BRPI0519452A2 - inibidores de cxcr2 - Google Patents

inibidores de cxcr2

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Publication number
BRPI0519452A2
BRPI0519452A2 BRPI0519452-0A BRPI0519452A BRPI0519452A2 BR PI0519452 A2 BRPI0519452 A2 BR PI0519452A2 BR PI0519452 A BRPI0519452 A BR PI0519452A BR PI0519452 A2 BRPI0519452 A2 BR PI0519452A2
Authority
BR
Brazil
Prior art keywords
inhibitors
cxcr2 inhibitors
compounds
formula
pharmaceutically acceptable
Prior art date
Application number
BRPI0519452-0A
Other languages
English (en)
Inventor
Juergen Dedio
Holger Heitsch
Werngard Czechtizky
Sven Grueneberg
Stephen Shimshock
Carolina Lanter
Rosy Sher
Aleksandra Weichsel
Stephanie Knieps
Raymond W Kosley
Hui Li
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of BRPI0519452A2 publication Critical patent/BRPI0519452A2/pt

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
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Abstract

INIBIDORES DE CXCR2. A presente invenção refere-se a compostos de fórmula I onde RI, R2, X, A, B, D e Y1 a Y4 têm os significados indicados nas reivindicações, e/ou um sal farmaceuticamente aceitável e/ou uma pró-droga dos mesmos. Devido a suas propriedades como inibidores de receptores de quimiocinas, especialmente inibidores de CXCR2, os compostos de fórmula I e os sais e pró-drogas farmaceuticamente aceitáveis dos mesmos são adequados para a prevenção e tratamento de doenças mediadas por quimiocinas.
BRPI0519452-0A 2004-12-30 2005-12-17 inibidores de cxcr2 BRPI0519452A2 (pt)

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EP04031009A EP1676834A1 (en) 2004-12-30 2004-12-30 Fused bicyclic carboxamide derivates for use as CXCR2 inhibitors in the treatment of inflammation
PCT/EP2005/013624 WO2006069656A1 (en) 2004-12-30 2005-12-17 Fused bicyclic carboxamide derivatives for use as cxcr2 inhibitors in the treatment of inflammation

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EP1676834A1 (en) * 2004-12-30 2006-07-05 Sanofi-Aventis Deutschland GmbH Fused bicyclic carboxamide derivates for use as CXCR2 inhibitors in the treatment of inflammation
AR055319A1 (es) 2005-03-17 2007-08-15 Wyeth Corp Derivados de isoquinoleina, composiciones farmaceuticas y usos

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RU2007128949A (ru) 2009-02-10
CA2592430A1 (en) 2006-07-06
RU2404962C2 (ru) 2010-11-27
NZ556192A (en) 2010-06-25
WO2006069656A1 (en) 2006-07-06
US7919628B2 (en) 2011-04-05
EP1836158B1 (en) 2012-02-01
MA29113B1 (fr) 2007-12-03
NO20073932L (no) 2007-08-09
CN101094830A (zh) 2007-12-26
US20110184177A1 (en) 2011-07-28
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AR055830A1 (es) 2007-09-12
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ZA200704089B (en) 2008-09-25
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PE20060855A1 (es) 2006-10-10
AU2005321609B2 (en) 2011-02-17
EP1676834A1 (en) 2006-07-05
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IL184173A (en) 2011-10-31

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