BRPI0814781A8 - ''proteína, sequência de ácido nucleico, método para a produção de ácido itacônico, vetor, célula hospedeira, e, uso de um ácido cis-aconítico descarboxilase'' - Google Patents

''proteína, sequência de ácido nucleico, método para a produção de ácido itacônico, vetor, célula hospedeira, e, uso de um ácido cis-aconítico descarboxilase''

Info

Publication number
BRPI0814781A8
BRPI0814781A8 BRPI0814781A BRPI0814781A BRPI0814781A8 BR PI0814781 A8 BRPI0814781 A8 BR PI0814781A8 BR PI0814781 A BRPI0814781 A BR PI0814781A BR PI0814781 A BRPI0814781 A BR PI0814781A BR PI0814781 A8 BRPI0814781 A8 BR PI0814781A8
Authority
BR
Brazil
Prior art keywords
cis
production
host cell
vector
protein
Prior art date
Application number
BRPI0814781A
Other languages
English (en)
Inventor
Johanna Van Der Werf Maria
Petrus Maria Caspers Martinus
Van Luijk Nicole
Jan Punt Peter
Original Assignee
Tno
Dutch Dna Biotech B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tno, Dutch Dna Biotech B V filed Critical Tno
Publication of BRPI0814781A2 publication Critical patent/BRPI0814781A2/pt
Publication of BRPI0814781A8 publication Critical patent/BRPI0814781A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

PROTEÍNA, SEQUÊNCIA DE ÁCIDO NUCLEICO, MÉTODO PARA A PRODUÇÃO DE ÁCIDO ITACÔNICO, VETOR, CÉLULA HOSPEDEIRA, E, USO DE UM ÁCIDO CIS-ACONÍTICO DESCARBOXILASE. A invenção refere-se à produção de ácido itacônico em microorganismos por introdução em uma célula hospedeira apropriada de um gene codificando para a enzima ácido cis-aconítico descarboxilase, preferivelmente derivada de A. terreus. Outra parte da invenção são as células hospedeiras, preferivelmente de A. niger, providas com os genes acima mencionados.
BRPI0814781A 2007-07-20 2008-07-21 ''proteína, sequência de ácido nucleico, método para a produção de ácido itacônico, vetor, célula hospedeira, e, uso de um ácido cis-aconítico descarboxilase'' BRPI0814781A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07112895A EP2017344A1 (en) 2007-07-20 2007-07-20 Production of itaconic acid
PCT/NL2008/050499 WO2009014437A1 (en) 2007-07-20 2008-07-21 Production of itaconic acid

Publications (2)

Publication Number Publication Date
BRPI0814781A2 BRPI0814781A2 (pt) 2014-10-21
BRPI0814781A8 true BRPI0814781A8 (pt) 2017-01-31

Family

ID=38787782

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0814781A BRPI0814781A8 (pt) 2007-07-20 2008-07-21 ''proteína, sequência de ácido nucleico, método para a produção de ácido itacônico, vetor, célula hospedeira, e, uso de um ácido cis-aconítico descarboxilase''

Country Status (4)

Country Link
US (1) US8440436B2 (pt)
EP (2) EP2017344A1 (pt)
BR (1) BRPI0814781A8 (pt)
WO (1) WO2009014437A1 (pt)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8673601B2 (en) 2007-01-22 2014-03-18 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
WO2009045637A2 (en) 2007-08-10 2009-04-09 Genomatica, Inc. Methods for the synthesis of acrylic acid and derivatives from fumaric acid
CN101978042B (zh) 2008-01-22 2017-03-08 基因组股份公司 利用合成气或其它气态碳源和甲醇的方法和有机体
WO2009102205A1 (en) * 2008-02-14 2009-08-20 Wageningen Universiteit Nucleotide sequences coding for cis-aconitic decarboxylase and use thereof
US8642298B2 (en) 2008-03-05 2014-02-04 Nederlandse Organisatie Voor Toegepast—Natuurwetenschappelijk Onderzoek Tno Production of itaconic acid
EP2262901B1 (en) 2008-03-05 2018-11-21 Genomatica, Inc. Primary alcohol producing organisms
CN102066551B (zh) 2008-03-27 2013-10-09 基因组股份公司 用于产生己二酸和其他化合物的微生物
WO2009135074A2 (en) 2008-05-01 2009-11-05 Genomatica, Inc. Microorganisms for the production of methacrylic acid
US8129154B2 (en) 2008-06-17 2012-03-06 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
EP2373781A4 (en) 2008-12-16 2012-10-10 Genomatica Inc MICRO-ORGANISMS AND METHODS OF CONVERTING SYNGAS AND OTHER CARBON RESOURCES IN USEFUL PRODUCTS
BRPI1013505A2 (pt) 2009-04-30 2018-02-14 Genomatica Inc organismos para a produção de isopropanol, n-butanol, e isobutanol
EP4321615A3 (en) 2009-04-30 2024-02-21 Genomatica, Inc. Organisms for the production of 1,3-butanediol
DK2427544T3 (da) 2009-05-07 2019-10-07 Genomatica Inc Mikroorganismer og fremgangsmåder til biosyntese af adipat, hexamethylendiamin og 6-aminokapronsyre
US8143036B2 (en) 2009-05-11 2012-03-27 Industrial Technology Research Institute Genetically modified microorganisms for producing itaconic acid with high yields
BRPI1012877A2 (pt) 2009-05-15 2016-04-05 Genomatica Inc organismo para produção de ciclohexanona
EP2440669A4 (en) 2009-06-10 2013-08-28 Genomatica Inc MICROOGANISMS AND PROCEDURES FOR THE CARBON EFFECTIVE BIOSYNTHESIS MEK AND 2-BUTANOL
US8338158B2 (en) 2009-06-30 2012-12-25 Industrial Technology Research Institute Cis-aconitate decarboxylase mutants having improved enzymatic activity
WO2011017560A1 (en) 2009-08-05 2011-02-10 Genomatica, Inc. Semi-synthetic terephthalic acid via microorganisms that produce muconic acid
US8192965B2 (en) * 2009-08-25 2012-06-05 Industrial Technology Research Institute Producing Itaconic acid in yeast using glycerol as the substrate
EP2933338A3 (en) 2009-09-09 2016-01-06 Genomatica, Inc. Microorganisms and methods for the co-production of isopropanol with primary alcohols, diols and acids
US8377666B2 (en) 2009-10-13 2013-02-19 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds, and methods related thereto
KR20180014240A (ko) 2009-10-23 2018-02-07 게노마티카 인코포레이티드 아닐린의 제조를 위한 미생물
US8268607B2 (en) 2009-12-10 2012-09-18 Genomatica, Inc. Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol
EP2529011A4 (en) 2010-01-29 2015-07-15 Genomatica Inc MICROORGANISMS AND METHODS FOR BIOSYNTHESIS OF P-TOLUATE AND TEREPHTHALATE
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US8637286B2 (en) 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
KR101814648B1 (ko) 2010-05-05 2018-01-04 게노마티카 인코포레이티드 부타디엔을 생합성하기 위한 미생물 및 방법
BR112013001635A2 (pt) 2010-07-26 2016-05-24 Genomatica Inc micro-organismo e métodos para a biossíntese de aromáticos, 2, 4-pentadienoato e 1,3-butadieno
US10738333B2 (en) 2018-04-30 2020-08-11 Ut-Battelle, Llc Production of itaconic acid and related molecules from aromatic compounds
EP2744906B1 (en) 2011-08-19 2019-05-22 Genomatica, Inc. Microorganisms and methods for producing 2,4-pentadienoate, butadiene, propylene, 1,3-butanediol and related alcohols
CN103834582B (zh) * 2012-11-22 2016-04-27 中国科学院青岛生物能源与过程研究所 一种提高衣康酸发酵产量的菌株及其构建和利用菌株生产衣康酸的方法
CN104822832A (zh) * 2012-11-23 2015-08-05 帝斯曼知识产权资产管理有限公司 衣康酸和衣康酸甲酯生产
BR112015020904A2 (pt) 2013-03-15 2017-10-10 Genomatica Inc microrganismos e métodos para produção de butadieno e compostos relacionados por assimilação de formiato
EP2981610A1 (en) 2013-04-05 2016-02-10 Université du Luxembourg Biotechnological production of itaconic acid
EP2992105A1 (en) 2013-05-02 2016-03-09 Dutch DNA Biotech B.V. Novel organic acid pathway
TWI628191B (zh) 2014-03-19 2018-07-01 財團法人工業技術研究院 融合多胜肽、編碼此融合多胜肽之核酸分子、含此核酸分子之載體或細胞以及藉由此細胞產生衣康酸的方法
LU92409B1 (en) 2014-03-21 2015-09-22 Philipps Universit T Marburg Means and methods for itaconic acid production
US20170191089A1 (en) * 2014-05-28 2017-07-06 Dsm Ip Assets B.V. Itaconic acid and itaconate methylester and dimethylester production
WO2016004334A1 (en) 2014-07-03 2016-01-07 Genomatica, Inc. Microorganisms for producing 4c-5c compounds with unsaturation and methods related thereto
US10487342B2 (en) 2014-07-11 2019-11-26 Genomatica, Inc. Microorganisms and methods for the production of butadiene using acetyl-CoA
EP3741865B1 (en) 2014-09-18 2024-03-13 Genomatica, Inc. Non-natural microbial organisms with improved energetic efficiency
WO2016131818A1 (en) 2015-02-16 2016-08-25 Dsm Ip Assets B.V. Process for producing itaconic acid under anaerobic conditions
CN110036114B (zh) 2016-08-26 2023-09-29 勒萨弗尔公司 提高的衣康酸生产
EP3533878A1 (en) 2018-02-28 2019-09-04 Dutch DNA Biotech B.V. Process for producing citramalic acid employing aspergillus
CN108795789A (zh) * 2018-07-02 2018-11-13 山东省食品发酵工业研究设计院 一种高产衣康酸解脂耶氏酵母工程菌株及其构建方法、发酵工艺与应用
CN111944706B (zh) * 2020-08-06 2022-06-03 中国科学院青岛生物能源与过程研究所 一种产衣康酸的重组土曲霉菌株及其构建方法与应用
CN112011469B (zh) * 2020-08-26 2022-07-05 中国科学院青岛生物能源与过程研究所 一种产反式乌头酸的重组土曲霉菌株及其构建方法与应用
CN112011470B (zh) * 2020-08-26 2022-07-05 中国科学院青岛生物能源与过程研究所 一种产反式乌头酸的基因工程菌及其构建方法与应用
CN112011468B (zh) * 2020-08-26 2022-07-05 中国科学院青岛生物能源与过程研究所 一种产反式乌头酸的重组土曲霉及其制备方法与应用
CN112029671B (zh) * 2020-08-26 2022-07-05 中国科学院青岛生物能源与过程研究所 一种产反式乌头酸的重组土曲霉菌株及其制备方法与应用
KR102682476B1 (ko) * 2021-07-19 2024-07-04 포항공과대학교 산학협력단 이타콘산을 생산하는 신규 대사 경로 및 이를 이용한 이타콘산의 생산 방법
CN114657075A (zh) * 2022-02-10 2022-06-24 天津科技大学 一种生产衣康酸的黑曲霉菌株、方法及应用
CN116004677B (zh) * 2022-11-25 2024-02-13 华东理工大学 一种生产衣康酸的里氏木霉工程菌的构建方法及应用
WO2026074205A1 (en) * 2024-10-04 2026-04-09 Fundació Institut D’Investigació Sanitària Pere Virgili (Iispv) Enzymes capable of reducing succinate levels and uses thereof
EP4721816A1 (en) * 2024-10-04 2026-04-08 Fundació Institut d'Investigació Sanitària Pere Virgili (IISPV) Enzymes capable of reducing succinate levels and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5637485A (en) * 1993-03-12 1997-06-10 Rhone-Poulenc Chimie Production of itaconic acid by fermentation
US6391583B1 (en) * 1998-12-18 2002-05-21 Wisconsin Alumni Research Foundation Method of producing antihypercholesterolemic agents

Also Published As

Publication number Publication date
US20100311132A1 (en) 2010-12-09
EP2183367A1 (en) 2010-05-12
US8440436B2 (en) 2013-05-14
WO2009014437A1 (en) 2009-01-29
EP2017344A8 (en) 2009-05-13
EP2183367B1 (en) 2019-05-22
BRPI0814781A2 (pt) 2014-10-21
EP2017344A1 (en) 2009-01-21

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]