BRPI0517613A - oligonucleotìdeos lna e tratamento de cáncer - Google Patents

oligonucleotìdeos lna e tratamento de cáncer

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Publication number
BRPI0517613A
BRPI0517613A BRPI0517613-1A BRPI0517613A BRPI0517613A BR PI0517613 A BRPI0517613 A BR PI0517613A BR PI0517613 A BRPI0517613 A BR PI0517613A BR PI0517613 A BRPI0517613 A BR PI0517613A
Authority
BR
Brazil
Prior art keywords
lna
oligonucleotides
inhibition
survivin
deoxynucleotide
Prior art date
Application number
BRPI0517613-1A
Other languages
English (en)
Inventor
Lene Sonderbye Kjaerulff
Marlene Asklund
Majken Westergaard
Christoph Rosenbohm
Margit Wissenbach
Bo Hansen
Original Assignee
Santaris Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santaris Pharma As filed Critical Santaris Pharma As
Publication of BRPI0517613A publication Critical patent/BRPI0517613A/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/319—Chemical structure of the backbone linked by 2'-5' linkages, i.e. having a free 3'-position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

OLIGONUCLEOTìDEOS LNA E TRATAMENTO DE CáNCER. A presente invenção refere-se a oligonucleotídeos LNA que têm uma (sub)seqüência da fórmula geral 5' -(¬Me ¬C~ x~)(T~ x~)¬ ME¬C~ x~A~ s~A~ s~t~ s~c~ s~c~ s~a~ s~t~ s~g~ s~g ~s~ ¬Me ¬C-~x ~A~ x~(G~ x~)(c)- 3', e de preferência, da fórmula geral 5' - ¬Me ¬C~ x~T~ x~ ¬Me ¬C~ x~A~ s~a~ s~t~ s~c~ s~c~ s~a~ s~t~ s~g~ s~g~ s~ ¬Me ¬C~ x~A~ x~G~ x~c-3', onde as letras maiúsculas designam um análogo de nucleotídeo LNA selecionado entre <225>-D-óxi-LNA, <225>-D-tio-LNA, <225>-D-amino-LNA, e <244>-L-óxi-LNA, as letras minúsculas designam um desoxinucleotídeo, o sublinhado designa um análogo de nucleotídeo LNA como definido acima ou um desoxinucleotídeo. Tais oligonucleotídeos LNA apresentam propriedades surpreendentemente boas com relação à inibição da expressão de survivina por meio de um mecanismo anti-sentido, e desta forma, levam à redução ou inibição do desenvolvimento de tumores in vivo. Os oligonucleotídeos são melhores do que outros oligonucleotídeos LNA que visam o mRNA da survivina, medido por leituras funcionais tais como indução de apoptose e inibição da proliferação, e são potentes na regulação descendente do mRNA de survivina e da proteína survivina em linhagens de células cancerosas transfectadas, e induzem melhor a apoptose em combinação com Taxol em comparação a outros nucleotídeos LNA.
BRPI0517613-1A 2004-11-09 2005-11-09 oligonucleotìdeos lna e tratamento de cáncer BRPI0517613A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62656104P 2004-11-09 2004-11-09
DKPA200401728 2004-11-09
PCT/DK2005/000719 WO2006050732A2 (en) 2004-11-09 2005-11-09 Lna oligonucleotides and the treatment of cancer

Publications (1)

Publication Number Publication Date
BRPI0517613A true BRPI0517613A (pt) 2008-10-14

Family

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BRPI0517613-1A BRPI0517613A (pt) 2004-11-09 2005-11-09 oligonucleotìdeos lna e tratamento de cáncer

Country Status (11)

Country Link
US (3) US20060154888A1 (pt)
EP (1) EP1824975B9 (pt)
JP (2) JP5107047B2 (pt)
KR (1) KR20070095882A (pt)
AU (1) AU2005304110B2 (pt)
BR (1) BRPI0517613A (pt)
CA (1) CA2586701C (pt)
IL (1) IL183053A0 (pt)
MX (1) MX2007005557A (pt)
NZ (1) NZ555645A (pt)
WO (1) WO2006050732A2 (pt)

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Publication number Publication date
MX2007005557A (es) 2008-02-15
AU2005304110A1 (en) 2006-05-18
JP2012184262A (ja) 2012-09-27
US20090181914A1 (en) 2009-07-16
NZ555645A (en) 2009-08-28
AU2005304110B2 (en) 2009-06-11
JP5107047B2 (ja) 2012-12-26
WO2006050732A3 (en) 2007-05-31
IL183053A0 (en) 2007-09-20
EP1824975A2 (en) 2007-08-29
CA2586701A1 (en) 2006-05-18
JP2008518980A (ja) 2008-06-05
EP1824975B1 (en) 2010-09-22
KR20070095882A (ko) 2007-10-01
US20120322848A1 (en) 2012-12-20
EP1824975B9 (en) 2011-04-20
US20060154888A1 (en) 2006-07-13
US8173428B2 (en) 2012-05-08
CA2586701C (en) 2014-06-03
WO2006050732A2 (en) 2006-05-18

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