BRPI0606740A2 - compostos de bis arila e heteroarila substituìdas como antagonistas de 5ht2a seletivos - Google Patents

compostos de bis arila e heteroarila substituìdas como antagonistas de 5ht2a seletivos

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Publication number
BRPI0606740A2
BRPI0606740A2 BRPI0606740-9A BRPI0606740A BRPI0606740A2 BR PI0606740 A2 BRPI0606740 A2 BR PI0606740A2 BR PI0606740 A BRPI0606740 A BR PI0606740A BR PI0606740 A2 BRPI0606740 A2 BR PI0606740A2
Authority
BR
Brazil
Prior art keywords
heteroaryl compounds
selective
compounds substituted
antagonists
bis aryl
Prior art date
Application number
BRPI0606740-9A
Other languages
English (en)
Inventor
David Mark Fink
Helen Katherine Smith
Richard Simon Todd
Hazel Hunt
Paul Robert Eastwood
Original Assignee
Aventis Pharma Inc
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Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of BRPI0606740A2 publication Critical patent/BRPI0606740A2/pt

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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
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    • C07D277/62—Benzothiazoles
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
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  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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Abstract

COMPOSTOS DE BIS ARILA E HETEROARILA SUBSTITUìDAS COMO ANTAGONISTAS DE 5HT2 2A2 SELETIVOS. A presente invenção refere-se a uma série de compostos de bis arila e heteroarila substituidas da fórmula (1): em que X, Y, Z, A, 6, D, Ar, R2 12 e R2 22 são como definidos aqui. Os compostos desta invenção são antagonistas de 5HT2 2A2 seletivos, e são portanto, úteis no tratamento de uma variedade de doenças incluindo porém não limitado a uma ampla variedade de distúrbios do sono como descrito e reivindicado aqui.
BRPI0606740-9A 2005-02-10 2006-02-10 compostos de bis arila e heteroarila substituìdas como antagonistas de 5ht2a seletivos BRPI0606740A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65191105P 2005-02-10 2005-02-10
PCT/US2006/004879 WO2006086705A1 (en) 2005-02-10 2006-02-10 Substituted bis aryl and heteroaryl compounds as selective 5ht2a antagonists

Publications (1)

Publication Number Publication Date
BRPI0606740A2 true BRPI0606740A2 (pt) 2009-07-14

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BRPI0606740-9A BRPI0606740A2 (pt) 2005-02-10 2006-02-10 compostos de bis arila e heteroarila substituìdas como antagonistas de 5ht2a seletivos

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US (1) US7625889B2 (pt)
EP (1) EP1851199B1 (pt)
JP (1) JP5419355B2 (pt)
KR (1) KR20070107037A (pt)
CN (1) CN101115717A (pt)
AR (1) AR052903A1 (pt)
AU (1) AU2006213634A1 (pt)
BR (1) BRPI0606740A2 (pt)
CA (1) CA2598429A1 (pt)
CR (1) CR9260A (pt)
DO (1) DOP2006000032A (pt)
GT (1) GT200600042A (pt)
IL (1) IL185173A0 (pt)
MA (1) MA29289B1 (pt)
MX (1) MX2007008606A (pt)
NO (1) NO20074583L (pt)
PA (1) PA8662501A1 (pt)
PE (1) PE20061088A1 (pt)
RU (1) RU2007133655A (pt)
TN (1) TNSN07272A1 (pt)
TW (1) TW200640859A (pt)
UY (1) UY29372A1 (pt)
WO (1) WO2006086705A1 (pt)

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JP5529876B2 (ja) 2008-10-17 2014-06-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｍｍｐ−１３阻害剤として有用なヘテロアリール置換インドール化合物
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