BRPI0518449A2 - mÉtodos para produzir cÉlulas mamÍferas - Google Patents
mÉtodos para produzir cÉlulas mamÍferasInfo
- Publication number
- BRPI0518449A2 BRPI0518449A2 BRPI0518449-5A BRPI0518449A BRPI0518449A2 BR PI0518449 A2 BRPI0518449 A2 BR PI0518449A2 BR PI0518449 A BRPI0518449 A BR PI0518449A BR PI0518449 A2 BRPI0518449 A2 BR PI0518449A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- mammalian cells
- insulin
- grow
- ability
- Prior art date
Links
- 210000004962 mammalian cell Anatomy 0.000 title abstract 3
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 8
- 102000004877 Insulin Human genes 0.000 abstract 4
- 108090001061 Insulin Proteins 0.000 abstract 4
- 229940125396 insulin Drugs 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0031—Serum-free culture media
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Sustainable Development (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
MÉTODOS PARA PRODUZIR CÉLULAS MAMÍFERAS. A presente invenção refere-se aos métodos para produzir céluIas mamíferas tendo características realçadas, tais como taxas de cresci- mento mais rápido e a capacidade para cultivar até densidades celulares mais altas. A invenção também refere-se aos métodos para produzir células tendo a capacidade para cultivar em meios carecendo de components, tais como insulina e substitutos de insulina. A invenção também refere-se às células mamíferas isoIadas tendo características de crescimento melhorada e/ou a capacidade para cultivar em meios carecendo de components, tais como insulina e substitutos de insulina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62931904P | 2004-11-19 | 2004-11-19 | |
| PCT/US2005/042182 WO2006055915A2 (en) | 2004-11-19 | 2005-11-21 | Methods for producing mammalian cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0518449A2 true BRPI0518449A2 (pt) | 2008-11-18 |
Family
ID=36407847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0518449-5A BRPI0518449A2 (pt) | 2004-11-19 | 2005-11-21 | mÉtodos para produzir cÉlulas mamÍferas |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8809049B2 (pt) |
| EP (1) | EP1824964A4 (pt) |
| JP (1) | JP2008520250A (pt) |
| KR (1) | KR20070086417A (pt) |
| CN (1) | CN101061216A (pt) |
| AU (1) | AU2005306356A1 (pt) |
| BR (1) | BRPI0518449A2 (pt) |
| CA (1) | CA2588652A1 (pt) |
| EA (1) | EA200701099A1 (pt) |
| IL (1) | IL183197A0 (pt) |
| IS (1) | IS8646A (pt) |
| MX (1) | MX2007005928A (pt) |
| NO (1) | NO20073094L (pt) |
| WO (1) | WO2006055915A2 (pt) |
| ZA (1) | ZA200704058B (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ599338A (en) | 2007-06-27 | 2013-11-29 | Marinepolymer Tech Inc | Complexes of il-15 and il-15ralpha and uses thereof |
| JP2013535981A (ja) * | 2010-08-20 | 2013-09-19 | ワイス・エルエルシー | 成長因子不含適合細胞の細胞培養 |
| KR101591671B1 (ko) * | 2011-04-29 | 2016-02-04 | 바이오콘 리서치 리미티드 | 항체의 이질성을 감소시키는 방법 및 그 항체의 제조방법 |
| CN108642030A (zh) | 2012-12-10 | 2018-10-12 | 生化学工业株式会社 | 新重组因子c、其制造方法、及内毒素的测定法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0665280B2 (ja) | 1987-03-04 | 1994-08-24 | 味の素株式会社 | タンパクゲル化剤及びそれを用いるタンパクのゲル化方法 |
| US5156964A (en) * | 1990-08-16 | 1992-10-20 | Cetus Corporation | Methods for adapting cells for increased product production through exposure to ammonia |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| USH1532H (en) | 1993-11-03 | 1996-05-07 | Genetics Institute, Inc. | Adaption of mammalian cell lines to high cell densities |
| US6475725B1 (en) * | 1997-06-20 | 2002-11-05 | Baxter Aktiengesellschaft | Recombinant cell clones having increased stability and methods of making and using the same |
| EP1586650A1 (de) * | 2004-04-16 | 2005-10-19 | ProBioGen AG | Eingriff in den Energiestoffwechsel von eukaryontenzellen zur Selektion und Expressionssteigerung |
-
2005
- 2005-11-21 BR BRPI0518449-5A patent/BRPI0518449A2/pt not_active IP Right Cessation
- 2005-11-21 KR KR20077013867A patent/KR20070086417A/ko not_active Withdrawn
- 2005-11-21 WO PCT/US2005/042182 patent/WO2006055915A2/en not_active Ceased
- 2005-11-21 US US11/667,927 patent/US8809049B2/en active Active
- 2005-11-21 EA EA200701099A patent/EA200701099A1/ru unknown
- 2005-11-21 AU AU2005306356A patent/AU2005306356A1/en not_active Abandoned
- 2005-11-21 MX MX2007005928A patent/MX2007005928A/es not_active Application Discontinuation
- 2005-11-21 CA CA 2588652 patent/CA2588652A1/en not_active Abandoned
- 2005-11-21 EP EP05851941A patent/EP1824964A4/en not_active Withdrawn
- 2005-11-21 CN CNA200580039597XA patent/CN101061216A/zh active Pending
- 2005-11-21 JP JP2007543359A patent/JP2008520250A/ja not_active Withdrawn
-
2007
- 2007-05-15 IL IL183197A patent/IL183197A0/en unknown
- 2007-05-15 IS IS8646A patent/IS8646A/is unknown
- 2007-05-18 ZA ZA200704058A patent/ZA200704058B/xx unknown
- 2007-06-18 NO NO20073094A patent/NO20073094L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200704058B (en) | 2009-11-25 |
| IS8646A (is) | 2007-05-15 |
| CN101061216A (zh) | 2007-10-24 |
| WO2006055915A3 (en) | 2007-06-21 |
| EP1824964A2 (en) | 2007-08-29 |
| IL183197A0 (en) | 2007-08-19 |
| JP2008520250A (ja) | 2008-06-19 |
| AU2005306356A1 (en) | 2006-05-26 |
| WO2006055915A2 (en) | 2006-05-26 |
| US8809049B2 (en) | 2014-08-19 |
| US20080131929A1 (en) | 2008-06-05 |
| EP1824964A4 (en) | 2009-04-01 |
| KR20070086417A (ko) | 2007-08-27 |
| MX2007005928A (es) | 2007-06-22 |
| NO20073094L (no) | 2007-08-20 |
| CA2588652A1 (en) | 2006-05-26 |
| EA200701099A1 (ru) | 2007-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |
|
| B15K | Others concerning applications: alteration of classification |
Ipc: C12N 5/00 (2006.01) |