BRPI0518497A2 - adjuvante particulado para terapia hifu e uso do mesmo - Google Patents
adjuvante particulado para terapia hifu e uso do mesmoInfo
- Publication number
- BRPI0518497A2 BRPI0518497A2 BRPI0518497-5A BRPI0518497A BRPI0518497A2 BR PI0518497 A2 BRPI0518497 A2 BR PI0518497A2 BR PI0518497 A BRPI0518497 A BR PI0518497A BR PI0518497 A2 BRPI0518497 A2 BR PI0518497A2
- Authority
- BR
- Brazil
- Prior art keywords
- enhancement agent
- hifu treatment
- treatment
- particle
- target location
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
- A61K41/0033—Sonodynamic cancer therapy with sonochemically active agents or sonosensitizers, having their cytotoxic effects enhanced through application of ultrasounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasonic imaging preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Radiology & Medical Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Plant Substances (AREA)
- Surgical Instruments (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
Abstract
Adjuvante particulado para terapia HIFU e uso do mesmo. A presente invenção descreve um agente particulado de incremento para um tratamento por ultra-som focalizado de alta intensidade (HIFU), o qual pode incrementar o depósito de energia acústica no local alvo durante o tratamento HIFU. O agente de incremento compreende uma fase descontínua formada por um material de núcleo encapsulado por um material de formação de uma membrana e por uma fase contínua compreendendo um meio aquoso; a fase descontínua é dispersa de modo uniforme na fase contínua e o tamanho de partícula da fase descontínua fica dentro da faixa de 0,1-8 im; a quantidade de material de formação da membrana no agente particulado de incremento é de 0,1-100 g/l; o material do núcleo compreende um líquido que não sofre uma transição liquido-gás a 38-1 00 °C e a quantidade do material de núcleo no agente particulado de incremento é de 5-200 ml/l. O agente particulado de incremento em emulsão de flúor carbono para um tratamento de tipo HIFU da presente invenção pode mudar, de forma significativa, o ambiente acústico do local alvo e pode aumentar o depósito de energia acústica no local alvo durante o tratamento HIFU. Eventualmente, a capacidade do tratamento HIFU clínico em reduzir as células de tumores pode ser significativamente aumentada. Desta forma, a presente invenção descreve o uso de um agente particulado de incremento em emulsão de flúor carbono para um tratamento de tipo HIFU durante um tratamento HIFU.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200510000348A CN100574811C (zh) | 2005-01-10 | 2005-01-10 | 一种高强度聚焦超声治疗用微粒类助剂及其应用 |
| PCT/CN2005/001392 WO2006072201A1 (fr) | 2005-01-10 | 2005-09-02 | Adjuvant sous forme de particules pour un traitement hifu et son utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0518497A2 true BRPI0518497A2 (pt) | 2008-11-25 |
Family
ID=36647409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0518497-5A BRPI0518497A2 (pt) | 2005-01-10 | 2005-09-02 | adjuvante particulado para terapia hifu e uso do mesmo |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20080139973A1 (pt) |
| EP (1) | EP1842559B1 (pt) |
| JP (1) | JP2008526787A (pt) |
| KR (1) | KR20070094620A (pt) |
| CN (1) | CN100574811C (pt) |
| AT (1) | ATE478683T1 (pt) |
| AU (1) | AU2005324274B2 (pt) |
| BR (1) | BRPI0518497A2 (pt) |
| CA (1) | CA2593658C (pt) |
| DE (1) | DE602005023217D1 (pt) |
| ES (1) | ES2348723T3 (pt) |
| RU (1) | RU2360700C2 (pt) |
| WO (1) | WO2006072201A1 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2721271C (en) | 2008-04-09 | 2017-12-12 | Julian Itzcovitz | A medical system comprising a percutaneous probe |
| EP2515772A4 (en) * | 2009-12-22 | 2017-02-08 | Avon Products, Inc. | Coupling emulsions for use with ultrasound devices |
| EP2768396A2 (en) | 2011-10-17 | 2014-08-27 | Butterfly Network Inc. | Transmissive imaging and related apparatus and methods |
| DK2846841T3 (en) | 2012-05-09 | 2017-02-27 | Sintef Tto As | ULTRASOUND CONTACT FLOW |
| US9667889B2 (en) | 2013-04-03 | 2017-05-30 | Butterfly Network, Inc. | Portable electronic devices with integrated imaging capabilities |
| CN107261197B (zh) * | 2017-07-12 | 2020-05-01 | 安疗生命科学（武汉）有限公司 | 一种乳化碘油血管栓塞材料及其制备方法和应用 |
| CN109011228B (zh) * | 2018-09-06 | 2019-08-16 | 西安交通大学 | 一种高空间分辨率超声神经调控方法及系统 |
| WO2025075452A1 (ko) * | 2023-10-05 | 2025-04-10 | 주식회사 제이시스메디칼 | 피부 관리 장치 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5832829A (ja) * | 1981-08-22 | 1983-02-25 | Green Cross Corp:The | 血管造影剤 |
| US4767610A (en) * | 1984-10-19 | 1988-08-30 | The Regents Of The University Of California | Method for detecting abnormal cell masses in animals |
| US4987154A (en) * | 1986-01-14 | 1991-01-22 | Alliance Pharmaceutical Corp. | Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use |
| US6551576B1 (en) * | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
| US6613306B1 (en) * | 1990-04-02 | 2003-09-02 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| US5196183A (en) * | 1991-12-04 | 1993-03-23 | Sterling Winthrop Inc. | Contrast agents for ultrasound imaging |
| US5716597A (en) * | 1993-06-04 | 1998-02-10 | Molecular Biosystems, Inc. | Emulsions as contrast agents and method of use |
| CA2119327A1 (en) * | 1993-07-19 | 1995-01-20 | David Crawford Gibbon | Method and means for detecting people in image sequences |
| ZA952485B (en) * | 1994-03-28 | 1995-12-15 | Nycomed Imaging As | Liposomes |
| US5605934A (en) * | 1995-03-23 | 1997-02-25 | Baxter International Inc. | Method of manufacturing and storing solutions |
| JP4418033B2 (ja) * | 1996-02-19 | 2010-02-17 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤のまたはそれに関する改良 |
| US6165442A (en) * | 1996-02-19 | 2000-12-26 | Nycomed Imaging As | Thermally stabilized ultrasound contrast agent |
| CN1380106A (zh) * | 2001-11-20 | 2002-11-20 | 张军 | 热疗栓塞剂及其使用方法 |
| CN1194763C (zh) * | 2002-09-06 | 2005-03-30 | 中国人民解放军第三军医大学 | 新型脂质体超声造影剂及其制备方法 |
-
2005
- 2005-01-10 CN CN200510000348A patent/CN100574811C/zh not_active Expired - Fee Related
- 2005-09-02 AT AT05781870T patent/ATE478683T1/de not_active IP Right Cessation
- 2005-09-02 WO PCT/CN2005/001392 patent/WO2006072201A1/zh not_active Ceased
- 2005-09-02 KR KR1020077015585A patent/KR20070094620A/ko not_active Ceased
- 2005-09-02 RU RU2007127666/15A patent/RU2360700C2/ru not_active IP Right Cessation
- 2005-09-02 EP EP05781870A patent/EP1842559B1/en not_active Expired - Lifetime
- 2005-09-02 US US11/794,931 patent/US20080139973A1/en not_active Abandoned
- 2005-09-02 ES ES05781870T patent/ES2348723T3/es not_active Expired - Lifetime
- 2005-09-02 JP JP2007549783A patent/JP2008526787A/ja active Pending
- 2005-09-02 BR BRPI0518497-5A patent/BRPI0518497A2/pt not_active IP Right Cessation
- 2005-09-02 DE DE602005023217T patent/DE602005023217D1/de not_active Expired - Lifetime
- 2005-09-02 CA CA2593658A patent/CA2593658C/en not_active Expired - Fee Related
- 2005-09-02 AU AU2005324274A patent/AU2005324274B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008526787A (ja) | 2008-07-24 |
| KR20070094620A (ko) | 2007-09-20 |
| CN1803198A (zh) | 2006-07-19 |
| CA2593658C (en) | 2011-06-07 |
| CA2593658A1 (en) | 2006-07-13 |
| RU2007127666A (ru) | 2009-01-27 |
| ATE478683T1 (de) | 2010-09-15 |
| EP1842559A1 (en) | 2007-10-10 |
| EP1842559A4 (en) | 2008-03-19 |
| EP1842559B1 (en) | 2010-08-25 |
| US20080139973A1 (en) | 2008-06-12 |
| AU2005324274A1 (en) | 2006-07-13 |
| WO2006072201A1 (fr) | 2006-07-13 |
| CN100574811C (zh) | 2009-12-30 |
| DE602005023217D1 (de) | 2010-10-07 |
| RU2360700C2 (ru) | 2009-07-10 |
| ES2348723T3 (es) | 2010-12-13 |
| AU2005324274B2 (en) | 2008-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 3A, 5A E 6A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |