BRPI0606472A2 - derivados de n-(hetero aril)-1h-indol-2-carboxamidas e sua utilização como ligantes do receptor vanilóide trpv1 - Google Patents
derivados de n-(hetero aril)-1h-indol-2-carboxamidas e sua utilização como ligantes do receptor vanilóide trpv1Info
- Publication number
- BRPI0606472A2 BRPI0606472A2 BRPI0606472-8A BRPI0606472A BRPI0606472A2 BR PI0606472 A2 BRPI0606472 A2 BR PI0606472A2 BR PI0606472 A BRPI0606472 A BR PI0606472A BR PI0606472 A2 BRPI0606472 A2 BR PI0606472A2
- Authority
- BR
- Brazil
- Prior art keywords
- trpv1
- receptor ligands
- vanilloid receptor
- indole
- heteroaryl
- Prior art date
Links
- 102000011040 TRPV Cation Channels Human genes 0.000 title abstract 2
- 108010062740 TRPV Cation Channels Proteins 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 title 1
- 102000003566 TRPV1 Human genes 0.000 abstract 2
- 101150016206 Trpv1 gene Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 229940053202 antiepileptics carboxamide derivative Drugs 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
DERIVADOS DE N-(HETERO ARIL)-1H-INDOL-2-CARBOXAMIDAS E SUA UTILIZAçãO COMO LIGANTES DO RECEPTOR VANILóIDE TRPV1. A presente invenção refere-se aos compostos de fórmula geral (I): na qual, n é igual a 0,1, 2 ou 3; X~ 1~, X~ 2~, X~ 3~, X~ 4~, Z~ 1~, Z~ 2~, Z~ 3~, Z~ 4~ e Z~ 5~ representam um átomo de hidrogênio ou certos substituintes específicos; W representa um grupo bicíclico fundido de fórmula: ligado ao átomo de nitrogênio pelas posições 1, 2, 3 ou 4; A representa um heteroçiclo eventualmente substituído de 5 a 7 cadeias, compreendendo de 1 a 3 heteroátomos escolhido(s) dentre O, S ou N. Esses compostos são ligantes do receptor vanilóide TRPV1 úteis notadamente para o tratamento da dor e da inflamação.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0550068A FR2880625B1 (fr) | 2005-01-07 | 2005-01-07 | Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
| PCT/FR2006/000008 WO2006072736A1 (fr) | 2005-01-07 | 2006-01-04 | DERIVES DE N- (HETEROARYL) -1H-IND0LE-2-CARB0XAMIDΞS ET LEUR UTILISATION COMME LIGANDS DU RECEPTEUR VANILLOIDE TRPVl |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0606472A2 true BRPI0606472A2 (pt) | 2009-06-30 |
Family
ID=34955041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0606472-8A BRPI0606472A2 (pt) | 2005-01-07 | 2006-01-04 | derivados de n-(hetero aril)-1h-indol-2-carboxamidas e sua utilização como ligantes do receptor vanilóide trpv1 |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US7407950B2 (pt) |
| EP (1) | EP1841737B1 (pt) |
| JP (1) | JP5242167B2 (pt) |
| KR (1) | KR101288698B1 (pt) |
| CN (1) | CN101115718B (pt) |
| AR (1) | AR052450A1 (pt) |
| AT (1) | ATE460397T1 (pt) |
| AU (1) | AU2006204405B2 (pt) |
| BR (1) | BRPI0606472A2 (pt) |
| CA (1) | CA2594418C (pt) |
| CR (1) | CR9210A (pt) |
| CY (1) | CY1110647T1 (pt) |
| DE (1) | DE602006012802D1 (pt) |
| DK (1) | DK1841737T3 (pt) |
| EA (1) | EA013264B1 (pt) |
| ES (1) | ES2342318T3 (pt) |
| FR (1) | FR2880625B1 (pt) |
| HR (1) | HRP20100297T1 (pt) |
| IL (1) | IL184268A (pt) |
| MA (1) | MA29239B1 (pt) |
| MX (1) | MX2007008308A (pt) |
| MY (1) | MY145932A (pt) |
| NO (1) | NO20073811L (pt) |
| NZ (1) | NZ556318A (pt) |
| PE (1) | PE20061019A1 (pt) |
| PL (1) | PL1841737T3 (pt) |
| PT (1) | PT1841737E (pt) |
| RS (1) | RS51358B (pt) |
| SI (1) | SI1841737T1 (pt) |
| TN (1) | TNSN07253A1 (pt) |
| TW (1) | TWI367879B (pt) |
| UA (1) | UA93668C2 (pt) |
| UY (1) | UY29327A1 (pt) |
| WO (1) | WO2006072736A1 (pt) |
| ZA (1) | ZA200705548B (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2874015B1 (fr) * | 2004-08-05 | 2006-09-15 | Sanofi Synthelabo | Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2888847B1 (fr) | 2005-07-22 | 2007-08-31 | Sanofi Aventis Sa | Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique |
| FR2903985B1 (fr) * | 2006-07-24 | 2008-09-05 | Sanofi Aventis Sa | Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2904316B1 (fr) | 2006-07-31 | 2008-09-05 | Sanofi Aventis Sa | Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique. |
| US7612211B2 (en) * | 2006-12-15 | 2009-11-03 | Janssen Pharmaceutica N.V. | Benzimidazole TRPV1 inhibitors |
| FR2911604B1 (fr) * | 2007-01-19 | 2009-04-17 | Sanofi Aventis Sa | Derives de n-(heteroaryl-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
| BRPI0812594A2 (pt) * | 2007-08-10 | 2015-06-23 | Lundbeck & Co As H | Composto ou sal ou hidrato do mesmo, composição farmacêutica, métodos para modulação da atividade de um receptor p2x7, para tratamento de uma condição responsiva á modulação do receptor p2x7 em um paciente, para inibição de morte de células gangliônicas retinais em um paciente, para determinação da presença ou ausência de receptor p2x7 em uma amostra, preparação farmacêutica acondicionada, e, uso de um composto ou sal ou hidrato do mesmo. |
| US8163901B2 (en) | 2008-01-09 | 2012-04-24 | Evotec Ag | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
| FR2926554B1 (fr) * | 2008-01-22 | 2010-03-12 | Sanofi Aventis | Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique |
| FR2926556B1 (fr) * | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique |
| FR2926555B1 (fr) * | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives bicycliques de carboxamides azabicycliques, leur preparation et leur application en therapeutique |
| EP3295794A1 (en) | 2010-07-27 | 2018-03-21 | Flex Pharma, Inc. | Methods and compositions for preventing and relieving muscle cramps and for recovery from neuromuscular irritability and fatigue following exercise |
| KR101293384B1 (ko) * | 2010-10-13 | 2013-08-05 | 주식회사 대웅제약 | 신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도 |
| WO2018136943A1 (en) | 2017-01-23 | 2018-07-26 | Flex Pharma, Inc. | Compositions and methods affecting exercise performance |
| WO2025161263A1 (zh) * | 2024-01-31 | 2025-08-07 | 深圳晶蛋生物医药科技有限公司 | 一种苯并吗啉类化合物及其应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
| DK0885215T3 (da) * | 1996-02-13 | 2006-08-14 | Abbott Lab | Nye benzo-1,3-dioxolyl- og benzofuranyl-substituerede pyrrolidinderivater som endthelinantagonister |
| ATE206701T1 (de) * | 1996-04-19 | 2001-10-15 | American Home Prod | Östrogene verbindungen |
| TR200101233T2 (tr) * | 1997-08-04 | 2002-06-21 | Abbott Laboratories | Endotelin antagonistleri. |
| ID24568A (id) * | 1997-11-06 | 2000-07-27 | American Home Prod | Kontrasepsi oral yang mengandung anti-estrogen plus progestin |
| PT1042287E (pt) * | 1997-12-24 | 2005-08-31 | Aventis Pharma Gmbh | Derivados de indole como inibidores do factor xa |
| HRP20000778B1 (en) * | 1998-05-15 | 2004-10-31 | Wyeth Corp | 2-phenyl-1-/4-(2-aminoethoxy)-benzyl/-indole in combination with estrogens |
| CO5180550A1 (es) * | 1999-04-19 | 2002-07-30 | Smithkline Beecham Corp | Inhibidores de fab i |
| AR030064A1 (es) * | 2000-07-06 | 2003-08-13 | Wyeth Corp | Metodos para inhibir los efectos uterotroficos de los agentes estrogenicos |
| EP1314733A1 (en) * | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indole-2-carboxamides as factor Xa inhibitors |
| WO2003068749A1 (en) * | 2002-02-15 | 2003-08-21 | Glaxo Group Limited | Vanilloid receptor modulators |
| EP1578418A2 (en) * | 2002-12-20 | 2005-09-28 | Bayer HealthCare AG | Use of substituted 2,5-diamidoindoles for the treatment of urological diseases |
| ES2337254T3 (es) * | 2003-02-14 | 2010-04-22 | Glaxo Group Limited | Derivados de carboxamida. |
| AR045979A1 (es) * | 2003-04-28 | 2005-11-23 | Astrazeneca Ab | Amidas heterociclicas |
| WO2004108133A2 (en) * | 2003-06-05 | 2004-12-16 | Vertex Pharmaceuticals Incorporated | Modulators of vr1 receptor |
| US7544803B2 (en) * | 2004-01-23 | 2009-06-09 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| FR2874015B1 (fr) * | 2004-08-05 | 2006-09-15 | Sanofi Synthelabo | Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
-
2005
- 2005-01-07 FR FR0550068A patent/FR2880625B1/fr not_active Expired - Fee Related
-
2006
- 2006-01-04 PL PL06704665T patent/PL1841737T3/pl unknown
- 2006-01-04 AU AU2006204405A patent/AU2006204405B2/en not_active Ceased
- 2006-01-04 AT AT06704665T patent/ATE460397T1/de active
- 2006-01-04 WO PCT/FR2006/000008 patent/WO2006072736A1/fr not_active Ceased
- 2006-01-04 RS RSP-2010/0259A patent/RS51358B/sr unknown
- 2006-01-04 EP EP06704665A patent/EP1841737B1/fr not_active Expired - Lifetime
- 2006-01-04 MY MYPI20060030A patent/MY145932A/en unknown
- 2006-01-04 EA EA200701451A patent/EA013264B1/ru not_active IP Right Cessation
- 2006-01-04 SI SI200630674T patent/SI1841737T1/sl unknown
- 2006-01-04 JP JP2007549933A patent/JP5242167B2/ja not_active Expired - Fee Related
- 2006-01-04 MX MX2007008308A patent/MX2007008308A/es active IP Right Grant
- 2006-01-04 BR BRPI0606472-8A patent/BRPI0606472A2/pt not_active Application Discontinuation
- 2006-01-04 AR ARP060100023A patent/AR052450A1/es unknown
- 2006-01-04 ZA ZA200705548A patent/ZA200705548B/xx unknown
- 2006-01-04 HR HR20100297T patent/HRP20100297T1/hr unknown
- 2006-01-04 PE PE2006000037A patent/PE20061019A1/es not_active Application Discontinuation
- 2006-01-04 ES ES06704665T patent/ES2342318T3/es not_active Expired - Lifetime
- 2006-01-04 CN CN2006800042385A patent/CN101115718B/zh not_active Expired - Fee Related
- 2006-01-04 DE DE602006012802T patent/DE602006012802D1/de not_active Expired - Lifetime
- 2006-01-04 CA CA2594418A patent/CA2594418C/fr not_active Expired - Fee Related
- 2006-01-04 DK DK06704665.6T patent/DK1841737T3/da active
- 2006-01-04 NZ NZ556318A patent/NZ556318A/en not_active IP Right Cessation
- 2006-01-04 PT PT06704665T patent/PT1841737E/pt unknown
- 2006-01-04 KR KR1020077018041A patent/KR101288698B1/ko not_active Expired - Fee Related
- 2006-01-05 UY UY29327A patent/UY29327A1/es not_active Application Discontinuation
- 2006-01-06 TW TW095100688A patent/TWI367879B/zh not_active IP Right Cessation
- 2006-04-01 UA UAA200709046A patent/UA93668C2/ru unknown
-
2007
- 2007-06-20 US US11/765,687 patent/US7407950B2/en not_active Expired - Fee Related
- 2007-06-26 CR CR9210A patent/CR9210A/es unknown
- 2007-06-27 IL IL184268A patent/IL184268A/en not_active IP Right Cessation
- 2007-07-03 TN TNP2007000253A patent/TNSN07253A1/fr unknown
- 2007-07-20 NO NO20073811A patent/NO20073811L/no not_active Application Discontinuation
- 2007-07-26 MA MA30112A patent/MA29239B1/fr unknown
-
2008
- 2008-06-20 US US12/143,066 patent/US7557134B2/en not_active Expired - Fee Related
-
2010
- 2010-06-01 CY CY20101100482T patent/CY1110647T1/el unknown
Also Published As
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| Publication | Publication Date | Title |
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