BRPI0607558A2 - derivados do ácido aminobutanóico, inibidor da carnitina palmitoil transferase(cpt) - Google Patents

derivados do ácido aminobutanóico, inibidor da carnitina palmitoil transferase(cpt)

Info

Publication number
BRPI0607558A2
BRPI0607558A2 BRPI0607558-4A BRPI0607558A BRPI0607558A2 BR PI0607558 A2 BRPI0607558 A2 BR PI0607558A2 BR PI0607558 A BRPI0607558 A BR PI0607558A BR PI0607558 A2 BRPI0607558 A2 BR PI0607558A2
Authority
BR
Brazil
Prior art keywords
cpt
inhibitor
acid derivatives
aminobutanoic acid
carnitine palmitoyl
Prior art date
Application number
BRPI0607558-4A
Other languages
English (en)
Inventor
Fabio Giannessi
Emanuela Tassoni
Maria Ornella Tinti
Roberto Conti
Natalina Dell Uomo
Tiziana Brunetti
Original Assignee
Sigma Tau Ind Famaceutiche Riu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Famaceutiche Riu filed Critical Sigma Tau Ind Famaceutiche Riu
Publication of BRPI0607558A2 publication Critical patent/BRPI0607558A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

DERIVADOS DO áCIDO AMINOBUTANóICO, INIBIDOR DA CARNITINA PALMITOIL TRANSFERASE (CPT). A presente invenção refere-se a uma nova classe de compostos com ação inibidora de carnitina palmitoil transferase (CPT), compostos farmacêuticos que contêm pelo menos um novo composto de acordo com a invenção e seu uso terapêutico no tratamento das condições hipergíicêmicas, tais como diabetes e patologias associadas a mesma, insuficiência cardíaca congestiva e obesidade.
BRPI0607558-4A 2005-03-02 2006-02-13 derivados do ácido aminobutanóico, inibidor da carnitina palmitoil transferase(cpt) BRPI0607558A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000090A ITRM20050090A1 (it) 2005-03-02 2005-03-02 Derivati dell'acido ammino-butanoico inibitore della cpt.
PCT/EP2006/001290 WO2006092204A1 (en) 2005-03-02 2006-02-13 Derivatives of aminobutanoic acid inhibiting cpt

Publications (1)

Publication Number Publication Date
BRPI0607558A2 true BRPI0607558A2 (pt) 2009-09-15

Family

ID=36090946

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607558-4A BRPI0607558A2 (pt) 2005-03-02 2006-02-13 derivados do ácido aminobutanóico, inibidor da carnitina palmitoil transferase(cpt)

Country Status (15)

Country Link
US (1) US20080161395A1 (pt)
EP (1) EP1853556A1 (pt)
JP (1) JP2008531613A (pt)
KR (1) KR20070114197A (pt)
CN (1) CN101133019A (pt)
AR (1) AR052677A1 (pt)
AU (1) AU2006220097B2 (pt)
BR (1) BRPI0607558A2 (pt)
CA (1) CA2599165A1 (pt)
EA (1) EA200701868A1 (pt)
IT (1) ITRM20050090A1 (pt)
MX (1) MX2007009007A (pt)
SG (1) SG159569A1 (pt)
TW (1) TW200640842A (pt)
WO (1) WO2006092204A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX363224B (es) * 2006-10-03 2019-03-15 Alnylam Pharmaceuticals Inc Formulaciones que contienen lipidos.
US8410150B2 (en) 2007-03-09 2013-04-02 University Health Network Inhibitors of carnitine palmitoyltransferase and treating cancer
CA2694724C (en) 2007-08-01 2017-09-12 University Health Network Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer
RU2502727C2 (ru) * 2008-04-29 2013-12-27 Ф.Хоффманн-Ля Рош Аг 4-триметиламмониобутираты в качестве ингибиторов срт2
MX2010008196A (es) * 2008-04-29 2010-08-11 Hoffmann La Roche Derivados de acido 4-dimetilaminobutirico.
JP7795519B2 (ja) * 2020-07-17 2026-01-07 サノフィ・パスツール 式－ｎｈ－ｃｘ－ａまたは－ｎｈ－ｃｘ－ｎｈ－ａの少なくとも１つの末端ラジカルを含む脂質化合物、それらを含有する組成物およびそれらの使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1299266B1 (it) * 1998-05-15 2000-02-29 Sigma Tau Ind Farmaceuti Inibitori reversibili della carnitina palmitoil trasferasi
US6822115B2 (en) * 1999-06-30 2004-11-23 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
US8410150B2 (en) 2007-03-09 2013-04-02 University Health Network Inhibitors of carnitine palmitoyltransferase and treating cancer

Also Published As

Publication number Publication date
AR052677A1 (es) 2007-03-28
MX2007009007A (es) 2007-09-14
SG159569A1 (en) 2010-03-30
CA2599165A1 (en) 2006-09-08
KR20070114197A (ko) 2007-11-29
JP2008531613A (ja) 2008-08-14
AU2006220097A1 (en) 2006-09-08
EP1853556A1 (en) 2007-11-14
TW200640842A (en) 2006-12-01
ITRM20050090A1 (it) 2006-09-03
EA200701868A1 (ru) 2008-02-28
CN101133019A (zh) 2008-02-27
US20080161395A1 (en) 2008-07-03
WO2006092204A1 (en) 2006-09-08
AU2006220097B2 (en) 2011-07-07

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUI DADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2211 DE 21/05/2013.