BRPI0519948A2 - composto, processo para a preparação de um composto, composição farmacêutica e método de tratamento de cáncer em um mamìfero - Google Patents
composto, processo para a preparação de um composto, composição farmacêutica e método de tratamento de cáncer em um mamìferoInfo
- Publication number
- BRPI0519948A2 BRPI0519948A2 BRPI0519948-4A BRPI0519948A BRPI0519948A2 BR PI0519948 A2 BRPI0519948 A2 BR PI0519948A2 BR PI0519948 A BRPI0519948 A BR PI0519948A BR PI0519948 A2 BRPI0519948 A2 BR PI0519948A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- alkyl
- mammal
- preparing
- aryl
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 2
- 241000124008 Mammalia Species 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- QGJZLNKBHJESQX-FZFNOLFKSA-N betulinic acid Chemical class C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C QGJZLNKBHJESQX-FZFNOLFKSA-N 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 150000001733 carboxylic acid esters Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
- C07J71/0047—Nitrogen only at position 2(3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/702—Specific hybridization probes for retroviruses
- C12Q1/703—Viruses associated with AIDS
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
COMPOSTO, PROCESSO PARA A PREPARAçãO DE UM COMPOSTO, COMPOSIçãO FARMACêUTICA E MéTODO DE TRATAMENTO DE CáNCER EM UM MAMìFERO. A presente invenção se refere a novos derivados de ácido betulínico de fórmula (1), onde R é C(=CH~ 2~)CH~ 3~ ou CH(CH~ 3~)~ 2~; R~ 2~ junto com o grupo carbonila adjacente forma um ácido carboxilico, éster de ácido carboxílico ou uma amida substituida; R~ 3~ ou R~ 4~ são hidrogênio ou arila desde que quando ambos não sáo independentemente hidrogênio ou alquila ou R~ 3~ e R~ 4~ são combinados entre si para formar um anel arila opcionalmente substituído com um grupo X, onde x é selecionado a partir do grupo de halogênio, alquila, ciano, nitro, alcóxi, amino ou amina substituida; Y é N ou O; e R~ 1~ é zero quando Y for O, e R~ 1~ é hidrogênio, alquila ou aril alquila quando Y for N, útil para a inibição de células tumorais cancerosas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN265DE2005 | 2005-02-09 | ||
| PCT/IN2005/000445 WO2006085334A2 (en) | 2005-02-09 | 2005-12-29 | Novel betulinic acid derivatives a-ring-condensed to a heterocyclic group |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0519948A2 true BRPI0519948A2 (pt) | 2009-12-01 |
Family
ID=36793451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0519948-4A BRPI0519948A2 (pt) | 2005-02-09 | 2005-12-29 | composto, processo para a preparação de um composto, composição farmacêutica e método de tratamento de cáncer em um mamìfero |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8022055B2 (pt) |
| EP (1) | EP1858910B1 (pt) |
| KR (1) | KR101068259B1 (pt) |
| AT (1) | ATE486886T1 (pt) |
| AU (1) | AU2005327442B2 (pt) |
| BR (1) | BRPI0519948A2 (pt) |
| CA (1) | CA2597300C (pt) |
| DE (1) | DE602005024623D1 (pt) |
| EA (1) | EA013158B1 (pt) |
| NZ (1) | NZ560734A (pt) |
| WO (1) | WO2006085334A2 (pt) |
| ZA (1) | ZA200706393B (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9062197B2 (en) * | 2009-03-27 | 2015-06-23 | Eastman Chemical Company | Polyester blends |
| PL227790B1 (pl) | 2015-08-13 | 2018-01-31 | Slaski Univ Medyczny W Katowicach | Fosfoniany acetylenowych pochodnych betuliny o działaniu przeciwnowotworowym, sposób ich wytwarzania i zastosowanie. |
| WO2019055119A1 (en) | 2017-09-14 | 2019-03-21 | Phoenix Biotechnology, Inc. | METHOD AND COMPOSITION FOR TREATING VIRAL INFECTION |
| MX2020002884A (es) | 2017-09-14 | 2020-10-05 | Phoenix Biotechnology Inc | Método y composición neuroprotectora mejorada para tratar afecciones neurológicas. |
| RU2020130238A (ru) | 2020-03-31 | 2022-03-14 | Феникс Байотекнолоджи, Инк. | Способ и композиции для лечения коронавирусной инфекции |
| EP4009981B1 (en) | 2020-03-31 | 2023-08-16 | Phoenix Biotechnology, Inc. | Method and compositions for treating coronavirus infection |
-
2005
- 2005-12-29 CA CA2597300A patent/CA2597300C/en not_active Expired - Fee Related
- 2005-12-29 AU AU2005327442A patent/AU2005327442B2/en not_active Ceased
- 2005-12-29 US US11/883,753 patent/US8022055B2/en not_active Expired - Fee Related
- 2005-12-29 KR KR1020077019465A patent/KR101068259B1/ko not_active Expired - Fee Related
- 2005-12-29 EP EP05850957A patent/EP1858910B1/en not_active Expired - Lifetime
- 2005-12-29 EA EA200701689A patent/EA013158B1/ru not_active IP Right Cessation
- 2005-12-29 DE DE602005024623T patent/DE602005024623D1/de not_active Expired - Lifetime
- 2005-12-29 BR BRPI0519948-4A patent/BRPI0519948A2/pt not_active IP Right Cessation
- 2005-12-29 WO PCT/IN2005/000445 patent/WO2006085334A2/en not_active Ceased
- 2005-12-29 AT AT05850957T patent/ATE486886T1/de not_active IP Right Cessation
- 2005-12-29 NZ NZ560734A patent/NZ560734A/en not_active IP Right Cessation
-
2007
- 2007-08-01 ZA ZA200706393A patent/ZA200706393B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2597300C (en) | 2012-11-27 |
| ATE486886T1 (de) | 2010-11-15 |
| NZ560734A (en) | 2010-09-30 |
| DE602005024623D1 (de) | 2010-12-16 |
| AU2005327442B2 (en) | 2011-09-01 |
| EP1858910A2 (en) | 2007-11-28 |
| KR20070107717A (ko) | 2007-11-07 |
| ZA200706393B (en) | 2009-11-25 |
| EP1858910B1 (en) | 2010-11-03 |
| CA2597300A1 (en) | 2006-08-17 |
| KR101068259B1 (ko) | 2011-09-28 |
| WO2006085334A2 (en) | 2006-08-17 |
| US8022055B2 (en) | 2011-09-20 |
| WO2006085334A3 (en) | 2007-06-14 |
| US20080293682A1 (en) | 2008-11-27 |
| EA200701689A1 (ru) | 2008-02-28 |
| AU2005327442A1 (en) | 2006-08-17 |
| EA013158B1 (ru) | 2010-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] |
Free format text: SOLICITA-SE A REGULARIZACAO DA PROCURACAO, UMA VEZ QUE BASEADO NO ARTIGO 216 1O DA LPI, O DOCUMENTO DE PROCURACAO DEVE SER APRESENTADO EM SUA FORMA AUTENTICADA; OU SEGUNDO PARECER DA PROCURADORIA NO 074/93, DEVE CONSTAR UMA DECLARACAO DE VERACIDADE, A QUAL DEVE SER ASSINADA POR UMA PESSOA DEVIDAMENTE AUTORIZADA A REPRESENTAR O INTERESSADO, DEVENDO A MESMA CONSTAR NO INSTRUMENTO DE PROCURACAO, OU NO SEU SUBSTABELECIMENTO. |
|
| B25D | Requested change of name of applicant approved |
Owner name: FRESENIUS KABI ONCOLOGY LTD. (IN) Free format text: ALTERADO DE: DABUR PHARMA LIMITED |
|
| B25G | Requested change of headquarter approved |
Owner name: FRESENIUS KABI ONCOLOGY LTD. (IN) Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 018090047309/SP DE 15/10/2009. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014. |