BRPI0607940A2 - process for the fermentative production of vitamin c, host cell and process for the production of cells - Google Patents
process for the fermentative production of vitamin c, host cell and process for the production of cellsInfo
- Publication number
- BRPI0607940A2 BRPI0607940A2 BRPI0607940-7A BRPI0607940A BRPI0607940A2 BR PI0607940 A2 BRPI0607940 A2 BR PI0607940A2 BR PI0607940 A BRPI0607940 A BR PI0607940A BR PI0607940 A2 BRPI0607940 A2 BR PI0607940A2
- Authority
- BR
- Brazil
- Prior art keywords
- production
- vitamin
- polynucleotides
- relates
- microorganisms
- Prior art date
Links
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title abstract 12
- 238000004519 manufacturing process Methods 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 6
- 229960005070 ascorbic acid Drugs 0.000 title abstract 2
- 238000012262 fermentative production Methods 0.000 title abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 8
- 108091033319 polynucleotide Proteins 0.000 abstract 8
- 239000002157 polynucleotide Substances 0.000 abstract 8
- 244000005700 microbiome Species 0.000 abstract 5
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 abstract 4
- 229930003268 Vitamin C Natural products 0.000 abstract 4
- 239000011718 vitamin C Substances 0.000 abstract 4
- 235000019154 vitamin C Nutrition 0.000 abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 239000002211 L-ascorbic acid Substances 0.000 abstract 1
- 235000000069 L-ascorbic acid Nutrition 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PROCESSO PARA A PRODUçãO FERMENTATIVA DE VITAMINA C, CéLULA HOSPEDEIRA E PROCESSO PARA A PRODUçãO DE CéLULAS. A presente invenção se refere a microorganismos recentemente identificados capazes de produção direta de ácido L-ascórbico (aqui depois também referido como Vitamina C). A invenção também se refere à seqúências de polinucleotídeo compreendendo genes que codificam proteínas as quais estão envolvidas na síntese de Vitamina C. A invenção também se caracteriza por polinucleotideos compreendendo as seqúências de polinucleotídeo de comprimento total dos novos genes e fragmentos das mesmas, novos polipeptídeos codificados por polinucleotídeos e fragmentos dos mesmos bem como seus equivalentes funcionais. A presente invenção também se refere ao uso dos referidos polinucleotideos e polipeptídeos como ferramentas biotecnológicas na produção de Vitamina C a partir de microorganismos, pelo que uma modificação dos referidos polinucleotídeos e/ou polipeptideos codificados tem um impacto direto ou indireto sobre o rendimento, produção e/ou eficácia de produção do produto da fermentação no referido microorganismo. Também incluídos são métodos/processos de uso dos polinucleotídeos e seqúéncias de polinucleotídeo modificadas para transformar microorganismos hospedeiros. A invenção também se refere a microorganismos geneticamente manipulados e seu uso para a produção direta de Vitamina C.PROCESS FOR THE FERMENTATIVE PRODUCTION OF VITAMIN C, HOST CELL AND PROCESS FOR CELL PRODUCTION. The present invention relates to newly identified microorganisms capable of direct production of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also relates to polynucleotide sequences comprising protein-encoding genes which are involved in the synthesis of Vitamin C. The invention is also characterized by polynucleotides comprising full length polynucleotide sequences of novel genes and fragments thereof, new encoded polypeptides by polynucleotides and fragments thereof as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said encoded polynucleotides and / or polypeptides has a direct or indirect impact on yield, production and / or production efficiency of the fermentation product in said microorganism. Also included are methods / methods of using polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for direct production of Vitamin C.
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05405109 | 2005-02-11 | ||
| EP05405090 | 2005-02-11 | ||
| EP05405111 | 2005-02-11 | ||
| EP05405089 | 2005-02-11 | ||
| EP05405110 | 2005-02-11 | ||
| EP05405066 | 2005-02-11 | ||
| EP05405094 | 2005-02-11 | ||
| EP05405170 | 2005-02-11 | ||
| EP05405112 | 2005-02-11 | ||
| PCT/EP2006/001214 WO2006084719A1 (en) | 2005-02-11 | 2006-02-10 | Fermentive vitamin c production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0607940A2 true BRPI0607940A2 (en) | 2009-10-20 |
Family
ID=41180861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0607940-7A BRPI0607940A2 (en) | 2005-02-11 | 2006-02-10 | process for the fermentative production of vitamin c, host cell and process for the production of cells |
Country Status (1)
| Country | Link |
|---|---|
| BR (1) | BRPI0607940A2 (en) |
-
2006
- 2006-02-10 BR BRPI0607940-7A patent/BRPI0607940A2/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according art. 34 industrial property law | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law | ||
| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) | ||
| B06F | Objections, documents and/or translations needed after an examination request according art. 34 industrial property law | ||
| B08F | Application fees: dismissal - article 86 of industrial property law | ||
| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2448 DE 05-12-2017 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |