BRPI0519466B8 - dispersão sólida estável de um derivado de alcalóide de vinca e processo para a fabricação do mesmo - Google Patents

dispersão sólida estável de um derivado de alcalóide de vinca e processo para a fabricação do mesmo

Info

Publication number
BRPI0519466B8
BRPI0519466B8 BRPI0519466A BRPI0519466A BRPI0519466B8 BR PI0519466 B8 BRPI0519466 B8 BR PI0519466B8 BR PI0519466 A BRPI0519466 A BR PI0519466A BR PI0519466 A BRPI0519466 A BR PI0519466A BR PI0519466 B8 BRPI0519466 B8 BR PI0519466B8
Authority
BR
Brazil
Prior art keywords
manufacturing
same
solid dispersion
vinca alkaloid
stable solid
Prior art date
Application number
BRPI0519466A
Other languages
English (en)
Inventor
Leverd Elie
Bougaret Jöel
Ibarra Marie-Dominique
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/025,348 external-priority patent/US20060147518A1/en
Priority claimed from FR0414069A external-priority patent/FR2880274B1/fr
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of BRPI0519466A2 publication Critical patent/BRPI0519466A2/pt
Publication of BRPI0519466B1 publication Critical patent/BRPI0519466B1/pt
Publication of BRPI0519466B8 publication Critical patent/BRPI0519466B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

dispersão sólida estável de um derivado de alcalóide de vinca e processo para a fabricação do mesmo. a presente invenção refere-se às dispersões sólidas e estáveis de um derivado hidrossolúvel de alcalóide1s de vinca em pelo menos um polietileno glicol com uma massa molecular entre 800 e 30.000.
BRPI0519466A 2004-12-30 2005-12-20 dispersão sólida estável de um derivado de alcalóide de vinca e processo para a fabricação do mesmo BRPI0519466B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11/025,348 US20060147518A1 (en) 2004-12-30 2004-12-30 Stable solid dispersion of a derivative of vinca alkaloid and process for manufacturing it
FR0414069 2004-12-30
US11/025,348 2004-12-30
FR0414069A FR2880274B1 (fr) 2004-12-30 2004-12-30 Dispersion solide stable d'un derive d'alcaloides de vinca et son procede de fabrication
PCT/EP2005/056965 WO2006069938A1 (en) 2004-12-30 2005-12-20 Stable solid dispersion of a derivative of vinca alkaloid and process for manufacturing it

Publications (3)

Publication Number Publication Date
BRPI0519466A2 BRPI0519466A2 (pt) 2009-02-03
BRPI0519466B1 BRPI0519466B1 (pt) 2020-10-20
BRPI0519466B8 true BRPI0519466B8 (pt) 2021-05-25

Family

ID=36046982

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0519466A BRPI0519466B8 (pt) 2004-12-30 2005-12-20 dispersão sólida estável de um derivado de alcalóide de vinca e processo para a fabricação do mesmo

Country Status (22)

Country Link
US (1) US9061015B2 (pt)
EP (1) EP1830817B1 (pt)
JP (1) JP5256739B2 (pt)
KR (1) KR101320408B1 (pt)
AR (1) AR052079A1 (pt)
AU (1) AU2005321346B2 (pt)
BR (1) BRPI0519466B8 (pt)
CA (1) CA2591056C (pt)
CY (1) CY1113868T1 (pt)
DK (1) DK1830817T3 (pt)
ES (1) ES2401992T3 (pt)
HR (1) HRP20130276T1 (pt)
IL (1) IL184095A (pt)
MX (1) MX2007008059A (pt)
NZ (1) NZ554793A (pt)
PL (1) PL1830817T3 (pt)
PT (1) PT1830817E (pt)
RS (1) RS52697B (pt)
RU (1) RU2412687C2 (pt)
SI (1) SI1830817T1 (pt)
TW (1) TWI419714B (pt)
WO (1) WO2006069938A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007098091A2 (en) * 2006-02-17 2007-08-30 Novacea, Inc. Treatment of hyperproliferative diseases with vinca alkaloid n-oxide and analogs
MX2009008487A (es) * 2007-02-09 2010-01-15 Poniard Pharmaceuticals Inc Picoplatino encapsulado.
FR2918567B1 (fr) * 2007-07-11 2012-08-03 Pf Medicament Composition pharmaceutique stable d'un sel hydrosoluble de vinorelbine.
FR2918566B1 (fr) * 2007-07-11 2009-10-09 Pierre Fabre Medicament Sa Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
EP3426665A1 (en) 2016-03-09 2019-01-16 Synbias Pharma AG Vinorelbine monotartrate and its pharmaceutical use

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6811088B2 (en) * 1993-05-28 2004-11-02 Symbol Technologies, Inc. Portable data collection system
HN1998000115A (es) 1997-08-21 1999-06-02 Warner Lambert Co Formas de dosificación farmacéuticas sólidas
NL1009780C2 (nl) 1998-07-31 2000-02-01 Peter Hubertus Elisabeth Van D Plantpot.
DE10000792A1 (de) * 2000-01-11 2001-07-19 Bernhard C Lippold Formulierungen von Wirkstoffen in Form einer festen Dispersion
US20020004070A1 (en) * 2000-02-24 2002-01-10 Rudnic Edward M. Antineoplastic product, use and formulation thereof
EP1289560A1 (en) * 2000-06-12 2003-03-12 SmithKline Beecham Corporation Novel solid dispersion compositions
IT1320176B1 (it) * 2000-12-22 2003-11-26 Nicox Sa Dispersioni solide di principi attivi nitrati.
US20030212102A1 (en) 2001-06-12 2003-11-13 Koretke Todd W Novel solid dispersion compositions
ATE462419T1 (de) * 2002-05-31 2010-04-15 Rp Scherer Technologies Llc Orale pharmazeutische zusammensetzung für weichkapseln mit vinorelbin und behandlungsverfahren
US20050048119A1 (en) * 2002-09-20 2005-03-03 Avinash Nangia Controlled release composition with semi-permeable membrane and poloxamer flux enhancer

Also Published As

Publication number Publication date
AU2005321346A1 (en) 2006-07-06
JP5256739B2 (ja) 2013-08-07
TW200635619A (en) 2006-10-16
AU2005321346A8 (en) 2011-10-13
PL1830817T3 (pl) 2013-06-28
NZ554793A (en) 2010-04-30
IL184095A0 (en) 2007-10-31
DK1830817T3 (da) 2013-04-02
TWI419714B (zh) 2013-12-21
RS52697B (sr) 2013-08-30
WO2006069938A1 (en) 2006-07-06
KR101320408B1 (ko) 2013-10-30
BRPI0519466B1 (pt) 2020-10-20
PT1830817E (pt) 2013-04-01
RU2007124572A (ru) 2009-01-10
ES2401992T3 (es) 2013-04-26
EP1830817A1 (en) 2007-09-12
IL184095A (en) 2015-08-31
SI1830817T1 (sl) 2013-04-30
JP2008526711A (ja) 2008-07-24
CA2591056A1 (en) 2006-07-06
KR20070094598A (ko) 2007-09-20
CA2591056C (en) 2013-11-12
EP1830817B1 (en) 2013-01-02
BRPI0519466A2 (pt) 2009-02-03
CY1113868T1 (el) 2016-07-27
RU2412687C2 (ru) 2011-02-27
HRP20130276T1 (hr) 2013-04-30
AU2005321346B2 (en) 2011-06-23
US9061015B2 (en) 2015-06-23
AR052079A1 (es) 2007-02-28
US20080089935A1 (en) 2008-04-17
MX2007008059A (es) 2007-07-17

Similar Documents

Publication Publication Date Title
CY1120257T1 (el) ΠΥΡΡΟΛΟ[2,3b]ΠΥΡΙΔΙΝ-4-ΥΛΑΜΙΝΕΣ ΚΑΙ ΠΥΡΡΟΛΟ[2,3b]ΠΥΡΙΜΙΔΙΝ-4-ΥΛΑΜΙΝΕΣ ΩΣ ΑΝΑΣΤΟΛΕΙΣ ΚΙΝΑΣΩΝ JANUS
NO20081364L (no) Amorfe faste dispersjoner
BRPI0414000A (pt) composição farmacêutica sólida, forma de dosagem, uso da composição farmacêutica, e, método para a preparação da composição
GT200100008A (es) Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto.
CY1120831T1 (el) Μεθοδοι μειωσης της συσσωματωσης toy il-1ra
WO2007064797A3 (en) Inhibitors of c-met and uses thereof
EP2258382A3 (en) Amylin and amylin agonists for treating psychiatric diseases and disorders
CY1111312T1 (el) Χρηση παλονοσετρονης για την αντιμετωπιση της μετεγχειρητικης ναυτιας καιτου εμετου
IL190632A0 (en) Biphenyl derivatives and pharmaceutical compositions containing the same
BR0318087A (pt) Método para produzir partìculas cerâmicas
UY27755A1 (es) Nuevas composiciones farmacéuticas basadas en anticolinérgicos e inhibidores.
WO2009111057A3 (en) Fulvestrant formulations
MXPA05013290A (es) Composiciones oftalmicas que contienen una combinacion sinergistica de dos polimeros.
WO2007106436A3 (en) Photoactive compounds and compositions and uses thereof
WO2008033643A3 (en) Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
TW200738240A (en) Pharmaceutical compositions
WO2006081276A8 (en) 3-heteroaryl-3-hydroxy-2-amino-propyl amines and related compounds having analgesic and/or immuno stimulant activity
WO2006108075A3 (en) Compositions and methods for enhancing drug sensitivity and treating drug resistant infections an diseases
BRPI0415108A (pt) camada básica reticulável para inserções fixadoras pelo processo de ponto duplo
SG145724A1 (en) Recombinant lubricin molecules and uses thereof
WO2004037750A3 (en) Short-acting sedative hypnotic agents for anesthesia and sedation
WO2006096810A3 (en) Methods and compositions for production, formulation and use of 1-aryl-3-azabicyclo[3.1.0] hexanes
BRPI0519466B8 (pt) dispersão sólida estável de um derivado de alcalóide de vinca e processo para a fabricação do mesmo
WO2007067519A3 (en) The use of neurotransmitters and neuropeptides for the treatment of dry eye diseases and related conditions
DE602004021713D1 (de) Pharmazeutische formulierungen mit kurzketten-sphingolipiden und ihre verwendung

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 20/10/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/12/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 20A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2860 DE 28-10-2025 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.