BRPI0607839A2 - compostos 1,1,1-triflúor-3-[(benzil)-(pirimidin-2-il)-amino]-propan- 2-ol substituìdos - Google Patents
compostos 1,1,1-triflúor-3-[(benzil)-(pirimidin-2-il)-amino]-propan- 2-ol substituìdosInfo
- Publication number
- BRPI0607839A2 BRPI0607839A2 BRPI0607839-7A BRPI0607839A BRPI0607839A2 BR PI0607839 A2 BRPI0607839 A2 BR PI0607839A2 BR PI0607839 A BRPI0607839 A BR PI0607839A BR PI0607839 A2 BRPI0607839 A2 BR PI0607839A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- propan
- benzyl
- amino
- pyrimidin
- Prior art date
Links
- GYLFNCHERDPPFL-UHFFFAOYSA-N 3-[benzyl(pyrimidin-2-yl)amino]-1,1,1-trifluoropropan-2-ol Chemical class N=1C=CC=NC=1N(CC(O)C(F)(F)F)CC1=CC=CC=C1 GYLFNCHERDPPFL-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000008214 LDL Cholesterol Methods 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 150000002632 lipids Chemical class 0.000 abstract 2
- 150000003626 triacylglycerols Chemical class 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 108010023302 HDL Cholesterol Proteins 0.000 abstract 1
- 108010010234 HDL Lipoproteins Proteins 0.000 abstract 1
- 102000015779 HDL Lipoproteins Human genes 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
COMPOSTOS 1,1,1-TRIFLúOR-3-[(BENZIL)-(PIRIMIDINI2-IL)-AMINO]-PROPAN- 2-OL SUBSTITUìDOS. Compostos 1,1,1-triflúor-3-[(benzil)-(pirimidin-2-il)amino]-propan-2-ol substituídos, composições farmacêuticas contendo tais compostos e uso de tais compostos para elevar determinados níveis de lipídeos no plasma, incluindo colesterol-lípoproteina de alta densidade e para abaixar determinados outros níveis de lípideo no plasma, tais como colesterol LDL e triglícerideos e conseqUentemente para tratar doenças que são exacerbadas por níveis baixos de colesterol HDL e/ou níveis altos de colesterol LDL e tríglícerídeos, tais como, aterosclerose e doenças cardiovasculares em alguns mamíferos, incluindo seres humanos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65574005P | 2005-02-23 | 2005-02-23 | |
| PCT/IB2006/000374 WO2006090250A1 (en) | 2005-02-23 | 2006-02-13 | Substituted 1,1,1-trifluoro-3-[(benzyl)-(pyrimidin-2-yl)-amino]-prop an-2-ol compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0607839A2 true BRPI0607839A2 (pt) | 2009-06-13 |
Family
ID=36215578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0607839-7A BRPI0607839A2 (pt) | 2005-02-23 | 2006-02-13 | compostos 1,1,1-triflúor-3-[(benzil)-(pirimidin-2-il)-amino]-propan- 2-ol substituìdos |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20100130784A1 (pt) |
| EP (1) | EP1856060A1 (pt) |
| JP (1) | JP2008545617A (pt) |
| KR (1) | KR20070096041A (pt) |
| CN (1) | CN101128438A (pt) |
| AU (1) | AU2006217630A1 (pt) |
| BR (1) | BRPI0607839A2 (pt) |
| CA (1) | CA2598869A1 (pt) |
| IL (1) | IL184677A0 (pt) |
| MX (1) | MX2007010243A (pt) |
| RU (1) | RU2007131537A (pt) |
| WO (1) | WO2006090250A1 (pt) |
| ZA (1) | ZA200705972B (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| US7790770B2 (en) * | 2005-11-23 | 2010-09-07 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| ATE547394T1 (de) | 2006-12-01 | 2012-03-15 | Bristol Myers Squibb Co | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen |
| JP4834699B2 (ja) * | 2007-07-30 | 2011-12-14 | 田辺三菱製薬株式会社 | 医薬組成物 |
| US20120179035A1 (en) * | 2011-01-07 | 2012-07-12 | General Electric Company | Medical device with motion sensing |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3924124B2 (ja) * | 1998-09-25 | 2007-06-06 | ファルマシア・コーポレーション | コレステロールエステル輸送タンパク質活性阻害に有効な置換された多環アリールおよびヘテロアリール第三級ヘテロアルキルアミン |
-
2006
- 2006-02-13 MX MX2007010243A patent/MX2007010243A/es unknown
- 2006-02-13 KR KR1020077019171A patent/KR20070096041A/ko not_active Abandoned
- 2006-02-13 CN CNA2006800058580A patent/CN101128438A/zh active Pending
- 2006-02-13 AU AU2006217630A patent/AU2006217630A1/en not_active Abandoned
- 2006-02-13 JP JP2007556678A patent/JP2008545617A/ja active Pending
- 2006-02-13 WO PCT/IB2006/000374 patent/WO2006090250A1/en not_active Ceased
- 2006-02-13 BR BRPI0607839-7A patent/BRPI0607839A2/pt not_active IP Right Cessation
- 2006-02-13 RU RU2007131537/04A patent/RU2007131537A/ru not_active Application Discontinuation
- 2006-02-13 US US11/720,765 patent/US20100130784A1/en not_active Abandoned
- 2006-02-13 EP EP06710438A patent/EP1856060A1/en not_active Withdrawn
- 2006-02-13 CA CA002598869A patent/CA2598869A1/en not_active Abandoned
-
2007
- 2007-07-17 IL IL184677A patent/IL184677A0/en unknown
- 2007-07-19 ZA ZA200705972A patent/ZA200705972B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008545617A (ja) | 2008-12-18 |
| CA2598869A1 (en) | 2006-08-31 |
| ZA200705972B (en) | 2009-02-25 |
| AU2006217630A1 (en) | 2006-08-31 |
| CN101128438A (zh) | 2008-02-20 |
| EP1856060A1 (en) | 2007-11-21 |
| WO2006090250A1 (en) | 2006-08-31 |
| IL184677A0 (en) | 2007-12-03 |
| RU2007131537A (ru) | 2009-03-27 |
| KR20070096041A (ko) | 2007-10-01 |
| MX2007010243A (es) | 2007-09-07 |
| US20100130784A1 (en) | 2010-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 4A, 5A E 6A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012. |