BRPI0519337A2 - composto de pirazol heteroarilas éteis no tratamento de doenÇas mediadas pela tnf-alfa e il-1 - Google Patents

composto de pirazol heteroarilas éteis no tratamento de doenÇas mediadas pela tnf-alfa e il-1

Info

Publication number
BRPI0519337A2
BRPI0519337A2 BRPI0519337-0A BRPI0519337A BRPI0519337A2 BR PI0519337 A2 BRPI0519337 A2 BR PI0519337A2 BR PI0519337 A BRPI0519337 A BR PI0519337A BR PI0519337 A2 BRPI0519337 A2 BR PI0519337A2
Authority
BR
Brazil
Prior art keywords
tnf
alpha
compound
treatment
pyrazole
Prior art date
Application number
BRPI0519337-0A
Other languages
English (en)
Inventor
Laszlo Revesz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0519337A2 publication Critical patent/BRPI0519337A2/pt

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Immunology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

COMPOSTOS DE PIRAZOL HETEROARILAS éTEIS NO TRATAMENTO DE DOENÇAS MEDIADAS PELA TNF-ALFA E IL-1. A presente invenção refere-se a um composto da fórmula I em que os groupos de RI a R4, X e Y, são tal como definido na especificação, útil para tratar as doenças mediadas pela TNF-c e a IL-1.
BRPI0519337-0A 2004-12-16 2005-12-14 composto de pirazol heteroarilas éteis no tratamento de doenÇas mediadas pela tnf-alfa e il-1 BRPI0519337A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0427604.4A GB0427604D0 (en) 2004-12-16 2004-12-16 Organic compounds
PCT/EP2005/013453 WO2006063820A1 (en) 2004-12-16 2005-12-14 Pyrazolo-heteroaryl compounds useful to treat tnf-alpha and il-1 mediated diseases

Publications (1)

Publication Number Publication Date
BRPI0519337A2 true BRPI0519337A2 (pt) 2009-01-20

Family

ID=34090176

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0519337-0A BRPI0519337A2 (pt) 2004-12-16 2005-12-14 composto de pirazol heteroarilas éteis no tratamento de doenÇas mediadas pela tnf-alfa e il-1

Country Status (17)

Country Link
US (1) US20090258874A1 (pt)
EP (1) EP1833477B1 (pt)
JP (1) JP2008524141A (pt)
KR (1) KR20070087607A (pt)
CN (1) CN101076333A (pt)
AT (1) ATE469646T1 (pt)
AU (1) AU2005315849B2 (pt)
BR (1) BRPI0519337A2 (pt)
CA (1) CA2586543A1 (pt)
DE (1) DE602005021697D1 (pt)
ES (1) ES2345207T3 (pt)
GB (1) GB0427604D0 (pt)
MX (1) MX2007007218A (pt)
PL (1) PL1833477T3 (pt)
PT (1) PT1833477E (pt)
RU (1) RU2007126968A (pt)
WO (1) WO2006063820A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101011956B1 (ko) * 2005-08-25 2011-01-31 에프. 호프만-라 로슈 아게 Ｐ３８ ｍαｐ 키나아제 저해제 및 이의 사용 방법
BRPI0615270A2 (pt) * 2005-08-25 2009-08-04 Hoffmann La Roche pirazol fundido como inibidores de p38 map cinase
US20120232062A1 (en) * 2009-10-20 2012-09-13 Eiger Biopharmaceuticals, Inc. Azaindazoles to treat flaviviridae virus infection
US8362023B2 (en) 2011-01-19 2013-01-29 Hoffmann-La Roche Inc. Pyrazolo pyrimidines
US11466017B2 (en) 2011-03-10 2022-10-11 Board Of Regents, The University Of Texas System Heterocyclic inhibitors of PTPN11
WO2013017479A1 (en) 2011-07-29 2013-02-07 Cellzome Limited Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
WO2013017480A1 (en) 2011-07-29 2013-02-07 Cellzome Limited Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
US20140323504A1 (en) 2011-09-20 2014-10-30 Cellzome Limited Pyrazolo[4,3-c]Pyridine Derivatives As Kinase Inhibitors
WO2014113942A1 (en) * 2013-01-23 2014-07-31 Merck Sharp & Dohme Corp. Btk inhibitors
JP7044375B2 (ja) 2016-05-31 2022-03-30 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム Ｐｔｐｎ１１の複素環式阻害剤
CN112313232B (zh) 2018-05-02 2024-03-08 Jw中外制药公司 新型杂环衍生物
JP7297871B2 (ja) 2018-05-02 2023-06-26 ナビール ファーマ，インコーポレイティド Ｐｔｐｎ１１の置換されたヘテロ環式インヒビター
WO2020033828A1 (en) 2018-08-10 2020-02-13 Board Of Regents, The University Of Texas System 6-(4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(2,3-dichlorophenyl)-2-methylpyrimidin-4(3h)-one derivatives and related compounds as ptpn11 (shp2) inhibitors for treating cancer
KR20230112685A (ko) * 2020-11-25 2023-07-27 르네오 파마슈티컬스, 인크. Ppar-델타 작용제의 제조 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2309206T3 (es) * 2001-10-02 2008-12-16 Smithkline Beecham Corporation Compuestos quimicos.
RU2301233C2 (ru) * 2002-03-07 2007-06-20 Ф.Хоффманн-Ля Рош Аг Бициклические пиридины и пиримидины в качестве ингибиторов киназы р38
TW200400034A (en) * 2002-05-20 2004-01-01 Bristol Myers Squibb Co Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors
NZ541836A (en) * 2003-02-27 2008-12-24 Palau Pharma Sa Pyrazolopyridine derivatives
KR100844864B1 (ko) * 2004-02-27 2008-07-09 에프. 호프만-라 로슈 아게 헤테로아릴-융합 피라졸로 유도체
JP2007523938A (ja) * 2004-02-27 2007-08-23 エフ．ホフマン−ラ　ロシュ　アーゲー ピラゾールの縮合誘導体

Also Published As

Publication number Publication date
MX2007007218A (es) 2007-08-14
KR20070087607A (ko) 2007-08-28
EP1833477A1 (en) 2007-09-19
CN101076333A (zh) 2007-11-21
WO2006063820A1 (en) 2006-06-22
PL1833477T3 (pl) 2010-11-30
AU2005315849A1 (en) 2006-06-22
RU2007126968A (ru) 2009-01-27
EP1833477B1 (en) 2010-06-02
CA2586543A1 (en) 2006-06-22
JP2008524141A (ja) 2008-07-10
PT1833477E (pt) 2010-08-20
ATE469646T1 (de) 2010-06-15
US20090258874A1 (en) 2009-10-15
ES2345207T3 (es) 2010-09-17
GB0427604D0 (en) 2005-01-19
DE602005021697D1 (de) 2010-07-15
AU2005315849B2 (en) 2009-05-28

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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