BRPI0514295A - 1, 5-difenilpirazóis - Google Patents

1, 5-difenilpirazóis

Info

Publication number
BRPI0514295A
BRPI0514295A BRPI0514295-4A BRPI0514295A BRPI0514295A BR PI0514295 A BRPI0514295 A BR PI0514295A BR PI0514295 A BRPI0514295 A BR PI0514295A BR PI0514295 A BRPI0514295 A BR PI0514295A
Authority
BR
Brazil
Prior art keywords
diphenylpyrazoles
hsp90
diphenylpyrosols
medicament
diseases
Prior art date
Application number
BRPI0514295-4A
Other languages
English (en)
Inventor
Hans-Michael Eggenweiler
Michael Wolf
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BRPI0514295A publication Critical patent/BRPI0514295A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

1,5-DIFENILPIRAZóIS. A presente invenção refere-se a novos derivados de 1,5-difenilpirazol da fórmula (I) em que - R¬ ¹¬ - R¬ 6¬ têm os significados indicados na reivindicação 1, são inibidores de HSP90 e podem ser empregados para a preparação de um medicamento apara o tratamento de doenças em que a inibição, regulação e/ou modulação de HSP90 desempenham um papel.
BRPI0514295-4A 2004-08-13 2005-07-14 1, 5-difenilpirazóis BRPI0514295A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004039280A DE102004039280A1 (de) 2004-08-13 2004-08-13 1,5-Diphenyl-pyrazole
PCT/EP2005/007657 WO2006018082A1 (de) 2004-08-13 2005-07-14 1,5-diphenyl-pyrazole

Publications (1)

Publication Number Publication Date
BRPI0514295A true BRPI0514295A (pt) 2008-06-10

Family

ID=35262026

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514295-4A BRPI0514295A (pt) 2004-08-13 2005-07-14 1, 5-difenilpirazóis

Country Status (15)

Country Link
US (1) US7932401B2 (pt)
EP (1) EP1776346B1 (pt)
JP (1) JP4879895B2 (pt)
KR (1) KR20070040811A (pt)
CN (1) CN101006061A (pt)
AR (1) AR050454A1 (pt)
AU (1) AU2005274540B2 (pt)
BR (1) BRPI0514295A (pt)
CA (1) CA2576531C (pt)
DE (1) DE102004039280A1 (pt)
ES (1) ES2426189T3 (pt)
MX (1) MX2007001692A (pt)
RU (1) RU2007108859A (pt)
WO (1) WO2006018082A1 (pt)
ZA (1) ZA200702098B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS52642B (sr) 2004-11-18 2013-06-28 Synta Pharmaceuticals Corp. Jedinjenja triazola koja modulišu aktivnost hsp90
US20090215742A1 (en) * 2005-05-03 2009-08-27 Pfizer, Inc. Amide resorcinol compounds
DE102006023336A1 (de) * 2006-05-18 2007-11-22 Merck Patent Gmbh 1,5-Diphenyl-pyrazole II
DE102006023337A1 (de) * 2006-05-18 2007-11-22 Merck Patent Gmbh Triazolderivate II
FR2907453B1 (fr) 2006-10-24 2008-12-26 Sanofi Aventis Sa Nouveaux derives du fluorene,compositions les contenant et utilisation
CN101821247A (zh) 2007-10-12 2010-09-01 艾科尔公司 作为hsp90抑制剂的抗癌用5-(2-羟基苯基)四唑化合物
LT5623B (lt) * 2008-04-30 2010-01-25 Biotechnologijos Institutas, , 5-aril-4-(5-pakeistieji 2,4-dihidroksifenil)-1,2,3-tiadiazolai kaip hsp90 šaperono slopikliai ir tarpiniai junginiai jiems gauti
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
WO2011133520A1 (en) 2010-04-19 2011-10-27 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
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US20080085904A1 (en) 2008-04-10
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EP1776346A1 (de) 2007-04-25
JP4879895B2 (ja) 2012-02-22
CA2576531A1 (en) 2006-02-23
AU2005274540A1 (en) 2006-02-23
US7932401B2 (en) 2011-04-26
DE102004039280A1 (de) 2006-02-23
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