BRPI0606872A2 - uso de pirimidilaminobenzamidas para o tratamento de doenças que respondem à modulação de atividade de tie-2 quinase - Google Patents

uso de pirimidilaminobenzamidas para o tratamento de doenças que respondem à modulação de atividade de tie-2 quinase

Info

Publication number
BRPI0606872A2
BRPI0606872A2 BRPI0606872-3A BRPI0606872A BRPI0606872A2 BR PI0606872 A2 BRPI0606872 A2 BR PI0606872A2 BR PI0606872 A BRPI0606872 A BR PI0606872A BR PI0606872 A2 BRPI0606872 A2 BR PI0606872A2
Authority
BR
Brazil
Prior art keywords
respond
modulation
diseases
tie
treatment
Prior art date
Application number
BRPI0606872-3A
Other languages
English (en)
Inventor
Paul W Manley
Juergen Mestan
Georg Martiny-Baron
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0606872A2 publication Critical patent/BRPI0606872A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)

Abstract

USO DE PIRIMIDILAMINOBENZAMIDAS PARA O TRATAMENTO DE DOENçAS QUE RESPONDEM à MODULAçãO DE ATIVIDADE DE TIE-2 QUINASE. A presente invenção refere-se ao uso de compostos de pirimidilaminobenzamida para a preparação de um fármaco para tratamento de doenças que respondem à modulação de quinase, especialmente atividade de Tie-2 quinase, especialmente para tratamento curativo e/ou profilático de leucemia, síndromes mielodisplásticas ou hipertensão pulmonar, e a um método para tratamento de doenças que respondem à modulação de atividade de quinase, especialmente atividade de Tie-2 quinase.
BRPI0606872-3A 2005-01-28 2006-01-26 uso de pirimidilaminobenzamidas para o tratamento de doenças que respondem à modulação de atividade de tie-2 quinase BRPI0606872A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64789505P 2005-01-28 2005-01-28
US66240405P 2005-03-16 2005-03-16
PCT/EP2006/000686 WO2006079539A2 (en) 2005-01-28 2006-01-26 Use of pyrimidylaminobenzamides for the treatment of diseases that respond to modulation of tie-2 kinase activity

Publications (1)

Publication Number Publication Date
BRPI0606872A2 true BRPI0606872A2 (pt) 2009-07-21

Family

ID=36273382

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606872-3A BRPI0606872A2 (pt) 2005-01-28 2006-01-26 uso de pirimidilaminobenzamidas para o tratamento de doenças que respondem à modulação de atividade de tie-2 quinase

Country Status (17)

Country Link
US (1) US20080114001A1 (pt)
EP (1) EP1843771B1 (pt)
JP (2) JP5373288B2 (pt)
KR (2) KR20130100371A (pt)
CN (1) CN101203224B (pt)
AT (1) ATE525073T1 (pt)
AU (1) AU2006208638B2 (pt)
BR (1) BRPI0606872A2 (pt)
CA (1) CA2594687C (pt)
CY (1) CY1112568T1 (pt)
DK (1) DK1843771T3 (pt)
ES (1) ES2373912T3 (pt)
MX (1) MX2007009135A (pt)
PL (1) PL1843771T3 (pt)
PT (1) PT1843771E (pt)
RU (1) RU2404776C2 (pt)
WO (1) WO2006079539A2 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2391199T3 (es) * 2005-12-06 2012-11-22 Novartis Ag Derivados de pirimidilaminobenzamida para el tratamiento de neurofibromatosis
JP2009537606A (ja) * 2006-05-25 2009-10-29 ノバルティス アクチエンゲゼルシャフト チロシンキナーゼ阻害剤
EP1923053A1 (en) * 2006-09-27 2008-05-21 Novartis AG Pharmaceutical compositions comprising nilotinib or its salt
EP2152079A4 (en) 2007-06-04 2011-03-09 Avila Therapeutics Inc HETEROCYCLIC COMPOUNDS AND USES THEREOF
RU2011109078A (ru) * 2008-08-13 2012-09-20 Новартис АГ (CH) Лечение легочной артериальной гипертензии
US9207782B2 (en) 2010-12-16 2015-12-08 Lg Electronics Inc. Remote controller, remote controlling method and display system having the same
AU2020259450A1 (en) * 2019-04-18 2021-11-18 EyePoint Pharmaceuticals, Inc. Methods of treating hypertension with activators of Tie-2

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0672041T3 (da) * 1993-10-01 2002-02-25 Novartis Ag Farmakologisk aktive pyridinderivater og fremgangsmåder til fremstilling deraf
MY129541A (en) * 1996-06-25 2007-04-30 Novartis Ag Substituded 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators
HK1046402A1 (zh) * 1999-06-03 2003-01-10 Basf Aktiengesellschaft Benzothiazinone和benzoxazinone化合物
US20030199525A1 (en) * 2002-03-21 2003-10-23 Hirst Gavin C. Kinase inhibitors
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
GB0222514D0 (en) * 2002-09-27 2002-11-06 Novartis Ag Organic compounds
JP4942297B2 (ja) * 2002-10-25 2012-05-30 ジ アドミニストレイターズ オブ ザ チューレン エデュケイショナル ファンド 肺高血圧症の処置を目的としたｎ−｛５−［４−（４−メチルピペラジノメチル）−ベンゾイルアミド］−２−メチルフェニル｝−４−（３−ピリジル）−２−ピリジン−アミンの使用
US8178570B2 (en) * 2003-04-09 2012-05-15 Exelixis, Inc. Tie-2 modulators and methods of use
CN1826324B (zh) * 2003-05-22 2011-12-07 雅培制药有限公司 吲唑、苯并异*唑和苯并异噻唑激酶抑制剂
WO2004108672A1 (en) * 2003-06-02 2004-12-16 Abbott Laboratories Isoindolin-1-one compounds as kinase inhibitors
AR045037A1 (es) * 2003-07-10 2005-10-12 Aventis Pharma Sa Tetrahidro-1h-pirazolo [3,4-c] piridinas sustituidas, composiciones que las contienen y su utilizacion.
GB0325031D0 (en) * 2003-10-27 2003-12-03 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
RU2404776C2 (ru) 2010-11-27
WO2006079539A3 (en) 2007-11-29
RU2007132255A (ru) 2009-03-10
KR101325424B1 (ko) 2013-11-04
PL1843771T3 (pl) 2012-02-29
WO2006079539A2 (en) 2006-08-03
CY1112568T1 (el) 2016-02-10
KR20130100371A (ko) 2013-09-10
KR20070104567A (ko) 2007-10-26
ATE525073T1 (de) 2011-10-15
PT1843771E (pt) 2011-12-02
CN101203224B (zh) 2010-11-03
ES2373912T3 (es) 2012-02-10
CA2594687A1 (en) 2006-08-03
AU2006208638B2 (en) 2010-03-04
US20080114001A1 (en) 2008-05-15
CN101203224A (zh) 2008-06-18
JP2008528531A (ja) 2008-07-31
AU2006208638A1 (en) 2006-08-03
EP1843771A2 (en) 2007-10-17
CA2594687C (en) 2013-10-29
JP2013213042A (ja) 2013-10-17
DK1843771T3 (da) 2012-01-16
JP5373288B2 (ja) 2013-12-18
EP1843771B1 (en) 2011-09-21
MX2007009135A (es) 2007-09-06

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.