BRPI0512624A - compostos heteroarila e fenilsulfamoìla substituìdos - Google Patents

compostos heteroarila e fenilsulfamoìla substituìdos

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Publication number
BRPI0512624A
BRPI0512624A BRPI0512624-0A BRPI0512624A BRPI0512624A BR PI0512624 A BRPI0512624 A BR PI0512624A BR PI0512624 A BRPI0512624 A BR PI0512624A BR PI0512624 A BRPI0512624 A BR PI0512624A
Authority
BR
Brazil
Prior art keywords
compounds
phenylsulfamoyl
hdl cholesterol
levels
substituted heteroaryl
Prior art date
Application number
BRPI0512624-0A
Other languages
English (en)
Inventor
Ernest Seiichi Hamanaka
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BRPI0512624A publication Critical patent/BRPI0512624A/pt

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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/27—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
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    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
    • C07C323/49—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to sulfur atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

COMPOSTOS HETEROARILA E FENILSULFAMOìLA SUBSTITUìDOS A presente invenção diz respeito a compostos heteroarila e fenilsulfamoíla substituídos, composições farmacêuticas contendo tais compostos e o uso de tais compostos como agonistas do receptor ativado por proliterador de peroxissomo (PPAR) . Ativadores PPAR alfa, composições farmacêuticas contendo tais compostos e o uso de tais compostos para elevar certos níveis de lipídio de plasma, incluindo colesterol lipoproteína de alta densidade, e reduzir certos outros níveis de lipídio de plasma, tais como colesterol HDL e triglicerídeos e, de forma correspondente, tratar doenças que são exacerbadas por baixos níveis de colesterol HDL e/ou altos níveis de colesterol HDL e triglicerídeos, tais como aterosclerose e doenças cardiovasculares, em mamíferos, incluindo humanos. Os compostos são também usados para o tratamento de balanço de energia negativa (NEB) e doenças associadas em ruminantes.
BRPI0512624-0A 2004-06-29 2005-06-17 compostos heteroarila e fenilsulfamoìla substituìdos BRPI0512624A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58372104P 2004-06-29 2004-06-29
PCT/IB2005/002007 WO2006003495A1 (en) 2004-06-29 2005-06-17 Substituted heteroaryl- and phenylsulfamoyl compounds

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BRPI0512624A true BRPI0512624A (pt) 2008-03-25

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IL180426A0 (en) 2007-06-03
EA200602273A1 (ru) 2007-06-29
AR054665A1 (es) 2007-07-11
AP2007003889A0 (en) 2007-02-28
PA8638001A1 (es) 2006-06-02
TNSN06447A1 (fr) 2008-02-22
MA28703B1 (fr) 2007-06-01
PE20060415A1 (es) 2006-06-02
NL1029360C2 (nl) 2006-07-12
US20050288340A1 (en) 2005-12-29
CA2573193A1 (en) 2006-01-12
GT200500173A (es) 2006-03-02
US20060229363A1 (en) 2006-10-12
ECSP067125A (es) 2007-03-29
SV2006002158A (es) 2006-05-09
MX2007000289A (es) 2007-04-10
TW200611690A (en) 2006-04-16
WO2006003495A1 (en) 2006-01-12
CR8881A (es) 2007-03-19
UY28988A1 (es) 2006-01-31
US20080090829A1 (en) 2008-04-17
JP2008505170A (ja) 2008-02-21
NL1029360A1 (nl) 2005-12-30
KR20070030287A (ko) 2007-03-15
AU2005258906A1 (en) 2006-01-12
CN101287718A (zh) 2008-10-15
NO20070511L (no) 2007-03-22
ZA200610783B (en) 2008-06-25
EP1765796A1 (en) 2007-03-28

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