hydraulic actuator unit
US8343976B2 (en) * 2009-04-20 2013-01-01 Institute For Oneworld Health Compounds, compositions and methods comprising pyrazole derivatives
EP2484361B1 (en) 2009-09-28 2015-11-11 Kowa Company, Ltd. Agent for reducing visceral fat weight
US9447078B2 (en) 2012-01-20 2016-09-20 Acucela Inc. Substituted heterocyclic compounds for disease treatment
EA024873B1 (ru) 2012-09-27 2016-10-31 Кова Компани, Лтд. Терапевтическое средство при дислипидемии
KR20160045042A (ko) 2013-08-28 2016-04-26 교와 가부시키가이샤 지질 이상증 치료제
US11799737B1 (en) * 2021-06-30 2023-10-24 Juniper Networks, Inc. Topology-based graphical user interface for network management systems

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3508665A1 (de) * 1985-03-12 1986-09-18 Hoechst Ag, 6230 Frankfurt Heterocyclische sulfide und ihre anwendung als immunmodulatoren
JPS62212590A (ja) * 1986-03-14 1987-09-18 Matsushita Electric Ind Co Ltd 路面凍結警告装置
CA2044755A1 (en) * 1990-06-18 1991-12-19 Bunji Natsume Pyrazolecarboxamide, insecticidal and miticidal composition, and fungicidal composition for use in agriculture and horticulture
ZA9610046B (en) * 1995-12-01 1997-07-10 Ciba Geigy Process for preparing 2-chlorothiazole compounds
US6548676B1 (en) * 1996-12-19 2003-04-15 Syngenta Crop Protection, Inc. Preparation of thiazoles
CZ296558B6 (cs) * 1996-12-19 2006-04-12 Syngenta Participations Ag Zpusob prípravy derivátu thiazolu a meziprodukt tohoto zpusobu
WO1999018066A1 (en) * 1997-10-02 1999-04-15 Sankyo Company, Limited Amidocarboxylic acid derivatives
WO2002076959A1 (en) 2001-03-23 2002-10-03 Takeda Chemical Industries, Ltd. Five-membered heterocyclic alkanoic acid derivative
BR0209711A (pt) * 2001-05-29 2004-11-03 Kyoto Pharma Ind Composto heterocìclico e seu uso medicinal
HUP0400023A2 (hu) * 2001-05-29 2004-04-28 Kyoto Pharmaceutical Industries, Ltd. Új heterociklusos származékok és gyógyászati alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
WO2005077962A2 (en) 2004-02-10 2005-08-25 Purdue Research Foundation Crowned dithiocarbamate metal complexes and methods for their use
GB0403148D0 (en) * 2004-02-12 2004-03-17 Smithkline Beecham Corp Chemical compounds
WO2007020829A1 (ja) * 2005-08-12 2007-02-22 Shima Seiki Mfg., Ltd. パイピング部を有する編地の編成方法およびその編地

Also Published As

Publication number Publication date
AU2005301626A1 (en) 2006-05-11
KR20070085687A (ko) 2007-08-27
CA2587023A1 (en) 2006-05-11
AU2005301626B2 (en) 2011-11-17
EP1816128A4 (en) 2009-11-18
JPWO2006049232A1 (ja) 2008-05-29
EP1816128A1 (en) 2007-08-08
US8026370B2 (en) 2011-09-27
CA2587023C (en) 2011-11-01
WO2006049232A1 (ja) 2006-05-11
CN101068797A (zh) 2007-11-07
TW200626564A (en) 2006-08-01
US20080167307A1 (en) 2008-07-10
KR100918523B1 (ko) 2009-09-21
TWI359810B (en) 2012-03-11
JP4939226B2 (ja) 2012-05-23

Similar Documents

Publication Publication Date Title
BRPI0517065A (pt) derivado de ácido carboxìlico que contém anel de tiazol e uso farmacêutico deste
NO20080784L (no) Histondeacetylaseinhibitorer
BRPI0913457A2 (pt) &#34;composto, composição farmacêutica, e, uso do composto&#34;
BRPI0621386B8 (pt) composição farmacêutica para o uso externo
AR108819A2 (es) Formas polimórficas de un inhibidor macrocíclico de vhc
BRPI0408347B8 (pt) derivados de pirimidina, seu uso, e composição e combinação farmacêuticas
BRPI0518459A2 (pt) composto ou um sal farmaceuticamente aceitÁvel do mesmo, composiÇço farmacÊutica, uso de um composto, e, processo para preparar o composto ou um sal farmaceuticamente aceitÁvel do mesmo
EP1591120A4 (en) RECEPTOR AGONISTS
BRPI0813140C1 (pt) método para a preparação de ácido desoxicólico (dca) ou um éster desse ou um sal farmaceuticamente aceitável desse e composto intermediário
UY30300A1 (es) Compuestos triarílicos y sus derivados
BRPI0712889A8 (pt) composto, processo para a preparação de um composto, composto intermediário, e, composição farmacêutica.
UY30301A1 (es) Ácidos bifenilcarboxílicos substituidos y sus derivados
CR9391A (es) Derivados de indanil-piperazinas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
EA200701810A1 (ru) Производное изоксазолина и новый способ его получения
AR049274A1 (es) Acido2-{[2-(2-metilaminopirimidin-4-il)-1h-indol-5-carbonil]amino}-3-(fenilpiridin-2-ilamino)propionico sustancialmente puro como inhibidor selectivo de la quinasa ikk-2
BRPI0615248A2 (pt) derivado tendo atividade agonista de ppar
ATE529181T1 (de) Neuartiges dispersionsmittel und zusammensetzungen daraus
EA200801365A1 (ru) Замещенные 5-фенил-3,6-дигидро-2-оксо-6h-1,3,4-тиадиазины
UY30552A1 (es) Combinaciones farmacologiicas en base a derivados sustituidos de la n-(5-{2-[1,1-dimetil-propilamino]-1-hidroxi-metil}-2-hidroxi-fenil)-metansulfonamida y aplicaciones
DE502006008710D1 (de) Substituierte tetrahydroisochinoline als mmp-inhibitoren, verfahren zu ihrer herstellung und ihre verwendung als medikament
AR052949A1 (es) Metabolitos derivados de piridina como antagonistas nk-1 para emesis
WO2007049729A3 (en) Amide compounds and their use
GT200600102A (es) Procedimiento para la preparacion de compuestos benzoxazol sustituidos
AR057555A1 (es) Un inhibidor de fosfodiesterasa-4 4-oxo-1-(3-sustituido fenil-1,4-dihidro-1,8-naftiridin-3-carboxamida y un procedimiento de preparacion del mismo
EP1872125A4 (en) ISOLATION OF INHIBITOR OF IRES-MEDIATED TRANSLATION

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: TANABE SEIYAKU CO., LTD. (JP)

Free format text: TRANSFERIDO POR FUSAO DE: MITSUBISHI PHARMA CORPORATION

B25D Requested change of name of applicant approved

Owner name: MITSUBISHI TANABE PHARMA CORPORATION (JP)

Free format text: ALTERADO DE: TANABE SEIYAKU CO., LTD.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2330 DE 01-09-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.