NO20073932L - Fuserte bicykliske karboksamidderivater for anvendelse som CXCR2 inhibitorer i behandlingen av inflammasjon - Google Patents
Fuserte bicykliske karboksamidderivater for anvendelse som CXCR2 inhibitorer i behandlingen av inflammasjonInfo
- Publication number
- NO20073932L NO20073932L NO20073932A NO20073932A NO20073932L NO 20073932 L NO20073932 L NO 20073932L NO 20073932 A NO20073932 A NO 20073932A NO 20073932 A NO20073932 A NO 20073932A NO 20073932 L NO20073932 L NO 20073932L
- Authority
- NO
- Norway
- Prior art keywords
- treatment
- inflammation
- fused bicyclic
- carboxamide derivatives
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 108010018951 Interleukin-8B Receptors Proteins 0.000 title abstract 2
- 206010061218 Inflammation Diseases 0.000 title 1
- 102000002791 Interleukin-8B Receptors Human genes 0.000 title 1
- 229940053202 antiepileptics carboxamide derivative Drugs 0.000 title 1
- 125000002619 bicyclic group Chemical group 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 102100028989 C-X-C chemokine receptor type 2 Human genes 0.000 abstract 1
- 102000009410 Chemokine receptor Human genes 0.000 abstract 1
- 108050000299 Chemokine receptor Proteins 0.000 abstract 1
- 102000019034 Chemokines Human genes 0.000 abstract 1
- 108010012236 Chemokines Proteins 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
Classifications
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
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| JP5232144B2 (ja) * | 2006-06-28 | 2013-07-10 | サノフイ | Cxcr2阻害剤 |
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| EP2094697A1 (en) * | 2006-11-23 | 2009-09-02 | Novartis AG | 5-sulfanylmethyl-pyrazolo [1,5-a]pyrimidin-7-ol derivatives as cxcr2 antagonists |
| RU2009123525A (ru) * | 2006-11-23 | 2010-12-27 | Новартис АГ (CH) | ПРОИЗВОДНЫЕ 5-СУЛЬФАНИЛМЕТИЛ[1,2,4}ТРИАЗОЛ[1,5-а]ПИРИМИДИН-7-ОЛА В КАЧЕСТВЕ АНТАГОНИСТОВ CXCR2 |
| KR101364353B1 (ko) * | 2006-11-30 | 2014-02-18 | 다우 아그로사이언시즈 엘엘씨 | 2-치환된-5-(1-알킬티오)알킬피리딘의 제조 방법 |
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| AU2013203591B2 (en) * | 2009-05-01 | 2017-01-19 | University Court Of The University Of Dundee | Treatment or prophylaxis of proliferative conditions |
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| RU2644565C2 (ru) * | 2012-06-19 | 2018-02-13 | Ф. Хоффманн-Ля Рош Аг | Новые бициклические соединения тиофениламида |
| RU2647587C2 (ru) * | 2012-09-12 | 2018-03-16 | Ф. Хоффманн-Ля Рош Аг | Неаннелированные тиофениламиды в качестве ингибиторов белков, связывающих жирные кислоты fabp 4 и/или 5 |
| WO2014114603A1 (en) * | 2013-01-24 | 2014-07-31 | F. Hoffmann-La Roche Ag | Substituted thiazole compounds |
| WO2014116849A1 (en) | 2013-01-24 | 2014-07-31 | Fibrogen, Inc. | Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid |
| CN106471004A (zh) * | 2014-02-28 | 2017-03-01 | 麦吉尔大学学术发展皇家学院 | 作为用于免疫疗法的apc活化剂的tc‑ptp抑制剂 |
| JP6543268B2 (ja) * | 2014-04-15 | 2019-07-10 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | 嚢胞性線維症膜コンダクタンス調節因子が媒介する疾患を処置するための医薬組成物 |
| EP3174851A1 (en) * | 2014-07-31 | 2017-06-07 | GlaxoSmithKline Intellectual Property Management Limited | Use of cxcr2 antagonists for the prevention and/or treatment of chemotherapy induced peripheral neuropathy (cipn) |
| CN105906608B (zh) * | 2016-05-03 | 2018-10-19 | 中山大学 | 8-氨基喹啉-松果体素杂联体及其药物组合物 |
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| WO2019109001A1 (en) | 2017-12-01 | 2019-06-06 | The Texas A&M University System | Angelman syndrome antisense treatment |
| AU2019216531A1 (en) | 2018-02-02 | 2020-09-24 | Maverix Oncology, Inc. | Small molecule drug conjugates of gemcitabine monophosphate |
| GB201807924D0 (en) * | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
| MX2021000293A (es) | 2018-07-09 | 2021-07-15 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos heterociclicos antihelminticos. |
| JP7637630B2 (ja) | 2019-03-19 | 2025-02-28 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 駆虫性アザベンゾチオフェンおよびアザベンゾフラン化合物 |
| CA3157798A1 (en) | 2019-11-12 | 2021-05-20 | Zhongli Gao | 6-membered heteroarylaminosulfonamides for treating diseases and conditions mediated by deficient cftr activity |
| WO2021113808A1 (en) * | 2019-12-05 | 2021-06-10 | Genzyme Corporation | Cftr-modulating arylamides |
| WO2021119753A1 (en) | 2019-12-18 | 2021-06-24 | Ctxt Pty Limited | Compounds |
| PH12022553222A1 (en) | 2020-05-29 | 2024-02-12 | Boehringer Ingelheim Animal Health Usa Inc | Anthelmintic heterocyclic compounds |
| CN111559991B (zh) * | 2020-06-01 | 2022-01-25 | 河南省锐达医药科技有限公司 | 一种萘胺类化合物及其盐的制备方法和应用 |
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| CN116041300B (zh) * | 2023-02-20 | 2024-04-26 | 沈阳药科大学 | 一种2,2-二甲基苯并吡喃类衍生物及其制备方法和应用 |
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| GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| WO2006040646A1 (en) | 2004-10-14 | 2006-04-20 | Pfizer, Inc. | Benzimidazole or indole amides as inhibitors of pin1 |
| BRPI0517567A (pt) | 2004-11-09 | 2008-06-17 | Smithkline Beecham Corp | composto ou um sal, solvato, ou derivado fisiologicamente funcional farmaceuticamente aceitável do mesmo, composição farmacêutica, usos de um composto ou um sal, solvato, ou derivado fisiologicamente funcional farmaceuticamente aceitável do mesmo e de uma composição farmacêutica, e, processo para preparar um composto |
| EP1676834A1 (en) * | 2004-12-30 | 2006-07-05 | Sanofi-Aventis Deutschland GmbH | Fused bicyclic carboxamide derivates for use as CXCR2 inhibitors in the treatment of inflammation |
| AR055319A1 (es) | 2005-03-17 | 2007-08-15 | Wyeth Corp | Derivados de isoquinoleina, composiciones farmaceuticas y usos |
-
2004
- 2004-12-30 EP EP04031009A patent/EP1676834A1/en not_active Withdrawn
-
2005
- 2005-12-17 WO PCT/EP2005/013624 patent/WO2006069656A1/en not_active Ceased
- 2005-12-17 BR BRPI0519452-0A patent/BRPI0519452A2/pt not_active Application Discontinuation
- 2005-12-17 CN CNA2005800454624A patent/CN101094830A/zh active Pending
- 2005-12-17 MX MX2007007068A patent/MX2007007068A/es active IP Right Grant
- 2005-12-17 KR KR1020077015119A patent/KR20070091634A/ko not_active Withdrawn
- 2005-12-17 NZ NZ556192A patent/NZ556192A/en not_active IP Right Cessation
- 2005-12-17 CA CA002592430A patent/CA2592430A1/en not_active Withdrawn
- 2005-12-17 RU RU2007128949/04A patent/RU2404962C2/ru not_active IP Right Cessation
- 2005-12-17 EP EP05818685A patent/EP1836158B1/en not_active Expired - Lifetime
- 2005-12-17 AT AT05818685T patent/ATE543795T1/de active
- 2005-12-17 JP JP2007548720A patent/JP5123667B2/ja not_active Expired - Fee Related
- 2005-12-17 AU AU2005321609A patent/AU2005321609B2/en not_active Ceased
- 2005-12-28 AR ARP050105577A patent/AR055830A1/es unknown
- 2005-12-28 TW TW094146875A patent/TW200639141A/zh unknown
- 2005-12-30 UY UY29322A patent/UY29322A1/es unknown
-
2006
- 2006-01-03 PE PE2006000027A patent/PE20060855A1/es not_active Application Discontinuation
-
2007
- 2007-05-21 ZA ZA200704089A patent/ZA200704089B/xx unknown
- 2007-06-24 IL IL184173A patent/IL184173A/en unknown
- 2007-06-26 MA MA30032A patent/MA29113B1/fr unknown
- 2007-06-29 US US11/771,958 patent/US7919628B2/en not_active Expired - Fee Related
- 2007-07-26 NO NO20073932A patent/NO20073932L/no unknown
-
2011
- 2011-04-04 US US13/079,522 patent/US8283479B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007007068A (es) | 2007-08-08 |
| JP5123667B2 (ja) | 2013-01-23 |
| EP1836158A1 (en) | 2007-09-26 |
| AU2005321609A1 (en) | 2006-07-06 |
| JP2008526695A (ja) | 2008-07-24 |
| RU2007128949A (ru) | 2009-02-10 |
| CA2592430A1 (en) | 2006-07-06 |
| RU2404962C2 (ru) | 2010-11-27 |
| NZ556192A (en) | 2010-06-25 |
| WO2006069656A1 (en) | 2006-07-06 |
| US7919628B2 (en) | 2011-04-05 |
| EP1836158B1 (en) | 2012-02-01 |
| MA29113B1 (fr) | 2007-12-03 |
| CN101094830A (zh) | 2007-12-26 |
| US20110184177A1 (en) | 2011-07-28 |
| BRPI0519452A2 (pt) | 2009-01-27 |
| TW200639141A (en) | 2006-11-16 |
| US8283479B2 (en) | 2012-10-09 |
| AR055830A1 (es) | 2007-09-12 |
| KR20070091634A (ko) | 2007-09-11 |
| ZA200704089B (en) | 2008-09-25 |
| UY29322A1 (es) | 2006-07-31 |
| US20080090854A1 (en) | 2008-04-17 |
| PE20060855A1 (es) | 2006-10-10 |
| AU2005321609B2 (en) | 2011-02-17 |
| EP1676834A1 (en) | 2006-07-05 |
| IL184173A0 (en) | 2007-10-31 |
| ATE543795T1 (de) | 2012-02-15 |
| IL184173A (en) | 2011-10-31 |
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