BRPI0605833A - pregabalina livre de ácido isobutilglutárico e um processo para sua preparação - Google Patents

pregabalina livre de ácido isobutilglutárico e um processo para sua preparação

Info

Publication number
BRPI0605833A
BRPI0605833A BRPI0605833-7A BRPI0605833A BRPI0605833A BR PI0605833 A BRPI0605833 A BR PI0605833A BR PI0605833 A BRPI0605833 A BR PI0605833A BR PI0605833 A BRPI0605833 A BR PI0605833A
Authority
BR
Brazil
Prior art keywords
pregabalin
preparation
acid free
isobutylglutaric acid
isobutylglutaric
Prior art date
Application number
BRPI0605833-7A
Other languages
English (en)
Inventor
Lilach Hedvati
Ziv Dee Noor
Claude Singer
Gideon Pilarski
Yuriy Raizi
Sharon Tomer
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of BRPI0605833A publication Critical patent/BRPI0605833A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PREGABALINA LIVRE DE áCIDO ISOBUTILGLUTáRICO E UM PROCESSO PAPA SUA PREPARAçãO é fornecida uma Pregabalina que apresenta um baixo nível de 3-ácido isobutilglutárico.
BRPI0605833-7A 2005-05-10 2006-05-10 pregabalina livre de ácido isobutilglutárico e um processo para sua preparação BRPI0605833A (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US67978405P 2005-05-10 2005-05-10
US68969905P 2005-06-09 2005-06-09
US73058405P 2005-10-26 2005-10-26
US73143405P 2005-10-27 2005-10-27
US73274505P 2005-11-01 2005-11-01
PCT/US2006/018266 WO2006122255A1 (en) 2005-05-10 2006-05-10 Pregabalin free of isobutylglutaric acid and a process for preparation thereof

Publications (1)

Publication Number Publication Date
BRPI0605833A true BRPI0605833A (pt) 2007-12-18

Family

ID=36954467

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0605833-7A BRPI0605833A (pt) 2005-05-10 2006-05-10 pregabalina livre de ácido isobutilglutárico e um processo para sua preparação

Country Status (9)

Country Link
US (1) US7462737B2 (pt)
EP (1) EP1879853A1 (pt)
JP (1) JP2008505980A (pt)
KR (1) KR20070067077A (pt)
BR (1) BRPI0605833A (pt)
CA (1) CA2604600A1 (pt)
IL (1) IL185028A0 (pt)
MX (1) MX2007000525A (pt)
WO (1) WO2006122255A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7763749B2 (en) 2005-05-10 2010-07-27 Teva Pharmaceutical Industries Ltd. Method for the preparation of Pregabalin and salts thereof
CA2604624A1 (en) 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
ES2398579T3 (es) 2005-09-19 2013-03-20 Teva Pharmaceutical Industries Ltd Una síntesis asimétrica de ácido (S)-(+)-3-(aminometil)-5-metilhexanoico
CA2681313C (en) 2007-03-22 2012-09-11 Teva Pharmaceutical Industries Ltd. Synthesis of (s)-(+)-3-(aminomethyl)-5-methyl hexanoic acid
WO2009004643A2 (en) * 2007-05-08 2009-01-08 Cadila Healthcare Limited An improved process for preparation of (s)-pregabalin and intermediates thereof
KR20090101462A (ko) * 2007-10-03 2009-09-28 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법
AR071259A1 (es) * 2007-11-30 2010-06-09 Medichem Sa Procedimiento para preparar un acido gamma-amino sustituido y composiciones farmaceuticas que contienen dicho compuesto
JP2010043063A (ja) 2008-05-09 2010-02-25 Agency For Science Technology & Research 川崎病の診断及び治療
EA019285B1 (ru) 2008-05-21 2014-02-28 Сандоз Аг Способ стереоселективного ферментативного гидролиза эфира 5-метил-3-нитрометилгексановой кислоты
WO2009147528A1 (en) * 2008-06-02 2009-12-10 Actavis Group Ptc Ehf Improved process for preparing pregabalin
JPWO2011078172A1 (ja) * 2009-12-25 2013-05-09 株式会社カネカ 光学活性３−置換グルタル酸モノアミドの製造法
EP2383255A1 (en) 2010-04-28 2011-11-02 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
WO2022256545A1 (en) * 2021-06-04 2022-12-08 Nevakar Injectables Inc. Injectable pregabalin formulations

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2053582T3 (es) * 1986-08-13 1994-08-01 Ciba Geigy Ag Procedimiento para la obtencion de derivados del acido 5-amino-4-hidroxivalerianico.
US6197819B1 (en) * 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
US5616793A (en) 1995-06-02 1997-04-01 Warner-Lambert Company Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5637767A (en) 1995-06-07 1997-06-10 Warner-Lambert Company Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
DE19530637A1 (de) 1995-08-21 1997-02-27 Bayer Ag Verfahren zur Herstellung von 2,2-Difluorbenzo[1.3]dioxolcarbaldehyden
GB9812413D0 (en) * 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
FR2781793B1 (fr) * 1998-08-03 2001-07-20 Prographarm Lab Procede de fabrication de granules de gabapentine enrobes
SK287303B6 (sk) 2000-01-27 2010-06-07 Warner-Lambert Company Spôsob prípravy derivátu (S)-3-kyano-5-metyl-hexánovej kyseliny, spôsob a medziprodukt na prípravu pregabalínu
DE10203122A1 (de) 2002-01-25 2003-07-31 Gruenenthal Gmbh Verfahren zur Herstellung von substituierten Acrylsäureestern bzw. deren Einsatz zur Herstellung von substituierten gamma-Aminosäuren
US20030225149A1 (en) 2002-04-30 2003-12-04 Blazecka Peter G. Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids
DE602005002253T2 (de) 2004-03-12 2008-05-29 Warner-Lambert Company Llc C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalin
JP2007530657A (ja) 2004-04-01 2007-11-01 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー Ｐキラル性ホスホランの調製および不斉合成でのその使用
UA82292C2 (uk) 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
RS51210B (sr) * 2004-06-21 2010-12-31 Warner-Lambert Company Llc. Dobijanje pregaballina i srodnih jedinjenja
WO2006008640A1 (en) 2004-07-15 2006-01-26 Pharmacia & Upjohn Company Llc Non-aqueous suspension containing a drug having an unpleasant taste
CN1634869A (zh) 2004-12-06 2005-07-06 北京阜康仁生物制药科技有限公司 普瑞巴林新晶型及其制备方法
US7763749B2 (en) * 2005-05-10 2010-07-27 Teva Pharmaceutical Industries Ltd. Method for the preparation of Pregabalin and salts thereof
US20060270871A1 (en) 2005-05-30 2006-11-30 Khanduri Chandra H Polymorphic form i of pregabalin and processes for its preparation
CN100410242C (zh) 2005-06-23 2008-08-13 江苏恩华药业股份有限公司 普瑞巴林中间体及其制备方法
CZ297970B6 (cs) 2005-08-10 2007-05-09 Zentiva, A. S Zpusob výroby (S)-3-(aminomethyl)-5-methyl-hexanové kyseliny (pregabalinu)
ITMI20061297A1 (it) 2006-07-04 2008-01-05 Laboratorio Chimico Int Spa Procedimento per la preparazione della'acido (r)-(-)-3-(carbamoilmetil)-5-metilesanoico e del pregabalin e intermedi di sintesi
CA2657544C (en) 2006-07-12 2013-05-28 Generics [Uk] Limited Process for preparing pregabalin
GB0614133D0 (en) 2006-07-15 2006-08-23 Pliva Istrazivanje I Razvoj D Process for preparing a pharmaceutical compound
US20080014280A1 (en) 2006-07-17 2008-01-17 Glenmark Pharmaceuticals Limited Amorphous pregabalin and process for the preparation thereof

Also Published As

Publication number Publication date
US7462737B2 (en) 2008-12-09
KR20070067077A (ko) 2007-06-27
EP1879853A1 (en) 2008-01-23
WO2006122255A1 (en) 2006-11-16
JP2008505980A (ja) 2008-02-28
CA2604600A1 (en) 2006-11-16
IL185028A0 (en) 2007-12-03
MX2007000525A (es) 2007-03-28
US20060276544A1 (en) 2006-12-07

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: CONFORME ARTIGO 10O DA RESOLUCAO 124/06, CABE SER ARQUIVADO REFERENTE AO NAO RECOLHIMENTO DA 5A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011.