BRPI1008661B8 - compostos derivados de aminopirazina, seu uso e composição farmacêutica - Google Patents

compostos derivados de aminopirazina, seu uso e composição farmacêutica

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Publication number
BRPI1008661B8
BRPI1008661B8 BRPI1008661A BRPI1008661A BRPI1008661B8 BR PI1008661 B8 BRPI1008661 B8 BR PI1008661B8 BR PI1008661 A BRPI1008661 A BR PI1008661A BR PI1008661 A BRPI1008661 A BR PI1008661A BR PI1008661 B8 BRPI1008661 B8 BR PI1008661B8
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BR
Brazil
Prior art keywords
alkyl
aminopyrazine
pharmaceutical composition
amino
halogen atom
Prior art date
Application number
BRPI1008661A
Other languages
English (en)
Inventor
Naito Haruna
Fujihara Hidetaka
Hori Katsutoshi
Asaki Tetsuo
Original Assignee
Nippon Shinyaku Co Ltd
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Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of BRPI1008661A2 publication Critical patent/BRPI1008661A2/pt
Publication of BRPI1008661B1 publication Critical patent/BRPI1008661B1/pt
Publication of BRPI1008661B8 publication Critical patent/BRPI1008661B8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

compostos derivados de aminopirazin e suas composições farmacêuticas. a presente invenção refere-se a um composto pela fórmula geral [1] satisfazendo o seguinte (i) ou (ii), ou um sal farmaceuticamente aceitável do composto, x é ch ou n; r1 é um átomo de halogênio; e r2 é h, um átomo de halogênio, cn, [2], [3], [8], [9], uma -o-alquila, um -o-(anel saturado), etc.; [2]: -c(rc)(rd((re) {rc a re cada são h, uma alquila, etc. }; [3]: -n(rf)(rg) {rf e rg cada são h, oh, amino, uma (hetero)arila, etc. }; [8]: -c(=o)rl {rl é uma alquila, oh, um alcóxi, amino, etc. }; [9] uma fenila (substituída); (ii) x é >c-c(=o)rb {rb é um amino (susbtituído), um alcóxi, oh, etc.}; r1 é um atomo de halogênio; r2 é h; r3 é h ou oh; e r3 e r4 cada são h ou uma alquila.
BRPI1008661A 2009-02-06 2010-02-05 compostos derivados de aminopirazina, seu uso e composição farmacêutica BRPI1008661B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2009-026470 2009-02-06
JP2009026470 2009-02-06
JP2009-276133 2009-12-04
JP2009276133 2009-12-04
PCT/JP2010/051722 WO2010090290A1 (ja) 2009-02-06 2010-02-05 アミノピラジン誘導体及び医薬

Publications (3)

Publication Number Publication Date
BRPI1008661A2 BRPI1008661A2 (pt) 2016-03-08
BRPI1008661B1 BRPI1008661B1 (pt) 2020-09-15
BRPI1008661B8 true BRPI1008661B8 (pt) 2021-05-25

Family

ID=42542181

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1008661A BRPI1008661B8 (pt) 2009-02-06 2010-02-05 compostos derivados de aminopirazina, seu uso e composição farmacêutica

Country Status (19)

Country Link
US (2) US8673891B2 (pt)
EP (1) EP2394999B1 (pt)
JP (1) JP5263304B2 (pt)
KR (1) KR101677778B1 (pt)
CN (1) CN102307869B (pt)
AU (1) AU2010211672B2 (pt)
BR (1) BRPI1008661B8 (pt)
CA (1) CA2751695C (pt)
DK (1) DK2394999T3 (pt)
ES (1) ES2453474T3 (pt)
HR (1) HRP20140265T1 (pt)
MX (1) MX2011008243A (pt)
MY (1) MY155374A (pt)
PL (1) PL2394999T3 (pt)
PT (1) PT2394999E (pt)
RU (1) RU2535217C2 (pt)
SI (1) SI2394999T1 (pt)
WO (1) WO2010090290A1 (pt)
ZA (1) ZA201105623B (pt)

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DK2394999T3 (da) 2014-05-05
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PT2394999E (pt) 2014-05-02
KR101677778B1 (ko) 2016-11-18
CA2751695C (en) 2017-11-28
JPWO2010090290A1 (ja) 2012-08-09
SI2394999T1 (sl) 2014-05-30
RU2535217C2 (ru) 2014-12-10
US8673891B2 (en) 2014-03-18
RU2011136825A (ru) 2013-03-20
CN102307869B (zh) 2014-10-22
BRPI1008661B1 (pt) 2020-09-15
EP2394999B1 (en) 2014-01-29
KR20110120932A (ko) 2011-11-04
CA2751695A1 (en) 2010-08-12
MY155374A (en) 2015-10-15
US20130131082A1 (en) 2013-05-23
US20110288065A1 (en) 2011-11-24
AU2010211672A1 (en) 2011-08-25
WO2010090290A1 (ja) 2010-08-12
JP5263304B2 (ja) 2013-08-14
EP2394999A1 (en) 2011-12-14
BRPI1008661A2 (pt) 2016-03-08
US8586591B2 (en) 2013-11-19
EP2394999A4 (en) 2012-10-10
MX2011008243A (es) 2011-08-17
PL2394999T3 (pl) 2014-06-30
ES2453474T3 (es) 2014-04-07
AU2010211672B2 (en) 2016-08-04
HRP20140265T1 (hr) 2014-04-25

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