BRPI0606871A2 - "processos e compostos para a preparação de derivados de naftilindol substituìdos - Google Patents

"processos e compostos para a preparação de derivados de naftilindol substituìdos

Info

Publication number: BRPI0606871A2
Authority: BR; Brazil
Prior art keywords: processes; preparation; substituted; compounds; derivatives
Prior art date: 2005-01-27

Application number

BRPI0606871-5A

Other languages

English (en)

Portuguese (pt)

Inventor

Vladimir A Dragan

John Richard Potoski

Wayne G Mcmahon

Xinxu Shi

Jean Louise Helom

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-01-27

Filing date

2006-01-25

Publication date

2009-07-21

2006-01-25 Application filed by Wyeth Corp filed Critical Wyeth Corp

2009-07-21 Publication of BRPI0606871A2 publication Critical patent/BRPI0606871A2/pt

Links

238000000034 method Methods 0.000 title abstract 4
238000002360 preparation method Methods 0.000 title abstract 3
XEQHAEZWPZICKJ-UHFFFAOYSA-N 2-naphthalen-1-yl-1h-indole Chemical class C1=CC=C2C(C3=CC4=CC=CC=C4N3)=CC=CC2=C1 XEQHAEZWPZICKJ-UHFFFAOYSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title abstract 2
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
102000012335 Plasminogen Activator Inhibitor 1 Human genes 0.000 abstract 2
108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 abstract 2
XZGLNCKSNVGDNX-UHFFFAOYSA-N 5-methyl-2h-tetrazole Chemical class CC=1N=NNN=1 XZGLNCKSNVGDNX-UHFFFAOYSA-N 0.000 abstract 1
LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 abstract 1
238000006036 Oppenauer oxidation reaction Methods 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
230000008878 coupling Effects 0.000 abstract 1
238000010168 coupling process Methods 0.000 abstract 1
238000005859 coupling reaction Methods 0.000 abstract 1
238000005661 deetherification reaction Methods 0.000 abstract 1
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
150000004780 naphthols Chemical class 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BRPI0606871-5A 2005-01-27 2006-01-25 "processos e compostos para a preparação de derivados de naftilindol substituìdos BRPI0606871A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US64761805P	2005-01-27	2005-01-27
PCT/US2006/002996 WO2006081455A1 (en)	2005-01-27	2006-01-25	Processes and compounds for the preparation of substituted naphthylindole derivatives

Publications (1)

Publication Number	Publication Date
BRPI0606871A2 true BRPI0606871A2 (pt)	2009-07-21

Family

ID=36570379

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0606871-5A BRPI0606871A2 (pt)	2005-01-27	2006-01-25	"processos e compostos para a preparação de derivados de naftilindol substituìdos

Country Status (21)

Country	Link
US (2)	US7323483B2 (no)
EP (1)	EP1856104A1 (no)
JP (1)	JP2008528618A (no)
KR (1)	KR20070103744A (no)
CN (1)	CN101111491A (no)
AR (1)	AR053437A1 (no)
AU (1)	AU2006208021A1 (no)
BR (1)	BRPI0606871A2 (no)
CA (1)	CA2595376A1 (no)
CR (1)	CR9215A (no)
GT (1)	GT200600032A (no)
HN (1)	HN2006003347A (no)
IL (1)	IL183712A0 (no)
MX (1)	MX2007008952A (no)
NI (1)	NI200700188A (no)
NO (1)	NO20072879L (no)
PE (1)	PE20061200A1 (no)
RU (1)	RU2007121255A (no)
TW (1)	TW200637850A (no)
WO (1)	WO2006081455A1 (no)
ZA (1)	ZA200706203B (no)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007092207A1 (en) *	2006-02-03	2007-08-16	Wyeth	Compositions for the delivery of substituted naphthyl indole derivatives and methods of their use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE903206A1 (en)	1989-09-07	1991-03-13	Abbott Lab	Indole-, benzofuran-, and benzothiophene-containing¹lipoxygenase-inhibiting compounds
US5151435A (en) *	1991-04-08	1992-09-29	Merck & Co., Inc.	Angiotensin ii antagonists incorporating an indole or dihydroindole
IL101785A0 (en)	1991-05-10	1992-12-30	Fujisawa Pharmaceutical Co	Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL109568A0 (en)	1993-05-19	1994-08-26	Fujisawa Pharmaceutical Co	Urea derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
US6756388B1 (en)	1993-10-12	2004-06-29	Pfizer Inc.	Benzothiophenes and related compounds as estrogen agonists
CA2134192A1 (en)	1993-11-12	1995-05-13	Michael L. Denney	5, 6-bicyclic glycoprotein iib/iiia antagonists
US5552412A (en)	1995-01-09	1996-09-03	Pfizer Inc	5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
IL120724A0 (en)	1995-09-01	1997-08-14	Lilly Co Eli	Indolyl neuropeptide Y receptor antagonists
JP2000516958A (ja)	1996-08-26	2000-12-19	ジェネティックス・インスチチュート・インコーポレーテッド	ホスホリパーゼ酵素の阻害剤
US6703527B2 (en) *	2001-05-24	2004-03-09	Nikken Chemicals Co., Ltd.	Method for oxidation of allyl alcohol
TWI224101B (en) *	2001-06-20	2004-11-21	Wyeth Corp	Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
TW591020B (en)	2001-06-20	2004-06-11	Wyeth Corp	6-(aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)

2006
- 2006-01-25 CN CNA2006800033140A patent/CN101111491A/zh active Pending
- 2006-01-25 KR KR1020077017498A patent/KR20070103744A/ko not_active Withdrawn
- 2006-01-25 CA CA002595376A patent/CA2595376A1/en not_active Abandoned
- 2006-01-25 RU RU2007121255/04A patent/RU2007121255A/ru not_active Application Discontinuation
- 2006-01-25 EP EP06719721A patent/EP1856104A1/en not_active Withdrawn
- 2006-01-25 MX MX2007008952A patent/MX2007008952A/es active IP Right Grant
- 2006-01-25 JP JP2007553280A patent/JP2008528618A/ja not_active Withdrawn
- 2006-01-25 AU AU2006208021A patent/AU2006208021A1/en not_active Abandoned
- 2006-01-25 WO PCT/US2006/002996 patent/WO2006081455A1/en not_active Ceased
- 2006-01-25 BR BRPI0606871-5A patent/BRPI0606871A2/pt not_active IP Right Cessation
- 2006-01-25 US US11/339,802 patent/US7323483B2/en not_active Expired - Fee Related
- 2006-01-26 TW TW095102979A patent/TW200637850A/zh unknown
- 2006-01-26 GT GT200600032A patent/GT200600032A/es unknown
- 2006-01-26 AR ARP060100283A patent/AR053437A1/es unknown
- 2006-01-26 PE PE2006000111A patent/PE20061200A1/es not_active Application Discontinuation
- 2006-01-30 HN HN2006003347A patent/HN2006003347A/es unknown
2007
- 2007-06-06 IL IL183712A patent/IL183712A0/en unknown
- 2007-06-06 NO NO20072879A patent/NO20072879L/no not_active Application Discontinuation
- 2007-06-28 CR CR9215A patent/CR9215A/es not_active Application Discontinuation
- 2007-07-26 ZA ZA200706203A patent/ZA200706203B/xx unknown
- 2007-07-27 NI NI200700188A patent/NI200700188A/es unknown
- 2007-11-28 US US11/946,109 patent/US20080071091A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AR053437A1 (es)	2007-05-09
NI200700188A (es)	2008-05-09
RU2007121255A (ru)	2009-03-10
TW200637850A (en)	2006-11-01
US20080071091A1 (en)	2008-03-20
KR20070103744A (ko)	2007-10-24
MX2007008952A (es)	2007-09-18
GT200600032A (es)	2006-11-14
CR9215A (es)	2007-11-23
CA2595376A1 (en)	2006-08-03
WO2006081455A1 (en)	2006-08-03
IL183712A0 (en)	2007-09-20
AU2006208021A1 (en)	2006-08-03
HN2006003347A (es)	2011-03-30
CN101111491A (zh)	2008-01-23
EP1856104A1 (en)	2007-11-21
NO20072879L (no)	2007-06-26
PE20061200A1 (es)	2006-12-19
JP2008528618A (ja)	2008-07-31
US7323483B2 (en)	2008-01-29
US20060183917A1 (en)	2006-08-17
ZA200706203B (en)	2009-12-30

Legal Events

Date	Code	Title	Description
2012-06-05	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 3A E 6A ANUIDADE(S).
2012-06-26	B08J	Incorrect entry in the gazette republished [chapter 8.10 patent gazette]	Free format text: REFERENTE A DESPACHO 8.6 NA RPI 2161 DE 05/06/2012. TEXTO CORRETO: REFERENTE A 6A ANUIDADE.
2013-09-03	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: REFERENTE AO NAO CUMPRIMENTO DESPACHO 8.6 NA RPI 2161 DE 05/06/2012, E DO DESPACHO 8.10 NA RPI 2164 DE 26/06/2012

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