BRPI0607026A2 - processos para redução do teor de proteìna e preservação do teror de polissacarìdeo capsular em caldo de lisato de streptococcus pneumonial celular complexo antes da purificação - Google Patents
processos para redução do teor de proteìna e preservação do teror de polissacarìdeo capsular em caldo de lisato de streptococcus pneumonial celular complexo antes da purificaçãoInfo
- Publication number
- BRPI0607026A2 BRPI0607026A2 BRPI0607026-4A BRPI0607026A BRPI0607026A2 BR PI0607026 A2 BRPI0607026 A2 BR PI0607026A2 BR PI0607026 A BRPI0607026 A BR PI0607026A BR PI0607026 A2 BRPI0607026 A2 BR PI0607026A2
- Authority
- BR
- Brazil
- Prior art keywords
- purification
- protein content
- preserving
- complex cellular
- reducing protein
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/06—Lysis of microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Sustainable Development (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
PROCESSOS PARA REDUçãO DO TEOR DE PROTEìNA E PRESERVAçãO DO TEROR DE POLISSACARìDEO CAPSULAR EM CALDO DE LISATO DE STREPTOCOCCUS PNEUMONIAL CELULAR COMPLEXO ANTES DA PURIFICAçãO. A presente invenção refere-se a um processo para redução do teor de proteína e preservação do teor de polissacarídeo capsular em um caldo de lisato de Streptococcus pneumoniae celular complexo antes de purificação. Utilização de redução de pH após lise celular resultou em um polissacarídeo purificado que vai de encontro consistentemente à especificação para proteína e maiores rendimentos de recuperação do polissacarídeo durante o processo de purificação.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66954605P | 2005-04-08 | 2005-04-08 | |
| US60/669,546 | 2005-04-08 | ||
| PCT/US2006/012134 WO2006110352A2 (en) | 2005-04-08 | 2006-03-31 | Separation of contaminants from streptococcus pneumoniae polysaccharide by ph manipulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0607026A2 true BRPI0607026A2 (pt) | 2009-07-28 |
| BRPI0607026B1 BRPI0607026B1 (pt) | 2022-02-15 |
Family
ID=36660782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0607026-4A BRPI0607026B1 (pt) | 2005-04-08 | 2006-03-31 | Processos para redução do teor de proteína e preservação do teor de polissacarídeo capsular em um caldo de lisado celular de streptococcus pneumoniae complexo antes da purificação |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7718791B2 (pt) |
| EP (2) | EP1866342B1 (pt) |
| JP (1) | JP5049264B2 (pt) |
| KR (1) | KR101317256B1 (pt) |
| CN (1) | CN101155833B (pt) |
| AR (1) | AR053843A1 (pt) |
| AU (1) | AU2006234984B2 (pt) |
| BR (1) | BRPI0607026B1 (pt) |
| CA (1) | CA2604362C (pt) |
| DK (2) | DK1866342T3 (pt) |
| ES (2) | ES2808126T3 (pt) |
| HU (1) | HUE050049T2 (pt) |
| IL (1) | IL186366A (pt) |
| MX (1) | MX2007012337A (pt) |
| NZ (1) | NZ562719A (pt) |
| PL (2) | PL1866342T3 (pt) |
| PT (2) | PT1866342T (pt) |
| SI (2) | SI1866342T1 (pt) |
| TR (1) | TR201820018T4 (pt) |
| WO (1) | WO2006110352A2 (pt) |
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| HUE059085T2 (hu) | 2007-03-23 | 2022-10-28 | Wyeth Llc | Streptococcus pneumoniae tokpoliszacharidok elõállítására szolgáló rövidített tisztítási eljárás |
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| AU2009335824B2 (en) * | 2008-12-18 | 2013-07-04 | Wyeth Llc | Method for controlling Streptococcus pneumoniae polysaccharide molecular weight using carbon |
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Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1115210A (en) | 1977-11-28 | 1981-12-29 | Dennis J. Carlo | Pneumococcal vaccine |
| US4242501A (en) * | 1979-08-08 | 1980-12-30 | American Cyanamid Company | Purification of pneumococcal capsular polysaccharides |
| FR2495939B1 (fr) | 1980-12-11 | 1985-10-11 | Merieux Inst | Procede de purification de polyosides de streptococcus pneumoniae et vaccin a base de polyosides ainsi purifies |
| BE889979A (fr) * | 1981-08-14 | 1982-02-15 | Smith Kline Rit | Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation |
| US5714354A (en) * | 1995-06-06 | 1998-02-03 | American Home Products Corporation | Alcohol-free pneumococcal polysaccharide purification process |
| CN1318103A (zh) * | 1998-07-27 | 2001-10-17 | 微生物技术有限公司 | 肺炎链球菌的核酸和蛋白质 |
| CN101586143A (zh) * | 2000-03-16 | 2009-11-25 | 费城儿童医院 | 调节肺炎球菌荚膜多糖的生产 |
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