BRPI0514361A - processo para a produção de dihidropteridinonas - Google Patents

processo para a produção de dihidropteridinonas

Info

Publication number
BRPI0514361A
BRPI0514361A BRPI0514361-6A BRPI0514361A BRPI0514361A BR PI0514361 A BRPI0514361 A BR PI0514361A BR PI0514361 A BRPI0514361 A BR PI0514361A BR PI0514361 A BRPI0514361 A BR PI0514361A
Authority
BR
Brazil
Prior art keywords
production
dihydropteridinones
teridinones
dihidrop
radicals
Prior art date
Application number
BRPI0514361-6A
Other languages
English (en)
Inventor
Guenter Linz
Gerd F Kraemer
Ludwig Gutschera
Geert Asche
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35907775&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0514361(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BRPI0514361A publication Critical patent/BRPI0514361A/pt
Publication of BRPI0514361A8 publication Critical patent/BRPI0514361A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/54—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCESSO PARA A PRODUçãO DE DIHIDROP-TERIDINONAS. Refere-se a um pmcesso para a produção de dihidropteridinonas da fórmula gemi (I) na qual os radicais L e R¬ 1¬- R¬ 5¬ têm os significados mencionados nas reivindicações e na descrição.
BRPI0514361A 2004-08-14 2005-08-11 dihidropteridinonas e processo para produção dos mesmos BRPI0514361A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04019365 2004-08-14
EP05001611 2005-01-27
PCT/EP2005/008734 WO2006018220A2 (de) 2004-08-14 2005-08-11 Verfahren zur herstellung von dihydropteridinonen

Publications (2)

Publication Number Publication Date
BRPI0514361A true BRPI0514361A (pt) 2008-06-10
BRPI0514361A8 BRPI0514361A8 (pt) 2018-04-17

Family

ID=35907775

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514361A BRPI0514361A8 (pt) 2004-08-14 2005-08-11 dihidropteridinonas e processo para produção dos mesmos

Country Status (30)

Country Link
US (3) US7759485B2 (pt)
EP (1) EP1778668B1 (pt)
JP (2) JP5094391B2 (pt)
KR (1) KR101214394B1 (pt)
CN (1) CN101023070B (pt)
AR (1) AR054078A1 (pt)
AU (1) AU2005274338B2 (pt)
BR (1) BRPI0514361A8 (pt)
CA (1) CA2576290C (pt)
CL (1) CL2010000204A1 (pt)
CY (1) CY1114564T1 (pt)
DK (1) DK1778668T3 (pt)
EA (1) EA013820B1 (pt)
EC (1) ECSP077248A (pt)
ES (1) ES2429873T3 (pt)
HR (1) HRP20130890T1 (pt)
IL (1) IL181303A (pt)
ME (1) ME01599B (pt)
MX (1) MX2007001852A (pt)
MY (2) MY150538A (pt)
NO (1) NO20070753L (pt)
NZ (1) NZ553650A (pt)
PE (2) PE20091582A1 (pt)
PL (1) PL1778668T3 (pt)
PT (1) PT1778668E (pt)
RS (1) RS52917B (pt)
SI (1) SI1778668T1 (pt)
TW (1) TWI355383B (pt)
UY (1) UY29061A1 (pt)
WO (1) WO2006018220A2 (pt)

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DE102004058337A1 (de) * 2004-12-02 2006-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
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US8546566B2 (en) * 2010-10-12 2013-10-01 Boehringer Ingelheim International Gmbh Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
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US9370535B2 (en) 2011-05-17 2016-06-21 Boehringer Ingelheim International Gmbh Method for treatment of advanced solid tumors
TW201414734A (zh) 2012-07-10 2014-04-16 Takeda Pharmaceutical 氮雜吲哚衍生物
US9714946B2 (en) 2013-03-14 2017-07-25 Dana-Farber Cancer Institute, Inc. Bromodomain binding reagents and uses thereof
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Also Published As

Publication number Publication date
CA2576290C (en) 2013-07-16
AR054078A1 (es) 2007-06-06
CL2010000204A1 (es) 2010-12-03
ECSP077248A (es) 2007-03-29
TW200621779A (en) 2006-07-01
JP2008509951A (ja) 2008-04-03
BRPI0514361A8 (pt) 2018-04-17
US20100249412A1 (en) 2010-09-30
NO20070753L (no) 2007-05-07
WO2006018220A3 (de) 2006-10-12
AU2005274338B2 (en) 2012-06-28
CA2576290A1 (en) 2006-02-23
PE20060644A1 (es) 2006-07-24
US8138341B2 (en) 2012-03-20
KR101214394B1 (ko) 2012-12-21
WO2006018220A8 (de) 2006-06-15
US20100249458A1 (en) 2010-09-30
PE20091582A1 (es) 2009-11-07
EP1778668A2 (de) 2007-05-02
MX2007001852A (es) 2007-03-28
EP1778668B1 (de) 2013-07-03
WO2006018220A2 (de) 2006-02-23
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MY150538A (en) 2014-01-30
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DK1778668T3 (da) 2013-09-30
SI1778668T1 (sl) 2013-11-29
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EA200700199A1 (ru) 2007-08-31
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IL181303A (en) 2015-10-29
RS52917B (sr) 2014-02-28
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US7759485B2 (en) 2010-07-20
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AU2005274338A1 (en) 2006-02-23
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NZ553650A (en) 2010-12-24
ME01599B (me) 2014-09-20
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IL181303A0 (en) 2007-07-04

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