BRPI0606834A2 - usos de óxido nìtrico (no), dispositivo não implantável configurado, processo para fabricação de dispositivo configurado, uso de polìmero eluente de óxido nìtrico (no) e método de tratamento - Google Patents

usos de óxido nìtrico (no), dispositivo não implantável configurado, processo para fabricação de dispositivo configurado, uso de polìmero eluente de óxido nìtrico (no) e método de tratamento

Info

Publication number
BRPI0606834A2
BRPI0606834A2 BRPI0606834-0A BRPI0606834A BRPI0606834A2 BR PI0606834 A2 BRPI0606834 A2 BR PI0606834A2 BR PI0606834 A BRPI0606834 A BR PI0606834A BR PI0606834 A2 BRPI0606834 A2 BR PI0606834A2
Authority
BR
Brazil
Prior art keywords
nitric oxide
eluting polymer
neuropathy
treatment method
manufacturing process
Prior art date
Application number
BRPI0606834-0A
Other languages
English (en)
Inventor
Tor Peters
Original Assignee
Nolabs Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05002935A external-priority patent/EP1690558A1/en
Priority claimed from EP05018269A external-priority patent/EP1757278A1/en
Application filed by Nolabs Ab filed Critical Nolabs Ab
Publication of BRPI0606834A2 publication Critical patent/BRPI0606834A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/114—Nitric oxide, i.e. NO
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/622—Microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/624—Nanocapsules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Surgery (AREA)
  • Materials Engineering (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

USOS DE óXIDO NìTRICO (NO), DISPOSITIVO NãO IMPLANTáVEL CONFIGURADO, PROCESSO PARA FABRICAçãO DE DISPOSITIVO CONFIGURADO, USO DE POLìMERO ELUENTE DE óXIDO NìTRICO (NO) E MéTODO DE TRATAMENTO. A presente invenção refere-se a um dispositivo que permite o tratamento alvo de neuropatia, tal como neuropatia periférica diabética, ou neuropatia e úlceras resultantes da mencionada neuropatia. O dispositivo compreende um polímero eluente de óxido nítrico (NO) disposto para ficar emcontato com a área de tratamento, de tal forma que uma dose terapêutica de óxido nítrico é eluída do mencionado polímero eluente de óxido nítrico para a mencionada área. O polímero eluente de óxido nítrico (NO) é integrado com umveículo, de tal forma que o veículo, durante o uso, regule e controle a eluição da dosagem terapêutica de óxido nítrico (NO). Além disso, é descrito um método de fabricação correspondente para o dispositivo.
BRPI0606834-0A 2005-02-11 2006-02-13 usos de óxido nìtrico (no), dispositivo não implantável configurado, processo para fabricação de dispositivo configurado, uso de polìmero eluente de óxido nìtrico (no) e método de tratamento BRPI0606834A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05002935A EP1690558A1 (en) 2005-02-11 2005-02-11 Device for treatment of diabetic disorders
US65276005P 2005-02-14 2005-02-14
EP05018269A EP1757278A1 (en) 2005-08-23 2005-08-23 Device, system, and method comprising microencapsulated liquid for release of nitric oxide from a polymer
US71100605P 2005-08-24 2005-08-24
PCT/EP2006/050891 WO2006084912A1 (en) 2005-02-11 2006-02-13 Device method, and use for treatment of neuropathy involving nitric oxide

Publications (1)

Publication Number Publication Date
BRPI0606834A2 true BRPI0606834A2 (pt) 2009-07-21

Family

ID=39188888

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606834-0A BRPI0606834A2 (pt) 2005-02-11 2006-02-13 usos de óxido nìtrico (no), dispositivo não implantável configurado, processo para fabricação de dispositivo configurado, uso de polìmero eluente de óxido nìtrico (no) e método de tratamento

Country Status (12)

Country Link
US (1) US8241650B2 (pt)
EP (2) EP2119459A1 (pt)
JP (2) JP5175107B2 (pt)
KR (1) KR20070105331A (pt)
BR (1) BRPI0606834A2 (pt)
CA (1) CA2594407C (pt)
DE (1) DE602006007808D1 (pt)
DK (1) DK1846058T3 (pt)
ES (1) ES2329930T3 (pt)
MX (1) MX2007009690A (pt)
PL (1) PL1846058T3 (pt)
WO (1) WO2006084912A1 (pt)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007523900A (ja) 2004-02-09 2007-08-23 ノクシライザー，インコーポレイテッド 一酸化窒素放出分子
BRPI0606834A2 (pt) * 2005-02-11 2009-07-21 Nolabs Ab usos de óxido nìtrico (no), dispositivo não implantável configurado, processo para fabricação de dispositivo configurado, uso de polìmero eluente de óxido nìtrico (no) e método de tratamento
ES2326387T3 (es) 2005-03-24 2009-10-08 Nolabs Ab Tratamiento cosmetico con oxido nitrico, dispositivo para llevar a cabo dicho tratamiento y procedimiento de fabricacion del mismo.
WO2006128121A2 (en) 2005-05-27 2006-11-30 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US8642093B2 (en) 2007-10-30 2014-02-04 The Invention Science Fund I, Llc Methods and systems for use of photolyzable nitric oxide donors
US8221690B2 (en) 2007-10-30 2012-07-17 The Invention Science Fund I, Llc Systems and devices that utilize photolyzable nitric oxide donors
US8980332B2 (en) 2007-10-30 2015-03-17 The Invention Science Fund I, Llc Methods and systems for use of photolyzable nitric oxide donors
US8877508B2 (en) 2007-10-30 2014-11-04 The Invention Science Fund I, Llc Devices and systems that deliver nitric oxide
US10080823B2 (en) 2007-10-30 2018-09-25 Gearbox Llc Substrates for nitric oxide releasing devices
US7846400B2 (en) 2007-10-30 2010-12-07 The Invention Science Fund I, Llc Substrates for nitric oxide releasing devices
US20100069887A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Multiple chamber ex vivo adjustable-release final dosage form
US20100069821A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex vivo modifiable medicament release-sites final dosage form
US20100068278A1 (en) 2008-09-16 2010-03-18 Searete Llc, A Limited Liablity Corporation Of The State Of Delaware Ex vivo modifiable medicament release-associations
GB0821345D0 (en) 2008-11-21 2008-12-31 P Q Silicas Uk Ltd Composition and dressing with nitric oxide
US9919072B2 (en) 2009-08-21 2018-03-20 Novan, Inc. Wound dressings, methods of using the same and methods of forming the same
ES2958410T3 (es) 2009-08-21 2024-02-08 Novan Inc Geles tópicos
ES2633618T3 (es) 2009-10-14 2017-09-22 Theravasc Inc. Formulaciones farmacéuticas de nitrito y sus usos
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
WO2012118829A2 (en) 2011-02-28 2012-09-07 Novan, Inc. Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same
US20150132345A1 (en) 2011-05-09 2015-05-14 Yossef Av-Gay Nitric oxide-sequestering topical formulations
WO2013006608A1 (en) 2011-07-05 2013-01-10 Novan, Inc. Topical compositions
WO2013006613A1 (en) 2011-07-05 2013-01-10 Novan, Inc. Methods of manufacturing topical compositions and apparatus for same
US11077194B2 (en) 2012-03-14 2021-08-03 Novan, Inc. Nitric oxide releasing pharmaceutical compositions
US10583037B2 (en) 2013-01-23 2020-03-10 Transqtronics, Llc. Heating device using exothermic chemical reaction
US9675817B2 (en) 2013-01-23 2017-06-13 Jonathan Isserow Heating device using exothermic chemical reaction
US10010445B2 (en) 2013-01-23 2018-07-03 Jonathan Isserow Treatment device using nanotechnology
US9636521B2 (en) 2013-07-12 2017-05-02 Jonathan Isserow Heat and light treatment device using nanotechnology
US9855211B2 (en) 2013-02-28 2018-01-02 Novan, Inc. Topical compositions and methods of using the same
KR101743124B1 (ko) 2013-03-07 2017-06-02 주식회사 아이센스 일산화질소를 저장, 전달 할 수 있는 나노섬유의 제조방법 및 이에 의하여 제조된 일산화질소를 저장, 전달 할 수 있는 나노섬유
US11813284B2 (en) 2013-08-08 2023-11-14 Novan, Inc. Topical compositions and methods of using the same
WO2016022170A1 (en) 2014-08-08 2016-02-11 Novan, Inc. Topical emulsions
KR101555523B1 (ko) 2014-02-28 2015-09-25 부산대학교 산학협력단 산화질소 방출성 상처치료 필름 및 이의 제조방법
USD747085S1 (en) 2014-06-06 2016-01-12 Sharone Piontkowski Insole
USD746568S1 (en) 2014-06-06 2016-01-05 Sharone Piontkowski Insole pads
US10322082B2 (en) 2014-07-11 2019-06-18 Novan, Inc. Topical antiviral compositions and methods of using the same
KR102495101B1 (ko) 2014-07-11 2023-02-02 노반, 인크. 국소 항바이러스 조성물 및 그의 사용 방법
WO2016010988A1 (en) 2014-07-14 2016-01-21 Novan, Inc. Nitric oxide releasing nail coating compositions, nitric oxide releasing nail coatings, and methods of using the same
RU2714313C2 (ru) * 2014-08-14 2020-02-14 Ром Энд Хаас Компани Полимер с высвобождаемым газом
WO2017019614A1 (en) 2015-07-28 2017-02-02 Novan, Inc. Combinations and methods for the treatment and/or prevention of fungal infections
USD810301S1 (en) 2016-02-14 2018-02-13 Laina Gossman Pair of midfoot insoles
JP7090549B2 (ja) 2016-03-02 2022-06-24 ノヴァン，インコーポレイテッド 炎症のための治療用組成物およびその治療方法
WO2017180822A1 (en) 2016-04-13 2017-10-19 Novan, Inc. Compositions, systems, kits, and methods for treating an infection
KR101888763B1 (ko) * 2016-05-13 2018-09-20 광운대학교 산학협력단 일산화질소 저장 및 전달을 위한 나노섬유
WO2018136845A1 (en) * 2017-01-21 2018-07-26 Biocrede Inc. Medical products and methods configured for controlled release of nitrous oxide
WO2018236803A1 (en) 2017-06-19 2018-12-27 Novan, Inc. Topical compositions and methods of using the same
KR102557290B1 (ko) * 2017-11-16 2023-07-20 기초과학연구원 일산화질소 방출성 고분자, 이를 포함하는 일산화질소 방출성 나노 구조체, 및 이를 이용한 일산화질소 전달 방법
CN112165935A (zh) 2018-03-01 2021-01-01 诺万公司 一氧化氮释放性栓剂及其使用方法
CN119345461A (zh) * 2024-09-20 2025-01-24 上海市第六人民医院 一种负载dnsp-11多肽peg微球的聚己内酯神经支架及其制备方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3754368A (en) * 1969-11-04 1973-08-28 Moore Perk Corp Sterile packaging method
US4182827A (en) * 1978-08-31 1980-01-08 Union Carbide Corporation Polyurethane hydrogels having enhanced wetting rates
US5814666A (en) 1992-04-13 1998-09-29 The United States As Represented By The Department Of Health And Human Services Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents
US5691423A (en) 1992-08-24 1997-11-25 The United States Of America As Represented By The Department Of Health And Human Services Polysaccharide-bound nitric oxide-nucleophile adducts
US5405919A (en) 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
US5632981A (en) * 1992-08-24 1997-05-27 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5650447A (en) * 1992-08-24 1997-07-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitric oxide-releasing polymers to treat restenosis and related disorders
US5466465A (en) * 1993-12-30 1995-11-14 Harrogate Holdings, Limited Transdermal drug delivery system
US6709681B2 (en) 1995-02-17 2004-03-23 Aberdeen University Acidified nitrite as an antimicrobial agent
US5519020A (en) 1994-10-28 1996-05-21 The University Of Akron Polymeric wound healing accelerators
US5714511A (en) * 1995-07-31 1998-02-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs
US5770645A (en) 1996-08-02 1998-06-23 Duke University Medical Center Polymers for delivering nitric oxide in vivo
US5958427A (en) 1996-11-08 1999-09-28 Salzman; Andrew L. Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications
SE512663C2 (sv) * 1997-10-23 2000-04-17 Biogram Ab Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
US6818018B1 (en) * 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US20040043068A1 (en) 1998-09-29 2004-03-04 Eugene Tedeschi Uses for medical devices having a lubricious, nitric oxide-releasing coating
WO2000022207A2 (en) 1998-10-01 2000-04-20 The University Of Akron Process and apparatus for the production of nanofibers
AU3703900A (en) 1999-02-24 2000-09-14 Nitromed, Inc. Nitrosated and nitrosylated steroids for the treatment of cardiovascular diseases and disorders
GB2354441A (en) 1999-08-06 2001-03-28 Mccormack Ltd Composition for treating dentine hypersensitivity
US6737447B1 (en) 1999-10-08 2004-05-18 The University Of Akron Nitric oxide-modified linear poly(ethylenimine) fibers and uses thereof
US6627301B2 (en) 2000-03-28 2003-09-30 Showa Denko Kabushiki Kaisha Magnetic recording medium
WO2001085013A2 (en) 2000-05-09 2001-11-15 Nitromed, Inc. Infrared thermography and methods of use
HUP0002628A2 (en) * 2000-07-14 2002-06-29 Keri Pharma Kft Pharmaceutical combinations for treating diabetes
US6780849B2 (en) * 2000-12-21 2004-08-24 Scimed Life Systems, Inc. Lipid-based nitric oxide donors
US20040009238A1 (en) * 2002-07-09 2004-01-15 Chris Miller Exogenenous nitric oxide gas (gNO) therapy in wound healing
US6706274B2 (en) 2001-01-18 2004-03-16 Scimed Life Systems, Inc. Differential delivery of nitric oxide
DE10119680A1 (de) * 2001-04-20 2002-11-14 Boehringer Ingelheim Pharma Verwendung von Radikalfänger-Verbindungen zur Behandlung und Verhinderung von no-abhängigen Störungen der Mikrozirkulation
US6520425B1 (en) 2001-08-21 2003-02-18 The University Of Akron Process and apparatus for the production of nanofibers
US6703046B2 (en) 2001-10-04 2004-03-09 Medtronic Ave Inc. Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use
AU2003205058A1 (en) * 2002-01-08 2003-07-24 Bernard Techologies, Inc. Antimicrobial body covering articles
US6695992B2 (en) 2002-01-22 2004-02-24 The University Of Akron Process and apparatus for the production of nanofibers
AU2003209850B2 (en) 2002-03-20 2009-09-03 The University Of Queensland Methods and compositions comprising nitric oxide donors and opioid analgesics
US20030203915A1 (en) 2002-04-05 2003-10-30 Xinqin Fang Nitric oxide donors, compositions and methods of use related applications
WO2003092763A1 (en) 2002-05-03 2003-11-13 Duke University Carbon nanotubules for storage of nitric oxide
US7211590B2 (en) 2002-08-01 2007-05-01 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
WO2004012874A1 (en) 2002-08-02 2004-02-12 The Government Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services Cross-linked nitric oxide-releasing polyamine coated substrates, compositions comprising same and method of making same
US7972137B2 (en) 2003-06-30 2011-07-05 Rosen Gerald M Anti-microbial dental formulations for the prevention and treatment of oral mucosal disease
NZ545001A (en) 2003-07-03 2009-09-25 Univ St Andrews Zeolites for delivery of nitric oxide
EP1677849A1 (en) 2003-10-14 2006-07-12 Cube Medical A/S A balloon for use in angioplasty
GB0326047D0 (en) 2003-11-07 2003-12-10 Univ Sheffield Substance
BRPI0606834A2 (pt) * 2005-02-11 2009-07-21 Nolabs Ab usos de óxido nìtrico (no), dispositivo não implantável configurado, processo para fabricação de dispositivo configurado, uso de polìmero eluente de óxido nìtrico (no) e método de tratamento

Also Published As

Publication number Publication date
DE602006007808D1 (de) 2009-08-27
PL1846058T3 (pl) 2009-12-31
CA2594407A1 (en) 2006-08-17
US8241650B2 (en) 2012-08-14
EP1846058A1 (en) 2007-10-24
US20080069848A1 (en) 2008-03-20
CA2594407C (en) 2014-06-10
EP1846058B1 (en) 2009-07-15
WO2006084912A1 (en) 2006-08-17
WO2006084912A8 (en) 2007-09-07
DK1846058T3 (da) 2009-11-23
JP5175107B2 (ja) 2013-04-03
KR20070105331A (ko) 2007-10-30
JP2013047241A (ja) 2013-03-07
EP2119459A1 (en) 2009-11-18
ES2329930T3 (es) 2009-12-02
MX2007009690A (es) 2007-10-15
JP2008530055A (ja) 2008-08-07

Similar Documents

Publication Publication Date Title
BRPI0606834A2 (pt) usos de óxido nìtrico (no), dispositivo não implantável configurado, processo para fabricação de dispositivo configurado, uso de polìmero eluente de óxido nìtrico (no) e método de tratamento
BRPI0606829A2 (pt) dispositivo configurado, processo para fabricação de dispositivo configurado, usos de polìmero eluente de óxido nìtrico(no), método de tratamento e uso de óxido nìtrico(no)
DK1871433T3 (da) Kosmetisk behandling med nitrogenoxid, anordning til udförelse af denne behandling samt fremstillingsproces dertil
BR112015027282A8 (pt) formulação líquida e kit compreendendo fenfluramina, e usos da mesma no tratamento de síndrome de dravet
CU20070203A7 (es) Composición farmacéutica que comprende una difenilurea sustituida con omega-carboxiarilo para el tratamiento del cáncer
BR112012006891A2 (pt) formulação de hydrogel compreendendo uma solução aquosa com potencial oxidativo redutivo
BRPI0617412B8 (pt) anticorpo antiglipicano-3, agente anticâncer compreendendo o mesmo, bem como seu uso e seu processo de produção
BRPI0607809A2 (pt) uso de uma composição compreendendo nanopartìculas, composição e kit
UY32177A (es) Tratamiento de diabetes en pacientes con control glucémico insuficiente a pesar de la terapia con fármaco, oral o no, antidiabético
BR112015022820A8 (pt) ensaio para selecionar um regime de tratamento para um indivíduo com depressão, uso de um composto compreendendo folato, composição e kit
BR112012031163A2 (pt) métodos de terapia combinada para tratamento de doenças proliferativas
UY30158A1 (es) Uso de derivados de benzo-heteroaril sulfamida para el tratamiento del dolor
NO20071426L (no) Kreft kombinasjonsbehandling omfattende AZD2171 og Imatinib
AR080891A1 (es) Proteina de fusion robo 1-fc y su utilizacion en el tratamiento de tumores
PL1913947T3 (pl) Terapia skojarzona do leczenia raka
WO2006100156A3 (en) Intravascular, interstitial or intraorgan medical access device, and manufacturing method thereof, involving nitric oxide
IL191797A0 (en) Combination of azd2171 and pemetrexed
BR112013010325A2 (pt) composições para o tratamento de úlceras periféricas de várias origens
JP2012516315A5 (pt)
BR112012027463A2 (pt) método terapêutico, composição farmacêutica, uso de tri-iodotironina (t3) ou de análogo bioquímico da mesma, tri-iodotironina (t3) ou um análogo bioquímico da mesma, e, kit
CO2022013055A2 (es) Tafoxiparina para el tratamiento de la preeclampsia
BR112014005966A2 (pt) composições para o tratamento de úlceras periféricas de várias origens
BRPI0520258A2 (pt) uso de uma composição farmacêutica, método para preparar uma composição farmacêutica, e, uso de uma quantidade eficaz de acetato de eslicarbazepina
BRPI0407742A (pt) uso de glicocorticóides para preparação de formulação utilizáveis no tratamento de angiogênese ocular patológica, bem como formulção assim obtida
DE602004016754D1 (de) Kombinationstherapie gegen krebserkrankungen mit azd2171 und zd1839

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012.