BRPI0606623A2 - solução de aspersão e/ou conservação para órgãos - Google Patents

solução de aspersão e/ou conservação para órgãos

Info

Publication number
BRPI0606623A2
BRPI0606623A2 BRPI0606623-2A BRPI0606623A BRPI0606623A2 BR PI0606623 A2 BRPI0606623 A2 BR PI0606623A2 BR PI0606623 A BRPI0606623 A BR PI0606623A BR PI0606623 A2 BRPI0606623 A2 BR PI0606623A2
Authority
BR
Brazil
Prior art keywords
organ
solution
sym
protein kinase
sprinkler
Prior art date
Application number
BRPI0606623-2A
Other languages
English (en)
Inventor
Lindon H Young
Original Assignee
Philadelphia College Of Osteopathic Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36678233&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0606623(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Philadelphia College Of Osteopathic Medicine filed Critical Philadelphia College Of Osteopathic Medicine
Publication of BRPI0606623A2 publication Critical patent/BRPI0606623A2/pt
Publication of BRPI0606623B1 publication Critical patent/BRPI0606623B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

SOLUçãO DE ASPERSãO E/OU CONSERVAçãO PARA ORGáOS. A presente invenção refere-se a uma solução para conservação, aspersão e/ou reperfusão de um órgão, especialmente o coração, para transplante. A solução contém inibidor(es) peptidico(s) da proteína quinase C <225>ll (PCK <225>ll) e/ou da proteína quinase C<sym> (PKC<sym>) e/ou ativador(es) peptídico(s) da proteína quinase C (PKC<sym>). Também são revelados métodos para uso da solução inventiva, incluindo métodos para conservar um árgão pra transplante, para proteger um árgão isquêmico de danos, para atenuar a disfunção do árgão após a isquemia, para manter a liberação de óxido nítrico e/ou inibir a liberação de superóxido num órgáo isquêmico, e para proteger um órgáo de danos quando isolado do sistema circulatório.
BRPI0606623A 2005-01-14 2006-01-13 solução para perfusão, conservação e/ou reperfusão para conservação de órgãos e métodos utilizando a mesma BRPI0606623B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/035,197 US20060160062A1 (en) 2005-01-14 2005-01-14 Perfusion and/or preservation solution for organs
PCT/US2006/001266 WO2006076590A2 (en) 2005-01-14 2006-01-13 Perfusion and/or preservation solution for organs

Publications (2)

Publication Number Publication Date
BRPI0606623A2 true BRPI0606623A2 (pt) 2009-07-07
BRPI0606623B1 BRPI0606623B1 (pt) 2018-12-11

Family

ID=36678233

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606623A BRPI0606623B1 (pt) 2005-01-14 2006-01-13 solução para perfusão, conservação e/ou reperfusão para conservação de órgãos e métodos utilizando a mesma

Country Status (15)

Country Link
US (3) US20060160062A1 (pt)
EP (1) EP1845773B1 (pt)
JP (1) JP2008526987A (pt)
CN (3) CN102763638A (pt)
AR (1) AR055022A1 (pt)
AU (1) AU2006204787B2 (pt)
BR (1) BRPI0606623B1 (pt)
CA (1) CA2595086C (pt)
CR (1) CR9250A (pt)
IL (1) IL184625A (pt)
MX (1) MX2007008584A (pt)
NZ (2) NZ560615A (pt)
RU (1) RU2397641C2 (pt)
WO (1) WO2006076590A2 (pt)
ZA (1) ZA200706337B (pt)

Families Citing this family (25)

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US8409846B2 (en) 1997-09-23 2013-04-02 The United States Of America As Represented By The Department Of Veteran Affairs Compositions, methods and devices for maintaining an organ
US12010987B2 (en) 2004-10-07 2024-06-18 Transmedics, Inc. Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
US8304181B2 (en) 2004-10-07 2012-11-06 Transmedics, Inc. Method for ex-vivo organ care and for using lactate as an indication of donor organ status
CN103931605B (zh) 2004-10-07 2015-11-18 特兰斯迈迪茨公司 用于活体外器官护理的系统和方法
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
DK2056851T3 (da) * 2005-12-09 2013-10-14 Philadelphia College Of Osteopathic Medicine Organkonservering og/eller -perfusion
US20070148628A1 (en) * 2005-12-09 2007-06-28 Philadelphia College Of Osteopathic Medicine Organ preservation and/or perfusion
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
US20090156488A1 (en) * 2007-09-12 2009-06-18 Zensun (Shanghai) Science & Technology Limited Use of neuregulin for organ preservation
US8420380B2 (en) 2008-01-31 2013-04-16 Transmedics, Inc. Systems and methods for ex vivo lung care
US20130011823A1 (en) 2011-04-14 2013-01-10 Hassanein Waleed H Organ care solution for ex-vivo machine perfusion of donor lungs
WO2013053076A1 (en) 2011-10-10 2013-04-18 Zensun （Shanghai）Science & Technology Limited Compositions and methods for treating heart failure
EP3895724B1 (en) 2013-05-22 2025-06-25 Zensun (Shanghai) Science and Technology, Co., Ltd. Extended release of neuregulin for treating heart failure
RU2535036C1 (ru) * 2013-09-26 2014-12-10 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний" Сибирского отделения Российской академии медицинских наук (ФГБУ "НИИ КПССЗ" СО РАМН) Способ презервирования миокарда при трансплантации
CN105916374B (zh) 2013-11-22 2021-11-05 索玛解有限公司 用于增加器官和组织保存溶液的稳定性和储存寿命的溶液
CN110946993A (zh) 2014-01-03 2020-04-03 上海泽生科技开发股份有限公司 纽兰格林制剂的配方
JP2017518301A (ja) 2014-06-02 2017-07-06 トランスメディクス， インク．Ｔｒａｎｓｍｅｄｉｃｓ， Ｉｎｃ． ｅｘ−ｖｉｖｏでの臓器管理システム
CN111407882A (zh) 2014-10-17 2020-07-14 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物
CA3155169A1 (en) 2014-12-12 2016-06-16 Tevosol, Inc. Apparatus and method for organ perfusion
CA2997267A1 (en) 2015-09-09 2017-03-16 Transmedics, Inc. Aortic cannula for ex vivo organ care system
ES2968062T3 (es) 2016-05-30 2024-05-07 Transmedics Inc Aparato y método de ventilación pulmonar ex vivo con presión exterior variable
KR20240142604A (ko) * 2017-08-25 2024-09-30 말린크로트 파마슈티칼스 아일랜드 리미티드 기관 생존력을 개선시키는 방법
CN108902131B (zh) * 2018-10-12 2019-08-02 嘉兴莱普晟医疗科技有限公司 一种用于离体心脏保存的常温灌注液
US11567408B2 (en) * 2019-10-15 2023-01-31 Rohm And Haas Electronic Materials Korea Ltd. Coating composition for use with an overcoated photoresist
US20230125482A1 (en) * 2020-03-24 2023-04-27 Young Therapeutics, Llc Protein kinase c modulators

Family Cites Families (17)

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US5843024A (en) * 1996-05-17 1998-12-01 Breonics, Inc. Solution and process for resuscitation and preparation of ischemically damaged tissue
US6447539B1 (en) * 1996-09-16 2002-09-10 Transvascular, Inc. Method and apparatus for treating ischemic heart disease by providing transvenous myocardial perfusion
WO1998017299A1 (en) * 1996-10-18 1998-04-30 The Board Of Trustees Of The Leland Stanford Junior University Isozyme-specific activators of protein kinase c, methods and compositions
US6054261A (en) * 1998-05-20 2000-04-25 Q-Pharma, Inc. Coenzyme Q10 compositions for organ protection during perfusion
FR2785501B1 (fr) * 1998-11-10 2001-01-05 Centre Nat Rech Scient Solution de perfusion et/ou de conservation et/ou de reperfusion lors de la transplantation d'organes
GB9905503D0 (en) * 1999-03-10 1999-05-05 Adprotech Plc Novel compound formulations and methods of delivery
JP5230042B2 (ja) * 1999-06-02 2013-07-10 株式会社ビーエムジー 動物の細胞または臓器の保存剤およびその保存方法。
JP2002060346A (ja) * 2000-05-19 2002-02-26 Chemo Sero Therapeut Res Inst 新規な虚血・再灌流障害抑制剤
JP2002060301A (ja) * 2000-08-17 2002-02-26 Seikagaku Kogyo Co Ltd 臓器保存液
GB0028414D0 (en) * 2000-11-22 2001-01-03 Univ Leeds Flush preservation solution
WO2002057413A2 (en) * 2001-01-18 2002-07-25 The Board Of Trustees Of The Leland Stanford Junior University Peptides for activation and inhibition of delta pkc
US6664266B2 (en) * 2002-03-14 2003-12-16 Children's Medical Center Corporation Axon regeneration with PKC inhibitiors
JP2005527209A (ja) * 2002-04-22 2005-09-15 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 疼痛管理のためのプロテインキナーゼＣγのペプチドインヒビター
EP2386310B1 (en) * 2002-08-28 2018-11-07 Dyax Corp. Methods for preserving organs and tissues
BRPI0410071A (pt) * 2003-05-08 2006-05-23 Wyeth Corp métodos para usar no diagnóstico e prognóstico da artrite em um paciente, para usar no monitoramento do curso da artrite em um paciente, para avaliar a eficácia de um tratamento para artrite em um paciente, para triar um composto capaz de inibir a artrite em um paciente e para tratar artrite em um paciente, e, molécula de sirna
US7265092B2 (en) * 2004-09-30 2007-09-04 Kai Pharmaceuticals, Inc. Pharmaceutical formulation
DK2056851T3 (da) * 2005-12-09 2013-10-14 Philadelphia College Of Osteopathic Medicine Organkonservering og/eller -perfusion

Also Published As

Publication number Publication date
CN102763637A (zh) 2012-11-07
US20060160062A1 (en) 2006-07-20
WO2006076590A2 (en) 2006-07-20
RU2007131008A (ru) 2009-02-20
EP1845773B1 (en) 2017-01-04
US20080311553A1 (en) 2008-12-18
BRPI0606623B1 (pt) 2018-12-11
AU2006204787B2 (en) 2012-07-05
CN102763638A (zh) 2012-11-07
NZ560615A (en) 2011-03-31
AR055022A1 (es) 2007-08-01
CN101128110A (zh) 2008-02-20
IL184625A0 (en) 2007-12-03
ZA200706337B (en) 2008-12-31
CA2595086A1 (en) 2006-07-20
EP1845773A4 (en) 2011-08-17
RU2397641C2 (ru) 2010-08-27
WO2006076590A3 (en) 2007-01-11
AU2006204787A1 (en) 2006-07-20
IL184625A (en) 2010-12-30
US8084195B2 (en) 2011-12-27
EP1845773A2 (en) 2007-10-24
US9029078B2 (en) 2015-05-12
CA2595086C (en) 2020-01-14
NZ588324A (en) 2012-02-24
US20120141973A1 (en) 2012-06-07
CR9250A (es) 2008-01-10
JP2008526987A (ja) 2008-07-24
MX2007008584A (es) 2008-01-14

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08G Application fees: restoration [chapter 8.7 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 11/12/2018, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 15A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2613 DE 02-02-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.