BRPI0606360A2 - método para melhorar a apoptose, método para tratar uma desordem proliferativa e método para tratar células cancerosas - Google Patents

método para melhorar a apoptose, método para tratar uma desordem proliferativa e método para tratar células cancerosas

Info

Publication number
BRPI0606360A2
BRPI0606360A2 BRPI0606360-8A BRPI0606360A BRPI0606360A2 BR PI0606360 A2 BRPI0606360 A2 BR PI0606360A2 BR PI0606360 A BRPI0606360 A BR PI0606360A BR PI0606360 A2 BRPI0606360 A2 BR PI0606360A2
Authority
BR
Brazil
Prior art keywords
treating
cancer cells
proliferative disorder
apoptosis
death receptor
Prior art date
Application number
BRPI0606360-8A
Other languages
English (en)
Inventor
Avi J Ashkenazi
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of BRPI0606360A2 publication Critical patent/BRPI0606360A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

MéTODO PARA MELHORAR A APOPTOSE, MéTODO PARA TRATAR UMA DESORDEM PROLIFERATIVA E MéTODO PARA TRATAR CéLULAS CANCEROSAS. São fornecidos métodos de uso dos ligantes de receptor de morte, tais como polipeptídeos de Apo-2 ligante/TRAIL ou anticorpos para receptor de morte, e inibidores de EGFR para tratar condições patológicas como, por exemplo, o câncer. As incorporações da invenção incluem métodos de uso da Apo2LITRAIL ou anticorpos para receptor de morte, tais como anticorpos DR5 e DR4, combinados com inibidores de EGFR, como Tarceva
BRPI0606360-8A 2005-02-18 2006-02-16 método para melhorar a apoptose, método para tratar uma desordem proliferativa e método para tratar células cancerosas BRPI0606360A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/061,258 US20060188498A1 (en) 2005-02-18 2005-02-18 Methods of using death receptor agonists and EGFR inhibitors
PCT/US2006/005459 WO2006089015A2 (en) 2005-02-18 2006-02-16 Methods of using death receptor agonists and egfr inhibitors

Publications (1)

Publication Number Publication Date
BRPI0606360A2 true BRPI0606360A2 (pt) 2009-06-23

Family

ID=36912953

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606360-8A BRPI0606360A2 (pt) 2005-02-18 2006-02-16 método para melhorar a apoptose, método para tratar uma desordem proliferativa e método para tratar células cancerosas

Country Status (13)

Country Link
US (1) US20060188498A1 (pt)
EP (1) EP1853300B1 (pt)
JP (2) JP2008532937A (pt)
KR (1) KR20070110852A (pt)
CN (1) CN101180072A (pt)
AU (1) AU2006214292A1 (pt)
BR (1) BRPI0606360A2 (pt)
CA (1) CA2595931A1 (pt)
IL (1) IL184827A0 (pt)
NO (1) NO20074740L (pt)
RU (1) RU2429006C2 (pt)
WO (1) WO2006089015A2 (pt)
ZA (1) ZA200706859B (pt)

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WO2012151317A1 (en) * 2011-05-03 2012-11-08 Genentech, Inc. Vascular disruption agents and uses thereof
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WO2015138638A1 (en) 2014-03-11 2015-09-17 Theraly Pharmaceuticals, Inc. Long acting trail receptor agonists for treatment of autoimmune diseases
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NO2776305T3 (pt) * 2014-04-23 2018-01-27
UA120108C2 (uk) 2014-12-12 2019-10-10 Мерк Патент Гмбх Комбінація похідної 6-оксо-1,6-дигідропіридазину, що має протиракову активність, з інгібітором рефр
CN105801495A (zh) * 2014-12-31 2016-07-27 徐州万邦金桥制药有限公司 一种盐酸厄洛替尼合成纯化方法
US11007251B2 (en) 2015-12-17 2021-05-18 The Johns Hopkins University Ameliorating systemic sclerosis with death receptor agonists
CN109195620B (zh) * 2016-04-07 2022-06-28 约翰霍普金斯大学 用死亡受体激动剂治疗胰腺炎和疼痛的组合物和方法
US11369618B2 (en) * 2016-06-17 2022-06-28 The Trustees Of The University Of Pennsylvania Compounds, compositions and methods for prevention and/or treatment of cancer
WO2019154230A1 (zh) * 2018-02-08 2019-08-15 四川大学华西医院 一种包含TRAIL和IgG结合结构域的融合蛋白及其用途
US11767353B2 (en) 2020-06-05 2023-09-26 Theraly Fibrosis, Inc. Trail compositions with reduced immunogenicity
TW202309022A (zh) 2021-04-13 2023-03-01 美商努法倫特公司 用於治療具egfr突變之癌症之胺基取代雜環
CN119371319A (zh) * 2024-10-25 2025-01-28 安徽尖峰北卡药业有限公司 一种用于埃罗替尼中间体生产工艺及其生产系统

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Also Published As

Publication number Publication date
EP1853300A2 (en) 2007-11-14
IL184827A0 (en) 2008-08-07
ZA200706859B (en) 2008-11-26
WO2006089015A2 (en) 2006-08-24
NO20074740L (no) 2007-11-14
RU2007134568A (ru) 2009-03-27
EP1853300B1 (en) 2014-07-23
CN101180072A (zh) 2008-05-14
AU2006214292A1 (en) 2006-08-24
KR20070110852A (ko) 2007-11-20
WO2006089015A3 (en) 2007-08-23
RU2429006C2 (ru) 2011-09-20
JP2012229237A (ja) 2012-11-22
JP2008532937A (ja) 2008-08-21
CA2595931A1 (en) 2006-08-24
US20060188498A1 (en) 2006-08-24

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
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