BRPI0712889A8 - composto, processo para a preparação de um composto, composto intermediário, e, composição farmacêutica. - Google Patents

composto, processo para a preparação de um composto, composto intermediário, e, composição farmacêutica.

Info

Publication number
BRPI0712889A8
BRPI0712889A8 BRPI0712889A BRPI0712889A BRPI0712889A8 BR PI0712889 A8 BRPI0712889 A8 BR PI0712889A8 BR PI0712889 A BRPI0712889 A BR PI0712889A BR PI0712889 A BRPI0712889 A BR PI0712889A BR PI0712889 A8 BRPI0712889 A8 BR PI0712889A8
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutical composition
preparation
intermediate compound
substituted
Prior art date
Application number
BRPI0712889A
Other languages
English (en)
Inventor
Guglielmotti Angelo
Garofalo Barbara
Garrone Beatrice
Maugeri Caterina
Mangano Giorgina
Furlotti Guido
Coletta Isabella
Polenzani Lorenzo
Alessandra Alisi Maria
Cazzolla Nicola
Ombrato Rosella
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Publication of BRPI0712889A2 publication Critical patent/BRPI0712889A2/pt
Publication of BRPI0712889A8 publication Critical patent/BRPI0712889A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

composto, processo para a preparação de um composto, composto intermediário, e, composição farmacêutica. composto de 2-arilindol substituído na posição 5, de fórmula (i): sendo que x, y, z, w, a, r e r1 têm os significados dados na descrição, uma composição farmacêutica compreendendo o mesmo, e também compostos intermediários e um processo de preparação para o mesmo.
BRPI0712889A 2006-07-14 2007-06-14 composto, processo para a preparação de um composto, composto intermediário, e, composição farmacêutica. BRPI0712889A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT001368A ITMI20061368A1 (it) 2006-07-14 2006-07-14 Composto 2-arilindolico sostituito in posizione 5, composizione farmaceutica che lo comprende nonche' composti intermedi e procedimento per prepararlo
ITMI2006A001368 2006-07-14
PCT/EP2007/055901 WO2008006663A1 (en) 2006-07-14 2007-06-14 2-arylindole derivatives as npges-i inhibitors

Publications (2)

Publication Number Publication Date
BRPI0712889A2 BRPI0712889A2 (pt) 2012-10-09
BRPI0712889A8 true BRPI0712889A8 (pt) 2018-01-02

Family

ID=37895798

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0712889A BRPI0712889A8 (pt) 2006-07-14 2007-06-14 composto, processo para a preparação de um composto, composto intermediário, e, composição farmacêutica.

Country Status (21)

Country Link
US (1) US8017644B2 (pt)
EP (1) EP2049480B1 (pt)
JP (1) JP5302191B2 (pt)
KR (2) KR20140091569A (pt)
CN (1) CN101490000B (pt)
AR (1) AR061973A1 (pt)
AU (1) AU2007271865B2 (pt)
BR (1) BRPI0712889A8 (pt)
CA (1) CA2655750C (pt)
DK (1) DK2049480T3 (pt)
EA (1) EA015689B1 (pt)
ES (1) ES2441594T3 (pt)
GE (1) GEP20115166B (pt)
IL (1) IL196000A (pt)
IT (1) ITMI20061368A1 (pt)
MX (1) MX2009000492A (pt)
PL (1) PL2049480T3 (pt)
PT (1) PT2049480E (pt)
SI (1) SI2049480T1 (pt)
UA (1) UA96759C2 (pt)
WO (1) WO2008006663A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2078711A1 (en) * 2007-12-28 2009-07-15 AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (Aza)indole derivative substituted in position 5, pharmaceutical composition comprising it, intermediate compounds and preparation process therefor
AU2010232729A1 (en) 2009-03-31 2011-10-20 Arqule, Inc. Substituted indolo-pyridinone compounds
WO2011077313A1 (en) 2009-12-22 2011-06-30 Pfizer Inc. Piperidinecarboxamides as mpges - 1 inhibitors
PH12014500326B1 (en) 2011-08-18 2018-01-10 Nippon Shinyaku Co Ltd Heterocyclic derivative and pharmaceutical drug
WO2013038308A1 (en) * 2011-09-15 2013-03-21 Glenmark Pharmaceuticals S.A. SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS mPGES-1 INHIBITORS
US10081629B2 (en) * 2014-04-14 2018-09-25 Jiangsu Hengrui Medicine Co., Ltd. Amide derivatives and pharmaceutically acceptable salts thereof, preparation method thereof and medicinal application thereof
WO2016021706A1 (ja) * 2014-08-08 2016-02-11 カズマパートナーズ株式会社 縮合複素環化合物
BR112020018094A2 (pt) 2018-03-08 2020-12-22 Incyte Corporation Compostos de aminopirazina diol como inibidores de pi3k-¿
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
WO2021040393A1 (ko) * 2019-08-26 2021-03-04 국제약품 주식회사 인돌 카복사미드 유도체 및 그를 포함하는 약제학적 조성물
WO2021231474A1 (en) * 2020-05-12 2021-11-18 Pmv Pharmaceuticals, Inc. METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004024655A2 (en) * 2002-09-12 2004-03-25 Avanir Pharmaceuticals Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation
RU2335490C2 (ru) 2003-02-07 2008-10-10 Оно Фармасьютикал Ко., Лтд. Соединения карбоновой кислоты, фармацевтическая композиция на их основе, способ лечения и применение
KR100747401B1 (ko) * 2003-09-03 2007-08-08 화이자 인코포레이티드 프로스타글란딘 ｅ2 길항제로서의 페닐 또는 피리딜 아미드 화합물
ITTO20040125A1 (it) * 2004-03-01 2004-06-01 Rotta Research Lab Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica
GB0410121D0 (en) * 2004-05-06 2004-06-09 Glaxo Group Ltd Compounds

Also Published As

Publication number Publication date
KR101440015B1 (ko) 2014-09-12
KR20090054962A (ko) 2009-06-01
CN101490000B (zh) 2012-10-03
WO2008006663A1 (en) 2008-01-17
EP2049480B1 (en) 2013-10-30
HK1124068A1 (en) 2009-08-07
CA2655750A1 (en) 2008-01-17
US20090186922A1 (en) 2009-07-23
AU2007271865A1 (en) 2008-01-17
PT2049480E (pt) 2013-12-16
EP2049480A1 (en) 2009-04-22
EA015689B1 (ru) 2011-10-31
ES2441594T3 (es) 2014-02-05
US8017644B2 (en) 2011-09-13
BRPI0712889A2 (pt) 2012-10-09
UA96759C2 (en) 2011-12-12
CA2655750C (en) 2014-09-09
PL2049480T3 (pl) 2014-03-31
JP5302191B2 (ja) 2013-10-02
KR20140091569A (ko) 2014-07-21
MX2009000492A (es) 2009-01-27
IL196000A (en) 2013-10-31
JP2009543766A (ja) 2009-12-10
IL196000A0 (en) 2009-09-01
AU2007271865B2 (en) 2013-02-21
ITMI20061368A1 (it) 2008-01-15
GEP20115166B (en) 2011-02-25
SI2049480T1 (sl) 2014-02-28
EA200970124A1 (ru) 2009-06-30
CN101490000A (zh) 2009-07-22
DK2049480T3 (da) 2014-01-20
AR061973A1 (es) 2008-08-10

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 12A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2518 DE 09-04-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.