BRPI0607191A2 - derivados de triazol - Google Patents

derivados de triazol

Info

Publication number
BRPI0607191A2
BRPI0607191A2 BRPI0607191-0A BRPI0607191A BRPI0607191A2 BR PI0607191 A2 BRPI0607191 A2 BR PI0607191A2 BR PI0607191 A BRPI0607191 A BR PI0607191A BR PI0607191 A2 BRPI0607191 A2 BR PI0607191A2
Authority
BR
Brazil
Prior art keywords
triazole derivatives
hsp10
hsp
medicament
inhibitors
Prior art date
Application number
BRPI0607191-0A
Other languages
English (en)
Inventor
Hans-Michael Eggenweiler
Michael Wolf
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BRPI0607191A2 publication Critical patent/BRPI0607191A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
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    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • A61P35/00—Antineoplastic agents
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
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Abstract

DERIVADOS DE TRIAZOL. A presente invenção refere-se a derivados de triazol da fórmula em que R^ 1^ - R^ 6^ e Y têm os significados indicados na Reivindicação 1, são inibidores de HSP9O e podem ser usados para a preparação de um medicamento para o tratamento de doenças nas quais a inibição, regulação e/ou modulação de HSP9O desempenha um papel.
BRPI0607191-0A 2005-02-17 2006-01-25 derivados de triazol BRPI0607191A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005007304A DE102005007304A1 (de) 2005-02-17 2005-02-17 Triazolderivate
PCT/EP2006/000631 WO2006087077A2 (de) 2005-02-17 2006-01-25 Hsp90 hemmende triazolderivate

Publications (1)

Publication Number Publication Date
BRPI0607191A2 true BRPI0607191A2 (pt) 2009-08-11

Family

ID=36636568

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607191-0A BRPI0607191A2 (pt) 2005-02-17 2006-01-25 derivados de triazol

Country Status (15)

Country Link
US (1) US8618285B2 (pt)
EP (1) EP1853570B1 (pt)
JP (1) JP5133068B2 (pt)
KR (1) KR101273043B1 (pt)
CN (1) CN101119978B (pt)
AR (1) AR052482A1 (pt)
AU (1) AU2006215902B2 (pt)
BR (1) BRPI0607191A2 (pt)
CA (1) CA2598017C (pt)
DE (1) DE102005007304A1 (pt)
ES (1) ES2394513T3 (pt)
MX (1) MX2007009777A (pt)
RU (1) RU2416605C2 (pt)
WO (1) WO2006087077A2 (pt)
ZA (1) ZA200707911B (pt)

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EP1857446B1 (en) * 2005-03-09 2013-05-01 Nippon Kayaku Kabushiki Kaisha Derivatives of 3-(2,4-dihydroxyphenyl)-1,2,4-triazole useful in the treatment of cancer
EP1922068A4 (en) * 2005-08-16 2010-08-11 Icagen Inc INHIBITORS OF VOLTAGE-CONTROLLED SODIUM CHANNELS
JP5118039B2 (ja) * 2005-08-18 2013-01-16 シンタ ファーマシューティカルズ コーポレーション Ｈｓｐ９０活性を調節するトリアゾール化合物
DE102006023336A1 (de) * 2006-05-18 2007-11-22 Merck Patent Gmbh 1,5-Diphenyl-pyrazole II
DE102006023337A1 (de) * 2006-05-18 2007-11-22 Merck Patent Gmbh Triazolderivate II
EP2034996A2 (en) * 2006-05-25 2009-03-18 Synta Pharmaceuticals Corporation Triazole compounds that modulate hsp90 activity
AU2007267859B2 (en) 2006-05-25 2012-04-12 Synta Pharmaceuticals Corp. Triazole compounds that modulate Hsp90 activity
US8034834B2 (en) 2006-05-25 2011-10-11 Synta Pharmaceuticals Corp. Method for treating proliferative disorders with HSP90 inhibitors
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FR2907453B1 (fr) 2006-10-24 2008-12-26 Sanofi Aventis Sa Nouveaux derives du fluorene,compositions les contenant et utilisation
WO2008057246A2 (en) * 2006-10-26 2008-05-15 Synta Pharmaceuticals Corp. Method for treating inflammatory disorders
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DE102007002715A1 (de) * 2007-01-18 2008-07-24 Merck Patent Gmbh Triazolderivat
WO2008112199A1 (en) * 2007-03-12 2008-09-18 Synta Pharmaceuticals Corp. Method for inhibiting topoisomerase ii
US8648104B2 (en) 2007-05-25 2014-02-11 Synta Pharmaceuticals Corp. Method for treating proliferative disorders associated with mutations in c-Met
KR20100057030A (ko) 2007-08-13 2010-05-28 신타 파마슈티칼스 코프. Ｈｓｐ90의 활성을 조절하는 트라이아졸 화합물
CN101821247A (zh) 2007-10-12 2010-09-01 艾科尔公司 作为hsp90抑制剂的抗癌用5-(2-羟基苯基)四唑化合物
KR100947696B1 (ko) 2007-11-23 2010-03-16 재단법인서울대학교산학협력재단 1,2,4-트리아졸 유도체를 함유하는 Ｈｓｐ９０ 억제제 및이를 이용한 항암제
WO2010017545A2 (en) * 2008-08-08 2010-02-11 Synta Pharamceuticals Corp. Triazole compounds that modulate hsp90 activity
CN101684103B (zh) * 2008-09-22 2011-04-06 天津药物研究院 1,2,4-三唑结构的化合物、其制备方法和用途
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
WO2011133520A1 (en) 2010-04-19 2011-10-27 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
JP2014532712A (ja) 2011-11-02 2014-12-08 シンタ ファーマシューティカルズ コーポレーション トポイソメラーゼｉ阻害剤とｈｓｐ９０阻害剤の組合せを使用する癌療法
WO2013067165A1 (en) 2011-11-02 2013-05-10 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with platinum-containing agents
WO2013074594A1 (en) 2011-11-14 2013-05-23 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with braf inhibitors
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KR101711732B1 (ko) * 2014-04-30 2017-03-02 경북대학교 산학협력단 3-아릴-1,2,4-트라이아졸 유도체 및 이의 용도
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WO2006087077A3 (de) 2006-11-02
CN101119978B (zh) 2012-05-23
RU2416605C2 (ru) 2011-04-20
ZA200707911B (en) 2008-10-29
CN101119978A (zh) 2008-02-06
RU2007134401A (ru) 2009-03-27
CA2598017A1 (en) 2006-08-24
AU2006215902A1 (en) 2006-08-24
CA2598017C (en) 2014-12-02
EP1853570B1 (de) 2012-10-24
HK1114839A1 (en) 2008-11-14
AU2006215902B2 (en) 2011-12-08
US20080182857A1 (en) 2008-07-31
US8618285B2 (en) 2013-12-31
ES2394513T3 (es) 2013-02-01
JP5133068B2 (ja) 2013-01-30
DE102005007304A1 (de) 2006-08-24
WO2006087077A2 (de) 2006-08-24
KR20070106720A (ko) 2007-11-05
MX2007009777A (es) 2007-08-21
JP2008530149A (ja) 2008-08-07
KR101273043B1 (ko) 2013-06-10
EP1853570A2 (de) 2007-11-14

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