BRPI0519174A2 - cepa recombinante de um microorganismo produtor de Ácido succÍnico, mÉtodo para produzir Ácido succÍnico, molÉcula de dna, plasmÍdeo de dna, e, cÉlula hospedeira - Google Patents

cepa recombinante de um microorganismo produtor de Ácido succÍnico, mÉtodo para produzir Ácido succÍnico, molÉcula de dna, plasmÍdeo de dna, e, cÉlula hospedeira

Info

Publication number
BRPI0519174A2
BRPI0519174A2 BRPI0519174-2A BRPI0519174A BRPI0519174A2 BR PI0519174 A2 BRPI0519174 A2 BR PI0519174A2 BR PI0519174 A BRPI0519174 A BR PI0519174A BR PI0519174 A2 BRPI0519174 A2 BR PI0519174A2
Authority
BR
Brazil
Prior art keywords
succinic acid
producing
dna
recombinant
host cell
Prior art date
Application number
BRPI0519174-2A
Other languages
English (en)
Inventor
Jian Yi
Susanne Kleff
Michael V Guettler
Original Assignee
Michigan Biotech Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michigan Biotech Inst filed Critical Michigan Biotech Inst
Publication of BRPI0519174A2 publication Critical patent/BRPI0519174A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

CEPA RECOMBINANTE DE UM MICROORGANISMO PRODUTOR DE ÁCIDO SUCCÍNICO, MÉTODO PARA PRODUZIR ÁCIDO SUCCÍNICO, MOLÉCULA DE DNA, PLASMÍDEO DE DNA, E, CÉLULA HOSPEDEIRA. São descritos microorganismos recombinantes para produzir ácidos orgânicos. Os microorganismos recombinantes expressam um polipeptídeo que possui a atividade enzimática de uma enzima que é utilizada no ciclo de pentose-fosfato. O microorganismo recombinante pode incluir Actinobacilius succinogenes recombinante que tem sido transformado para expressar um gene Zwischenferment (Zwf). Os microorganismos recombinantes podem ser úteis em processos de fermentação para produzir ácidos orgânicos tais como ácido succínico e ácido lático. Também são descritos plasmídeos novos que são úteis para transformar microorganismos para produzir microorganismos recombinantes que expressam enzimas tal como Zwf.
BRPI0519174-2A 2004-12-22 2005-12-16 cepa recombinante de um microorganismo produtor de Ácido succÍnico, mÉtodo para produzir Ácido succÍnico, molÉcula de dna, plasmÍdeo de dna, e, cÉlula hospedeira BRPI0519174A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63944304P 2004-12-22 2004-12-22
US64714105P 2005-01-26 2005-01-26
PCT/US2005/045714 WO2006083410A2 (en) 2004-12-22 2005-12-16 Recombinant microorganisms for increased production of organic acids

Publications (1)

Publication Number Publication Date
BRPI0519174A2 true BRPI0519174A2 (pt) 2008-12-30

Family

ID=36777690

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0519174-2A BRPI0519174A2 (pt) 2004-12-22 2005-12-16 cepa recombinante de um microorganismo produtor de Ácido succÍnico, mÉtodo para produzir Ácido succÍnico, molÉcula de dna, plasmÍdeo de dna, e, cÉlula hospedeira

Country Status (10)

Country Link
US (2) US8119377B2 (pt)
EP (2) EP2460872A1 (pt)
JP (2) JP5634659B2 (pt)
KR (1) KR101357015B1 (pt)
CN (1) CN101128577B (pt)
BR (1) BRPI0519174A2 (pt)
CA (1) CA2592449C (pt)
ES (1) ES2541538T3 (pt)
MX (1) MX2007007834A (pt)
WO (1) WO2006083410A2 (pt)

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WO2008153676A2 (en) * 2007-05-21 2008-12-18 The Regents Of The University Of California Pentose phosphate pathway and fermentation enzyme-encoding nucleotide sequences with refined translational kinetics and methods of making same
CA2696666C (en) * 2007-08-17 2019-07-09 Basf Se Succinic acid-producing member of the pasteurellaceae
WO2009065778A1 (en) 2007-11-20 2009-05-28 Dsm Ip Assets B.V. Succinic acid production in a eukaryotic cell
CN101896606B (zh) 2007-11-20 2016-12-21 帝斯曼知识产权资产管理有限公司 在重组酵母中生产二羧酸
EP2252685A2 (en) * 2008-03-13 2010-11-24 DSM IP Assets B.V. Selection of organisms capable of fermenting mixed substrates
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
US8431372B2 (en) * 2009-06-19 2013-04-30 Mbi International Fermentation method using a magnesium compound containing oxygen
EP2753187B2 (en) † 2011-08-30 2025-08-06 Caelus Pharmaceuticals B.V. Method for preventing and/or treating insulin resistance
WO2013130426A1 (en) * 2012-03-02 2013-09-06 Codexis, Inc. Recombinant host cells and processes for producing 1,3-butadiene through a 5-hydroxypent-3-enoate intermediate
CA2923794C (en) 2012-09-09 2021-07-27 Biocheminsights, Inc. Electrochemical bioreactor module and methods of using the same
WO2014055650A1 (en) 2012-10-02 2014-04-10 The Michigan Biotechnology Institute Integrated systems and methods for organic acid production
WO2014055670A1 (en) * 2012-10-02 2014-04-10 The Michigan Biotechynology Institute Recombinant microorganisms for producing organic acids
CN104178442B (zh) 2013-05-24 2017-10-31 中国科学院天津工业生物技术研究所 含有突变的lpdA基因的大肠杆菌及其应用
CN104178443B (zh) * 2013-05-24 2017-04-12 中国科学院天津工业生物技术研究所 生产丁二酸的重组大肠杆菌及其应用
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
KR102384227B1 (ko) 2015-05-18 2022-04-07 삼성전자주식회사 Nadph 생성이 증가된 유전적으로 조작된 효모 세포, 효모 세포 중 nadph 수준을 증가시키는 방법, 상기 효모 세포를 제조하는 방법 및 상기 효모 세포를 이용하여 락테이트를 생산하는 방법
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11319564B2 (en) * 2017-07-11 2022-05-03 Adisseo France S.A.S. Enhanced metabolite-producing yeast
KR102912596B1 (ko) 2020-07-24 2026-01-13 삼성전자주식회사 프로모터 영역을 포함하는 분리된 폴리뉴클레오티드, 그를 포함하는 숙주 세포 및 상기 숙주 세포를 이용하여 목적 유전자를 발현시키는 방법
CN113106129A (zh) * 2020-09-29 2021-07-13 安徽华恒生物科技股份有限公司 一种高转化率的d泛解酸内酯制备方法
CN116333900A (zh) * 2021-12-15 2023-06-27 中国科学院大连化学物理研究所 一种提高酵母菌株nadph和fadh2供应的方法、工程菌及其应用
WO2025229145A1 (en) 2024-05-02 2025-11-06 Stichting Amsterdam UMC Desulfovibrio piger species for prevention or treatment of hepatic steatosis
CN121203992A (zh) * 2025-11-28 2025-12-26 内蒙古伊品生物科技有限公司 一种葡萄糖-6-磷酸脱氢酶突变体及其在生产l-色氨酸中的应用

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Also Published As

Publication number Publication date
EP1838837A2 (en) 2007-10-03
EP1838837A4 (en) 2009-01-14
US8119377B2 (en) 2012-02-21
WO2006083410A3 (en) 2006-11-23
JP5634659B2 (ja) 2014-12-03
EP2460872A1 (en) 2012-06-06
CN101128577B (zh) 2013-06-19
US20080305533A1 (en) 2008-12-11
ES2541538T3 (es) 2015-07-21
US8431373B2 (en) 2013-04-30
CA2592449A1 (en) 2006-08-10
JP2012034702A (ja) 2012-02-23
KR20070108155A (ko) 2007-11-08
CA2592449C (en) 2015-11-24
WO2006083410A2 (en) 2006-08-10
JP5655217B2 (ja) 2015-01-21
MX2007007834A (es) 2007-09-04
EP1838837B1 (en) 2015-04-15
US20120164703A1 (en) 2012-06-28
JP2008525026A (ja) 2008-07-17
KR101357015B1 (ko) 2014-02-03
CN101128577A (zh) 2008-02-20

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements