BRPI0606504A2 - pirazolo piridinas substituìdas, composições que as contêm, processo de fabricação e utilização - Google Patents

pirazolo piridinas substituìdas, composições que as contêm, processo de fabricação e utilização

Info

Publication number
BRPI0606504A2
BRPI0606504A2 BRPI0606504-0A BRPI0606504A BRPI0606504A2 BR PI0606504 A2 BRPI0606504 A2 BR PI0606504A2 BR PI0606504 A BRPI0606504 A BR PI0606504A BR PI0606504 A2 BRPI0606504 A2 BR PI0606504A2
Authority
BR
Brazil
Prior art keywords
compositions containing
pyridines
substituted pyrazole
manufacturing process
preparation
Prior art date
Application number
BRPI0606504-0A
Other languages
English (en)
Inventor
Baptiste Ronan
Michel Tabart
Frank Halley
Eric Bacque
Catherine Souaille
Antonio Ugolini
Fabrice Viviani
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36593766&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0606504(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR0500555A external-priority patent/FR2880891B1/fr
Priority claimed from FR0507505A external-priority patent/FR2888579A1/fr
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of BRPI0606504A2 publication Critical patent/BRPI0606504A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PIRAZOLO PIRIDINAS SUBSTITUIDAS, COMPOSIçõES QUE AS CONTêM, PROCESSO DE FABRICAçãO E UTILIZAçãO. Pirazolo piridinas substituidas, composições que as contêm, processo de fabricação e utilização. A presente invenção se refere notadamente à preparação de pirazolo piridinas substituidas, às composições que as contêm, a seu processo de preparação, e a sua utilização como medicamento, em especial como agentes anticancerosos.
BRPI0606504-0A 2005-01-19 2006-01-18 pirazolo piridinas substituìdas, composições que as contêm, processo de fabricação e utilização BRPI0606504A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0500555A FR2880891B1 (fr) 2005-01-19 2005-01-19 Pyrazolo pyridines substituees, compositions les contenant, procede de fabrication et utilisation
FR0507505A FR2888579A1 (fr) 2005-07-13 2005-07-13 Pyrazolo pyridines substituees, compositions les contenant, procede de fabrication et utilisation
PCT/FR2006/000114 WO2006077319A1 (fr) 2005-01-19 2006-01-18 Pyrazolo pyridines substituees, compositions les contenant, procede de fabrication et utilisation

Publications (1)

Publication Number Publication Date
BRPI0606504A2 true BRPI0606504A2 (pt) 2009-06-30

Family

ID=36593766

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606504-0A BRPI0606504A2 (pt) 2005-01-19 2006-01-18 pirazolo piridinas substituìdas, composições que as contêm, processo de fabricação e utilização

Country Status (24)

Country Link
US (2) US8008322B2 (pt)
EP (1) EP1845978B1 (pt)
JP (1) JP2008527025A (pt)
KR (1) KR20070098923A (pt)
AR (1) AR052357A1 (pt)
AT (1) ATE477799T1 (pt)
AU (1) AU2006207442A1 (pt)
BR (1) BRPI0606504A2 (pt)
CA (1) CA2595041A1 (pt)
CY (1) CY1110926T1 (pt)
DE (1) DE602006016233D1 (pt)
DK (1) DK1845978T3 (pt)
HR (1) HRP20100624T8 (pt)
IL (1) IL184524A0 (pt)
MX (1) MX2007008790A (pt)
PA (1) PA8660301A1 (pt)
PE (1) PE20061119A1 (pt)
PL (1) PL1845978T3 (pt)
PT (1) PT1845978E (pt)
RU (1) RU2375360C2 (pt)
SI (1) SI1845978T1 (pt)
TW (1) TW200639173A (pt)
UY (1) UY29341A1 (pt)
WO (1) WO2006077319A1 (pt)

Families Citing this family (34)

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FR2871158A1 (fr) 2004-06-04 2005-12-09 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
FR2889526B1 (fr) 2005-08-04 2012-02-17 Aventis Pharma Sa 7-aza-indazoles substitues, compositions les contenant, procede de fabrication et utilisation
TW200815438A (en) * 2006-06-13 2008-04-01 Bayer Schering Pharma Ag Substituted pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
EP1870410A1 (en) * 2006-06-13 2007-12-26 Bayer Schering Pharma Aktiengesellschaft Substituted arylpyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
EP1932845A1 (en) * 2006-12-15 2008-06-18 Bayer Schering Pharma Aktiengesellschaft 3-H-pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
EP2125808A2 (en) * 2006-12-15 2009-12-02 Bayer Schering Pharma Aktiengesellschaft 3-h-pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
EP2042500A1 (en) * 2007-09-21 2009-04-01 Bayer Schering Pharma Aktiengesellschaft N-[4-(1-H-pyrazolo[3,4-c]pyridin-4-yl)phenyl]-N'-[(hetero)aryl]-urea compounds, pharmaceutical compositions comprising them, their preparation and their use as Tie2-kinase inhibitors
GB2467670B (en) * 2007-10-04 2012-08-01 Intellikine Inc Chemical entities and therapeutic uses thereof
TW200924762A (en) * 2007-11-02 2009-06-16 Vertex Pharma Kinase inhibitors
EP2070929A1 (en) 2007-12-11 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Alkynylaryl compounds and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
CA2711614A1 (en) 2008-01-08 2009-07-16 Array Biopharma Inc. Pyrrolopyridines as kinase inhibitors
CA2711741A1 (en) 2008-01-09 2009-07-16 Array Biopharma Inc. Pyrazolopyridines as kinase inhibitors
US8993580B2 (en) * 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
EP2252293B1 (en) * 2008-03-14 2018-06-27 Intellikine, LLC Kinase inhibitors and methods of use
BRPI0915231A2 (pt) 2008-07-08 2018-06-12 Intellikine Inc compostos inibidores de quinase e métodos de uso
US8476431B2 (en) * 2008-11-03 2013-07-02 Itellikine LLC Benzoxazole kinase inhibitors and methods of use
EP2408772B1 (en) * 2009-03-19 2015-07-01 Medical Research Council Technology Compounds
US8846673B2 (en) 2009-08-11 2014-09-30 Bristol-Myers Squibb Company Azaindazoles as kinase inhibitors and use thereof
US8222416B2 (en) * 2009-12-14 2012-07-17 Hoffmann-La Roche Inc. Azaindole glucokinase activators
GB201008134D0 (en) * 2010-05-14 2010-06-30 Medical Res Council Technology Compounds
US8916553B2 (en) 2010-07-26 2014-12-23 Bristol-Myers Squibb Company Sulfonamide compounds useful as CYP17 inhibitors
GB201015949D0 (en) 2010-09-22 2010-11-03 Medical Res Council Technology Compounds
WO2012064815A1 (en) 2010-11-12 2012-05-18 Bristol-Myers Squibb Company Substituted azaindazole compounds
US9295673B2 (en) 2011-02-23 2016-03-29 Intellikine Llc Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof
US20140161720A1 (en) * 2011-05-26 2014-06-12 The General Hospital Corporation Treatment of angiogenic- or vascular-associated diseases
EP2742046A1 (en) * 2011-08-12 2014-06-18 F.Hoffmann-La Roche Ag PYRAZOLO[3,4-c]PYRIDINE COMPOUNDS AND METHODS OF USE
EP2818473A4 (en) * 2012-02-20 2015-04-15 Takeda Pharmaceutical HETEROCYCLIC CONNECTION
RU2660429C2 (ru) * 2012-09-28 2018-07-06 Мерк Шарп И Доум Корп. Новые соединения, которые являются ингибиторами erk
DK2940014T3 (en) * 2012-12-28 2018-12-10 Crystalgenomics Inc 2,3-DIHYDRO-ISOINDOL-1-ON DERIVATIVE AS BTK KINase INHIBITORS AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME
TWI629275B (zh) * 2013-03-13 2018-07-11 賽諾菲公司 Ｎ－（４－（氮雜吲唑－６－基）－苯基）－磺醯胺及其作為醫藥之用途
CN103524421B (zh) * 2013-09-29 2015-04-01 镇江蓝德特药业科技有限公司 新型萘脲类衍生物及其医疗应用
IL277408B2 (en) 2018-04-05 2024-08-01 Merck Patent Gmbh Heteroaryl compounds as IRAK type II inhibitors and their use
UY38349A (es) 2018-08-30 2020-03-31 Array Biopharma Inc Compuestos de pirazolo[3,4-b]piridina como inhibidores de cinasas tam y met
MX2024007885A (es) * 2021-12-22 2024-09-23 Anaxis Pharma Pty Ltd Compuestos de arilsulfonamida.

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DK1320531T3 (da) * 2000-08-10 2011-01-03 Pfizer Italia Srl Bicyclo-pyrazoler, der er aktive som kinase inhibitorer, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger, der indeholder disse
JP4272338B2 (ja) * 2000-09-22 2009-06-03 バイエル アクチェンゲゼルシャフト ピリジン誘導体
FR2827603B1 (fr) * 2001-07-18 2003-10-17 Oreal Composes derives de diaminopyrazole substitues par un radical heteroaromatique et leur utilisation en teinture d'oxydation des fibres keratiniques
GB0128287D0 (en) * 2001-11-26 2002-01-16 Smithkline Beecham Plc Novel method and compounds
JP2006514918A (ja) * 2002-07-23 2006-05-18 スミスクライン ビーチャム コーポレーション キナーゼインヒビターとしてのピラゾロピリミジン
EP1545515A1 (en) * 2002-08-12 2005-06-29 Sugen, Inc. 3-pyrrolyl-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors
US7468376B2 (en) * 2003-02-27 2008-12-23 Palau Pharma, S.A. Pyrazolopyridine derivates
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DK1638941T3 (da) * 2003-05-22 2010-10-11 Abbott Lab Indazol-, benzisoxazol- og benzisothiazolkinaseinhibitorer
EP1648455A4 (en) 2003-07-23 2009-03-04 Exelixis Inc MODULATORS OF ALK PROTEIN (ANAPLASTIC LYMPHOMA KINASE) AND METHODS OF USE
JP2005325099A (ja) * 2004-04-12 2005-11-24 Sankyo Co Ltd チエノピリジン誘導体
WO2005110410A2 (en) * 2004-05-14 2005-11-24 Abbott Laboratories Kinase inhibitors as therapeutic agents
FR2871158A1 (fr) * 2004-06-04 2005-12-09 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
ATE554087T1 (de) * 2004-10-29 2012-05-15 Abbott Lab Neue kinaseinhibitoren
US7563781B2 (en) 2005-01-14 2009-07-21 Janssen Pharmaceutica Nv Triazolopyrimidine derivatives
EP1683796A1 (en) * 2005-01-24 2006-07-26 Schering Aktiengesellschaft Pyrazolopyridines, their preparation and their medical use
MX2007011041A (es) 2005-03-10 2008-02-22 Cgi Pharmaceuticals Inc Ciertas amidas sustituidas, metodo de elaboracion y metodo de uso de las mismas.
FR2889526B1 (fr) 2005-08-04 2012-02-17 Aventis Pharma Sa 7-aza-indazoles substitues, compositions les contenant, procede de fabrication et utilisation
BRPI0619672A2 (pt) 2005-11-09 2011-10-11 Memory Pharm Corp composto, composição farmacêutica, e, uso de um composto
TW200815437A (en) * 2006-06-13 2008-04-01 Bayer Schering Pharma Ag Substituted aminopyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
EP1870410A1 (en) * 2006-06-13 2007-12-26 Bayer Schering Pharma Aktiengesellschaft Substituted arylpyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
TW200815438A (en) * 2006-06-13 2008-04-01 Bayer Schering Pharma Ag Substituted pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same

Also Published As

Publication number Publication date
IL184524A0 (en) 2007-10-31
UY29341A1 (es) 2006-08-31
US8008322B2 (en) 2011-08-30
PA8660301A1 (es) 2006-09-08
JP2008527025A (ja) 2008-07-24
AR052357A1 (es) 2007-03-14
HRP20100624T1 (hr) 2010-12-31
US20080039491A1 (en) 2008-02-14
PL1845978T3 (pl) 2011-02-28
AU2006207442A1 (en) 2006-07-27
EP1845978A1 (fr) 2007-10-24
ATE477799T1 (de) 2010-09-15
US20110190337A1 (en) 2011-08-04
MX2007008790A (es) 2007-09-11
CY1110926T1 (el) 2015-06-10
SI1845978T1 (sl) 2010-12-31
PE20061119A1 (es) 2006-11-27
RU2375360C2 (ru) 2009-12-10
EP1845978B1 (fr) 2010-08-18
HRP20100624T8 (hr) 2011-01-31
TW200639173A (en) 2006-11-16
RU2007131274A (ru) 2009-02-27
CA2595041A1 (fr) 2006-07-27
KR20070098923A (ko) 2007-10-05
DK1845978T3 (da) 2010-12-13
WO2006077319A1 (fr) 2006-07-27
PT1845978E (pt) 2010-11-29
DE602006016233D1 (de) 2010-09-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012.