NO20074740L - Fremgangsmater for anvendelse av dodsreseptoragonister og EGFR-inhibitorer - Google Patents

Fremgangsmater for anvendelse av dodsreseptoragonister og EGFR-inhibitorer

Info

Publication number
NO20074740L
NO20074740L NO20074740A NO20074740A NO20074740L NO 20074740 L NO20074740 L NO 20074740L NO 20074740 A NO20074740 A NO 20074740A NO 20074740 A NO20074740 A NO 20074740A NO 20074740 L NO20074740 L NO 20074740L
Authority
NO
Norway
Prior art keywords
death receptor
egfr inhibitors
methods
receptor agonists
antibodies
Prior art date
Application number
NO20074740A
Other languages
English (en)
Norwegian (no)
Inventor
Avi J Ashkenazi
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of NO20074740L publication Critical patent/NO20074740L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
NO20074740A 2005-02-18 2007-09-17 Fremgangsmater for anvendelse av dodsreseptoragonister og EGFR-inhibitorer NO20074740L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/061,258 US20060188498A1 (en) 2005-02-18 2005-02-18 Methods of using death receptor agonists and EGFR inhibitors
PCT/US2006/005459 WO2006089015A2 (en) 2005-02-18 2006-02-16 Methods of using death receptor agonists and egfr inhibitors

Publications (1)

Publication Number Publication Date
NO20074740L true NO20074740L (no) 2007-11-14

Family

ID=36912953

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20074740A NO20074740L (no) 2005-02-18 2007-09-17 Fremgangsmater for anvendelse av dodsreseptoragonister og EGFR-inhibitorer

Country Status (13)

Country Link
US (1) US20060188498A1 (pt)
EP (1) EP1853300B1 (pt)
JP (2) JP2008532937A (pt)
KR (1) KR20070110852A (pt)
CN (1) CN101180072A (pt)
AU (1) AU2006214292A1 (pt)
BR (1) BRPI0606360A2 (pt)
CA (1) CA2595931A1 (pt)
IL (1) IL184827A0 (pt)
NO (1) NO20074740L (pt)
RU (1) RU2429006C2 (pt)
WO (1) WO2006089015A2 (pt)
ZA (1) ZA200706859B (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007530588A (ja) * 2004-03-23 2007-11-01 バイオジェン・アイデック・エムエイ・インコーポレイテッド レセプターカップリング剤およびその治療用途
CA2778435A1 (en) * 2008-11-06 2010-05-14 Wayne State University Vaccines targeting cellular death receptors
EP2480230A4 (en) * 2009-09-24 2015-06-10 Seattle Genetics Inc DR5 Ligand-HEILMITTELKONJUGATE
US20130064838A1 (en) * 2010-05-14 2013-03-14 Amgen Inc. Enhanced death receptor agonists
IT1402029B1 (it) 2010-10-14 2013-08-28 Italiana Sint Spa Procedimento per la preparazione di erlotinib
ITPD20110091A1 (it) * 2011-03-24 2012-09-25 Univ Padova Inibitori multitirosinchinasi utili per le patologie correlate: modelli farmacoforici, composti identificati tramite questi modelli, metodi per la loro preparazione, la loro formulazione e il loro impiego terapeutico.
MX2013012716A (es) * 2011-05-03 2014-03-21 Genentech Inc Agentes de disociacion vascular y sus usos.
CN102675225A (zh) * 2012-05-16 2012-09-19 浙江理工大学 一种盐酸埃罗替尼的合成方法
RU2580220C2 (ru) * 2012-11-07 2016-04-10 Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) РЕКОМБИНАНТНАЯ ПЛАЗМИДА рСрG-СytDA/upp ДЛЯ ЭКСПРЕССИ ГИБРИДНОГО БЕЛКА ЦИТОЗИНДЕЗАМИНАЗА-УРАЦИЛФОСФОРИБОЗИЛ ТРАНСФЕРАЗА, РЕКОМБИНАНТНАЯ ПЛАЗМИДА рСрG-СytDA/upp/VP22 ДЛЯ ЭКСПРЕССИИ ГИБРИДНОГО БЕЛКА ЦИТОЗИНДЕЗАМИНАЗА-УРАЦИЛФОСФОРИБОЗИЛ ТРАНСФЕРЕЗА-VP22, ЛЕЧЕБНАЯ КОМПОЗИЦИЯ ДЛЯ ТЕРАПИИ ОНКОЛОГИЧЕСКИХ ЗАБОЛЕВАНИЙ И СПОСОБ ЕЕ ПРИМЕНЕНИЯ
US9556203B2 (en) * 2013-10-04 2017-01-31 Piqur Therapeutics Ag Conformationally restricted P13K and mTOR inhibitors
CN103833853B (zh) * 2013-12-25 2019-05-17 河南大学 新型死亡受体激动性多价抗体及其在制备抗肿瘤药物中的应用
WO2015138638A1 (en) 2014-03-11 2015-09-17 Theraly Pharmaceuticals, Inc. Long acting trail receptor agonists for treatment of autoimmune diseases
JP6629753B2 (ja) * 2014-04-03 2020-01-15 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung がん治療剤の組合せ
NO2776305T3 (pt) * 2014-04-23 2018-01-27
EP3229806A1 (en) 2014-12-12 2017-10-18 Merck Patent GmbH Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with an egfr inhibitor
CN105801495A (zh) * 2014-12-31 2016-07-27 徐州万邦金桥制药有限公司 一种盐酸厄洛替尼合成纯化方法
DK3389696T3 (da) 2015-12-17 2024-12-16 Univ Johns Hopkins Ameliorating systemic sclerosis with death receptor agonists
KR102508650B1 (ko) 2016-04-07 2023-03-13 더 존스 홉킨스 유니버시티 사멸 수용체 작용제로써 췌장암 및 통증을 치료하기 위한 조성물 및 방법
JP7197370B2 (ja) * 2016-06-17 2022-12-27 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア がんの予防および/または治療のための化合物、組成物および方法
WO2019154230A1 (zh) * 2018-02-08 2019-08-15 四川大学华西医院 一种包含TRAIL和IgG结合结构域的融合蛋白及其用途
US11767353B2 (en) 2020-06-05 2023-09-26 Theraly Fibrosis, Inc. Trail compositions with reduced immunogenicity
TW202309022A (zh) 2021-04-13 2023-03-01 美商努法倫特公司 用於治療具egfr突變之癌症之胺基取代雜環
CN119371319A (zh) * 2024-10-25 2025-01-28 安徽尖峰北卡药业有限公司 一种用于埃罗替尼中间体生产工艺及其生产系统

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4657760A (en) 1979-03-20 1987-04-14 Ortho Pharmaceutical Corporation Methods and compositions using monoclonal antibody to human T cells
GB8430252D0 (en) 1984-11-30 1985-01-09 Beecham Group Plc Compounds
US5206344A (en) 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
US4902502A (en) * 1989-01-23 1990-02-20 Cetus Corporation Preparation of a polymer/interleukin-2 conjugate
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
AU661533B2 (en) * 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
GB9314893D0 (en) * 1993-07-19 1993-09-01 Zeneca Ltd Quinazoline derivatives
IL112249A (en) * 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
US5654307A (en) * 1994-01-25 1997-08-05 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
IL112248A0 (en) * 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5747498A (en) * 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
CA2230492C (en) 1995-09-21 2009-05-26 Genentech, Inc. Human growth hormone variants
US6030945A (en) * 1996-01-09 2000-02-29 Genentech, Inc. Apo-2 ligand
US5760041A (en) * 1996-02-05 1998-06-02 American Cyanamid Company 4-aminoquinazoline EGFR Inhibitors
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
SK284073B6 (sk) * 1996-04-12 2004-09-08 Warner-Lambert Company Polycyklické zlúčeniny, ich použitie a farmaceutické kompozície na ich báze
ATE227283T1 (de) * 1996-07-13 2002-11-15 Glaxo Group Ltd Kondensierte heterozyklische verbindungen als protein kinase inhibitoren
US7452538B2 (en) * 1997-01-28 2008-11-18 Human Genome Sciences, Inc. Death domain containing receptor 4 antibodies and methods
US6072047A (en) * 1997-02-13 2000-06-06 Immunex Corporation Receptor that binds trail
US6002008A (en) * 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
US6235883B1 (en) * 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
US6342369B1 (en) * 1997-05-15 2002-01-29 Genentech, Inc. Apo-2-receptor
ATE516354T1 (de) 1997-05-15 2011-07-15 Genentech Inc Apo-2-rezeptor
US6252050B1 (en) * 1998-06-12 2001-06-26 Genentech, Inc. Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method
JP3687900B2 (ja) * 1998-11-19 2005-08-24 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー チロシンキナーゼの不可逆的阻害剤であるn−[4−(3−クロロ−4−フルオロフェニルアミノ)−7−(3−モルホリン−4−イルプロポキシ)キナゾリン−6−イル]アクリルアミド
JP2005508162A (ja) * 2001-10-02 2005-03-31 ジェネンテック・インコーポレーテッド Apo−2リガンド変異体とその使用法
DK1450847T3 (da) * 2001-11-13 2010-12-13 Genentech Inc Apo2-ligand/TRAIL-formuleringer og anvendelser deraf
RU2240125C2 (ru) * 2002-11-12 2004-11-20 Государственное учреждение Гематологический научный центр РАМН СПОСОБ ЭФФЕКТИВНОЙ ИНДУКЦИИ АПОПТОЗА В СУСПЕНЗИОННЫХ КУЛЬТУРАХ ОПУХОЛЕВЫХ PH$$$ КЛЕТОК КОСТНОГО МОЗГА И ПЕРИФЕРИЧЕСКОЙ КРОВИ БОЛЬНЫХ Ph+ ЛЕЙКОЗАМИ С ПОМОЩЬЮ АНТИСЕНС ОЛИГОНУКЛЕОТИДОВ, СПЕЦИФИЧНЫХ К МРНК ГЕНОВ, ИНГИБИРУЮЩИХ АПОПТОЗ
US20040147428A1 (en) * 2002-11-15 2004-07-29 Pluenneke John D. Methods of treatment using an inhibitor of epidermal growth factor receptor
PL1622929T3 (pl) * 2003-05-09 2007-03-30 Genentech Inc Peptydy wiążące się z receptorem APO2L(TRAIL) oraz ich zastosowanie

Also Published As

Publication number Publication date
JP2012229237A (ja) 2012-11-22
CA2595931A1 (en) 2006-08-24
WO2006089015A3 (en) 2007-08-23
BRPI0606360A2 (pt) 2009-06-23
EP1853300A2 (en) 2007-11-14
AU2006214292A1 (en) 2006-08-24
EP1853300B1 (en) 2014-07-23
KR20070110852A (ko) 2007-11-20
IL184827A0 (en) 2008-08-07
CN101180072A (zh) 2008-05-14
JP2008532937A (ja) 2008-08-21
WO2006089015A2 (en) 2006-08-24
RU2007134568A (ru) 2009-03-27
RU2429006C2 (ru) 2011-09-20
US20060188498A1 (en) 2006-08-24
ZA200706859B (en) 2008-11-26

Similar Documents

Publication Publication Date Title
NO20074740L (no) Fremgangsmater for anvendelse av dodsreseptoragonister og EGFR-inhibitorer
NO20071789L (no) Fremgangsmate for anvendelse av dodsreseptorligander og CD20-antistoffer
NO20071790L (no) Fremgangsmater for anvendelse av dodsreseptorligander og CD20-antistoffer
NO20170633A1 (no) Forbindelser av indolamin-2,3-dioksygenase for anvendelse i behandling av kreft i kombinasjon med et anti-PD-1 antistoff .
EA201001223A1 (ru) Стабилизированные белковые композиции
CL2007001624A1 (es) Uso de un anticuerpo que se une a dll4 para el tratamiento de tumor, cancer o trastorno de proliferacion celular.
IL258880A (en) Diarylhydantoin compounds
MX2018005512A (es) Agentes de union de esclerostina.
WO2009005809A3 (en) Compositions and methods for treating and diagnosing cancer
NO20073981L (no) Criptobindende molekyler
CU20120095A7 (es) Antagonistas de pcsk9
CR10147A (es) "ligandos que tienen especificidad de enlace para vegf y/o egfr y métodos de uso de los mismos"
NO20084546L (no) Diagnostikk og behandlinger for tumorer
GB0724532D0 (en) Trail variants for treating cancer
CL2008003527A1 (es) Conjugado de anticuerpo o porcion de union de antigeno del mismo, que se une a la proteina tirosina quinasa 7 (ptk-7/cck4); composicion que lo comprende; acido nulceico cidificante del anticuerpo; vector y celula huesped; uso del conjugado para tratar o prevenir una enfermedad de celulas tumorales que expresan ptk7
DK2211180T3 (da) Anvendelse af protein SATB2 som markør til at skelne colorectal cancer fra andre former for cancer
NO20083397L (no) Anti-EphB4-antistoffer og fremgangsmater for anvendelse av disse
EA201190210A1 (ru) Ингибиторы связывания киназы с белком
DK1885746T3 (da) Sammensætninger relateret til opløselige G-protein-koblede receptorer (sGPCRs)
GEP20146176B (en) Agonist dr5 binding polypeptides
EA201190025A1 (ru) ПРИМЕНЕНИЕ АНТАГОНИСТОВ DR6 И p75 ДЛЯ ПРОМОТИРОВАНИЯ ВЫЖИВАНИЯ КЛЕТОК НЕРВНОЙ СИСТЕМЫ
NO20076391L (no) Sammensetninger og metoder for behandling av tilstander relatert til efrinsignaler med cupredoxin
NO20084795L (no) Fremgangsmate for a behandle, diagnostisere eller detektere kreft
NO20083050L (no) Forbindelser og fremgangsmater for hemming av interaksjon av Bcl-proteiner med bindingspartnere
ATE544751T1 (de) Chinolinderivate als crth2-rezeptorliganden

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application