BRPI0520054A2 - processo para a preparação de benzotiazinoindolas substituìdas - Google Patents
processo para a preparação de benzotiazinoindolas substituìdasInfo
- Publication number
- BRPI0520054A2 BRPI0520054A2 BRPI0520054-7A BRPI0520054A BRPI0520054A2 BR PI0520054 A2 BRPI0520054 A2 BR PI0520054A2 BR PI0520054 A BRPI0520054 A BR PI0520054A BR PI0520054 A2 BRPI0520054 A2 BR PI0520054A2
- Authority
- BR
- Brazil
- Prior art keywords
- sub
- substituted
- preparation
- alkyl
- general formula
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- QDYOCAAXRNVJLY-UHFFFAOYSA-N indolo[6,7-c][1,2]benzothiazine Chemical class C1=C[CH]C2=C(C3=C(C=C[N]3)C=C3)C3=NSC2=C1 QDYOCAAXRNVJLY-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- MLHVZUNBUWHKNY-UHFFFAOYSA-N 1-(benzenesulfonyl)-7-bromoindole Chemical class C1=2C(Br)=CC=CC=2C=CN1S(=O)(=O)C1=CC=CC=C1 MLHVZUNBUWHKNY-UHFFFAOYSA-N 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- -1 chloro, fluoro, amino Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
PROCESSO PARA A PREPARAçãO DE BENZOTIAZINOINDOLAS SUBSTITUìDAS. A presente invenção se refere a um processo para a preparação de benzotiazoindolas substituidas de fórmula geral (I), onde R~ 1~, R~ 2~ e R~ 4~, são independentemente selecionados a partir de hidrogênio, cloro, flúor, amino, nitro, dano, CHO, alquila C~ 1~-C~ 3~, perhalo alquila C~ 1~-C~ 3~, alcóxi C~ 1~-C~ 3~, arila, aralquila, aralcóxi, heterociclila C~ 5~-C~ 7~, heterociclilalquila C~ 5~-C~ 7~, heterociclilóxi C~ 5~-C~ 7~, acila, acetila, alquilamino, aminoalquila, amida, hidróxialquila, ácido carboxílico e os derivados dos mesmos, enquanto R~ 3~ é selecionado a partir de hidrogênio, alquila C~ 1~-C~ 3~, arila e ácido carboxílico e os derivados do mesmo que compreendem a ciclização do composto de fórmula geral II, (isto é, 1-benzenosulfonil-7-bromo-1H-indola substituido), onde R~ 1~, R~ 2~, R~ 3~ e R~4~ usam solventes e catalisadores adequados
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN225CH2005 | 2005-03-08 | ||
| IN225-CHE-2005 | 2005-03-08 | ||
| PCT/IN2005/000214 WO2006095360A1 (en) | 2005-03-08 | 2005-06-23 | Process for preparing substituted benzothiazinoindoles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0520054A2 true BRPI0520054A2 (pt) | 2009-11-17 |
| BRPI0520054B1 BRPI0520054B1 (pt) | 2018-07-10 |
Family
ID=35219651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0520054-7A BRPI0520054B1 (pt) | 2005-03-08 | 2005-06-23 | Processo para a preparação de benzotiazinoindolas substituídas |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20080119646A1 (pt) |
| EP (1) | EP1856132B1 (pt) |
| JP (1) | JP2008532996A (pt) |
| KR (1) | KR101097415B1 (pt) |
| CN (1) | CN101166746B (pt) |
| AT (1) | ATE427312T1 (pt) |
| AU (1) | AU2005328870B2 (pt) |
| BR (1) | BRPI0520054B1 (pt) |
| CA (1) | CA2600271C (pt) |
| CY (1) | CY1109144T1 (pt) |
| DE (1) | DE602005013702D1 (pt) |
| DK (1) | DK1856132T3 (pt) |
| EA (1) | EA012750B1 (pt) |
| ES (1) | ES2323535T3 (pt) |
| HR (1) | HRP20090352T1 (pt) |
| MX (1) | MX2007010980A (pt) |
| NO (1) | NO339034B1 (pt) |
| NZ (1) | NZ561880A (pt) |
| PL (1) | PL1856132T3 (pt) |
| PT (1) | PT1856132E (pt) |
| RS (1) | RS50802B (pt) |
| SI (1) | SI1856132T1 (pt) |
| WO (1) | WO2006095360A1 (pt) |
| ZA (1) | ZA200707326B (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103102329B (zh) * | 2013-01-24 | 2015-04-08 | 华东师范大学 | 一种2,3-二氢-[1,4]-苯并噻嗪类化合物的合成方法 |
| CN121064374A (zh) * | 2025-11-04 | 2025-12-05 | 振华新材料(东营)有限公司 | 一种制备稀土顺丁橡胶的连续聚合方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003249582B2 (en) * | 2002-06-21 | 2006-08-03 | Suven Life Sciences Limited | Tetracyclic arylsulfonyl indoles having serotonin receptor affinity |
| SI1581538T1 (sl) | 2002-12-18 | 2007-08-31 | Suven Life Sciences Ltd | Tetraciklični 3-substituirani indoli z afiniteto za receptor serotonina |
| WO2005005439A1 (en) | 2003-07-09 | 2005-01-20 | Suven Life Sciences Limited | Benzothiazino indoles |
-
2005
- 2005-06-23 EP EP05761235A patent/EP1856132B1/en not_active Expired - Lifetime
- 2005-06-23 RS RSP-2009/0281A patent/RS50802B/sr unknown
- 2005-06-23 DK DK05761235T patent/DK1856132T3/da active
- 2005-06-23 MX MX2007010980A patent/MX2007010980A/es active IP Right Grant
- 2005-06-23 PL PL05761235T patent/PL1856132T3/pl unknown
- 2005-06-23 US US11/885,389 patent/US20080119646A1/en not_active Abandoned
- 2005-06-23 ES ES05761235T patent/ES2323535T3/es not_active Expired - Lifetime
- 2005-06-23 EA EA200701910A patent/EA012750B1/ru not_active IP Right Cessation
- 2005-06-23 BR BRPI0520054-7A patent/BRPI0520054B1/pt not_active IP Right Cessation
- 2005-06-23 AT AT05761235T patent/ATE427312T1/de active
- 2005-06-23 PT PT05761235T patent/PT1856132E/pt unknown
- 2005-06-23 HR HR20090352T patent/HRP20090352T1/xx unknown
- 2005-06-23 KR KR1020077019843A patent/KR101097415B1/ko not_active Expired - Fee Related
- 2005-06-23 AU AU2005328870A patent/AU2005328870B2/en not_active Ceased
- 2005-06-23 JP JP2008500341A patent/JP2008532996A/ja active Pending
- 2005-06-23 SI SI200530681T patent/SI1856132T1/sl unknown
- 2005-06-23 NZ NZ561880A patent/NZ561880A/en not_active IP Right Cessation
- 2005-06-23 CN CN2005800494778A patent/CN101166746B/zh not_active Expired - Fee Related
- 2005-06-23 CA CA2600271A patent/CA2600271C/en not_active Expired - Fee Related
- 2005-06-23 WO PCT/IN2005/000214 patent/WO2006095360A1/en not_active Ceased
- 2005-06-23 DE DE602005013702T patent/DE602005013702D1/de not_active Expired - Lifetime
-
2007
- 2007-08-27 NO NO20074350A patent/NO339034B1/no not_active IP Right Cessation
- 2007-08-29 ZA ZA200707326A patent/ZA200707326B/xx unknown
-
2009
- 2009-06-02 CY CY20091100586T patent/CY1109144T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005328870B2 (en) | 2011-02-03 |
| MX2007010980A (es) | 2007-11-07 |
| SI1856132T1 (sl) | 2009-08-31 |
| HK1111998A1 (en) | 2008-08-22 |
| DK1856132T3 (da) | 2009-07-27 |
| EP1856132B1 (en) | 2009-04-01 |
| EA200701910A1 (ru) | 2008-02-28 |
| NO20074350L (no) | 2007-11-02 |
| CY1109144T1 (el) | 2014-07-02 |
| WO2006095360A1 (en) | 2006-09-14 |
| ES2323535T3 (es) | 2009-07-20 |
| CN101166746A (zh) | 2008-04-23 |
| NZ561880A (en) | 2009-01-31 |
| PT1856132E (pt) | 2009-06-09 |
| KR20070113211A (ko) | 2007-11-28 |
| CA2600271A1 (en) | 2006-09-14 |
| CN101166746B (zh) | 2011-09-28 |
| ATE427312T1 (de) | 2009-04-15 |
| ZA200707326B (en) | 2008-09-25 |
| KR101097415B1 (ko) | 2011-12-23 |
| DE602005013702D1 (de) | 2009-05-14 |
| EP1856132A1 (en) | 2007-11-21 |
| HRP20090352T1 (hr) | 2009-08-31 |
| JP2008532996A (ja) | 2008-08-21 |
| EA012750B1 (ru) | 2009-12-30 |
| CA2600271C (en) | 2013-09-24 |
| BRPI0520054B1 (pt) | 2018-07-10 |
| NO339034B1 (no) | 2016-11-07 |
| US20080119646A1 (en) | 2008-05-22 |
| PL1856132T3 (pl) | 2009-10-30 |
| AU2005328870A1 (en) | 2006-09-14 |
| RS50802B (sr) | 2010-08-31 |
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Legal Events
| Date | Code | Title | Description |
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| B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] |
Free format text: SOLICITA-SE A REGULARIZACAO DA PROCURACAO, UMA VEZ QUE BASEADO NO ARTIGO 216 1O DA LPI, O DOCUMENTO DE PROCURACAO DEVE SER APRESENTADO EM SUA FORMA AUTENTICADA; OU SEGUNDO PARECER DA PROCURADORIA NO 074/93, DEVE CONSTAR UMA DECLARACAO DE VERACIDADE, A QUAL DEVE SER ASSINADA POR UMA PESSOA DEVIDAMENTE AUTORIZADA A REPRESENTAR O INTERESSADO, DEVENDO A MESMA CONSTAR NO INSTRUMENTO DE PROCURACAO, OU NO SEU SUBSTABELECIMENTO. |
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] | ||
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 16A ANUIDADE. |
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| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2625 DE 27-04-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |