BRPI0520259A2 - composto derivado de diidropiridina ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto - Google Patents

composto derivado de diidropiridina ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto

Info

Publication number
BRPI0520259A2
BRPI0520259A2 BRPI0520259-0A BRPI0520259A BRPI0520259A2 BR PI0520259 A2 BRPI0520259 A2 BR PI0520259A2 BR PI0520259 A BRPI0520259 A BR PI0520259A BR PI0520259 A2 BRPI0520259 A2 BR PI0520259A2
Authority
BR
Brazil
Prior art keywords
alkyl
compound
pharmaceutically acceptable
acceptable salt
pharmaceutical composition
Prior art date
Application number
BRPI0520259-0A
Other languages
English (en)
Inventor
Gerritdina Geziena Gerritsma
Lars Anders Van Der Veen
Nicole Corine Renee Straten
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35837336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0520259(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Organon Nv filed Critical Organon Nv
Publication of BRPI0520259A2 publication Critical patent/BRPI0520259A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Quinoline Compounds (AREA)

Abstract

COMPOSTO DERIVADO DE DIIDROPIRIDINA OU UM SAL FARMACEUTICAMENTE ACEITáVEL DO MESMO, COMPOSIçãO FARMACêUTICA, E, USO DO COMPOSTO. A presente invenção diz respeito a derivados de diidropiridina tendo a fórmula geral (1) ou um sal farmaceuticamente aceitável do mesmo, em que R^ 1^ é alquila (1-6C), alquenila (2-6C), alquinila (2-6C), fenila, heteroarila (1-5C) R^ 2^ ,R^ 3^são independentemente alquila (1-4C), alquenila (2- 4C), alquinila (2-4C), alcóxi (1-4C), alquenilóxi (2-4C), alquinilóxi (2-4C), halogénio X é SO~ 2~, CH~ 2~, C(O) ou X é ausente R^ 4^ é alquila (1-6C), alquenila (2-6C), alquinila (2-6C), cicloalquila (3 -6C), cicloalquenila (3 -6C), cicloalquila (3 -6C) alquila (1 -4C), heterocicloalquila (2-6C), heterocicloalquila (2-6C) alquila (1-4C), arila (6-1OC), arila (6-10C) alquila (1-4C), heteroarila (1-9C) ou heteroarila (1 -9C) alquila (l-4C). Os compostos são úteis para o tratamento de distúrbios de fertilidade.
BRPI0520259-0A 2005-05-04 2005-05-04 composto derivado de diidropiridina ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto BRPI0520259A2 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2005/052042 WO2006117023A1 (en) 2005-05-04 2005-05-04 Dihydropyridine derivatives

Publications (1)

Publication Number Publication Date
BRPI0520259A2 true BRPI0520259A2 (pt) 2009-09-15

Family

ID=35837336

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0520259-0A BRPI0520259A2 (pt) 2005-05-04 2005-05-04 composto derivado de diidropiridina ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto

Country Status (22)

Country Link
US (1) US7994189B2 (pt)
EP (1) EP1879866B1 (pt)
JP (1) JP4869336B2 (pt)
CN (1) CN101171234B (pt)
AT (1) ATE502014T1 (pt)
AU (1) AU2005331482B2 (pt)
BR (1) BRPI0520259A2 (pt)
CA (1) CA2606521C (pt)
CY (1) CY1111642T1 (pt)
DE (1) DE602005027002D1 (pt)
DK (1) DK1879866T3 (pt)
ES (1) ES2361674T3 (pt)
HR (1) HRP20110344T1 (pt)
IL (1) IL186660A0 (pt)
MX (1) MX2007013745A (pt)
NO (1) NO20075579L (pt)
NZ (1) NZ562541A (pt)
PL (1) PL1879866T3 (pt)
PT (1) PT1879866E (pt)
RS (1) RS51784B (pt)
SI (1) SI1879866T1 (pt)
WO (1) WO2006117023A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA92009C2 (ru) * 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия
UA92008C2 (en) * 2005-05-04 2010-09-27 Н.В. Органон 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY
UA92007C2 (ru) * 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
TW200944523A (en) 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines
US8071587B2 (en) * 2009-05-27 2011-12-06 N. V. Organon (Dihydro)imidazoiso[5,1-A]quinolines
US8431564B2 (en) 2009-07-29 2013-04-30 Merck Sharp & Dohme B.V. Ring-annulated dihydropyrrolo[2,1-α]isoquinolines
TW201116531A (en) 2009-07-29 2011-05-16 Organon Nv Ring-annulated dihydropyrrolo[2,1-a]isoquinolines
TW201116515A (en) 2009-07-31 2011-05-16 Organon Nv Dihydrobenzoindazoles
US20150296779A1 (en) * 2012-11-28 2015-10-22 Stichting Dienst Landbouwkundig Onderzoek Substituted dihydropyridines for somatic embryogenesis in plants
CN110357993B (zh) * 2019-07-09 2020-05-05 清华大学 一种可作为抑菌添加剂的含1,4-二氢吡啶结构的新型高分子

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1070162B (de) 1959-12-03 Farbwerke Hoechst Aktiengesellschaft vormals Meister Lucius &. Brüning, Frankfurt/M Verfahren zur Herstellung von 5 - Brom - 3 - nitro - 4 - hydroxybenzaldehyd bzw. 5 - Chlor - 3 - nitro - 4 - hydroxybenzaldehyd
GB9318935D0 (en) 1992-10-20 1993-10-27 Zeneca Ltd Heterocyclic derivatives
DE4430639A1 (de) 1994-08-29 1996-03-07 Bayer Ag Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten
GB9515445D0 (en) * 1995-07-27 1995-09-27 Pharmacia Spa Dihydropyridine and pyridine derivatives and process for their preparation
CA2229201A1 (en) 1995-10-19 1997-04-24 Satoshi Sasaki Quinoline derivatives, their production and use
US6593335B1 (en) 1997-12-18 2003-07-15 Abbott Laboratories Potassium channel openers
CA2339018A1 (en) 1998-08-07 2000-02-17 Applied Research Systems Ars Holding N.V. Fsh mimetics for the treatment of infertility
EP1307193A1 (en) 2000-07-27 2003-05-07 Affymax Research Institute Agonists of follicle stimulating hormone activity
US8058441B2 (en) 2001-07-02 2011-11-15 N.V. Organon Tetrahydroquinoline derivatives
JP2003026630A (ja) 2001-07-13 2003-01-29 Taoka Chem Co Ltd カラーカプラー中間体用カルボン酸クロリド類の製造法
TWI322012B (en) * 2002-12-20 2010-03-21 Organon Nv Tetrahydroquinoline derivatives
UA92007C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
UA92008C2 (en) 2005-05-04 2010-09-27 Н.В. Органон 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY
UA92009C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия

Also Published As

Publication number Publication date
CY1111642T1 (el) 2015-10-07
CA2606521C (en) 2012-09-18
ES2361674T3 (es) 2011-06-21
MX2007013745A (es) 2008-01-24
NZ562541A (en) 2009-02-28
CA2606521A1 (en) 2006-11-09
EP1879866A1 (en) 2008-01-23
JP4869336B2 (ja) 2012-02-08
EP1879866B1 (en) 2011-03-16
US7994189B2 (en) 2011-08-09
PT1879866E (pt) 2011-06-01
RS51784B (sr) 2011-12-31
DE602005027002D1 (en) 2011-04-28
HRP20110344T1 (hr) 2011-06-30
AU2005331482A1 (en) 2006-11-09
AU2005331482B2 (en) 2011-06-02
US20090215773A1 (en) 2009-08-27
HK1110855A1 (en) 2008-07-25
WO2006117023A1 (en) 2006-11-09
JP2008540349A (ja) 2008-11-20
PL1879866T3 (pl) 2011-07-29
CN101171234B (zh) 2011-11-16
NO20075579L (no) 2008-01-18
SI1879866T1 (sl) 2011-06-30
IL186660A0 (en) 2008-01-20
DK1879866T3 (da) 2011-06-06
CN101171234A (zh) 2008-04-30
ATE502014T1 (de) 2011-04-15

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Legal Events

Date Code Title Description
B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

Free format text: SOLICITA-SE A REGULARIZACAO DA PROCURACAO, UMA VEZ QUE BASEADO NO ARTIGO 216 1O DA LPI, O DOCUMENTO DE PROCURACAO DEVE SER APRESENTADO EM SUA FORMA AUTENTICADA; OU SEGUNDO PARECER DA PROCURADORIA NO 074/93, DEVE CONSTAR UMA DECLARACAO DE VERACIDADE, A QUAL DEVE SER ASSINADA POR UMA PESSOA DEVIDAMENTE AUTORIZADA A REPRESENTAR O INTERESSADO, DEVENDO A MESMA CONSTAR NO INSTRUMENTO DE PROCURACAO, OU NO SEU SUBSTABELECIMENTO.

B08L Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 8A E 9A ANUIDADES.

B08I Publication cancelled [chapter 8.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2260 DE 29/04/2014 POR TER SIDO INDEVIDA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 8A, 9A, 10A, 11A, 12A, 13A, 14A E 15A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.