TW200640842A - Derivatives of aminobutanoic acid inhibiting CPT - Google Patents

Derivatives of aminobutanoic acid inhibiting CPT

Info

Publication number
TW200640842A
TW200640842A TW095105107A TW95105107A TW200640842A TW 200640842 A TW200640842 A TW 200640842A TW 095105107 A TW095105107 A TW 095105107A TW 95105107 A TW95105107 A TW 95105107A TW 200640842 A TW200640842 A TW 200640842A
Authority
TW
Taiwan
Prior art keywords
derivatives
aminobutanoic acid
cpt
acid inhibiting
inhibiting cpt
Prior art date
Application number
TW095105107A
Other languages
English (en)
Inventor
Fabio Giannessi
Emanuela Tassoni
Maria Ornella Tinti
Roberto Conti
Uomo Natalina Dell
Tiziana Brunetti
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of TW200640842A publication Critical patent/TW200640842A/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/16Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/17Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • C07D213/82Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
TW095105107A 2005-03-02 2006-02-15 Derivatives of aminobutanoic acid inhibiting CPT TW200640842A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000090A ITRM20050090A1 (it) 2005-03-02 2005-03-02 Derivati dell'acido ammino-butanoico inibitore della cpt.

Publications (1)

Publication Number Publication Date
TW200640842A true TW200640842A (en) 2006-12-01

Family

ID=36090946

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095105107A TW200640842A (en) 2005-03-02 2006-02-15 Derivatives of aminobutanoic acid inhibiting CPT

Country Status (15)

Country Link
US (1) US20080161395A1 (zh)
EP (1) EP1853556A1 (zh)
JP (1) JP2008531613A (zh)
KR (1) KR20070114197A (zh)
CN (1) CN101133019A (zh)
AR (1) AR052677A1 (zh)
AU (1) AU2006220097B2 (zh)
BR (1) BRPI0607558A2 (zh)
CA (1) CA2599165A1 (zh)
EA (1) EA200701868A1 (zh)
IT (1) ITRM20050090A1 (zh)
MX (1) MX2007009007A (zh)
SG (1) SG159569A1 (zh)
TW (1) TW200640842A (zh)
WO (1) WO2006092204A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3192788A1 (en) 2006-10-03 2017-07-19 Arbutus Biopharma Corporation Lipid containing formulations
CA2680366C (en) * 2007-03-09 2016-06-21 University Health Network Inhibitors of carnitine palmitoyltransferase and treating cancer
WO2009015485A1 (en) 2007-08-01 2009-02-05 University Health Network Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer
CA2722087C (en) * 2008-04-29 2013-07-09 F. Hoffmann-La Roche Ag 4-dimethylaminobutyric acid derivatives
WO2009132979A1 (en) 2008-04-29 2009-11-05 F. Hoffmann-La Roche Ag 4-trimethylammonio-butyrates as cpt2 inhibitors
KR20230041744A (ko) * 2020-07-17 2023-03-24 사노피 파스퇴르 화학식 -nh-cx-a 또는 -nh-cx-nh-a의 적어도 하나의 말단 라디칼을 포함하는 지질 화합물, 이를 포함하는 조성물 및 이의 용도

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1299266B1 (it) * 1998-05-15 2000-02-29 Sigma Tau Ind Farmaceuti Inibitori reversibili della carnitina palmitoil trasferasi
US6822115B2 (en) * 1999-06-30 2004-11-23 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
CA2680366C (en) 2007-03-09 2016-06-21 University Health Network Inhibitors of carnitine palmitoyltransferase and treating cancer

Also Published As

Publication number Publication date
ITRM20050090A1 (it) 2006-09-03
CA2599165A1 (en) 2006-09-08
EA200701868A1 (ru) 2008-02-28
SG159569A1 (en) 2010-03-30
AU2006220097B2 (en) 2011-07-07
AU2006220097A1 (en) 2006-09-08
CN101133019A (zh) 2008-02-27
MX2007009007A (es) 2007-09-14
EP1853556A1 (en) 2007-11-14
WO2006092204A1 (en) 2006-09-08
BRPI0607558A2 (pt) 2009-09-15
JP2008531613A (ja) 2008-08-14
AR052677A1 (es) 2007-03-28
US20080161395A1 (en) 2008-07-03
KR20070114197A (ko) 2007-11-29

Similar Documents

Publication Publication Date Title
PH12018500767A1 (en) Pharmaceutical composition, methods for treating and uses thereof
MX2009012285A (es) Inhibidores de diacilglicerol aciltransferasa.
IN2012DN01233A (zh)
GEP20115241B (en) Indole compound
IL187005A0 (en) Diacylglycerol acyltransferase inhibitors
WO2007104789A3 (en) Amylin derivatives
MY149648A (en) Carboxylalkylene-phenyl)-phenyl-oxalamides, method for the production thereof, and use of same as a medicament
PH12013500472A1 (en) Piperidinyl-substituted lactams as gpr119 modulators
MX2010002419A (es) (ciclopropilfenil) feniloxamidas, metodo para su produccion y uso como un medicamento.
IL202269A0 (en) Therapeutic treatment for metabolic syndrome, type 2 diabetes, obesity, or prediabetes
MX2009009416A (es) Derivados de bencimidazol y sus metodos de uso.
EA200900023A1 (ru) Применение замещенных 2-аминотетралинов для изготовления лекарственного средства для предупреждения, облегчения и/или лечения разных видов боли
DE602007004324D1 (en) 11-beta-hydroxysteroid-dehydrogenase-1-hemmer
IL185808A0 (en) Amide-substituted 8-n-benzimidazoles, metohd for the production thereof, and use of the same as medicaments
TN2011000172A1 (en) Therapeutic antiviral peptides
BR112012021771A2 (pt) métodos de uso de inibidores de contransportadores de sódio-glicose 1 e 2.
HK1207860A1 (zh) 用於治疗糖尿病及其相关病症的2-苯基-5-杂环基-四氢-2h-吡喃-3-胺化合物
IL193252A0 (en) N-hydroxyacrylamide compounds
WO2009124962A3 (en) Sulfonamides
BR112012013918A2 (pt) inibidores de diacil glicerol acil transferase
MX2010001866A (es) Derivados de azoloarina, metodo para su produccion, productos farmaceuticos que contienen estos compuestos y su uso.
MX2010009837A (es) Tiazolil-dihidro-indazoles.
TW200640842A (en) Derivatives of aminobutanoic acid inhibiting CPT
TN2011000531A1 (en) 5- alkynyl - pyridines
MY160300A (en) Acylbenzene derivative