BRPI0606761A2 - pirróis e imidazóis substituìdos, composições que os contêm, processo de produção e utilização - Google Patents

pirróis e imidazóis substituìdos, composições que os contêm, processo de produção e utilização

Info

Publication number
BRPI0606761A2
BRPI0606761A2 BRPI0606761-1A BRPI0606761A BRPI0606761A2 BR PI0606761 A2 BRPI0606761 A2 BR PI0606761A2 BR PI0606761 A BRPI0606761 A BR PI0606761A BR PI0606761 A2 BRPI0606761 A2 BR PI0606761A2
Authority
BR
Brazil
Prior art keywords
compositions containing
imidazoles
production process
substituted pyrroles
substituted
Prior art date
Application number
BRPI0606761-1A
Other languages
English (en)
Inventor
Baptiste Ronan
Frank Halley
Catherine Souaille
Fabrice Viviani
Youssef El-Ahmad
Eric Bacque
Michel Tabart
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of BRPI0606761A2 publication Critical patent/BRPI0606761A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PIRRóIS E IMIDAZóIS SUBSTITUìDOS, COMPOSIçõES QUE OS CONTêM, PROCESSO DE PRODUçãO E UTILIZAçãO. A presente invenção refere-se a pirróis e imidazóis substituidos, composições que os contêm, processo de produção e utilização. A presente invenção refere-se notadamente ao preparo de pirróis e imidazóis substituidos, às composições que os contêm, ao respectivo processo de preparo, e à respectiva utilização como medicamento, em particular como agentes anticancerosos.
BRPI0606761-1A 2005-02-03 2006-02-01 pirróis e imidazóis substituìdos, composições que os contêm, processo de produção e utilização BRPI0606761A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0501092A FR2881426B1 (fr) 2005-02-03 2005-02-03 Pyrolles et imidazoles substitues, compositions les contenant, procede de frabrication et utilisation
PCT/FR2006/000220 WO2006082309A1 (fr) 2005-02-03 2006-02-01 l-H-PYROLE-2-CARBOXAMIDES ET IMIDAZOLE-5-CARBOXAMIDES ET LEUR UTILISATION EN TANT MODULATEURS DES KINASES FAK, KDR ET TIE2 POUR TRAITER LE CANCER

Publications (1)

Publication Number Publication Date
BRPI0606761A2 true BRPI0606761A2 (pt) 2009-07-14

Family

ID=34954950

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606761-1A BRPI0606761A2 (pt) 2005-02-03 2006-02-01 pirróis e imidazóis substituìdos, composições que os contêm, processo de produção e utilização

Country Status (20)

Country Link
US (1) US7560571B2 (pt)
EP (1) EP1856043B1 (pt)
JP (1) JP2008528661A (pt)
KR (1) KR20070103420A (pt)
CN (1) CN101133023A (pt)
AR (1) AR053540A1 (pt)
AT (1) ATE512133T1 (pt)
AU (1) AU2006210343A1 (pt)
BR (1) BRPI0606761A2 (pt)
CA (1) CA2595987A1 (pt)
EA (1) EA012267B1 (pt)
FR (1) FR2881426B1 (pt)
IL (1) IL184710A0 (pt)
MA (1) MA29264B1 (pt)
MX (1) MX2007009442A (pt)
NO (1) NO20074414L (pt)
TW (1) TW200640857A (pt)
UY (1) UY29361A1 (pt)
WO (1) WO2006082309A1 (pt)
ZA (1) ZA200706338B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2881742B1 (fr) 2005-02-10 2007-09-07 Aventis Pharma Sa Pyrroles substitues, compositions les contenant, procede de fabrication et utilisation
WO2007117692A2 (en) * 2006-04-11 2007-10-18 Vertex Pharmaceuticals Incorporated Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases
EP2307456B1 (en) 2008-06-27 2014-10-15 Amgen Inc. Ang-2 inhibition to treat multiple sclerosis
US8470857B2 (en) * 2008-08-15 2013-06-25 N30 Pharmaceuticals, Inc. Pyrrole inhibitors of S-nitrosoglutathione reductase as therapeutic agents
DK2315590T3 (da) * 2008-08-15 2012-11-19 N30 Pharmaceuticals Inc Pyrrolinhibitorer af S-nitrosoglutathionreduktase
ES2610158T3 (es) * 2008-08-15 2017-04-26 Nivalis Therapeutics, Inc. Nuevos inhibidores pirrólicos de S-nitrosoglutatión reductasa como agentes terapéuticos
CN102775354A (zh) * 2011-05-10 2012-11-14 无锡立诺康医药科技有限公司 一种合成4-芳基-5-羧酸咪唑及其酯的工艺方法
JP6348492B2 (ja) 2012-08-10 2018-06-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ブルトン型チロシンキナーゼ（ｂｔｋ）阻害剤としてのヘテロ芳香族化合物
JP6486954B2 (ja) 2014-01-29 2019-03-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｂｔｋ阻害剤としてのピラゾール化合物
CN108368086B (zh) 2015-12-16 2021-01-08 勃林格殷格翰国际有限公司 可用于治疗自身免疫疾病的二吡唑基衍生物
EP3402789B1 (en) 2016-01-13 2020-03-18 Boehringer Ingelheim International Gmbh Isoquinolones as btk inhibitors
EP3886854A4 (en) 2018-11-30 2022-07-06 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
CN119528787A (zh) * 2023-08-31 2025-02-28 上海柏狮生物科技有限公司 以异腈和Michael受体制备一系列沃诺拉赞中间体的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020173507A1 (en) * 2000-08-15 2002-11-21 Vincent Santora Urea compounds and methods of uses
GB0107901D0 (en) 2001-03-29 2001-05-23 Cyclacel Ltd Anti-cancer compounds
WO2003072541A2 (en) * 2001-09-27 2003-09-04 Smithkline Beecham Corporation Chemical compounds
US20040138269A1 (en) * 2002-10-11 2004-07-15 Sugen, Inc. Substituted pyrroles as kinase inhibitors
EP1633709A1 (en) * 2003-04-30 2006-03-15 Pfizer Products Inc. Anti-diabetic agents
DE10354060A1 (de) * 2003-11-19 2005-06-02 Merck Patent Gmbh Pyrrolderivate
US7183285B2 (en) * 2004-04-29 2007-02-27 Pharmix Corp. Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
FR2881742B1 (fr) 2005-02-10 2007-09-07 Aventis Pharma Sa Pyrroles substitues, compositions les contenant, procede de fabrication et utilisation

Also Published As

Publication number Publication date
JP2008528661A (ja) 2008-07-31
FR2881426A1 (fr) 2006-08-04
EA012267B1 (ru) 2009-08-28
ZA200706338B (en) 2008-11-26
MX2007009442A (es) 2008-03-10
AR053540A1 (es) 2007-05-09
UY29361A1 (es) 2006-08-31
AU2006210343A1 (en) 2006-08-10
TW200640857A (en) 2006-12-01
US7560571B2 (en) 2009-07-14
US20080045542A1 (en) 2008-02-21
KR20070103420A (ko) 2007-10-23
CA2595987A1 (fr) 2006-08-10
ATE512133T1 (de) 2011-06-15
WO2006082309A1 (fr) 2006-08-10
EA200701648A1 (ru) 2008-02-28
CN101133023A (zh) 2008-02-27
EP1856043A1 (fr) 2007-11-21
EP1856043B1 (fr) 2011-06-08
FR2881426B1 (fr) 2007-03-30
NO20074414L (no) 2007-11-05
MA29264B1 (fr) 2008-02-01
IL184710A0 (en) 2007-12-03

Similar Documents

Publication Publication Date Title
BRPI0606504A2 (pt) pirazolo piridinas substituìdas, composições que as contêm, processo de fabricação e utilização
CR9463A (es) Pirrolinas sustituidas, composiciones que las contienen, proceso de fabricacion y utilizacion
BR112012010706A2 (pt) composto, composição farmacêutica, combinação do produto farmacêutico, uso de um composto, e, métodos para o tratamento de uma doença ou condição, e para inibir um bromodomínio
CR11802A (es) Derivados de indazoles sustituidos con fenilo o piridinilo
BR112014007193A2 (pt) derivados de pirazoloquinolinona, preparação dos mesmos e uso terapêutico dos mesmos
UY31080A1 (es) Derivados de pirazol sustituidos con heteroarilo utiles para tratar trastornos hiperproliferativos y enfermedades asociadas con angiogénesis
SV2011003855A (es) Heteroarilos sustituidos
BR112015005940A2 (pt) processo para a preparação de nanopartículas terapêuticas
ECSP099320A (es) Compuestos de tetrahidropirrolopiracina sustituida y su aplicación en medicamentos
BRPI0606761A2 (pt) pirróis e imidazóis substituìdos, composições que os contêm, processo de produção e utilização
CR10247A (es) Dimeros de derivados de artemisinina, su preparacion y su aplicacion en terapeutica
BR112015002464B8 (pt) processo para a preparação de carbamat-benzoxazinona, carbamat-benzoxazinona e uso da carbamat-benzoxazinona
SV2009003429A (es) Derivados de 7-alquinil-1,8-naftiridonas, su preparacion y su aplicacion en terapeutica
BR112012024339A2 (pt) invólucros para tampão desintegráveis e suas aplicações
CO6321288A2 (es) Sales de compuestos inhibidores de vih
NI200900078A (es) Pirazoles sustituidos, composiciones que los contienen, procedimiento de fabricación y utilización.
BRPI0702573A8 (pt) Sílicas precipitadas que têm propriedades de superfície especiais
BRPI0516663A (pt) bengamidas que possuem um ciclocaprolactama substituìdo, processo de preparo, composições que os contém e a utilização
BRPI0908569B8 (pt) estimuladores de secreção de insulina derivados de piridopirazinonas, seu uso, e composição farmacêutica
ECSP088472A (es) Derivados de 9-cloro-15-desoxiprostaglandina, procesos para su preparación y su uso como medicamento
BRPI0516666A (pt) 2-alcóxi-3,4,5-trihidróxi-alquilamidas, o respectivo preparo, composições que as contém e a respectiva utilização
CR9231A (es) Pirroles sustituidos, composiciones que los contienen, procesos de fabricacion y utilizacion
DOP2006000015A (es) Pirazolo piridinas sustituidas, composiciones que las contienen, procedimiento de fabricación
BR112012031471A2 (pt) mistura para tratamento de fertilizantes
BRPI0702817A (pt) compostos de naftaleno, processo para sua preparação e composições farmacêuticas que contêm esses compostos

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012.